Cusco Region Luxury Vacations

Book a Luxury Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Top Luxury vacation packages in Cusco Region

Price found within the past 48 hours. Click for updated prices.
Terra Andina Colonial Mansion

Terra Andina Colonial Mansion

Cusco Historic Center
$408
per person
Dec 19 - Dec 26
found 17 hours ago
Roundtrip flight included
Lima (LIM) to Cusco (CUZ)
8.8/10 Excellent! (999 reviews)
Casa Del Sol Machupicchu

Casa Del Sol Machupicchu

$1,011
per person
Dec 11 - Dec 14
found 15 hours ago
Roundtrip non-stop flight included
Miami (MIA) to Cusco (CUZ)
8.8/10 Excellent! (756 reviews)
Inkaterra Machu Picchu Pueblo Hotel

Inkaterra Machu Picchu Pueblo Hotel

$1,265
per person
Dec 11 - Dec 14
found 15 hours ago
Roundtrip non-stop flight included
Miami (MIA) to Cusco (CUZ)
9/10 Wonderful! (234 reviews)
Excelente todo, la comida, el servicio, los chicos k te ayudan con las maletas

Reviewed on Sep 30, 2026

Palacio Nazarenas, A Belmond Hotel, Cusco

Palacio Nazarenas, A Belmond Hotel, Cusco

Cusco Historic Center
Save 100% on your flight
$2,276
per person
Nov 15 - Nov 20
found 3 hours ago
Roundtrip flight included
Lima (LIM) to Cusco (CUZ)
10/10 Exceptional! (94 reviews)
Sumaq Machu Picchu Hotel

Sumaq Machu Picchu Hotel

$1,633
per person
Dec 11 - Dec 14
found 15 hours ago
Roundtrip non-stop flight included
Miami (MIA) to Cusco (CUZ)
9.2/10 Wonderful! (510 reviews)
We can’t say enough about Antonio, he helped us so much. He was always pleasant and willing to give us whatever we needed. We loved all the staff.

Reviewed on Sep 12, 2026

Don't see what you're looking for?
See all available trips from Columbus to Cusco Region
View all trips

5* Luxury vacations in Cusco Region

Price found within the past 48 hours. Click for updated prices.
Sumaq Machu Picchu Hotel

Sumaq Machu Picchu Hotel

$1,633
per person
Dec 11 - Dec 14
found 15 hours ago
Roundtrip non-stop flight included
Miami (MIA) to Cusco (CUZ)
9.2/10 Wonderful! (510 reviews)
We can’t say enough about Antonio, he helped us so much. He was always pleasant and willing to give us whatever we needed. We loved all the staff.

Reviewed on Sep 12, 2026

Palacio Nazarenas, A Belmond Hotel, Cusco

Palacio Nazarenas, A Belmond Hotel, Cusco

Cusco Historic Center
Save 100% on your flight
$2,276
per person
Nov 15 - Nov 20
found 3 hours ago
Roundtrip flight included
Lima (LIM) to Cusco (CUZ)
10/10 Exceptional! (94 reviews)
Sanctuary Lodge, A Belmond Hotel, Machu Picchu

Sanctuary Lodge, A Belmond Hotel, Machu Picchu

$3,659
per person
Dec 11 - Dec 14
found 15 hours ago
Roundtrip non-stop flight included
Miami (MIA) to Cusco (CUZ)
9.2/10 Wonderful! (377 reviews)
What a great group of friendly staff! From arriving at the train station to be met by Ruben who took care of the luggage, got us into the bus and by the time we were up at the hotel our bags were ready for us. Upon arrival we were greeted by Anthony "our shaman". Took care of every detail and gave us a lot of historical information. Have to say everyone from the front desk to the restaurant and bar were excellent and made our (short) stay worth it. Thanks to all!

Reviewed on Sep 15, 2026

Don't see what you're looking for?
See all available trips from Columbus to Cusco Region
View all trips

3 Night Luxury vacations in Cusco Region

Price found within the past 48 hours. Click for updated prices.
Aranwa Cusco Boutique Hotel

Aranwa Cusco Boutique Hotel

Cusco Historic Center
Save 100% on your flight
$415
per person
Nov 26 - Nov 29
found 1 day ago
Roundtrip flight included
Lima (LIM) to Cusco (CUZ)
9.8/10 Exceptional! (625 reviews)
I would recommend this place to anyone... the ambiance is gorgeous, the rooms are lovely, the staff is phenomenal and the location is perfect for being in the center of the historical district.

Reviewed on Sep 26, 2026

Casa Del Sol Machupicchu

Casa Del Sol Machupicchu

$1,011
per person
Dec 11 - Dec 14
found 15 hours ago
Roundtrip non-stop flight included
Miami (MIA) to Cusco (CUZ)
8.8/10 Excellent! (756 reviews)
Inkaterra Machu Picchu Pueblo Hotel

Inkaterra Machu Picchu Pueblo Hotel

$1,265
per person
Dec 11 - Dec 14
found 15 hours ago
Roundtrip non-stop flight included
Miami (MIA) to Cusco (CUZ)
9/10 Wonderful! (234 reviews)
Excelente todo, la comida, el servicio, los chicos k te ayudan con las maletas

Reviewed on Sep 30, 2026

Don't see what you're looking for?
See all available trips from Columbus to Cusco Region
View all trips

4 Night Luxury vacations in Cusco Region

Price found within the past 48 hours. Click for updated prices.
Palacio Manco Capac by Ananay Hotels

Palacio Manco Capac by Ananay Hotels

Cusco Historic Center
$620
per person
Dec 26 - Dec 30
found 21 hours ago
Roundtrip flight included
Lima (LIM) to Cusco (CUZ)
9.6/10 Exceptional! (360 reviews)
Our room was very well maintained. We appreciated Henry's welcome and orientation as well as he helped my wife when she came down with altitude sickness and provided the oxygen tank when she needed it early in the morning. We also liked the complimentary breakfast and our server was very helpful and our extra orders for food was cooked to perfection. Our room was cleaned regularly. The issues we had were that we never received the iron we requested. All other hotels immediately provided an iron for our clothes. Our room was also located across the garden, so if we needed to refill the filtered drinking water, we had to walk across the outdoor garden and past the reception desk and into the next rooms where the water fountain was located. It's fine if it is during the day, but at night it was cold, raining at times and inconvenient. We also did not like the Muna, Cocoa teas and coffee. Which was very surprising since the coffee and Muna tea everywhere we stayed, like Lima and Urubamba and other places in the sacred valley including the small restaurants were excellent. Overall this hotel has great views of Cusco and surrounding Andes. It is on a very steep hill so just be mindful. Thank you.

Reviewed on Sep 22, 2026

Palacio Nazarenas, A Belmond Hotel, Cusco

Palacio Nazarenas, A Belmond Hotel, Cusco

Cusco Historic Center
$2,539
per person
Nov 26 - Nov 30
found 1 day ago
Roundtrip non-stop flight included
Los Angeles (LAX) to Cusco (CUZ)
10/10 Exceptional! (94 reviews)
Casa Del Sol Machupicchu

Casa Del Sol Machupicchu

$1,888
per person
Dec 15 - Dec 19
found 1 day ago
Roundtrip flight included
Sacramento (SMF) to Cusco (CUZ)
8.8/10 Excellent! (756 reviews)
Don't see what you're looking for?
See all available trips from Columbus to Cusco Region
View all trips

All you need to know about luxury vacations in Cusco Region

What can I expect from a luxury Cusco Region vacation?

Luxury means the very finest of the things you enjoy most. Indulge your every waking moment—and restful night—with a luxury Cusco Region vacation. Sip handcrafted cocktails by an infinity pool, sink into bliss at a full-service spa with a massage cabana on the beach, and chat, cheers, and laugh through exquisite breakfasts, lunches, and dinners with spectacular views. 

How can I find all-inclusive luxury vacation packages in Cusco Region?

By refining your filters, the most opulent all-inclusive vacation packages will appear before your eyes. Check the 5* filter to find truly sensational stays. You barely need to lift a finger. 

Can I book a cheap Cusco Region luxury vacation?

Affordable luxury is only ever a few clicks away. Enter your travel dates and sort the grandiose getaways on offer by price to see the most fiscally friendly retreats first. Filter by budget, too, to find your perfect balance of luxury. Right now, luxury vacations start at $408. Prices and availability are subject to change. Additional terms may apply.

How can I book a luxury family vacation in Cusco Region?

Tailor your luxury family escape by checking the filters that set the whole family’s hearts a-flutter. Whether that’s wet and wild water parks, heavenly hot tubs, or the kid-quieting magic of free Wi-Fi. 

Can I book a package in Cusco Region with a luxury vacation home?

A private paradise is true luxury! Filter by property type for houses, villas, and apartments. For an amazingly affordable all-in-one luxury experience, book your accommodation, airfare, and car rental as a package.   

How can I find the best luxury vacation deals in Cusco Region?

Find absolute delight in the dropdown! Simply sort your tempting search results by deals to find that lean-budget luxury. For a budget conscious stay, consider booking a stay away from big cities or outside the peak months.

Can I book a luxury holiday in Cusco Region with free cancellation and/or flexible dates?

Freedom and flexibility are the greatest luxuries of all. Get both when you filter by payment option and book a trip with free cancellation or on a buy now, pay later plan. 

Why should I book my luxury trip to Cusco Region with Expedia?

A luxurious trip follows a stress-free booking experience. Find, build, and book the most glorious of getaways in seconds—with ATOL protection for added peace of mind.

Top Luxury Cusco Region Hotels

Palacio del Inka, A Luxury Collection Hotel by Marriott

Palacio del Inka, A Luxury Collection Hotel by Marriott

Plazoleta Santo Domingo No 259 Cusco Cusco
  • 6 min walk from Plaza de Armas
$386 nightly
$386 total
Oct 30 - Oct 31
Go for a luxurious stay at Palacio del Inka, A Luxury Collection Hotel by Marriott, where you can enjoy amenities like Champagne service, pillowtop beds, and ...
9.6/10 Exceptional! (1,003 reviews)
"Spectacular well run hotel in Cusco. Service was impeccable."

Reviewed on Oct 5, 2026

Palacio del Inka, A Luxury Collection Hotel by Marriott
JW Marriott El Convento Cusco

JW Marriott El Convento Cusco

Esquina De La Calle Ruinas 432 Cusco Cusco
  • 3 min walk from Plaza de Armas
$419 nightly
$419 total
Oct 23 - Oct 24
Treat yourself to some luxurious accommodations at JW Marriott El Convento Cusco, where you can enjoy amenities like memory foam beds, late night room service, ...
JW Marriott El Convento Cusco
Monasterio, A Belmond Hotel, Cusco

Monasterio, A Belmond Hotel, Cusco

Plazoleta Nazarenas 337 Cusco Cusco
  • 3 min walk from Plaza de Armas
$671 nightly
$671 total
Oct 10 - Oct 11
Stay in the lap of luxury at Monasterio, A Belmond Hotel, Cusco, where you can enjoy amenities like 24-hour room service, plush bedding, and more. Deluxe amenities ...
Monasterio, A Belmond Hotel, Cusco
See all 2,448 properties in Cusco Region
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Things to do

Cusco: #1 Rainbow Mountain & Red Valley Day Trip with Meals

Cusco: #1 Rainbow Mountain & Red Valley Day Trip with Meals

$19
per adult
100% of travellers recommend
Cusco: #1 Rainbow Mountain & Red Valley Day Trip with Meals
Cusco: Half-Day City Tour with Sacsayhuaman and Q'enco

Cusco: Half-Day City Tour with Sacsayhuaman and Q'enco

$14
per adult
100% of travellers recommend
Cusco: Half-Day City Tour with Sacsayhuaman and Q'enco
Picture 7 for Activity From Cusco: Excursion to Humantay lake from Cusco

Cusco: Humantay Lake Tour with Breakfast and Buffet Lunch

$21
per adult
100% of travellers recommend
Cusco: Humantay Lake Tour with Breakfast and Buffet Lunch
See all activities in Cusco Region

More vacations you might like

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.