Central Mexico Vacations from $266

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • payments icon

    Better together

    Save up to $1,045 when you book a flight and hotel together*
    lob hotels icon

    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
    lob packages icon

    Rest easy

    Plan, book, and manage your trip all in one place

Your Central Mexico Vacation

Do and see more with a vacation package to Central Mexico. Whether you're going for the nightlife, markets, dining, or something else entirely, our package deals make travel planning hassle-free. Your trip to Central Mexico wouldn't be complete without exploring some of its most well-known cities, starting with Mexico City. Two of the top attractions here include Autódromo Hermanos Rodríguez and Zócalo. Puebla is another favorite with Central Mexico travelers. Visitors to this exciting destination love Angelopolis Commercial Center and Great Pyramid of Cholula. From the instant you book your Central Mexico vacation to the second you come back home, Expedia has your back each step of the way.

The Latest Central Mexico vacation packages

Price found within the past 48 hours. Click for updated prices.
Xoxula by Inmense
Apartamento en La Condesa
Baja California 279 Apartments
Casa 63 Hotel Boutique & Spa
Pueblo Bonito Vantage San Miguel de Allende
Don't see what you're looking for?
See all available trips from Columbus to Central Mexico
View all trips

Where to stay in Central Mexico

Find the best Central Mexico areas and neighborhoods for the activities you enjoy most. Learn more about Central Mexico

Discover the most popular places to visit in Central Mexico

Central Mexico Hotel Deals

Camino Real Aeropuerto Mexico

Camino Real Aeropuerto Mexico

4 out of 5
Mexico City
Fully refundableReserve now, pay when you stay
$134 nightly
The price is $160 total per night from Sep 2 to Sep 3
$160 total
Sep 2 - Sep 3
Total includes taxes and fees
8.6/10 Excellent! (11,013 reviews)
"Due to flight cancellations and airline mixups, I was stranded in the Mexico city airport overnight and this hotel was a lifesaver, especially as I was travelling with two young kids. Facilities are clean Staff is friendly and it’s great to have a hotel in the airport that I can walk to have a clean ..."

Reviewed on Aug 18, 2025

Camino Real Aeropuerto Mexico
Hyatt Regency Mexico City

Hyatt Regency Mexico City

5 out of 5
Campos Eliseos No. 204 Polanco, Chapultepec, Mexico City
Fully refundableReserve now, pay when you stay
$193 nightly
The price is $231 total per night from Sep 7 to Sep 8
$231 total
Sep 7 - Sep 8
Total includes taxes and fees
9.2/10 Wonderful! (1,160 reviews)
"The ultimate hotel in polanco, got all the amenities you need."

Reviewed on Aug 14, 2025

Hyatt Regency Mexico City
Barceló México Reforma

Barceló México Reforma

4.5 out of 5
Paseo De La Reforma 1, Mexico City
Fully refundableReserve now, pay when you stay
$120 nightly
The price is $143 total per night from Sep 2 to Sep 3
$143 total
Sep 2 - Sep 3
Total includes taxes and fees
9.2/10 Wonderful! (4,750 reviews)
"It is a great hotel option to stay in CDMX. The breakfast options are tasty and the personnel are very friendly."

Reviewed on Aug 18, 2025

Barceló México Reforma
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More vacations you might like

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.