$582 Cheap Flights from St. Louis (STL) to Tupelo (TUP)

View $582 flight on Mon, Oct 20, 2025Opens in a new window

Popular airlines from St. Louis Lambert Intl. Airport (STL) to Tupelo, MS (TUP-Tupelo Regional)

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Cheap Flights from St. Louis to Tupelo (STL-TUP)

Prices were available within the past 7 days and start at $582 for one-way flights and $380 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

United
Thu, Nov 27 - Tue, Dec 9
STL
St. Louis
TUP
Tupelo
$380 Roundtrip, found 8 hours ago
$380
Roundtrip
found 8 hours ago
Select United flight, departing Thu, Nov 27 from St. Louis to Tupelo, returning Tue, Dec 9, priced at $380 found 8 hours ago
United
Mon, Nov 17 - Tue, Dec 2
STL
St. Louis
TUP
Tupelo
$387 Roundtrip, found 8 hours ago
$387
Roundtrip
found 8 hours ago
Select United flight, departing Mon, Nov 17 from St. Louis to Tupelo, returning Tue, Dec 2, priced at $387 found 8 hours ago
United
Tue, Dec 2 - Sat, Dec 13
STL
St. Louis
TUP
Tupelo
$394 Roundtrip, found 8 hours ago
$394
Roundtrip
found 8 hours ago
Select United flight, departing Tue, Dec 2 from St. Louis to Tupelo, returning Sat, Dec 13, priced at $394 found 8 hours ago
United
Tue, Nov 4 - Tue, Nov 18
STL
St. Louis
TUP
Tupelo
$397 Roundtrip, found 8 hours ago
$397
Roundtrip
found 8 hours ago
Select United flight, departing Tue, Nov 4 from St. Louis to Tupelo, returning Tue, Nov 18, priced at $397 found 8 hours ago
United
Sat, Nov 15 - Tue, Dec 2
STL
St. Louis
TUP
Tupelo
$417 Roundtrip, found 8 hours ago
$417
Roundtrip
found 8 hours ago
Select United flight, departing Sat, Nov 15 from St. Louis to Tupelo, returning Tue, Dec 2, priced at $417 found 8 hours ago
United
Mon, Nov 17 - Fri, Dec 5
STL
St. Louis
TUP
Tupelo
$419 Roundtrip, found 8 hours ago
$419
Roundtrip
found 8 hours ago
Select United flight, departing Mon, Nov 17 from St. Louis to Tupelo, returning Fri, Dec 5, priced at $419 found 8 hours ago
United
Thu, Nov 27 - Mon, Dec 8
STL
St. Louis
TUP
Tupelo
$420 Roundtrip, found 8 hours ago
$420
Roundtrip
found 8 hours ago
Select United flight, departing Thu, Nov 27 from St. Louis to Tupelo, returning Mon, Dec 8, priced at $420 found 8 hours ago
United
Mon, Nov 17 - Tue, Nov 25
STL
St. Louis
TUP
Tupelo
$424 Roundtrip, found 18 hours ago
$424
Roundtrip
found 18 hours ago
Select United flight, departing Mon, Nov 17 from St. Louis to Tupelo, returning Tue, Nov 25, priced at $424 found 18 hours ago
United
Sun, Nov 23 - Sat, Dec 6
STL
St. Louis
TUP
Tupelo
$426 Roundtrip, found 8 hours ago
$426
Roundtrip
found 8 hours ago
Select United flight, departing Sun, Nov 23 from St. Louis to Tupelo, returning Sat, Dec 6, priced at $426 found 8 hours ago
United
Mon, Nov 24 - Mon, Dec 8
STL
St. Louis
TUP
Tupelo
$429 Roundtrip, found 8 hours ago
$429
Roundtrip
found 8 hours ago
Select United flight, departing Mon, Nov 24 from St. Louis to Tupelo, returning Mon, Dec 8, priced at $429 found 8 hours ago
United
Sun, Oct 26 - Tue, Nov 11
STL
St. Louis
TUP
Tupelo
$439 Roundtrip, found 8 hours ago
$439
Roundtrip
found 8 hours ago
Select United flight, departing Sun, Oct 26 from St. Louis to Tupelo, returning Tue, Nov 11, priced at $439 found 8 hours ago
United
Tue, Dec 2 - Sun, Dec 14
STL
St. Louis
TUP
Tupelo
$441 Roundtrip, found 8 hours ago
$441
Roundtrip
found 8 hours ago
Select United flight, departing Tue, Dec 2 from St. Louis to Tupelo, returning Sun, Dec 14, priced at $441 found 8 hours ago

Alternative airports near Tupelo

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Tupelo Regional TUP. Cheapest and Closest option available. Average driving time to city center is 8 minutes. Flights from $491
TUP
Tupelo Regional
CheapestClosest
Average driving time to city center8 min
Flights from $491

Frequently asked questions

How much does a flight from Lambert-St. Louis Intl. Airport (STL) to Tupelo Regional Airport (TUP) cost?
Secure a cheap one-way flight from $582 or cheap return flight from $380 from Lambert-St. Louis Intl. Airport (STL) to Tupelo Regional Airport (TUP) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Lambert-St. Louis Intl. Airport (STL) to Tupelo Regional Airport (TUP)?
The cheapest month to fly from STL to TUP is November, when demand is low. Off-peak months are usually when airlines offer lower prices between these airports.
What is the cheapest airline that flies from Lambert-St. Louis Intl. Airport (STL) to Tupelo Regional Airport (TUP)?
To find the cheapest airline that'll fly you from STL to TUP, use Expedia's filter tool. Customize your search based on your travel style, such as preferred carriers and ideal departure window. You can then sort your results by "Price (lowest to highest)" to see the cheapest flights first.
How many flights per day from Lambert-St. Louis Intl. Airport (STL) to Tupelo Regional Airport (TUP)?
You'll have to book a flight with a layover if you're traveling from Lambert-St. Louis Intl. Airport (STL) to Tupelo Regional Airport (TUP). Direct flights don't operate daily on this route. However, just filter your search to include one or more stops to discover an option that works for you.
What day of the week has the most flights from STL to TUP?
Friday is generally the busiest day for flights, while Tuesday tends to be the quietest.* Keep in mind that flight schedules can vary depending on a range of factors, such as the season and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Lambert-St. Louis Intl. Airport (STL) to Tupelo Regional Airport (TUP)?
To avoid possible delays on the Lambert-St. Louis Intl. Airport (STL) to Tupelo Regional Airport (TUP) route, fly before 3 PM. Flights after this time have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Lambert-St. Louis Intl. Airport (STL) to Tupelo Regional Airport (TUP) last-minute?
Waiting until just before your trip to book a flight from STL to TUP often results in higher prices. While you might find some last-minute discounts, they aren't always guaranteed. Allow some flexibility in your schedule for a better chance of snagging a bargain.
Is it cheaper to book a STL to TUP flight and hotel package?
Securing a STL to TUP flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your travels all in one place. Pick from our wide range of hotels and then add activities, flights and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Lambert-St. Louis Intl. Airport (STL) to Tupelo Regional Airport (TUP)?
Typically, you can cancel or modify your STL to TUP flight. However, there may be additional charges, especially if you booked over 24 hours ago. Check your itinerary for the airline's policies and fees on flight changes, or if you want further information, go to our Customer Service portal.

Travel information

Travel information

Origin airport
Lambert-St. Louis Intl.
Destination airport
Tupelo Regional
Roundtrip price
$380
Distance
321 mi

Book with confidence

Book with confidence

St. Louis to Tupelo Flights

The cheapest times to fly from St. Louis to Tupelo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from St. Louis to Tupelo are during the month of November. You can find some of the cheapest flights from St. Louis to Tupelo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from St. Louis to Tupelo

Sunday is one of the best days to book for cheap flights from St. Louis to Tupelo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from St. Louis to Tupelo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from St. Louis to Tupelo in 2025. You can also book with separate airlines for your outbound and return journeys, from $582 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap St. Louis to Tupelo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your St. Louis to Tupelo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

St. Louis to Tupelo Flights

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