Title: Visit Santa Cruz: 2026 Travel Guide for Santa Cruz, Bolivia | Expedia.com [Santa Cruz Hotels](https://expedia.com/Destinations-In-Santa-Cruz.d6297178.Hotel-Destinations)[Vacation Rentals in Santa Cruz](https://expedia.com/Destinations-In-Santa-Cruz.d6297178.Vacation-Rental-Destinations)[Santa Cruz Flights](https://expedia.com/Destinations-In-Santa-Cruz.d6297178.Flight-Destinations)[Things to do in Santa Cruz](https://expedia.com/Things-To-Do-In-Santa-Cruz.d6297178.Travel-Guide-Activities)[Car Rentals in Santa Cruz](https://expedia.com/Destinations-In-Santa-Cruz.d6297178.Car-Rental-Destinations)[Santa Cruz Vacations](https://expedia.com/Santa-Cruz.d6297178.Destination-Travel-Guides) # Santa Cruz ## Bolivia ![Lake Titicaca which includes general coastal views and a park](https://images.trvl-media.com/place/6053553/c22e3c92-bd89-4998-8279-debb63bcb80e.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Lake Titicaca which includes general coastal views and a park](https://images.trvl-media.com/place/6053553/c22e3c92-bd89-4998-8279-debb63bcb80e.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Lake Titicaca showing general coastal views](https://images.trvl-media.com/place/6053553/d30003cf-36bf-47c4-a856-8f27b62f9d97.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![San Lorenzo Cathedral showing heritage elements, a church or cathedral and heritage architecture](https://images.trvl-media.com/place/6098830/2e73ba4d-fa61-44c6-a724-28b25c241f10.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Strait of Tiquina showing a bay or harbor and a lake or waterhole](https://images.trvl-media.com/place/553248635175056644/70715e48-f239-409a-b288-1f4960b90c59.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ### Popular cities in Santa Cruz [Santa Cruz Known for Shopping, Cathedrals and Excursions ](https://expedia.com/Santa-Cruz.dx6053940) Experience Bolivia as the locals see it in the country’s busiest city, where the museums, public squares and churches give you a glimpse into their everyday lives. ## Reasons to visit - Plaza 24 de Septiembre - San Lorenzo Cathedral [Explore City](https://expedia.com/Santa-Cruz.dx6053940)[Find Hotels](https://expedia.com/Santa-Cruz-Hotels.d6053940.Travel-Guide-Hotels) [Samaipata Known for Hiking, Mountains and Forests ](https://expedia.com/Samaipata.dx6200976) Come to Samaipata and enjoy its hiking, mountain views, and UNESCO site. [Explore City](https://expedia.com/Samaipata.dx6200976)[Find Hotels](https://expedia.com/Samaipata-Hotels.d6200976.Travel-Guide-Hotels) [Warnes ](https://expedia.com/Warnes.dx6352296) Venture to sights like Warnes Plaza as you discover the local area in Warnes. [Explore City](https://expedia.com/Warnes.dx6352296)[Find Hotels](https://expedia.com/Warnes-Hotels.d6352296.Travel-Guide-Hotels) [Montero ](https://expedia.com/Montero.dx553248635975872931) Check out Warnes Plaza—just one of the sights to explore around Montero. [Explore City](https://expedia.com/Montero.dx553248635975872931)[Find Hotels](https://expedia.com/Montero-Hotels.d553248635975872931.Travel-Guide-Hotels) [San Jose de Chiquitos Known for Sunny, Culture and Forests ](https://expedia.com/San-Jose-De-Chiquitos.dx6344854) San Jose de Chiquitos awaits: its sunny weather, culture, churches, and more! [Explore City](https://expedia.com/San-Jose-De-Chiquitos.dx6344854)[Find Hotels](https://expedia.com/San-Jose-De-Chiquitos-Hotels.d6344854.Travel-Guide-Hotels) [Cuevas Known for Natural parks ](https://expedia.com/Cuevas.dx6350209) Explore Cuevas: its parks and more! [Explore City](https://expedia.com/Cuevas.dx6350209)[Find Hotels](https://expedia.com/Cuevas-Hotels.d6350209.Travel-Guide-Hotels) ## Cities in Santa Cruz ![San Lorenzo Cathedral showing a garden](https://images.trvl-media.com/place/6098830/62a42b3d-1dbd-4a81-8566-cea655ebca33.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Santa Cruz Experience Bolivia as the locals see it in the country’s busiest city, where the museums, public squares and churches give you a glimpse into their everyday lives. ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. 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