$169 Cheap Flights from Knoxville (TYS) to Islip (ISP)

View $169 flight on Wed, May 6, 2026Opens in a new window

Popular airlines from McGhee Tyson Airport (TYS) to MacArthur Airport (ISP)

Cheap Flights from Knoxville to Islip (TYS-ISP)

Prices were available within the past 7 days and start at $169 for one-way flights and $426 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Southwest Airlines
Mon, Mar 16 - Sat, Mar 21
TYS
Knoxville
ISP
Islip
$426 Roundtrip, found 4 days ago
$426
Roundtrip
found 4 days ago
Select Southwest Airlines flight, departing Mon, Mar 16 from Knoxville to Islip, returning Sat, Mar 21, priced at $426 found 4 days ago
Southwest Airlines
Mon, Mar 16 - Sat, Mar 21
TYS
Knoxville
ISP
Islip
$431 Roundtrip, found 4 days ago
$431
Roundtrip
found 4 days ago
Select Southwest Airlines flight, departing Mon, Mar 16 from Knoxville to Islip, returning Sat, Mar 21, priced at $431 found 4 days ago
Southwest Airlines
Mon, Mar 16 - Sat, Mar 21
TYS
Knoxville
ISP
Islip
$434 Roundtrip, found 4 days ago
$434
Roundtrip
found 4 days ago
Select Southwest Airlines flight, departing Mon, Mar 16 from Knoxville to Islip, returning Sat, Mar 21, priced at $434 found 4 days ago
Southwest Airlines
Fri, Mar 27 - Mon, Mar 30
TYS
Knoxville
ISP
Islip
$439 Roundtrip, found 1 day ago
$439
Roundtrip
found 1 day ago
Select Southwest Airlines flight, departing Fri, Mar 27 from Knoxville to Islip, returning Mon, Mar 30, priced at $439 found 1 day ago
Southwest Airlines
Mon, Mar 16 - Sat, Mar 21
TYS
Knoxville
ISP
Islip
$439 Roundtrip, found 4 days ago
$439
Roundtrip
found 4 days ago
Select Southwest Airlines flight, departing Mon, Mar 16 from Knoxville to Islip, returning Sat, Mar 21, priced at $439 found 4 days ago
Southwest Airlines
Mon, Mar 16 - Sat, Mar 21
TYS
Knoxville
ISP
Islip
$444 Roundtrip, found 4 days ago
$444
Roundtrip
found 4 days ago
Select Southwest Airlines flight, departing Mon, Mar 16 from Knoxville to Islip, returning Sat, Mar 21, priced at $444 found 4 days ago
Southwest Airlines
Fri, Mar 27 - Mon, Mar 30
TYS
Knoxville
ISP
Islip
$447 Roundtrip, found 1 day ago
$447
Roundtrip
found 1 day ago
Select Southwest Airlines flight, departing Fri, Mar 27 from Knoxville to Islip, returning Mon, Mar 30, priced at $447 found 1 day ago
Southwest Airlines
Mon, Mar 16 - Sat, Mar 21
TYS
Knoxville
ISP
Islip
$452 Roundtrip, found 4 days ago
$452
Roundtrip
found 4 days ago
Select Southwest Airlines flight, departing Mon, Mar 16 from Knoxville to Islip, returning Sat, Mar 21, priced at $452 found 4 days ago
Southwest Airlines
Mon, Mar 16 - Sat, Mar 21
TYS
Knoxville
ISP
Islip
$459 Roundtrip, found 4 days ago
$459
Roundtrip
found 4 days ago
Select Southwest Airlines flight, departing Mon, Mar 16 from Knoxville to Islip, returning Sat, Mar 21, priced at $459 found 4 days ago
Southwest Airlines
Mon, Mar 16 - Sat, Mar 21
TYS
Knoxville
ISP
Islip
$464 Roundtrip, found 4 days ago
$464
Roundtrip
found 4 days ago
Select Southwest Airlines flight, departing Mon, Mar 16 from Knoxville to Islip, returning Sat, Mar 21, priced at $464 found 4 days ago

Frequently asked questions

How much does a flight from McGhee Tyson Airport (TYS) to MacArthur Airport (ISP) cost?
Grab a cheap one-way flight from $169 or cheap return flight from $426 from McGhee Tyson Airport (TYS) to MacArthur Airport (ISP) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from McGhee Tyson Airport (TYS) to MacArthur Airport (ISP)?
Planning your getaway for March is a great way to save, as it's the cheapest month for flights between TYS and ISP. You'll often find the lowest fares during off-peak months.
What is the cheapest airline that flies from McGhee Tyson Airport (TYS) to MacArthur Airport (ISP)?
To find the cheapest airline flying from TYS to ISP, use Expedia's filter tool. Customize your search based on your travel needs, such as preferred carriers and number of stops. You can then sort your results by "Price (lowest to highest)" to see the cheapest fares upfront.
How many flights per day from McGhee Tyson Airport (TYS) to MacArthur Airport (ISP)?
Direct flights from McGhee Tyson Airport (TYS) to MacArthur Airport (ISP) aren't available daily, so you'll have to take a flight with a layover. Explore your options with Expedia's filter tool. Enter your travel details and pick either "1 Stop" or "2+ Stops."
What day of the week has the most flights from TYS to ISP?
You'll generally find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can change from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from McGhee Tyson Airport (TYS) to MacArthur Airport (ISP)?
Opt for a flight from McGhee Tyson Airport (TYS) to MacArthur Airport (ISP) that leaves before 3 PM to reduce the risk of delays and cancellations. Later departures have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Islip from McGhee Tyson Airport (TYS)?
If you're flying on a direct flight from McGhee Tyson Airport (TYS) to Islip, LaGuardia Airport (LGA) is the only airport you can land at.
Is it cheaper to buy a plane ticket from McGhee Tyson Airport (TYS) to MacArthur Airport (ISP) last-minute?
Waiting until just before your departure to book your flight from TYS to ISP generally means paying more. Although you may find some last-minute offers, they aren't always guaranteed. Allow some flexibility in your schedule to boost your chances of getting a bargain.
Is it cheaper to book a TYS to ISP flight and hotel package?
Compared with arranging flights and hotels separately, booking a TYS to ISP flight and hotel package with Expedia could lead to significant savings. Better yet, having it all in one place takes the hassle out of planning your trip. Simply pick your flights and select from our extensive range of stays, then tailor your trip with other add-ons like tours, car rentals and activities.
Can I cancel or change the date of my flight from McGhee Tyson Airport (TYS) to MacArthur Airport (ISP)?
If you reserved your TYS to ISP flight in the last 24 hours, you may be able to modify or cancel it without fees. Depending on the airline and the fare type you purchased, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal if you'd like more information.

Travel information

Origin airport
McGhee Tyson
Destination airport
MacArthur
Roundtrip price
$426
Distance
682 mi

Book with confidence

Knoxville to Islip Flights

The cheapest times to fly from Knoxville to Islip

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Knoxville to Islip are during the month of March. You can find some of the cheapest flights from Knoxville to Islip with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Knoxville to Islip

Sunday is one of the best days to book for cheap flights from Knoxville to Islip: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Knoxville to Islip

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Knoxville to Islip in 2025. You can also book with separate airlines for your outbound and return journeys, from $169 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Knoxville to Islip flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Knoxville to Islip airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Knoxville to Islip Flights

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*Available to One Key members.