A calm lake with a row of canoes on the shore and a single canoe on the water.

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Check availability on Southern Minnesota 4 Star Hotels

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Our top choices for Southern Minnesota 4-star hotels

An indoor swimming pool with a curved design, surrounded by palm trees and a white pool ladder.
A modern hotel lobby with a reception desk, a digital information kiosk, and a patterned floor.
A modern hotel with a prominent neon sign, multiple floors, and a well-maintained lawn area.
A hotel room with a large bed, a desk, a chair, and a view of the outdoors through the window.

1. Treasure Island Resort & Casino

Treasure Island Resort & Casino
Welch
United States
Bill
$75 nightly
$84 total
Oct 11 - Oct 12
Total with taxes and fees
Treasure Island Resort & Casino
A restaurant with wooden tables and bar stools, a bar area with a counter, and multiple televisions mounted on the walls.
A bar with wooden stools and a neon sign.
An indoor swimming pool with a slide, seating area, and a large frog statue.
A hotel room with two beds, a desk, a chair, and a mirror.

2. AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic
Rochester
United States
Jeanne
$73 nightly
$84 total
Oct 25 - Oct 26
Total with taxes and fees
AmericInn by Wyndham Rochester Near Mayo Clinic
A swimming pool with a glass ceiling, a neon sign for the KAFFLER HOTEL, and a view of the city skyline at dusk.
A bar area with a long counter, multiple bar stools, and a television mounted above the bar.
A hotel room with a large bed, a desk, a chair, a microwave, and a framed picture on the wall.
A hotel entrance with a modern design, large windows, and a sign indicating it's a Grand Hotel.

3. Kahler Grand Hotel

Kahler Grand Hotel
Downtown Rochester
United States
Maria
$147 nightly
$169 total
Oct 28 - Oct 29
Total with taxes and fees
Kahler Grand Hotel
An indoor swimming pool with a wooden ceiling, clear blue water, and seating areas around the pool.
A hotel room with two beds, a desk, a chair, a television, and a window with curtains.
A coffee station with a coffee machine, cups, and a Bigelow tea display.
A café with multiple tables and chairs, a kitchen area with appliances, and a clock on the wall.

4. Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area
Kutzky Park
United States
Jose
$71 nightly
$82 total
Oct 5 - Oct 6
Total with taxes and fees
Med City Inn & Suites - Mayo Clinic Area
An indoor swimming pool with slides, seating areas, and a covered section with umbrellas.
A modern kitchen with black cabinets, white countertops, and a tiled backsplash. There are pendant lights, a refrigerator, and a coffee machine.
A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.
A hotel room with a kitchen area, a bed, a TV, and a seating area.

5. Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Rochester
United States
Vicky
$95 nightly
$109 total
Oct 9 - Oct 10
Total with taxes and fees
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
An outdoor patio area with yellow umbrellas, wicker furniture, and a sign for Centerstone Plaza Hotel.
A modern reception area with a wooden reception desk, glass pendant lights, and a long hallway with seating.
A restaurant interior with wooden tables, chairs, and a stone wall.
A garden with a water feature, rocks, and yellow umbrellas.

6. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Historic Southwest
United States
Van
$102 nightly
$118 total
Oct 11 - Oct 12
Total with taxes and fees
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
A poolside area with wicker chairs and potted plants, a tiled floor, and a clear view of the pool.
A reception area with a wooden reception desk, a clock, and a wall-mounted display.
A restaurant with a bar area, wooden chairs, and a stone wall.
A hotel room with a sofa, two beds, a large window, and a framed artwork on the wall.

7. Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area
Downtown Rochester
United States
Dana
$137 nightly
$158 total
Oct 24 - Oct 25
Total with taxes and fees
Kahler Inn and Suites - Mayo Clinic Area
A hotel pool area with multiple lounge chairs, a pool, and a second-floor balcony with windows.
A bar area with wooden bar stools, a counter, and a menu board.
A spacious lobby with a stone fireplace, leather seating, a staircase with glass railings, and a view of the outside through large windows.
A brick building with a sign reading "Riverport Inn & Suites" and two flags.

8. Express Suites Riverport Inn & Suites

Express Suites Riverport Inn & Suites
Winona
United States
Louise
$120 nightly
$134 total
Oct 5 - Oct 6
Total with taxes and fees
Express Suites Riverport Inn & Suites
An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.
A modern indoor pool area with lounge chairs and a pool.
A modern bar area with seating and a counter.
A modern dining area with round tables and chairs, a large painting on the wall, and a flat-screen TV mounted above a geometric-patterned wall.

9. Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area
Downtown Rochester
United States
Kathy
$118 nightly
$136 total
Oct 17 - Oct 18
Total with taxes and fees
Hyatt House Rochester/Mayo Clinic Area
A spacious outdoor dining area with modern furniture and large windows offering views of the city.
A reception desk with a modern design, featuring a wooden panel and a wall adorned with framed botanical artwork.
A modern interior with a wooden ceiling, a large black shelving unit, and a refrigerator stocked with beverages.
A modern hotel room with a large bed, a sofa, a small table, a desk, and a wardrobe.

10. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG
Downtown Rochester
United States
thomas
$107 nightly
$123 total
Oct 23 - Oct 24
Total with taxes and fees
Hotel Indigo Rochester – Mayo Clinic Area by IHG
A room with a fireplace, two leather armchairs, a sofa, and a large window providing a view of the outdoors.
A reception area with a curved counter, ceiling lights, and a potted plant.
A long, narrow hotel corridor with a carpeted floor, light fixtures along the walls, and a ceiling with recessed lighting.
A hotel room with a bed, a sink, a microwave, and a window with curtains.

11. Brentwood Inn & Suites

Brentwood Inn & Suites
Downtown Rochester
United States
Daniel
$106 nightly
$122 total
Oct 29 - Oct 30
Total with taxes and fees
Brentwood Inn & Suites
A modern indoor patio with a fire feature, seating, and large windows.
A modern interior with a seating area, a bookshelf, and a window with a view of trees.
A modern hotel lobby with a large glass wall, a green wall mural, and a seating area with sofas and chairs.
A reception area with a curved reception desk, wooden shelving, and a green moss wall with the text "I ♥ EVEN".

12. EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG
Kutzky Park
United States
Rici
$134 nightly
$154 total
Oct 23 - Oct 24
Total with taxes and fees
EVEN Hotel Rochester - Mayo Clinic Area by IHG
A La Quinta Inn & Suites hotel with a well-lit entrance, a parking area, and a clear view of the building's facade.
A hotel reception area with wooden reception desks, a cityscape mural on the wall, and a check-in counter with a bookshelf.
An indoor swimming pool with a slide, seating areas, and a lifeguard station.
A buffet counter with a variety of food items, a coffee station, and a beverage dispenser.

13. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
Rochester
United States
Kathryn
$71 nightly
$82 total
Oct 11 - Oct 12
Total with taxes and fees
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.
A modern lounge area with seating arrangements, a reception desk, and a patterned wall.
A coffee station with four coffee dispensers, a stack of disposable cups, and a tray with various coffee-related items.
A hotel room with a bed, a desk, a chair, a TV, and a bathroom visible through an open door.

14. Hampton Inn Rochester-South

Hampton Inn Rochester-South
Rochester
United States
dennis
$106 nightly
$122 total
Oct 11 - Oct 12
Total with taxes and fees
Hampton Inn Rochester-South
A spacious interior with a herringbone wood floor, a kitchen area with granite countertops, and a staircase with patterned carpet.
A buffet setup with multiple serving stations, a chalkboard with ice cream popsicle decorations, and a coffee station with various beverage dispensers.
A hotel room with a large bed, two bedside tables with lamps, a wooden door, and three framed pictures on the wall.
The entrance to AmericInn by Wyndham, featuring a stone facade, a blue sign with stars, and a number 240.

15. AmericInn by Wyndham Mankato Event Center

AmericInn by Wyndham Mankato Event Center
Mankato
United States
richard
$79 nightly
$88 total
Oct 11 - Oct 12
Total with taxes and fees
AmericInn by Wyndham Mankato Event Center
A modern outdoor seating area with a built-in fireplace, two wooden chairs, a table, and a sofa.
A gym with various exercise equipment, including treadmills, stationary bikes, and weight machines.
A modern urban street with tall buildings, a pedestrian walkway, and a parking area.
A hotel room with a kitchenette, a bed, a sofa, a small table, and a window with curtains.

16. Staybridge Suites Rochester - Mayo Clinic Area by IHG

Staybridge Suites Rochester - Mayo Clinic Area by IHG
Kutzky Park
United States
Sheri
$109 nightly
$125 total
Nov 1 - Nov 2
Total with taxes and fees
Staybridge Suites Rochester - Mayo Clinic Area by IHG
A modern hotel lobby with multiple seating areas, including a central dining table with chairs, a bar area, and a seating section with cushioned chairs.
A hotel reception desk with a modern design, a clock, and a digital screen.
A modern lounge area with a curved sofa, a round table, and a seating area with chairs.
A modern conference room with a long table, multiple chairs, and a wooden partition.

17. SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
Kutzky Park
United States
Jackie
$112 nightly
$128 total
Nov 1 - Nov 2
Total with taxes and fees
SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
A historic brick building labeled "St. James Hotel" with a classic street lamp and hanging flower basket.
An outdoor patio area with tables and chairs, a brick building labeled "St. James Hotel" in the background, and a clear sky.
A bar area with a large vase of flowers, two lit candles, and a glass of whiskey on the counter.
An outdoor seating area with wicker chairs and tables, a bar with bottles and a decorative vase, and string lights above.

18. St James Hotel, a Historic Hotel of America

St James Hotel, a Historic Hotel of America
Red Wing
United States
Nicholas
$158 nightly
$174 total
Nov 1 - Nov 2
Total with taxes and fees
St James Hotel, a Historic Hotel of America
A garden with a variety of flowers, trees, and a stone wall.
A spacious hallway with a wooden staircase, multiple seating areas, and a large window providing a view of the outdoors.
A kitchen with wooden cabinets, a dining table, and a stone accent wall.
A cozy living room with a stone fireplace, a wooden ceiling, and a comfortable sofa.

19. The Stone House Country Escape near Wells, MN

The Stone House Country Escape near Wells, MN
Wells
$155 nightly
$166 total
Nov 1 - Nov 2
Total with taxes and fees
The Stone House Country Escape near Wells, MN
An outdoor seating area with brick walls, green railings, and hanging flower baskets.
A spacious living area with leather sofas, a coffee table with magazines, and a stone fireplace.
A bar area with wooden chairs and tables, a bar counter with bottles and glasses, and a television screen displaying a sports game.
A hotel with a central clock tower, multiple windows, and a parking lot with cars.

20. The Plaza Hotel & Suites Winona

The Plaza Hotel & Suites Winona
Winona
United States
Christopher
$145 nightly
$162 total
Nov 1 - Nov 2
Total with taxes and fees
The Plaza Hotel & Suites Winona
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Learn more about Southern Minnesota

Discover the family-friendly area of Southern Minnesota—an opera house, a college vibe, and sights from Mount Kato Ski Area to Blakeslee Stadium.

See all hotels in Southern Minnesota
A cityscape with a river, a bridge, and a prominent building with a clock tower.
Photo by Don Anderson

Top Southern Minnesota Hotel Reviews

Find out more about Southern Minnesota

Southern Minnesota Four Star Hotel Information

When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Southern Minnesota, Minnesota are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Southern Minnesota 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service.

Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Southern Minnesota. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Southern Minnesota, Minnesota, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop.

Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Southern Minnesota hotels offer everything your heart desires.

Frequently asked questions

What are the best 4-star hotels in Southern Minnesota?
According to reviews by Expedia customers, The Towers At Kahler Grand Hotel is among the favorites in Southern Minnesota. Offering plenty of amenities and a high level of service, this 4-star hotel in Rochester promises a relaxing stay.
How much does it cost to stay in a 4-star hotel in Southern Minnesota?
Expedia can help you easily track down the ideal 4-star hotel for your stay in Southern Minnesota. Use our filter tool to fine-tune your search by things like amenities, budget and star rating and get access to terrific deals in a few clicks.
  • Search for the lowest price from $112
What's the difference between 5-star and 4-star hotels in Southern Minnesota?
Offering an inviting guest experience and upmarket surroundings, 4-star hotels are a terrific option for your Southern Minnesota break. These kinds of stays generally feature lots of handy amenities that make it a breeze to unpack and unwind — think pillowtop mattresses, pools and restaurants. Or live the high life at a 5-star hotel designed to indulge you in exclusive perks and amenities. A personalized service, premium toiletries and fine dining are typically included at these swanky retreats.

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