Title: Visit Santa Cruz: 2026 Travel Guide for Santa Cruz, Bolivia | Expedia.com

[Santa Cruz Hotels](https://expedia.com/Destinations-In-Santa-Cruz.d6297178.Hotel-Destinations)[Vacation Rentals in Santa Cruz](https://expedia.com/Destinations-In-Santa-Cruz.d6297178.Vacation-Rental-Destinations)[Santa Cruz Flights](https://expedia.com/Destinations-In-Santa-Cruz.d6297178.Flight-Destinations)[Things to do in Santa Cruz](https://expedia.com/Things-To-Do-In-Santa-Cruz.d6297178.Travel-Guide-Activities)[Car Rentals in Santa Cruz](https://expedia.com/Destinations-In-Santa-Cruz.d6297178.Car-Rental-Destinations)[Santa Cruz Vacations](https://expedia.com/Santa-Cruz.d6297178.Destination-Travel-Guides)

# Santa Cruz

## Bolivia

![Lake Titicaca which includes general coastal views and a park](https://images.trvl-media.com/place/6053553/c22e3c92-bd89-4998-8279-debb63bcb80e.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh)

![Lake Titicaca which includes general coastal views and a park](https://images.trvl-media.com/place/6053553/c22e3c92-bd89-4998-8279-debb63bcb80e.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh)

![Lake Titicaca showing general coastal views](https://images.trvl-media.com/place/6053553/d30003cf-36bf-47c4-a856-8f27b62f9d97.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh)

![San Lorenzo Cathedral showing heritage elements, a church or cathedral and heritage architecture](https://images.trvl-media.com/place/6098830/2e73ba4d-fa61-44c6-a724-28b25c241f10.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh)

![Strait of Tiquina showing a bay or harbor and a lake or waterhole](https://images.trvl-media.com/place/553248635175056644/70715e48-f239-409a-b288-1f4960b90c59.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh)

### Popular cities in Santa Cruz

[Santa Cruz

Known for Shopping, Cathedrals and Excursions

](https://expedia.com/Santa-Cruz.dx6053940)

Experience Bolivia as the locals see it in the country’s busiest city, where the museums, public squares and churches give you a glimpse into their everyday lives.

## Reasons to visit

- Plaza 24 de Septiembre
- San Lorenzo Cathedral

[Explore City](https://expedia.com/Santa-Cruz.dx6053940)[Find Hotels](https://expedia.com/Santa-Cruz-Hotels.d6053940.Travel-Guide-Hotels)

[Samaipata

Known for Hiking, Mountains and Forests

](https://expedia.com/Samaipata.dx6200976)

Come to Samaipata and enjoy its hiking, mountain views, and UNESCO site. 

[Explore City](https://expedia.com/Samaipata.dx6200976)[Find Hotels](https://expedia.com/Samaipata-Hotels.d6200976.Travel-Guide-Hotels)

[Warnes

](https://expedia.com/Warnes.dx6352296)

Venture to sights like Warnes Plaza as you discover the local area in Warnes.

[Explore City](https://expedia.com/Warnes.dx6352296)[Find Hotels](https://expedia.com/Warnes-Hotels.d6352296.Travel-Guide-Hotels)

[Montero

](https://expedia.com/Montero.dx553248635975872931)

Check out Warnes Plaza—just one of the sights to explore around Montero.

[Explore City](https://expedia.com/Montero.dx553248635975872931)[Find Hotels](https://expedia.com/Montero-Hotels.d553248635975872931.Travel-Guide-Hotels)

[San Jose de Chiquitos

Known for Sunny, Culture and Forests

](https://expedia.com/San-Jose-De-Chiquitos.dx6344854)

San Jose de Chiquitos awaits: its sunny weather, culture, churches, and more! 

[Explore City](https://expedia.com/San-Jose-De-Chiquitos.dx6344854)[Find Hotels](https://expedia.com/San-Jose-De-Chiquitos-Hotels.d6344854.Travel-Guide-Hotels)

[Cuevas

Known for Natural parks

](https://expedia.com/Cuevas.dx6350209)

Explore Cuevas: its parks and more! 

[Explore City](https://expedia.com/Cuevas.dx6350209)[Find Hotels](https://expedia.com/Cuevas-Hotels.d6350209.Travel-Guide-Hotels)

## Cities in Santa Cruz

![San Lorenzo Cathedral showing a garden](https://images.trvl-media.com/place/6098830/62a42b3d-1dbd-4a81-8566-cea655ebca33.jpg?impolicy=fcrop&w=512&h=288&q=medium)

### Santa Cruz

Experience Bolivia as the locals see it in the country’s busiest city, where the museums, public squares and churches give you a glimpse into their everyday lives.

![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh)

## 

The Annual Vacation Sale

Members save up to 40% on hotels and homes. Plan this year’s big trip and save.

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## Explore a world of travel with Expedia

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- [Hotels near Plaza 24 de Septiembre ](https://www.expedia.com/Plaza-24-De-Septiembre-Hotels.0-l6098828-0.Travel-Guide-Filter-Hotels)
- [Santa Cruz Hotels ](https://www.expedia.com/Santa-Cruz-Hotels.d6053940.Travel-Guide-Hotels)
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- [Cheap Hotels in Santa Cruz ](https://www.expedia.com/Santa-Cruz-Hotels-Cheap-Hotels.0-0-d6053940-tCheapHotels.Travel-Guide-Filter-Hotels)
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- [Flights to Santa Cruz ](https://www.expedia.com/Cheap-Flights-To-Santa-Cruz.d6053940.Travel-Guide-Flights)

- [Visit Santa Cruz ](https://www.expedia.com/Santa-Cruz.dx6053940)
- [San Lorenzo Cathedral ](https://www.expedia.com/San-Lorenzo-Cathedral-Santa-Cruz.d6098830.Vacation-Attraction)
- [Plaza 24 de Septiembre ](https://www.expedia.com/Plaza-24-De-Septiembre-Santa-Cruz.d6098828.Vacation-Attraction)
- [Franco Aleman Cultural Center ](https://www.expedia.com/Franco-Aleman-Cultural-Center-Santa-Cruz.d553248621532371069.Vacation-Attraction)
- [Sacred Art Museum ](https://www.expedia.com/Sacred-Art-Museum-Santa-Cruz.d553248621563217782.Vacation-Attraction)
- [La Recova Artisan Walk ](https://www.expedia.com/La-Recova-Artisan-Walk-Santa-Cruz.d553248621532371683.Vacation-Attraction)
- [Santa Cruz Vacations ](https://www.expedia.com/Santa-Cruz.d6053940.Destination-Travel-Guides)

- [Car rentals near Santa Cruz ](https://www.expedia.com/Car-Rentals-In-Santa-Cruz.d6053940.Car-Rental-Guide)
- [Enterprise Rental Cars in Santa Cruz ](https://www.expedia.com/Enterprise-Car-Rentals-In-Santa-Cruz.d6053940-c15.Car-Rental-Guide-Suppliers)
- [Europcar Rental Cars in Santa Cruz ](https://www.expedia.com/Europcar-Car-Rentals-In-Santa-Cruz.d6053940-c14.Car-Rental-Guide-Suppliers)
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- [Ace Rental Cars in Santa Cruz ](https://www.expedia.com/Ace-Car-Rentals-In-Santa-Cruz.d6053940-c2.Car-Rental-Guide-Suppliers)
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- [Santa Cruz Vacation Rentals ](https://www.expedia.com/Santa-Cruz-Vacation-Rentals.d6053940.Travel-Guide-VacationRentals)

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