A steel bridge with a sunset in the background.

Find Resorts & Hotels with Spas in Cairo, IL

Check availability on Cairo Resorts & Hotels with Spas

Tonight
Oct 17 - Oct 18
Tomorrow
Oct 18 - Oct 19
Next weekend
Oct 23 - Oct 25
In two weeks
Oct 30 - Nov 1
No exact matches found, but these alternatives could be just right

Recommended hotels in Cairo

A hotel lobby with a reception desk, seating area, and a large window.
A hotel lobby with a reception desk, two armchairs, a coffee table, and large windows with potted plants.
A Quality Inn hotel with a green sign, a covered outdoor area, and a parking lot.
A hotel room with a desk, chair, television, and a lamp.

1. Quality Inn Cairo I-57

Quality Inn Cairo I-57
Cairo
$68 nightly
$76 total
Nov 13 - Nov 14
Total with taxes and fees
Quality Inn Cairo I-57
A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.
A hotel with a covered entrance, a sign for the brand, and a parking lot with cars.
A restaurant with wooden cabinets, a refrigerator, and a counter with various items. There are tables and chairs for dining.
A reception area with a sofa, a coffee table, a potted plant, and a framed picture on the wall.

2. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
Charleston
$60 nightly
$67 total
Oct 18 - Oct 19
Total with taxes and fees
Super 8 by Wyndham Charleston/Sikeston East MO
A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.
A bathroom with a sink, mirror, towel rack, shower, and toilet.
A motel with a sign reading "Eagle Inn" and a parking lot with several cars.
A hotel room with two beds, a nightstand, a lamp, and a window with curtains.

3. Eagle Inn Charleston

Eagle Inn Charleston
Charleston
$66 nightly
$74 total
Oct 18 - Oct 19
Total with taxes and fees
Eagle Inn Charleston
A building with a fountain and flower beds in front.
A reception area with a stone wall, wooden cabinets, and a sign for The Riverstone Hotel.
A modern kitchen with dark wooden cabinets, a central island, and a ceiling fan.
A hotel room with a large bed, two bedside tables with lamps, a chair, a small table, and a picture on the wall.

4. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
Charleston
$66 nightly
$74 total
Oct 19 - Oct 20
Total with taxes and fees
The Riverstone Hotel Charleston-Sikeston
A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a painting on the wall.
A bathroom with a bathtub, a towel rack, and a showerhead.
A reception desk with a computer, a framed picture on the wall, and a vase with flowers.
A compact room with a television on a cabinet, a microwave, a small refrigerator, a table, and a chair.

5. La Center Motel

La Center Motel
La Center
$65 nightly
$70 total
Oct 18 - Oct 19
Total with taxes and fees
La Center Motel
A loft-style room with a wooden interior, a sofa, a table with a pumpkin decoration, and a staircase leading to an upper level.
A wooden cabin with a triangular roof, a front door, and a small porch with chairs.
A cabin interior with a wooden interior, a staircase, a bed, a sofa, and a dining area.
A loft-style bedroom with a wooden ladder leading to a lofted sleeping area, a bed with black bedding, and a small kitchenette with a microwave and sink.

6. Peaceful secluded cabin located near Horseshoe Lake

Peaceful secluded cabin located near Horseshoe Lake
Miller City
$206 nightly
$218 total
Oct 19 - Oct 20
Total with taxes and fees
Peaceful secluded cabin located near Horseshoe Lake
A compact RV interior with a kitchenette, a seating area, and a window providing a view outside.
A compact RV interior with a bed, kitchenette, and seating area.
A white RV with a 'Passport' brand name, a sliding door, and a small window.
A white recreational vehicle with a 'Passport' brand name, a sliding door, and a small window.

7. Cozy 1-bedroom recreational vehicle in peaceful La Center. Sleeps 5.

Cozy 1-bedroom recreational vehicle in peaceful La Center. Sleeps 5.
La Center
$90 nightly
$96 total
Oct 18 - Oct 19
Total with taxes and fees
Cozy 1-bedroom recreational vehicle in peaceful La Center. Sleeps 5.
A cozy room with a wooden table and chairs, a large window, and a door with a sign.
A narrow bathroom with a wooden floor, a white sink, a mirror, and a 'NO SMOKING' sign.
A room with a bed, desk, chair, and a small kitchenette.
A small, single-story building with a wooden exterior and large windows.

8. Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake
Olive Branch
$133 nightly
$140 total
Oct 18 - Oct 19
Total with taxes and fees
Cozy cabins on beautiful Horseshoe Lake
A bathroom with a wooden shower enclosure, a toilet, a sink with a mirror, and three wall-mounted lights.
A wooden-paneled room with a framed picture of dogs, a Keurig coffee maker, a tray with cups and a tissue box.
A small, single-story building with a wooden exterior and large windows.
A compact room with a wooden wall, a flat-screen TV mounted above a wooden cabinet, a microwave, and a blue dresser with drawers.

9. The Rested Duck Mallard Room

The Rested Duck Mallard Room
Olive Branch
$133 nightly
$140 total
Oct 18 - Oct 19
Total with taxes and fees
The Rested Duck Mallard Room
A room with a pool table, a sofa, and a dining table with chairs.
A spacious room with a large wooden dining table, several chairs, a ceiling fan, and a television.
A kitchen with wooden paneling, a cabinet with glass doors, a gray water heater, a white refrigerator, and a wooden barrel.
A ping pong table in a room with wooden walls and large windows.

10. Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge

Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge
Villa Ridge
$252 nightly
$267 total
Oct 19 - Oct 20
Total with taxes and fees
Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge
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Choose what matters most at spa hotels in Cairo

Pool
Breakfast included
Hot tub
4 stars
5 stars

Top Cairo Hotel Reviews

Eagle Inn Charleston

Eagle Inn Charleston

10/10 Excellent
"Great"
Jackson 1-night trip
Posted 7 months ago
Eagle Inn Charleston

Frequently asked questions

Looking for a spa hotel in Cairo?
Treat yourself to some time in a luxurious spa hotel and you won't regret it. Check out the historical sites and restaurants in Cairo—your day trip starts here. Enjoy the opera and riverfront during your vacation. Hotels with spas are the perfect way to break out of your routine and add a layer of luxury to your vacation.
What's there to see and do in Cairo?
When you're in Cairo, enjoy exploring the sights and attractions here including Mississippi River, Ohio River Valley, and Fort Defiance State Park. If you have a little extra time during your trip, you might want to check out Ballard Wildlife Management Area and Columbus-Belmont State Park.
What is a Cairo spa hotel?
Spa hotels in Cairo provide lodging and have an on-site spa offering services including couples massages and beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.

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