A town with a prominent church and mountains in the background.

Find 5 Star Hotels in Mendrisio from $104

  • Upfront pricing

    Our total price for your stay includes taxes and fees

  • Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices
    Learn about One Key

  • Be picky

    Search almost a million properties worldwide

Check availability on Mendrisio 5 Star Hotels

Tonight
Sep 24 - Sep 25
Tomorrow
Sep 25 - Sep 26
This weekend
Sep 25 - Sep 27
Next weekend
Oct 2 - Oct 4

Our top choices for Mendrisio 5-star hotels

A room with a sofa, a coffee table, a decorative sculpture, a painting, and a window with a view of greenery.
A hotel with a pool, outdoor seating, and a view of the surrounding forest.
A restaurant with large windows, a bar area, and a view of a body of water and mountains.
A hotel with a pool, outdoor seating, and a view of the sea.

1. Grand Hotel Villa Serbelloni

Grand Hotel Villa Serbelloni
Historic Center
United States
David
$853 nightly
$950 total
Oct 25 - Oct 26
Total with taxes and fees
Grand Hotel Villa Serbelloni
An outdoor dining area with tables and chairs, overlooking a lake and mountains.
A large, multi-story building with a stone facade and multiple balconies, overlooking a body of water and a mountainous landscape.
A modern living room with a sofa, coffee table, and dining area. A large glass door leads to a balcony with a scenic view of a lake and hills.
A wooden deck overlooking a lake with a boat and a town in the background.

2. Mandarin Oriental, Lago di Como

Mandarin Oriental, Lago di Como
Cazzanore
United States
Christopher
$1,345 nightly
$1,491 total
Oct 22 - Oct 23
Total with taxes and fees
Mandarin Oriental, Lago di Como
A modern building with a water feature in front.
A breakfast table with croissants, fruit, and coffee, overlooking a lake with mountains in the background.
A hotel room with a large bed, a view of a lake and mountains, and a patterned wall.
A restaurant with a marble floor, white tablecloths, and a person in the kitchen.

3. Swiss Diamond Boutique Hotel La Romantica

Swiss Diamond Boutique Hotel La Romantica
Melide
United States
Hafeez
$304 nightly
$327 total
Oct 24 - Oct 25
Total with taxes and fees
Swiss Diamond Boutique Hotel La Romantica
A grand staircase with ornate metal railings and red curtains, leading to a richly decorated area with a chandelier.
A dining table with plates of food and wine glasses, overlooking a lake with boats and a hilly town in the background.
A grand staircase with ornate metal railings and red curtains.
A hotel room with a bed, two armchairs, a sofa, a coffee table, and a desk with a lamp. There are large windows with curtains, a view of a body of water and buildings.

4. Palazzo Venezia

Palazzo Venezia
Como City Centre
Canada
Hanif
$925 nightly
$1,029 total
Oct 23 - Oct 24
Total with taxes and fees
Palazzo Venezia
A resort with a pool, sun loungers, and a mountain backdrop.
A luxurious room with a grand ceiling, elegant furniture, and a view of the sea.
A balcony with a wooden floor, a table with chairs, a vase with flowers, and a view of mountains and a lake.
A garden with palm trees and pink flowers, a stone balustrade, and a mountain in the background.

5. Grand Hotel Tremezzo

Grand Hotel Tremezzo
Tremezzina
United States
Jose
$1,059 nightly
$1,176 total
Oct 19 - Oct 20
Total with taxes and fees
Grand Hotel Tremezzo
A pool area with lounge chairs and umbrellas, surrounded by mountains and a body of water.
A hotel room with a large window offering a view of a lake and mountains.
A modern hotel room with a marble archway leading to a balcony with a scenic view.
A modern interior with a marble archway leading to a balcony with a view of a lake and mountains.

6. The Lake Como EDITION

The Lake Como EDITION
Griante
United States
Lydia
$745 nightly
$831 total
Oct 22 - Oct 23
Total with taxes and fees
The Lake Como EDITION
A modern indoor pool area with a glass barrier, lounge chairs, and a stone column.
A modern indoor pool area with clear glass walls, lounge chairs, and a minimalist design.
A hotel entrance with a grand archway, large windows, and potted plants.
A marina with numerous boats docked, surrounded by lush greenery and residential buildings on a hillside.

7. Palazzo San Gottardo Lake Como, a Radisson Collection

Palazzo San Gottardo Lake Como, a Radisson Collection
Como City Centre
United States
sebastian
$461 nightly
$518 total
Oct 25 - Oct 26
Total with taxes and fees
Palazzo San Gottardo Lake Como, a Radisson Collection
A table set for two with a view of a lake and a town in the background.
A waterfront hotel with multiple balconies, a marina, and a view of the lake.
A dining area with round tables, chairs, and a scenic view of a lake and mountains.
A swimming pool with a dining area and a view of mountains.

8. Swiss Diamond Hotel & SPA

Swiss Diamond Hotel & SPA
Vico Morcote
United States
Aida
$476 nightly
$506 total
Oct 25 - Oct 26
Total with taxes and fees
Swiss Diamond Hotel & SPA
A modern indoor pool area with a view of a lake and mountains.
A luxurious room with a chandelier, a sofa, a table with a lamp, a vase with flowers, and a view of the mountains through the window.
A luxurious room with a large bed, a sofa, a television, and a view of the mountains.
A luxurious dining area with elegant decor, a view of a lake, and mountains in the background.

9. Hotel Splendide Royal

Hotel Splendide Royal
Loreto
United Arab Emirates
Abdulaziz
$584 nightly
$606 total
Sep 27 - Sep 28
Total with taxes and fees
Hotel Splendide Royal
A large, two-story building with a symmetrical facade, a central entrance, and a well-maintained garden with a fountain.
A scenic view of a lake surrounded by mountains, with a gazebo and outdoor seating area in the foreground.
A pool area with a clear view of mountains, surrounded by lush greenery and a building with a balcony.
A view of a balcony with a chair, a table with a bottle of wine, and a vase of flowers.

10. Villa Principe Leopoldo

Villa Principe Leopoldo
Loreto
United States
Sandeep
$446 nightly
$473 total
Oct 11 - Oct 12
Total with taxes and fees
Villa Principe Leopoldo
A view through a glass door to an outdoor seating area with wicker chairs and a wooden deck.
A bar area with a view of a lake and mountains.
A view through a glass door leading to a courtyard with a central flower bed, a fountain, and a clear sky.
A pool area with lounge chairs and umbrellas, overlooking a lake with mountains in the background.

11. Boutique Hotel Stresa

Boutique Hotel Stresa
Stresa
United States
kathleen
$386 nightly
$432 total
Oct 23 - Oct 24
Total with taxes and fees
Boutique Hotel Stresa
A pool area with lounge chairs and a view of a lake and mountains.
A beachside resort with sun loungers, umbrellas, and a wooden deck overlooking a lake with mountains in the background.
A spacious living area with a large wooden table, comfortable seating, and a view through a large window.
An outdoor dining area with tables and chairs, large windows, and a view of a lake and mountains.

12. Grand Hotel Victoria Concept & Spa, by R Collection Hotels

Grand Hotel Victoria Concept & Spa, by R Collection Hotels
Menaggio
United States
Jacques
$696 nightly
$766 total
Oct 24 - Oct 25
Total with taxes and fees
Grand Hotel Victoria Concept & Spa, by R Collection Hotels
A swimming pool with a mountain backdrop.
A marina with boats docked, a beach area with umbrellas, and a building with a yellow facade.
A deck with a sofa, a swing, and a table, overlooking a lake and mountains.
A modern lounge with comfortable seating, large windows offering a view of a lake and mountains, and a stylish ceiling light fixture.

13. ARIA Retreat & SPA - The Leading Hotels of the World

ARIA Retreat & SPA - The Leading Hotels of the World
Porlezza
United States
Semih
$925 nightly
$1,024 total
Oct 11 - Oct 12
Total with taxes and fees
ARIA Retreat & SPA - The Leading Hotels of the World
A table set with breakfast items and a scenic view of a mountain and lake.
A modern indoor space with a glass ceiling, seating area with sofas and chairs, and a view of greenery outside.
A buffet with various fruits, nuts, and pastries.
A couple in a hot tub surrounded by lush greenery.

14. Grand Hotel Villa Castagnola

Grand Hotel Villa Castagnola
Cassarate
United Kingdom
Param
$596 nightly
$630 total
Oct 15 - Oct 16
Total with taxes and fees
Grand Hotel Villa Castagnola
A woman sitting by a large window overlooking a scenic valley, with breakfast items on a side table.
A hotel room with a large bed, a TV, a breakfast tray, and a view of a city and mountains.
A pool area with red and white striped canopies, a clear view of a cityscape in the background, and a palm tree in the foreground.
A dining area with wicker chairs and tables, large windows with a view of trees and mountains, and a patterned bench.

15. Nuvole Garden Hotel

Nuvole Garden Hotel
Brunate
United States
Eric
$724 nightly
$808 total
Oct 6 - Oct 7
Total with taxes and fees
Nuvole Garden Hotel
An indoor swimming pool with a modern ceiling design, clear water, and lounge chairs along the side.
A modern hotel room with a large balcony, a view of a city and lake, wicker furniture, and a table with a vase of flowers.
A modern hotel room with a large bed, a seating area with a table and chairs, and a balcony with a view of the city and mountains.
An outdoor terrace with round tables and chairs, overlooking a lake and mountains.

16. The View Lugano

The View Lugano
Paradiso
United States
Bobby
$812 nightly
$854 total
Oct 4 - Oct 5
Total with taxes and fees
The View Lugano
An aerial view of a resort with a central swimming pool surrounded by lounge chairs and umbrellas, set against a backdrop of mountains and a lake.
A large, multi-story building with a symmetrical facade, surrounded by lush greenery and a lake.
An outdoor dining area with tables and chairs, umbrellas, and a view of the landscape.
A table with a bottle of wine, two glasses, a vase with flowers, a bowl of fruits, and a cheese board.

17. Collina d'Oro Resort & SPA

Collina d'Oro Resort & SPA
Collina d'Oro
United States
Inna
$215 nightly
$234 total
Oct 18 - Oct 19
Total with taxes and fees
Collina d'Oro Resort & SPA
A modern building with a pool, surrounded by a well-maintained lawn and mountains in the background.
A hotel room with a large bed, a dining table with a tea set, two chairs, and a view of mountains and a lake.
A room with a view of a lake and mountains, a table with a bottle and glasses, and two chairs.
A modern two-story house with a balcony overlooking a lake and mountains.

18. Bianca Relais - by R Collection Hotels

Bianca Relais - by R Collection Hotels
Oggiono
United Kingdom
Poh Boon
$260 nightly
$286 total
Oct 23 - Oct 24
Total with taxes and fees
Bianca Relais - by R Collection Hotels
A balcony with wicker chairs, a small round table with a tray of items, and a view of a lake with mountains in the background.
A bathroom with a tiled wall, a shower area, and a bench.
A modern kitchen with a large island, built-in appliances, and a view to the outdoors.
A pool area with lounge chairs and umbrellas, a clear view of a lake, and mountains in the background.

19. MUSA Lago Di Como

MUSA Lago Di Como
Sala Comacina
United States
Dominique
$1,011 nightly
$1,123 total
Oct 19 - Oct 20
Total with taxes and fees
MUSA Lago Di Como
A lakeside resort with outdoor seating areas, a gazebo, and a view of the lake and surrounding mountains.
A resort with a swimming pool surrounded by manicured gardens, a lake, and mountains in the background.
A window with white curtains, a view of a lake, and a forested mountain in the background.
A stone-walled room with two cushioned seating areas and a lantern.

20. Passalacqua

Passalacqua
Moltrasio
United Kingdom
Pavel
Passalacqua
Save an average of 15% on thousands of hotels when you're signed in

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Mendrisio.
Idea Hotel Milano Malpensa Airport

Idea Hotel Milano Malpensa Airport

Via Della Chiesa, 27 Somma Lombardo VA
$93 nightly
$106 total
Oct 17 - Oct 18
Total with taxes and fees
7.6/10 Good! (1,006 reviews)
Idea Hotel Milano Malpensa Airport
Hotel Osteria della Pista

Hotel Osteria della Pista

Via Verbano 1 Casorate Sempione VA
$95 nightly
$104 total
Oct 25 - Oct 26
Total with taxes and fees
Hotel Osteria della Pista
Hotel Barchetta Excelsior

Hotel Barchetta Excelsior

Piazza Cavour 1 Como CO
$229 nightly
$263 total
Oct 21 - Oct 22
Total with taxes and fees
Hotel Barchetta Excelsior
Still don't see what you're looking for?
See all properties in Mendrisio.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Mendrisio

Tucked between Lake Lugano and Generoso Mount, this charming town invites you to explore its cultural treasures at Museum d'Art and Galleria Baumgartner. Bargain hunters flock to FoxTown Factory Stores while nature lovers can discover the UNESCO-listed Monte San Giorgio with its remarkable fossil deposits.

See all hotels in Mendrisio
A town with a prominent church and mountains in the background.

Top Mendrisio Hotel Reviews

Grand Hotel Tremezzo

Grand Hotel Tremezzo

10/10 Excellent
"Great Establishment!"
Jose 2-night trip
Posted 3 months ago
Grand Hotel Tremezzo

Find out more about Mendrisio

Treat yourself on your next getaway. After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made Mendrisio so popular in the last year. There's no reason to delay a getaway to Mendrisio any longer. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Book one of Expedia's luxurious 5-star hotels in Mendrisio and get ready to be pampered like never before. Don't wait any longer!

5-Star Hotels in Mendrisio

You'll have a wonderful time at one of these 5-star hotels. Michelin-starred restaurants, concierges, and in-room massages are all at the ready. You're sure to find exactly the accommodation you need. You can also look forward to an outstanding experience and fantastic customer care, so get ready for a wonderful adventure. How do you want to relax? A full-body massage to help your cares fall away? A concierge to help you pick out your next adventure? Beautiful furniture, delectable chocolate desserts, and even space for your family pet in some cases...these hotels will leave you amazed.

Ready for experiences outside your hotel room? You're in luck. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. Whatever you plan to do, the 5-star hotels in Mendrisio are waiting for you to relax after an exciting day. Ready to learn more? Then check out our listings and pick the perfect accommodation for your needs.

Make Your Escape

The results are in, and Mendrisio 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Expedia can help you land a great deal on accommodation. It's time to plan your next great escape. Select one of Expedia's Mendrisio 5-star hotels today and soothe yourself in total tranquility tomorrow.

Frequently asked questions

What are the best 5-star hotels in Mendrisio?
According to Expedia guest reviews, Swiss Diamond Hotel & SPA, Resort Collina dOro and The View Lugano are some of the top 5-star hotels in Mendrisio. Featuring top-of-the-line amenities and excellent service, you'll enjoy a luxurious and comfortable stay.
How much does it cost to stay in a 5-star hotel in Mendrisio?
How much you pay for a 5-star hotel in Mendrisio depends on factors such as when you plan to go and the length of your getaway. A top tip for landing an awesome deal? Use our pricing filters to compare all of the available accommodations for your selected dates.
  • Search for the lowest price per night from $104
What makes a hotel 5 stars in Mendrisio?
Faultless guest service is the defining feature of every 5-star hotel in Mendrisio. From the second you arrive, staff ensure your every need is met, whether recommending activities and tours or providing a turn-down service. On top of that, hotels have to offer upscale conveniences to be considered for a 5-star rating. These can include luxury baths, an on-site spa, swimming pools, fine dining kitchens and knowledgeable concierge.

Explore a world of travel with Expedia