Title: The Best 2 Star Hotels in Depew, NY from $50 | Expedia.com [Depew Travel Guide](https://expedia.com/Depew.dx6338362)[Hotels in Depew](https://expedia.com/Depew-Hotels.d6338362.Travel-Guide-Hotels)[Vacation Rentals in Depew](https://expedia.com/Depew-Vacation-Rentals.d6338362.Travel-Guide-VacationRentals)[Flights to Depew](https://expedia.com/Cheap-Flights-To-Depew.d6338362.Travel-Guide-Flights)[Things to do in Depew](https://expedia.com/Things-To-Do-In-Depew.d6338362.Travel-Guide-Activities)[Car Rentals in Depew](https://expedia.com/Car-Rentals-In-Depew.d6338362.Car-Rental-Guide)[Depew Vacation Packages](https://expedia.com/Depew.d6338362.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Depew 2 Star Hotels Tonight [Mar 13 - Mar 14](https://www.expedia.com/Hotel-Search?regionId=6338362&startDate=2026-03-13&endDate=2026-03-14&adults=2&star=20&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 14 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=6338362&startDate=2026-03-14&endDate=2026-03-15&adults=2&star=20&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=6338362&startDate=2026-03-13&endDate=2026-03-15&adults=2&star=20&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 20 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=6338362&startDate=2026-03-20&endDate=2026-03-22&adults=2&star=20&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Depew 2-star hotels ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/980000/973800/973773/ee46454f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/980000/973800/973773/1edd14d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/980000/973800/973773/328c49a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/980000/973800/973773/95428045.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites Buffalo-Airport by IHG [](https://www.expedia.com/Buffalo-Hotels-Holiday-Inn-Express-Hotel-Suites-Buffalo-Airport.h973773.Hotel-Information) Buffalo 8.2/10 Very Good (1,002 reviews) "Loved the close proximity to the airport and the shuttle!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ann $110 nightly $125 total Apr 5 - Apr 6 Total with taxes and fees [](https://www.expedia.com/Buffalo-Hotels-Holiday-Inn-Express-Hotel-Suites-Buffalo-Airport.h973773.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/10000/6300/6258/f9a47442.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/10000/6300/6258/a56cf142.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/10000/6300/6258/a928a880.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/10000/6300/6258/b2330a35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG [](https://www.expedia.com/Buffalo-Hotels-Holiday-Inn-Express-Suites-Buffalo-Downtown-Medical-CTR.h6258.Hotel-Information) Downtown Buffalo 8.6/10 Excellent (1,001 reviews) "Easy and safe area to walk around." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Robert $104 nightly $121 total Apr 5 - Apr 6 Total with taxes and fees [](https://www.expedia.com/Buffalo-Hotels-Holiday-Inn-Express-Suites-Buffalo-Downtown-Medical-CTR.h6258.Hotel-Information) ![Suite, 1 King Bed with Sofa bed, Non Smoking | Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/90000/85100/85007/9d03cce3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/90000/85100/85007/ae021a7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/90000/85100/85007/77375700.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, Non Smoking (2 Double Beds & Sofa Bed) | Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/90000/85100/85007/278a83c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sleep Inn & Suites Buffalo Airport [](https://www.expedia.com/Buffalo-Hotels-Sleep-Inn-Suites-Buffalo-Airport.h85007.Hotel-Information) Buffalo 8.0/10 Very Good (2,010 reviews) "Nice hotel" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Nilanjan $73 nightly $83 total Apr 5 - Apr 6 Total with taxes and fees [](https://www.expedia.com/Buffalo-Hotels-Sleep-Inn-Suites-Buffalo-Airport.h85007.Hotel-Information) ![Rooftop terrace](https://images.trvl-media.com/lodging/19000000/18570000/18567300/18567279/3274a349.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed | Premium bedding, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/19000000/18570000/18567300/18567279/a305e7d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/19000000/18570000/18567300/18567279/ea0d463b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/19000000/18570000/18567300/18567279/2685a465.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Grand Island - Niagara Falls by IHG [](https://www.expedia.com/Niagara-Falls-Hotels-Holiday-Inn-Express-Grand-Island-Niagara-Falls.h18567279.Hotel-Information) Grand Island 9.0/10 Wonderful (1,712 reviews) "Large rooms, great breakfast, very friendly staff, location was great " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Diane $82 nightly $94 total Mar 22 - Mar 23 Total with taxes and fees [](https://www.expedia.com/Niagara-Falls-Hotels-Holiday-Inn-Express-Grand-Island-Niagara-Falls.h18567279.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/9000000/8140000/8130600/8130557/d64d0a69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/9000000/8140000/8130600/8130557/4a83a7cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed | Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/9000000/8140000/8130600/8130557/327eb062.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/9000000/8140000/8130600/8130557/2df8aedb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Cheektowaga North East by IHG [](https://www.expedia.com/Buffalo-Hotels-Holiday-Inn-Express-Cheektowaga-North-East.h8130557.Hotel-Information) Buffalo 8.4/10 Very Good (1,275 reviews) "Rooms were clean and well kept. Breakfast had a nice variety and staff were very pleasant." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) sharon $119 nightly $135 total Apr 5 - Apr 6 Total with taxes and fees [](https://www.expedia.com/Buffalo-Hotels-Holiday-Inn-Express-Cheektowaga-North-East.h8130557.Hotel-Information) ![Deluxe Room, 2 Double Beds (Smoke Free) | 1 bedroom, desk, blackout drapes, free WiFi](https://images.trvl-media.com/lodging/1000000/10000/900/816/dec8cb3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, blackout drapes, free WiFi](https://images.trvl-media.com/lodging/1000000/10000/900/816/d1c4663a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/900/816/760d0b9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/900/816/b68133b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Red Roof Inn Buffalo - Niagara Airport [](https://www.expedia.com/Buffalo-Hotels-Red-Roof-Inn-Buffalo-Niagara-Airport.h816.Hotel-Information) Bowmansville 7.2/10 Good (1,000 reviews) "Parking was easy. Room was clean." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gary $54 nightly $61 total Mar 17 - Mar 18 Total with taxes and fees [](https://www.expedia.com/Buffalo-Hotels-Red-Roof-Inn-Buffalo-Niagara-Airport.h816.Hotel-Information) ![Blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/10000/2200/2196/e531e69e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/2200/2196/a1859ccd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Laundry room](https://images.trvl-media.com/lodging/1000000/10000/2200/2196/7c123407.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/2200/2196/w2990h2005x0y16-ce4bee0a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairbridge Inn Express Buffalo Airport Williamsville [](https://www.expedia.com/Buffalo-Hotels-FairBridge-Inn-Express-Buffalo-Airport-Williamsville.h2196.Hotel-Information) Buffalo 4.6/10 (1,013 reviews) "the place is dirty" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Klen $49 nightly $56 total Mar 22 - Mar 23 Total with taxes and fees [](https://www.expedia.com/Buffalo-Hotels-FairBridge-Inn-Express-Buffalo-Airport-Williamsville.h2196.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/70000/66600/66581/2db1a2f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/70000/66600/66581/a57eee4e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/70000/66600/66581/764d9cbe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/70000/66600/66581/1f31d14d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn University [](https://www.expedia.com/Buffalo-Hotels-Comfort-Inn-University.h66581.Hotel-Information) Buffalo 8.2/10 Very Good (1,261 reviews) "Clean comfortable good breakfast and reasonable price." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tracy $85 nightly $96 total Mar 15 - Mar 16 Total with taxes and fees [](https://www.expedia.com/Buffalo-Hotels-Comfort-Inn-University.h66581.Hotel-Information) ![Individually furnished, blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/20000/18300/18259/32fdc4c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18300/18259/33c94b3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/18300/18259/be5e54fa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18300/18259/5eeb423c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Buffalo, NY - Airport - Williamsville [](https://www.expedia.com/Buffalo-Hotels-Motel-6-Buffalo.h18259.Hotel-Information) Buffalo 6.2/10 (1,237 reviews) "Clean rooms great staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Julian $44 nightly $50 total Apr 5 - Apr 6 Total with taxes and fees [](https://www.expedia.com/Buffalo-Hotels-Motel-6-Buffalo.h18259.Hotel-Information) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/560000/558600/558591/139ee991.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/560000/558600/558591/a196e14b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 6:30 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/560000/558600/558591/b33f35a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business center](https://images.trvl-media.com/lodging/1000000/560000/558600/558591/295249d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Near Walden Galleria Mall [](https://www.expedia.com/Buffalo-Hotels-Quality-Inn-Near-Walden-Galleria-Mall.h558591.Hotel-Information) Buffalo 8.0/10 Very Good (1,001 reviews) "Good location for our visit for a concert at Keybank. Room was clean, bed was comfortable." ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Melissa $84 nightly $96 total Apr 2 - Apr 3 Total with taxes and fees [](https://www.expedia.com/Buffalo-Hotels-Quality-Inn-Near-Walden-Galleria-Mall.h558591.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/10000/5200/5183/46db5598.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/10000/5200/5183/73648063.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/5200/5183/1726aaa7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Accessible, Refrigerator | Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/10000/5200/5183/285a6583.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Summit Inn [](https://www.expedia.com/Niagara-Falls-Hotels-Best-Western-Summit-Inn.h5183.Hotel-Information) Niagara Falls 8.6/10 Excellent (1,439 reviews) "Good for family " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mirnes $72 nightly $82 total Mar 15 - Mar 16 Total with taxes and fees [](https://www.expedia.com/Niagara-Falls-Hotels-Best-Western-Summit-Inn.h5183.Hotel-Information) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/51000000/50710000/50706500/50706489/47e39417.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/51000000/50710000/50706500/50706489/e4b647bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 9:00 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/51000000/50710000/50706500/50706489/83cfb229.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/51000000/50710000/50706500/50706489/bdc29a88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Buffalo - Amherst, NY [](https://www.expedia.com/Buffalo-Hotels-Hampton-Inn-Buffalo-Amherst.h50706489.Hotel-Information) Buffalo 9.4/10 Exceptional (1,997 reviews) "I was very happy with my stay, staff were accommodating and breakfast was good." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brendan $107 nightly $121 total Mar 29 - Mar 30 Total with taxes and fees [](https://www.expedia.com/Buffalo-Hotels-Hampton-Inn-Buffalo-Amherst.h50706489.Hotel-Information) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/30000/23200/23120/2bb1d8bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/23200/23120/3e56ff70.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/30000/23200/23120/3e600969.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking, Kitchenette (with Sofabed) | Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/30000/23200/23120/5d80963b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Galleria Inn & Suites [](https://www.expedia.com/Buffalo-Hotels-Best-Western-Plus-Galleria-Inn-Suites.h23120.Hotel-Information) Buffalo 6.6/10 (1,002 reviews) "Clean room nice bathroom nice bed spacious" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kenji $80 nightly $91 total Mar 15 - Mar 16 Total with taxes and fees [](https://www.expedia.com/Buffalo-Hotels-Best-Western-Plus-Galleria-Inn-Suites.h23120.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/3000000/2610000/2602900/2602862/96d94ac5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/3000000/2610000/2602900/2602862/7076cfa9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/3000000/2610000/2602900/2602862/e7e23415.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2610000/2602900/2602862/0e90b800.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Candlewood Suites Buffalo - Amherst by IHG [](https://www.expedia.com/Buffalo-Hotels-Candlewood-Suites-Buffalo-Amherst.h2602862.Hotel-Information) Buffalo 8.6/10 Excellent (975 reviews) "Nice dinette and clean. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lauren $107 nightly $122 total Mar 22 - Mar 23 Total with taxes and fees [](https://www.expedia.com/Buffalo-Hotels-Candlewood-Suites-Buffalo-Amherst.h2602862.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/12000000/11570000/11567700/11567601/19142b97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/12000000/11570000/11567700/11567601/b8f80038.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed with Sofa bed | Desk, laptop workspace, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/12000000/11570000/11567700/11567601/dd2ec4e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/12000000/11570000/11567700/11567601/11075ee5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Springhill Suites Buffalo Airport [](https://www.expedia.com/Buffalo-Hotels-Springhill-Suites-Buffalo-Airport.h11567601.Hotel-Information) Buffalo 9.0/10 Wonderful (847 reviews) "room was clean and breakfast was great" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Jacob $121 nightly $138 total Mar 23 - Mar 24 Total with taxes and fees [](https://www.expedia.com/Buffalo-Hotels-Springhill-Suites-Buffalo-Airport.h11567601.Hotel-Information) ![Suite, 1 King Bed, Non Smoking, Jetted Tub | Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/7000000/6790000/6785900/6785857/ed7545be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/7000000/6790000/6785900/6785857/9d77ced9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/7000000/6790000/6785900/6785857/ce122a7c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast](https://images.trvl-media.com/lodging/7000000/6790000/6785900/6785857/ff355930.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western on the Avenue [](https://www.expedia.com/Buffalo-Hotels-Best-Western-On-The-Avenue.h6785857.Hotel-Information) Downtown Buffalo 8.6/10 Excellent (1,001 reviews) "Very helpful staff, clean rooms and breakfast was second to none" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Brent $127 nightly $149 total Mar 22 - Mar 23 Total with taxes and fees [](https://www.expedia.com/Buffalo-Hotels-Best-Western-On-The-Avenue.h6785857.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/540000/532900/532803/a3f43f95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking | In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/540000/532900/532803/fabc5866.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/540000/532900/532803/f135dcfd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/540000/532900/532803/84b2e870.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Hamburg - Buffalo South [](https://www.expedia.com/Buffalo-Hotels-Comfort-Inn-And-Suites-Hamburg.h532803.Hotel-Information) Hamburg 7.2/10 Good (1,002 reviews) "It was great, great staff, loved it." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Becky $95 nightly $108 total Apr 5 - Apr 6 Total with taxes and fees [](https://www.expedia.com/Buffalo-Hotels-Comfort-Inn-And-Suites-Hamburg.h532803.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/3000000/2520000/2511100/2511057/483ccd5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, Accessible, Non Smoking (2 Bed, Mobility Tub) | In-room safe, individually furnished, desk, laptop workspace](https://images.trvl-media.com/lodging/3000000/2520000/2511100/2511057/bfe6e5d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/3000000/2520000/2511100/2511057/6c1a30bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2520000/2511100/2511057/w5757h3838x0y0-87d5f77b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites Hamburg by IHG [](https://www.expedia.com/Buffalo-Hotels-Holiday-Inn-Express-Hotel-Suites-Hamburg.h2511057.Hotel-Information) Hamburg 8.8/10 Excellent (1,001 reviews) "Staff was friendly and courteous at all levels. Breakfast was well stocked and common areas kept neat and tidy. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ange $112 nightly $127 total Apr 5 - Apr 6 Total with taxes and fees [](https://www.expedia.com/Buffalo-Hotels-Holiday-Inn-Express-Hotel-Suites-Hamburg.h2511057.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/130000/126900/126836/a429a676.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/130000/126900/126836/dbce5670.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/130000/126900/126836/6c12c2ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/130000/126900/126836/08466402.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sleep Inn Amherst - Buffalo North near University [](https://www.expedia.com/Buffalo-Hotels-Sleep-Inn.h126836.Hotel-Information) Buffalo 8.8/10 Excellent (1,146 reviews) "Clean rooms and nice pool Staff is very 👍 " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) allyson $92 nightly $105 total Apr 12 - Apr 13 Total with taxes and fees [](https://www.expedia.com/Buffalo-Hotels-Sleep-Inn.h126836.Hotel-Information) ![BBQ/picnic area](https://images.trvl-media.com/lodging/22000000/21330000/21330000/21329922/9b6ff48b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Accessible, Bathtub (Hearing) | Blackout drapes, iron/ironing board, free cribs/infant beds, free WiFi](https://images.trvl-media.com/lodging/22000000/21330000/21330000/21329922/41e7c029.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/22000000/21330000/21330000/21329922/08bebab4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/22000000/21330000/21330000/21329922/1899cc3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru by Hilton Williamsville Buffalo Airport [](https://www.expedia.com/Buffalo-Hotels-Tru-By-Hilton-Williamsville-Buffalo-Airport.h21329922.Hotel-Information) Buffalo 8.8/10 Excellent (1,002 reviews) "Clean and a nice stay. " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Alide $106 nightly $120 total Mar 22 - Mar 23 Total with taxes and fees [](https://www.expedia.com/Buffalo-Hotels-Tru-By-Hilton-Williamsville-Buffalo-Airport.h21329922.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F2Star-Depew-Hotels.s20-0-d6338362.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F2Star-Depew-Hotels.s20-0-d6338362.Travel-Guide-Filter-Hotels) ## Explore similar 3-star hotels Many 3-star hotels have the same amenities as 2-star hotels. See all 3-star hotels in Depew. ![Buffalo Airport Hotel](https://images.trvl-media.com/lodging/1000000/30000/26100/26001/19bd0f50_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Buffalo Airport Hotel 4600 Genesee St Buffalo NY $95 nightly $108 total Mar 29 - Mar 30 Total with taxes and fees 8/10 Very Good! (2,906 reviews) [](https://expedia.com/Buffalo-Hotels-Buffalo-Airport-Hotel.h26001.Hotel-Information) ![M Hotel Buffalo](https://images.trvl-media.com/lodging/1000000/20000/11300/11231/2c4d5593_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### M Hotel Buffalo 2040 Walden Ave Buffalo NY $84 nightly $96 total Mar 29 - Mar 30 Total with taxes and fees 7.4/10 Good! (2,666 reviews) [](https://expedia.com/Buffalo-Hotels-Millennium-Buffalo.h11231.Hotel-Information) ![Garden Place Hotel](https://images.trvl-media.com/lodging/2000000/1070000/1060800/1060721/40afc3e4_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Garden Place Hotel 6615 Transit Road Buffalo NY $95 nightly $108 total Apr 12 - Apr 13 Total with taxes and fees 7.8/10 Good! (2,316 reviews) [](https://expedia.com/Buffalo-Hotels-Garden-Place-Hotel.h1060721.Hotel-Information) Still don't see what you're looking for? [See all properties in Depew.](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F15%2F2026&endDate=3%2F16%2F2026®ionId=6338362&star=20) You can also use these popular filters to refine your search. [Pool](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F15%2F2026&endDate=3%2F16%2F2026®ionId=6338362&star=20&star=20&amenities=POOL)[Spa](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F15%2F2026&endDate=3%2F16%2F2026®ionId=6338362&star=20&star=20&amenities=SPA_ON_SITE)[Hot tub](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F15%2F2026&endDate=3%2F16%2F2026®ionId=6338362&star=20&star=20&amenities=HOT_TUB)[Breakfast included](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F15%2F2026&endDate=3%2F16%2F2026®ionId=6338362&star=20&star=20&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F15%2F2026&endDate=3%2F16%2F2026®ionId=6338362&star=20&star=20&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Top Depew Hotel Reviews ## Find out more about Depew When you've got to get away to a new or favorite destination without breaking the bank, Depew awaits with top 2 Star hotels and a change of scenery. Discover a new favorite coffee shop or hiking trail nearby and relax, or stay on your feet visiting the top attractions that draw of visitors. You're about to find out why locals and travelers alike love this place. ### The Right Place at the Ideal Price Thanks to several convenient locations and comfortable amenities, you'll find 2 Star Hotel that suits your vacation style. Stay here and be one of the first guests to leave a review and share your thoughts. So, savor the comfort of a well-kept room and attentive hospitality. With our travel deals, the world is wide open to you one hotel at a time, and the jet-setting starts in Depew. ### Book a Stay in a 2-Star Hotel Today Plan your trip to Depew now with Expedia's easy online travel booking and start relaxing before you even leave the house. If you need a break from the crowds, you may find that this region offers just the reprieve you've been looking for. Take advantage of the 2 Star Hotel availability and easy-going atmosphere. ## Frequently asked questions ### How much does it cost to stay in a 2-star hotel in Depew? ### What is the difference between a 2-star Depew hotel and a 3-star hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - Other - [Hotels near Reinstein Woods Nature Preserve and Environmental Education Center ](https://www.expedia.com/Reinstein-Woods-Nature-Preserve-And-Environmental-Education-Center-Hotels.0-l553248621561173660-0.Travel-Guide-Filter-Hotels) - [Hotels near Buffalo-Depew Station ](https://www.expedia.com/Buffalo-Depew-Station-Hotels.d6194293.Travel-Guide-Hotels) - [Hotels near Buffalo Niagara Intl. ](https://www.expedia.com/Buffalo-Niagara-Intl-Airport-Hotels.0-aBUF-0.Travel-Guide-Filter-Hotels) - [Hotels near Stiglmeier Park ](https://www.expedia.com/Stiglmeier-Park-Hotels.0-l553248621558133903-0.Travel-Guide-Filter-Hotels) - [Hotels near Lancaster Opera House ](https://www.expedia.com/Lancaster-Opera-House-Hotels.0-l553248621532664862-0.Travel-Guide-Filter-Hotels) - 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