Title: The Best 5 Star Hotels in Southern Oregon, OR from $159 | Expedia.com

[Southern Oregon Travel Guide](https://expedia.com/Southern-Oregon.dx6054375)[Hotels in Southern Oregon](https://expedia.com/Southern-Oregon-Hotels.d6054375.Travel-Guide-Hotels)[Vacation Rentals in Southern Oregon](https://expedia.com/Southern-Oregon-Vacation-Rentals.d6054375.Travel-Guide-VacationRentals)[Flights to Southern Oregon](https://expedia.com/Cheap-Flights-To-Southern-Oregon.d6054375.Travel-Guide-Flights)[Things to do in Southern Oregon](https://expedia.com/Things-To-Do-In-Southern-Oregon.d6054375.Travel-Guide-Activities)[Car Rentals in Southern Oregon](https://expedia.com/Car-Rentals-In-Southern-Oregon.d6054375.Car-Rental-Guide)[Southern Oregon Vacation Packages](https://expedia.com/Southern-Oregon.d6054375.Destination-Travel-Guides)

![Crater Lake National Park which includes a lake or waterhole and mountains](https://images.trvl-media.com/place/6025867/2cfc37b5-96f1-4d3e-b803-0077b7a14107.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/6025867/2cfc37b5-96f1-4d3e-b803-0077b7a14107.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check availability on Southern Oregon 5 Star Hotels

Tonight

[Feb 26 - Feb 27](https://www.expedia.com/Hotel-Search?regionId=6054375&startDate=2026-02-26&endDate=2026-02-27&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Feb 27 - Feb 28](https://www.expedia.com/Hotel-Search?regionId=6054375&startDate=2026-02-27&endDate=2026-02-28&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Feb 27 - Mar 1](https://www.expedia.com/Hotel-Search?regionId=6054375&startDate=2026-02-27&endDate=2026-03-01&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Mar 6 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=6054375&startDate=2026-03-06&endDate=2026-03-08&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

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## Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Southern Oregon.

![Compass by Margaritaville in Medford](https://images.trvl-media.com/lodging/77000000/76140000/76138500/76138485/b7be0ede_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Compass by Margaritaville in Medford

2399 S Pacific Hwy Medford OR

$146 nightly

$163 total

Mar 1 - Mar 2

Total with taxes and fees

9.6/10 Exceptional! (1,009 reviews)

[](https://expedia.com/Medford-Hotels-Compass-By-Margaritaville-In-Medford.h76138485.Hotel-Information)

![McCall House Boutique Inn](https://images.trvl-media.com/lodging/16000000/15160000/15153100/15153095/c4aac0d0_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### McCall House Boutique Inn

153 Oak St Ashland OR

$142 nightly

$159 total

Feb 27 - Feb 28

Total with taxes and fees

9.2/10 Wonderful! (588 reviews)

[](https://expedia.com/Medford-Hotels-McCall-House-Boutique-Inn.h15153095.Hotel-Information)

![Hummingbird Estate Wine & Suites](https://images.trvl-media.com/lodging/39000000/38910000/38900300/38900286/6a1781f9_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Hummingbird Estate Wine & Suites

1677 Old Stage Rd Central Point OR

$160 nightly

$163 total

Mar 26 - Mar 27

Total with taxes and fees

9.6/10 Exceptional! (155 reviews)

[](https://expedia.com/Medford-Hotels-Hummingbird-Estate-Wine-Suites.h38900286.Hotel-Information)

Still don't see what you're looking for?

[See all properties in Southern Oregon.](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F27%2F2026&endDate=2%2F28%2F2026&regionId=6054375&star=50)

You can also use these popular filters to refine your search.

[Pool](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F27%2F2026&endDate=2%2F28%2F2026&regionId=6054375&star=50&star=50&amenities=POOL)[Spa](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F27%2F2026&endDate=2%2F28%2F2026&regionId=6054375&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F27%2F2026&endDate=2%2F28%2F2026&regionId=6054375&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F27%2F2026&endDate=2%2F28%2F2026&regionId=6054375&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F27%2F2026&endDate=2%2F28%2F2026&regionId=6054375&star=50&star=50&amenities=WATER_PARK)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Learn more about Southern Oregon

Escape to a place of scenic contrasts, where you will discover the deepest lake in the United States, spectacular marble caves and a wild river.

[See all hotels in Southern Oregon](https://www.expedia.com/Hotel-Search?startDate=2026-03-12&endDate=2026-03-13&adults=2&regionId=6054375)

![Crater Lake National Park which includes a lake or waterhole and mountains](https://images.trvl-media.com/place/6025867/2cfc37b5-96f1-4d3e-b803-0077b7a14107.jpg?impolicy=fcrop&w=900&h=506&p=1&q=high)

## Top Southern Oregon Hotel Reviews

## Find out more about Southern Oregon

## Southern Oregon Five Star Hotel Information

If you’re searching for the celebrity treatment, the 5 star hotels in Southern Oregon are your dreams come true. From sprawling resorts to fancy hot spots, theseSouthern Oregon 5 star hotels immerse each traveler in the most elite experience money can buy. Want to unwind with a VIP-worthy spa treatment? These hotels have the leisure you're looking for.

Interested in sampling world-class cuisine? The on-site restaurants at the 5 stars hotels in Southern Oregon, Oregon, let you do just that. You’ll even be able to book a room (or perhaps a penthouse?) at first-rate hotels near the region’s can’t-miss sights and most bustling shopping centers. Plus, many globe-trotters who visit Southern Oregon five star hotels find incredible rates and deep discounts thanks to Expedia, so you can score a deal without sacrificing an ounce of quality.

Everything you could possibly want (and a few things you didn’t know you needed): That’s what you’ll receive when you stay at Southern Oregon 5 star hotels.

## Frequently asked questions

### How much does it cost to stay in a 5-star hotel in Southern Oregon?

> - Search for the lowest price per night from $159

### What makes a hotel 5 stars in Southern Oregon?

### Are there any 5-star all-inclusive resorts in Southern Oregon?

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