Title: Top Independent in Central, SC - Expedia.com [Central Travel Guide](https://expedia.com/Central.dx10503)[Hotels in Central](https://expedia.com/Central-Hotels.d10503.Travel-Guide-Hotels)[Vacation Rentals in Central](https://expedia.com/Central-Vacation-Rentals.d10503.Travel-Guide-VacationRentals)[Flights to Central](https://expedia.com/Cheap-Flights-To-Central.d10503.Travel-Guide-Flights)[Car Rentals in Central](https://expedia.com/Car-Rentals-In-Central.d10503.Car-Rental-Guide)[Central Vacation Packages](https://expedia.com/Central.d10503.Destination-Travel-Guides) ![Todd Creek Falls](https://images.trvl-media.com/place/10503/baefe116-5881-466e-b320-6ded2828ee1d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/10503/baefe116-5881-466e-b320-6ded2828ee1d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ## Check prices for these dates Tonight [Mar 7 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=10503&startDate=2026-03-07&endDate=2026-03-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 8 - Mar 9](https://www.expedia.com/Hotel-Search?regionId=10503&startDate=2026-03-08&endDate=2026-03-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=10503&startDate=2026-03-13&endDate=2026-03-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Mar 20 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=10503&startDate=2026-03-20&endDate=2026-03-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FCentral-Hotels-Independent.0-0-d10503--bIndependent.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FCentral-Hotels-Independent.0-0-d10503--bIndependent.Travel-Guide-Filter-Hotels) ## Top Central Hotel Reviews ![Quality Inn & Suites Easley - Greenville](https://images.trvl-media.com/lodging/1000000/30000/24700/24698/94758a40_y.jpg) ### Quality Inn & Suites Easley - Greenville 8/10 Good "Clean room Friendly Staff" [](https://expedia.com/Easley-Hotels-Quality-Inn-Suites.h24698.Hotel-Information) ![Days Inn by Wyndham Anderson](https://images.trvl-media.com/lodging/1000000/10000/6400/6344/bea0c9d1_y.jpg) ### Days Inn by Wyndham Anderson 10/10 Excellent "I was at this location from Sunday to Friday this week, and I’m so grateful for how helpful and kind everyone on the staff was. My room was clean, of course, but the front desk team really went above and beyond to help me get through the work week. Breakfast was great too, the waffles and coffee were a perfect start to the day. I’ll be back this way later this year and will proudly book this location again! " [](https://expedia.com/Anderson-Hotels-Days-Inn-By-Wyndham-Anderson.h6344.Hotel-Information) ![Comfort Inn & Suites Clemson - University Area](https://images.trvl-media.com/lodging/1000000/20000/19100/19019/60d71ae1_y.jpg) ### Comfort Inn & Suites Clemson - University Area 8/10 Good "Yes" [](https://expedia.com/Anderson-Hotels-Comfort-Inn-Suites-Clemson-University-Area.h19019.Hotel-Information) ![Hampton Inn & Suites Seneca-Clemson Area](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/8f736b3a_y.jpg) ### Hampton Inn & Suites Seneca-Clemson Area 10/10 Excellent "Clean" [](https://expedia.com/Anderson-Hotels-Hampton-Inn-Suites-Seneca-Clemson-Area.h6696886.Hotel-Information) ![The Shepherd Hotel Downtown Clemson](https://images.trvl-media.com/lodging/88000000/87690000/87688200/87688155/bd45b45c_y.jpg) ### The Shepherd Hotel Downtown Clemson 10/10 Excellent "Top notch hotel. Staff is amazing. If you visit, be sure to check out the outdoor space on the 7th floor. Excellent views and areas to sit and chat or work. Room was clean and the bed was wonderfully comfortable. " [](https://expedia.com/Clemson-Hotels-The-Shepherd-Hotel-Downtown-Clemson.h87688155.Hotel-Information) ![Lakeside Lodge Clemson](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/db449d90_y.jpg) ### Lakeside Lodge Clemson 8/10 Good "I got a great corner room this time. Just wish the hottub was open at night. Very weird that it's not. " [](https://expedia.com/Anderson-Hotels-Lakeside-Lodge-Clemson.h40217319.Hotel-Information) ![Tru by Hilton Seneca Clemson](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/83732283_y.jpg) ### Tru by Hilton Seneca Clemson 10/10 Excellent "was great " [](https://expedia.com/Anderson-Hotels-Tru-By-Hilton-Seneca-Clemson.h34323330.Hotel-Information) ![Days Inn by Wyndham Seneca / Clemson Area](https://images.trvl-media.com/lodging/1000000/20000/14900/14854/56ab80ce_y.jpg) ### Days Inn by Wyndham Seneca / Clemson Area 2/10 Terrible "Don't get a chance to park " [](https://expedia.com/Anderson-Hotels-Days-Inn-By-Wyndham-Seneca-Clemson-Area.h14854.Hotel-Information) ![Clemson University's James F. Martin Inn](https://images.trvl-media.com/lodging/9000000/8480000/8475000/8474950/ad943919_y.jpg) ### Clemson University's James F. Martin Inn 10/10 Excellent "Excellent stay " [](https://expedia.com/Anderson-Hotels-Clemson-Universitys-James-F-Martin-Inn.h8474950.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - [Hotels near Southern Wesleyan University ](https://www.expedia.com/Southern-Wesleyan-University-Hotels.0-l6228746-0.Travel-Guide-Filter-Hotels) - [Norris Hotels ](https://www.expedia.com/Norris-Hotels.d553248634999366947.Travel-Guide-Hotels) - [Clemson Hotels ](https://www.expedia.com/Clemson-Hotels.d6594.Travel-Guide-Hotels) - [Hotels near Clemson Station ](https://www.expedia.com/Clemson-Station-Hotels.d6194530.Travel-Guide-Hotels) - [America's Best Inns Hotels in Clemson ](https://www.expedia.com/Clemson-Hotels-Americas-Best-Inns.0-0-d6594--bAmericasBestInns.Travel-Guide-Filter-Hotels) - [Hotels near Clemson University ](https://www.expedia.com/Clemson-University-Hotels.0-l6127431-0.Travel-Guide-Filter-Hotels) - [La Quinta Inn & Suites Hotels in Clemson ](https://www.expedia.com/Clemson-Hotels-La-Quinta-Inn-Suites.0-0-d6594--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) - [Hilton Hotels in Clemson ](https://www.expedia.com/Clemson-Hotels-Hilton-Hotels.0-0-d6594--bHiltonHotels.Travel-Guide-Filter-Hotels) - [Wyndham Hotels in Clemson ](https://www.expedia.com/Clemson-Hotels-Wyndham-Hotels.0-0-d6594--bWyndhamHotels.Travel-Guide-Filter-Hotels) - [Marriott Hotels & Resorts in Clemson ](https://www.expedia.com/Clemson-Hotels-Marriott-Hotels-Resorts.0-0-d6594--bMarriottHotelsResorts.Travel-Guide-Filter-Hotels) - [Best Western Hotels in Clemson ](https://www.expedia.com/Clemson-Hotels-Best-Western.0-0-d6594--bBestWestern.Travel-Guide-Filter-Hotels) - [Hotels near Larry W. 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