A historic church with two towers, surrounded by a plaza with palm trees and a white building with a red roof.

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Our top choices for La Guardia 4-star hotels

1. TRYP by Wyndham Santa Cruz

TRYP by Wyndham Santa Cruz
4.0 star property
Equipetrol
9.2 out of 10, Wonderful, (185 reviews)
"Beautiful hotel. Spacious room. House cleaning came every day. We got new towels every day and toiletries in the bathroom were refilled every day. Staff were friendly. View from the breakfast room was beautiful. Location of the hotel is good."
Canada
Kristina
$99 nightly
The price is $99
Nov 8 - Nov 9
TRYP by Wyndham Santa Cruz

2. Camino Real Hotel

Camino Real Hotel
4.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (456 reviews)
"The food is excellent quality and delicious! Friendly staff"
United States
Wendy
$122 nightly
The price is $122
Dec 6 - Dec 7
Camino Real Hotel

3. Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
4.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (290 reviews)
"The room was very clean and the breakfast was fantastic. Overall it was a great experience."
United States
Scott
$74 nightly
The price is $74
Nov 13 - Nov 14
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

4. Hotel Maywa

Hotel Maywa
4.0 star property
Santa Cruz
9.2 out of 10, Wonderful, (10 reviews)
"The structure and service was fantastic"
United States
Alex
$41 nightly
The price is $41
Nov 8 - Nov 9
Hotel Maywa

5. Swissôtel Santa Cruz De La Sierra

Swissôtel Santa Cruz De La Sierra
4.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (91 reviews)
"Great room, spacious, quiet and the shower was great"
United States
GONZALO
$131 nightly
The price is $131
Nov 27 - Nov 28
Swissôtel Santa Cruz De La Sierra

6. Gran Hotel Santa Cruz

Gran Hotel Santa Cruz
4.5 star property
Centro Histórico
$56 nightly
The price is $56
Nov 8 - Nov 9
Gran Hotel Santa Cruz

7. Buganvillas Hotel Suites & Spa

Buganvillas Hotel Suites & Spa
4.0 star property
Santa Cruz
7.4 out of 10, Good, (93 reviews)
"The correct description would be that it is a Air & B without a Stowe/owen/kitchen supplies but with a refrigerator. What they claim at the web page IS NOT correct. The pool is correct and there is a restaurant, a one man show. We were the only ones at breakfast, one day no one was even there. A scam. Majority are residents in this complex. The ladies at the receptions was sweet though and did their best. "
Sweden
Charlotte
Buganvillas Hotel Suites & Spa

8. Royal Lodge Hotel

Royal Lodge Hotel
4.5 star property
Santa Cruz
6.4 out of 10, (29 reviews)
"Esta cerrado, ya no deberia dejar reservar, se nota q tiene tiempo fuera de servicio."
Argentina
Anonymous traveler
Royal Lodge Hotel
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Learn more about La Guardia

Explore the lush Guembe Biocenter where butterflies dance through tropical gardens and exotic birds call from the canopy. Sports fans can catch local soccer matches at Ramon Tahuichi Aguilera Stadium, then head to nearby Ventura Mall for shopping and dining.

A church with a bell tower and a large tree in front.

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La Guardia Four Star Hotel Information

When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in La Guardia, Santa Cruz are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the La Guardia 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service.

Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in La Guardia. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in La Guardia, Santa Cruz, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop.

Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star La Guardia hotels offer everything your heart desires.

Frequently asked questions

How much does it cost to stay in a 4-star hotel in La Guardia?
With Expedia's handy filter tool, bagging a fabulous deal on a 4-star hotel in La Guardia just got simpler. Start by entering your chosen arrival date and length of your vacation. Then sort the results by price and pick a hotel that best matches your budget and style.

  • Search for the lowest price from $113

What's the difference between 5-star and 4-star hotels in La Guardia?
If you choose to vacation at a 4-star hotel in La Guardia, you'll usually find loads of conveniences to ensure you're relaxed, such as a restaurant, pool and gym. You can look forward to excellent service and upmarket accommodations. Pick a 5-star hotel and you'll get a few extra bells and whistles — think on-site spas, 24-hour front desk and nightly turndown services. You'll most likely get additional amenities and first-class services at a 5-star getaway, though both are fabulous options for luxury guests.
Does La Guardia have any 4-star all-inclusive resorts?
Enjoy a stress-free vacation experience where just about everything is included in the one upfront rate by using our "All inclusive" filter. Keeping to your budget is simple when your meals, accommodations and activities are already taken care of. Want more options? Browse the amazing offers on our standard 4-star hotels in and around La Guardia.

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