Title: The Best 5 Star Hotels in Florence, KY from $150 | Expedia.com [Florence Travel Guide](https://expedia.com/Florence.dx8099)[Hotels in Florence](https://expedia.com/Florence-Hotels.d8099.Travel-Guide-Hotels)[Vacation Rentals in Florence](https://expedia.com/Florence-Vacation-Rentals.d8099.Travel-Guide-VacationRentals)[Flights to Florence](https://expedia.com/Cheap-Flights-To-Florence.d8099.Travel-Guide-Flights)[Things to do in Florence](https://expedia.com/Things-To-Do-In-Florence.d8099.Travel-Guide-Activities)[Car Rentals in Florence](https://expedia.com/Car-Rentals-In-Florence.d8099.Car-Rental-Guide)[Florence Vacation Packages](https://expedia.com/Florence.d8099.Destination-Travel-Guides) ![Lodging Image](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Florence 5 Star Hotels Tonight [Mar 9 - Mar 10](https://www.expedia.com/Hotel-Search?regionId=8099&startDate=2026-03-09&endDate=2026-03-10&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 10 - Mar 11](https://www.expedia.com/Hotel-Search?regionId=8099&startDate=2026-03-10&endDate=2026-03-11&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=8099&startDate=2026-03-13&endDate=2026-03-15&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 20 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=8099&startDate=2026-03-20&endDate=2026-03-22&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Florence-Hotels.s50-0-d8099.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Florence-Hotels.s50-0-d8099.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Florence. ![Hilton Cincinnati Netherland Plaza](https://images.trvl-media.com/lodging/1000000/10000/5900/5818/3a03c8ac_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hilton Cincinnati Netherland Plaza 35 W 5th St Cincinnati OH $126 nightly $150 total Apr 5 - Apr 6 Total with taxes and fees 8/10 Very Good! (1,383 reviews) [](https://expedia.com/Cincinnati-Hotels-Hilton-Cincinnati-Netherland-Plaza.h5818.Hotel-Information) ![21c Museum Hotel Cincinnati](https://images.trvl-media.com/lodging/6000000/5290000/5287100/5287002/0545274a_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### 21c Museum Hotel Cincinnati 609 Walnut St Cincinnati OH $156 nightly $187 total Apr 5 - Apr 6 Total with taxes and fees 8.6/10 Excellent! (1,009 reviews) [](https://expedia.com/Cincinnati-Hotels-21c-Museum-Hotel-Cincinnati.h5287002.Hotel-Information) ![Hyatt Regency Cincinnati](https://images.trvl-media.com/lodging/1000000/20000/18700/18646/defb1a9d_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hyatt Regency Cincinnati 151 West Fifth Street Cincinnati OH $178 nightly $212 total Mar 22 - Mar 23 Total with taxes and fees [](https://expedia.com/Cincinnati-Hotels-Hyatt-Regency-Cincinnati.h18646.Hotel-Information) Still don't see what you're looking for? [See all properties in Florence.](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F10%2F2026&endDate=3%2F11%2F2026®ionId=8099&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F10%2F2026&endDate=3%2F11%2F2026®ionId=8099&star=50&star=50&amenities=POOL)[Spa](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F10%2F2026&endDate=3%2F11%2F2026®ionId=8099&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F10%2F2026&endDate=3%2F11%2F2026®ionId=8099&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F10%2F2026&endDate=3%2F11%2F2026®ionId=8099&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F10%2F2026&endDate=3%2F11%2F2026®ionId=8099&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about Florence Swing by the iconic 'Florence Y'all' water tower before exploring the city's antique treasures at Florence Antique Mall. Tee off at World of Golf or catch a thrilling game at UC Health Stadium for a perfect blend of leisure and excitement. [See all hotels in Florence](https://www.expedia.com/Hotel-Search?startDate=2026-03-23&endDate=2026-03-24&adults=2®ionId=8099) ![Panorama photo of vivid Christmas lights reflected in water, Florence Kentucky](https://images.trvl-media.com/place/8099/1f71e7f7-0a1d-4fea-a3d9-825da0701d13.jpg?impolicy=fcrop&w=900&h=197&p=1&q=high) ## Top Florence Hotel Reviews ## Find out more about Florence There's nothing wrong with enjoying the finer things in life. Add further pleasure on your next trip to Florence by treating yourself to the best of the best when it comes to lodging. It's an ideal fusion. There's no reason to delay a getaway to Florence any longer. You'll join the multitudes of vacationers who have made Florence so fashionable in the last year. The accommodations in Florence also offer great customer service, averaging 3.7 in our ranking system, so you know you'll be taken care of. Don't wait any longer. Reserve one of our 5-star hotels in Florence and indulge in the finer things in life for a while. ### Book the Best Florence 5-Star Hotels You can expect superior customer service from your hotel. Top-notch service, delicious meals, and personalized service are all waiting for you. You're sure to find exactly the accommodation you need. You'll be pleased to note that the hotels in Florence offer great customer service, averaging 3.7 in our ranking system, so you know you're in good hands. What creature comforts do you want in your lodging? 24-hour room service, so you can order that filet mignon in the wee hours of the morning? A body scrub that will leave you feeling great? Butler services? No matter what you want on a perfect getaway, you're bound to find it here. Ready for experiences outside your hotel room? We've got you covered. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. Whatever you plan to do, the 5-star hotels in Florence are the perfect place to relax after a busy day. Ready to learn more? Then explore the 581 reviews various guests have left on Expedia and get to know these places. ### Make Your Escape The results are in, and Florence 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. Don't put off your dream vacation any longer -- Expedia can help you land a great deal on accommodation. Pick out one of our Florence 5-star hotels today and soothe yourself in the lap of luxury tomorrow. ## Frequently asked questions ### How much does it cost to stay in a 5-star hotel in Florence? > - Search for the lowest price per night from $150 ### What makes a hotel 5 stars in Florence? ### Are there any 5-star all-inclusive resorts in Florence? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - [Hotels near World of Golf ](https://www.expedia.com/World-Of-Golf-Hotels.0-l6209403-0.Travel-Guide-Filter-Hotels) - [Hotels near Florence Mall ](https://www.expedia.com/Florence-Mall-Hotels.0-l553248633992151559-0.Travel-Guide-Filter-Hotels) - [Hotels near UC Health Stadium ](https://www.expedia.com/UC-Health-Stadium-Hotels.0-l6142205-0.Travel-Guide-Filter-Hotels) - [Hotels near Florence Antique Mall ](https://www.expedia.com/Florence-Antique-Mall-Hotels.0-l553248621560669184-0.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Erlanger ](https://www.expedia.com/3Star-Erlanger-Hotels.s30-0-d7008.Travel-Guide-Filter-Hotels) - 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