--- title: "$112 Cheap Flights to San Luis - Expedia" description: "Looking for cheap flights to San Luis? Many airlines offer no change fee on selected flights and book now to earn your airline miles on top of our rewards! Find great 2026 San Luis flight deals now!" canonical: "https://www.expedia.com/Cheap-Flights-To-San-Luis.d553248635943694119.Travel-Guide-Flights" language: en-US market: US currency: USD prices_as_of: 2026-11-14T07:39:59Z --- # $112 Cheap Flights to San Luis [View $112 flight on Sun, Jan 3, 2027](https://www.expedia.com/Flights-Search?leg1=from:MCO,to:MDE,departure:1/3/2027TANYT&trip=oneway&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:111.50&airProductToken=AQovCi0IxnISAzU0NBjMcCDsICjSw6EDMLzFoQM4RUAAWAFqBFBDXzFyB1IyMVlNTjQSDAgBEAEYASoCRjkyABgBIgQIARABKAIoAygEMA0) ## Popular airlines to San Luis [Avianca](https://www.expedia.com/Flights-Search?leg1=from:CMH,to:San%20Luis,%20Antioquia,%20Colombia,departure:11/28/2026TANYT&leg2=from:San%20Luis,%20Antioquia,%20Colombia,to:CMH,departure:12/5/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AV"}}]) [LATAM Airlines Group](https://www.expedia.com/Flights-Search?leg1=from:CMH,to:San%20Luis,%20Antioquia,%20Colombia,departure:11/28/2026TANYT&leg2=from:San%20Luis,%20Antioquia,%20Colombia,to:CMH,departure:12/5/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"LA"}}]) [JetBlue Airways](https://www.expedia.com/Flights-Search?leg1=from:CMH,to:San%20Luis,%20Antioquia,%20Colombia,departure:11/28/2026TANYT&leg2=from:San%20Luis,%20Antioquia,%20Colombia,to:CMH,departure:12/5/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"B6"}}]) [American Airlines](https://www.expedia.com/Flights-Search?leg1=from:CMH,to:San%20Luis,%20Antioquia,%20Colombia,departure:11/28/2026TANYT&leg2=from:San%20Luis,%20Antioquia,%20Colombia,to:CMH,departure:12/5/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AA"}}]) [Aeromexico](https://www.expedia.com/Flights-Search?leg1=from:CMH,to:San%20Luis,%20Antioquia,%20Colombia,departure:11/28/2026TANYT&leg2=from:San%20Luis,%20Antioquia,%20Colombia,to:CMH,departure:12/5/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AM"}}]) [Copa](https://www.expedia.com/Flights-Search?leg1=from:CMH,to:San%20Luis,%20Antioquia,%20Colombia,departure:11/28/2026TANYT&leg2=from:San%20Luis,%20Antioquia,%20Colombia,to:CMH,departure:12/5/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"CM"}}]) [United](https://www.expedia.com/Flights-Search?leg1=from:CMH,to:San%20Luis,%20Antioquia,%20Colombia,departure:11/28/2026TANYT&leg2=from:San%20Luis,%20Antioquia,%20Colombia,to:CMH,departure:12/5/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"UA"}}]) ### Be in the know Get alerts if flight prices drop or rise\* ### Book smarter Save up to 30% on select hotels after you book a flight\* ### Earn twice Earn your airline miles on top of our OneKeyCash [Learn about One Key](https://www.expedia.com/welcome-one-key) ## How much is the cheapest flight to San Luis? Prices were available within the past 7 days and start at $112 for one-way flights and $276 for roundtrip, for the period specified. Prices and availability are subject to change. All deals One way Roundtrip [Select JetBlue Airways flight, departing Tue, Feb 2 from Columbus to Medellín, returning Tue, Feb 9, priced at $468 Found 3 days ago](https://www.expedia.com/Flights-Search?leg1=from:CMH,to:MDE,departure:2/2/2027TANYT&leg2=from:MDE,to:CMH,departure:2/9/2027TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:467.69&airProductToken=AQpcCi0IwmwSBDE1MDcYgjsg5VoolJSkAzC-laQDOExAAFgBagJETnIIUEMwUVVFWTEKKwjCbBICNDEY5Vog7CAokJekAzDnmKQDOExAAVgBagJETnIIUEMwUVVFWTESCggBEAEYASoCQjYYASIECAEQASgCKAMoBDAB) Tue, Feb 2 - Tue, Feb 9 · CMH · MDE · Roundtrip [Select Frontier Airlines flight, departing Tue, Feb 9 from Columbus to Medellín, returning Tue, Feb 16, priced at $471 Found 7 hours ago](https://www.expedia.com/Flights-Search?leg1=from:CMH,to:MDE,departure:2/9/2027TANYT&leg2=from:MDE,to:CMH,departure:2/16/2027TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:470.05&airProductToken=AQpfCi4IxnISBDE2MTIYgjsgzHAo%5F-ikAzCU6qQDOEVAAFgBagRQQ18xcgdSMjFaTUM0Ci0IxnISAzU0NBjMcCDsICiX76QDMPzwpAM4RUABWAFqBFBDXzFyB1IyMVpNQzQKXwotCMZyEgM1NDUY7CAgzHAogrWlAzDytqUDOEVAAFgBagRQQ18xcgdSMjFaTUM0Ci4IxnISBDE2MTEYzHAggjso072lAzDnvqUDOEVAAVgBagRQQ18xcgdSMjFaTUM0EgoIARABGAEqAkY5GAEiBAgBEAEoAigDKAQwDQ) Tue, Feb 9 - Tue, Feb 16 · CMH · MDE · Roundtrip [Select United flight, departing Tue, Feb 9 from Columbus to Medellín, returning Tue, Feb 16, priced at $749 Found 7 hours ago](https://www.expedia.com/Flights-Search?leg1=from:CMH,to:MDE,departure:2/9/2027TANYT&leg2=from:MDE,to:CMH,departure:2/16/2027TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:748.09&airProductToken=AQqoAQo2CNWCARIEMzQ4NxiCOyCuHCio5KQDMJHlpAM4TEAAWAFqCjFfYmFzaWNlY29yCExOWDhIVUJMCjYI1YIBEgQyMjEyGK4cIIg4KL7lpAMw8-akAzhMQABYAWoKMV9iYXNpY2Vjb3IITE5YOEhVQkwKNgjVggESBDE2NzUYiDgg7CAooeikAzC-6qQDOExAAFgBagoxX2Jhc2ljZWNvcghMTlg4SFVCTApwCjYI1YIBEgQxNjc2GOwgIIg4KOyzpQMwl7alAzhMQABYAWoKMV9iYXNpY2Vjb3IITE5YOEhVQkwKNgjVggESBDIwODYYiDgggjso3LilAzD8uaUDOExAAFgBagoxX2Jhc2ljZWNvcghMTlg4SFVCTBIKCAEQARgBKgJVQRgBIgQIARABKAIoAygEMAs) Tue, Feb 9 - Tue, Feb 16 · CMH · MDE · Roundtrip [Select American Airlines flight, departing Thu, Jan 28 from Columbus to Medellín, returning Thu, Feb 4, priced at $749 Found 2 days ago](https://www.expedia.com/Flights-Search?leg1=from:CMH,to:MDE,departure:1/28/2027TANYT&leg2=from:MDE,to:CMH,departure:2/4/2027TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:748.09&airProductToken=AQplCjEIwYIBEgQzNjQyGII7IIwCKMLcowMw992jAzhCQABYAWoFQkFTSUNyCE9MWDhJSEJaCjAIwYIBEgM5MjMYjAIg7CAov-GjAzCR46MDOEJAAVgBagVCQVNJQ3IIT0xYOElIQloKZQowCMGCARIDOTI0GOwgIIwCKK6rpAMwi62kAzhCQABYAWoFQkFTSUNyCE9MWDhJSEJaCjEIwYIBEgQyNTcxGIwCIII7KIKvpAMwsrCkAzhCQAFYAWoFQkFTSUNyCE9MWDhJSEJaEgoIARABGAEqAkFBGAEiBAgBEAEoAigDKAQwCw) Thu, Jan 28 - Thu, Feb 4 · CMH · MDE · Roundtrip [Select Delta flight, departing Tue, Jan 26 from Columbus to Medellín, returning Mon, Feb 8, priced at $761 Found 1 day ago](https://www.expedia.com/Flights-Search?leg1=from:CMH,to:MDE,departure:1/26/2027TANYT&leg2=from:MDE,to:CMH,departure:2/8/2027TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:760.79&airProductToken=AQqwAQo1CMSYARIEMTQ3ORiCOyDgXCjox6MDMM7IowM4RUAAWAFqCU1BSU5CQVNJQ3IIVExYTjdOQlAKNAjEmAESAzk4MRjgXCDBMyjByaMDMN7LowM4RUABWAFqCU1BSU5CQVNJQ3IIVExYTjdOQlAKQQjEmAESBDYwOTEYwTMg7CAops2jAzDnzaMDOEVAAVgBaglNQUlOQkFTSUNyCFRMWE43TkJQegoIzIIBEgQ0MDI4CrABCkEIxJgBEgQ3NDAzGOwgIMEzKMfYpAMwg9mkAzhFQABYAWoJTUFJTkJBU0lDcghUTFhON05CUHoKCMyCARIENDAwOQo0CMSYARIDOTgzGMEzIOBcKKfcpAMw2t6kAzhFQAFYAWoJTUFJTkJBU0lDcghUTFhON05CUAo1CMSYARIEMTQ1ORjgXCCCOyjN36QDMKngpAM4RUABWAFqCU1BSU5CQVNJQ3IIVExYTjdOQlASCggBEAEYASoCREwYASIECAEQASgCKAMoBDAB) Tue, Jan 26 - Mon, Feb 8 · CMH · MDE · Roundtrip ## Find the cheapest month to fly from Columbus (CMH) to Medellín (MDE) ### January is typically the cheapest month to fly From $468 - $1,063 per traveler. View flights in January Insights are based on prices from searches for economy trips of 10 days or less on our sites in the last 12 months. Insights are informative only and current prices may differ. ## Book with confidence ### Tips to find the cheapest flights to San Luis #### The cheapest day to fly Get started finding a cheap flight to San Luis on Expedia by either choosing a deal on this page or entering into the search bar your travel dates, origin airport, and whether you want roundtrip or one-way airfare. You can filter for flexibility, number of stops, airline, and departure/arrival times to find the best flight for you. #### The cheapest month to fly January is the cheapest month to fly to San Luis. This coincides with the low season when fewer people travel. Whichever month you travel in, though, be sure to book at least a month in advance if you want to score cheap tickets to San Luis. ARC's data shows that domestic flights booked 28 days or more before departure are typically 24% cheaper than those booked last minute. #### The most affordable time to book a flight Typically, a Sunday can be the cheapest time to book a flight to San Luis, according to ARC’s data. On average, you could save between 6% and 13% by booking on a Sunday instead of a Friday, which is the most expensive day to make a reservation. #### The cheapest round-trip tickets to San Luis The lowest price for round-trip flights to San Luis in 2026 starts from $276, while one-way tickets start from from $112\. Expedia's effective search tool is one of the best ways to find a budget airfare. Simply enter your dates, and within seconds, it'll show you a vast selection of the cheapest flights to San Luis. If you have a preferred departure time or airline, you can use the handy filters to customize your search. #### The cheapest airlines flying to San Luis Frontier Airlines, JetBlue Airways, Copa, Air Canada, United, American Airlines, Delta are just some of the airlines that can typically offer cheap tickets to San Luis. You can find their most affordable flights by using the “airline” search filter and then sorting prices from low to high. As a trusted partner of the world's leading airlines, Expedia offers you some of the best airfare deals to San Luis and countless more destinations worldwide. #### The most affordable airports to fly into To view the cheapest airports to fly into for San Luis, simply order your search results from lowest to highest price. Expedia's search tool compares flight prices for all airports close to your destination, so you don't have to manually search them one by one to find the cheapest flight to San Luis. If you have a preferred place to fly into, take advantage of the “arrival airport” filter to narrow down your search on Expedia. #### Save with a package With Expedia's amazing [package deals](https://www.expedia.com/package-deals), you could save hundreds of dollars by booking your San Luis plane tickets together with your accommodations, car rental, or activities. Just select the search wizard's “package” option to view some of the cheapest deals. Look out for the green savings label to see how much you're saving. #### Date flexibility for the cheapest flights to San Luis If you can be flexible with your travel dates, it's a good idea to broaden your search by comparing prices on different days. This will open up more options, meaning you could uncover a less expensive flight to San Luis. #### Stopover savings The cheapest tickets to San Luis are sometimes those with a stopover. Book one of these flights, and you'll change planes at an airport en route to San Luis. While the overall travel time might be longer than a non-stop flight, you may decide it's worth it for the money saved. #### Get Expedia's Price Drop Protection Price Drop Protection means that if your flight gets cheaper after booking, you'll be credited the difference\*. This gives you peace of mind that you're getting one of the cheapest flights to San Luis for your chosen departure. Expedia's Price Drop Protection is available for a small fee but is free to One Key Gold and Platinum tier members. *\*Terms apply.* #### Use our Price Tracking feature Expedia's Price Tracking feature is another great tool that removes the guesswork from finding cheap flights to San Luis. Simply download the free Expedia app to your smart device and activate San Luis flight price alerts for your travel dates. There's even a price predictor tool that uses historical data to indicate the best time to book, giving you peace of mind that you'll nab the lowest prices. #### Book with Expedia As well as Price Drop Protection and Price Tracking, Expedia's close partnership with a vast selection of the world's leading airlines means you're sure to find cheap flights to San Luis. Plus, the One Key rewards program lets you earn real cash rewards on most bookings that you can use to save money on future trips. Best of all, it's free to join, and members often unlock exclusive discounts, too. *Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023\. The percentages you see are averages.* ## Frequently Asked Questions ### What month is the cheapest to fly to San Luis? January is the cheapest month to travel to San Luis. Demand is lower then, so you're likely to get a good deal. Booking your trip outside of school breaks and public holidays can also help you save. ### Which US cities fly direct to San Luis? You can fly to San Luis without stopovers from US cities like Miami and Fort Lauderdale. Just click on "Direct flights only" when browsing flights to San Luis on Expedia. Then, compare the available options and decide on the most convenient departure for your getaway. ### How to find a cheap flight to San Luis? To snag cheap flights to San Luis, book ahead of time and travel during the low season. Want some insider advice? Fly on a Thursday and you'll save 16% on average compared to those who jet off on a Sunday.\* Sign up for price tracking on the [Expedia app](https://www.expedia.com/app) and we'll let you know if prices drop. *\*Best day of the week to book, depart and ideal booking window recommendations based on average round-trip ticket prices for January through August 2023, sourced from Airline Reporting Corporation's (ARC) global airline sales database. Percentages noted are averages.* ### How to get a cheap last-minute flight to San Luis? While booking in advance is generally the best way to save money, don't worry if your San Luis trip is last minute. It's still possible to find cheap flights to San Luis, especially if your plans have a little wiggle room. Try switching up your trip dates, exploring different ticket options or departing from an alternative airport. ### How far in advance should I book a flight to San Luis? To pick up the best deals on domestic journeys, book your flight to San Luis 28 days ahead of your travel dates. For international flights, it's between two and four months in advance. This improves your chances of getting your preferred departure dates and seats.\* *\*Best day of the week to book, depart and ideal booking window recommendations based on average round-trip ticket prices for January through August 2023, sourced from Airline Reporting Corporation's (ARC) global airline sales database. Percentages noted are averages.* ### Which day of the week is the cheapest day to buy a plane ticket to San Luis? Sundays are typically the best day to book a cheap flight to San Luis, with savings of about 8% on average compared to Fridays. If you choose to purchase tickets on a Friday, expect to pay more as this is often the most expensive day.\* *\*Best day of the week to book, depart and ideal booking window recommendations based on average round-trip ticket prices for January through August 2023, sourced from Airline Reporting Corporation's (ARC) global airline sales database. Percentages noted are averages.* ### Which airlines fly to San Luis? A total of 12 carriers connect 32 airports across the world to San Luis. Here are a few of the major airlines to San Luis, where Jose Maria Cordova Intl. Airport (MDE) is the major arrival point: - AVIANCA - LATAM Airlines - Copa Airlines - Wingo ### Where do you fly into San Luis? The main airport to fly to San Luis is Jose Maria Cordova Intl. Airport (MDE). There's also the option to touch down at Enrique Olaya Herrera Airport (EOH) when flying to San Luis. ### How far is the airport from central San Luis? Landing at Jose Maria Cordova Intl. Airport (MDE) puts you around 30 mi west of central San Luis. ### Can I save money by booking a San Luis trip package? It's possible to save hundreds of dollars if you secure a [San Luis flight and hotel package deal](https://www.expedia.com/San-Luis.d553248635943694119.Destination-Travel-Guides) on Expedia. And you'll save yourself hassle by having all your travel plans in one place. Try bundling flights and accommodations with extras like tours and car rentals for your own personalized San Luis break. ### Can I change or cancel my flight to San Luis? If you booked your flight to San Luis within the last 24 hours, you can typically change or cancel it without fees. After that, additional costs may apply depending on the airline's terms of service. For more information, visit our [Customer Service Portal](https://www.expedia.com/service/?langid=1033). Bear in mind that some flights are non-refundable, so you may receive a credit toward future travel rather than a direct refund. When browsing on Expedia, check the "No cancel fee" or "Changes included" boxes to find tickets with flexible change policies. ## Travel information | Destination city name | Medellín | | ----------------------------- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | Destination airport | Jose Maria Cordova Intl. Airport | | Destination airport IATA code | MDE | | Airlines serving | Avianca, LATAM Airlines Group, JetBlue Airways, American Airlines, Aeromexico, Copa, United, Delta, Frontier Airlines, Air Canada, Sterling Blue, Air Europa, KLM, B & H Airlines, Iberia, TAP Portugal, Lufthansa, WestJet, Volaris, Turkish Airlines, Viva Aerobus, GOL Linhas Aereas S.A., ITA Airways, Aerolineas Argentinas, Qatar Airways, Etihad Airways, Emirates, Saudi Arabian Airlines, W1, Hahn Air Technologies | | Popular airline | Avianca | | Roundtrip price | $468 | ## Explore a world of travel with Expedia - [Lodging](?equalTargetTab=tab-0) - [Flights](?equalTargetTab=tab-1) - [Packages](?equalTargetTab=tab-2) - [Cars](?equalTargetTab=tab-3) - [Vacation Rentals](?equalTargetTab=tab-4) - [Things to Do](?equalTargetTab=tab-5) - [Hotels with Air Conditioning in Guatapé](https://www.expedia.com/Guatape-Hotels-Hotels-With-Air-Conditioning.0-0-d6154953-tHotelswithAirConditioning.Travel-Guide-Filter-Hotels) - [Hotels on the Lake in Guatapé](https://www.expedia.com/Guatape-Hotels-Lakefront-Hotels.0-0-d6154953-tLakefrontHotels.Travel-Guide-Filter-Hotels) - 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[Rv Parks in Cocorná](https://www.expedia.com/Cocorna-RV-Parks.d6270705-aaRVParks.Travel-Guide-Accommodation) - [4 Star Hotels in Guatapé](https://www.expedia.com/4Star-Guatape-Hotels.s40-0-d6154953.Travel-Guide-Filter-Hotels) - [Cabin Rentals in Guatapé](https://www.expedia.com/Guatape-Cabins.d6154953-aaCabins.Travel-Guide-Accommodation) - [5 Star Hotels in Cocorná](https://www.expedia.com/5Star-Cocorna-Hotels.s50-0-d6270705.Travel-Guide-Filter-Hotels) - [Apartments in Cocorná](https://www.expedia.com/Cocorna-Apartments.d6270705-aaApartments.Travel-Guide-Accommodation) - [Casino Hotels in Guatapé](https://www.expedia.com/Guatape-Hotels-Casino-Hotel.0-0-d6154953-tCasinoHotel.Travel-Guide-Filter-Hotels) - [Hotels with Free Breakfast in Guatapé](https://www.expedia.com/Guatape-Hotels-Hotels-With-Complimentary-Breakfast.0-0-d6154953-tHotelswithComplimentaryBreakfast.Travel-Guide-Filter-Hotels) - [Hotels with Bars in Guatapé](https://www.expedia.com/Guatape-Hotels-Bar-Hotel.0-0-d6154953-tBarHotel.Travel-Guide-Filter-Hotels) - [San Luis Hotels](https://www.expedia.com/San-Luis-Hotels.d553248635943694119.Travel-Guide-Hotels) - [Flights to Guatapé](https://www.expedia.com/Cheap-Flights-To-Guatape.d6154953.Travel-Guide-Flights) - [Flights from Fort Lauderdale (FLL) to Medellín (MDE)](https://www.expedia.com/lp/flights/fll/mde/fort-lauderdale-to-medellin) - [Flights from Boston (BOS) to Medellín (MDE)](https://www.expedia.com/lp/flights/bos/mde/boston-to-medellin) - [Flights from Cartagena (CTG) to Medellín (MDE)](https://www.expedia.com/lp/flights/ctg/mde/cartagena-to-medellin) - [Flights to El Santuario](https://www.expedia.com/Cheap-Flights-To-El-Santuario.d553248635943694289.Travel-Guide-Flights) - [Flights from Bogotá (BOG) to Medellín (MDE)](https://www.expedia.com/lp/flights/bog/mde/bogota-to-medellin) - [Flights to Cocorná](https://www.expedia.com/Cheap-Flights-To-Cocorna.d6270705.Travel-Guide-Flights) - [Flights from Guatapé](https://www.expedia.com/lp/flights/6154953/flights-from-guatape) - [Flights to Marinilla](https://www.expedia.com/Cheap-Flights-To-Marinilla.d6294332.Travel-Guide-Flights) - [Flights to San Roque](https://www.expedia.com/Cheap-Flights-To-San-Roque.d553248635810200528.Travel-Guide-Flights) - [Flights from Philadelphia (PHL) to Medellín (MDE)](https://www.expedia.com/lp/flights/phl/mde/philadelphia-to-medellin) - [Flights from Chicago (ORD) to Medellín (MDE)](https://www.expedia.com/lp/flights/ord/mde/chicago-to-medellin) - [Flights from Miami (MIA) to Medellín (MDE)](https://www.expedia.com/lp/flights/mia/mde/miami-to-medellin) - [Flights to El Carmen de Viboral](https://www.expedia.com/Cheap-Flights-To-El-Carmen-De-Viboral.d3000397191.Travel-Guide-Flights) - [Flights to San Rafael](https://www.expedia.com/Cheap-Flights-To-San-Rafael.d553248635933209788.Travel-Guide-Flights) - [Flights from Orlando (MCO) to Medellín (MDE)](https://www.expedia.com/lp/flights/mco/mde/orlando-to-medellin) - [Flights to José María Córdova Intl.](https://www.expedia.com/Cheap-Flights-To-Jose-Maria-Cordova-Intl.d4539469.Travel-Guide-Flights) - [Flights to San Antonio de Pereira](https://www.expedia.com/Cheap-Flights-To-San-Antonio-De-Pereira.d553248635892116200.Travel-Guide-Flights) - [Flights to Alejandria](https://www.expedia.com/Cheap-Flights-To-Alejandria.d6345924.Travel-Guide-Flights) - [Flights from José María Córdova Intl.](https://www.expedia.com/lp/airports/mde/flights-from-jose-maria-cordova-intl-airport) - [Flights to Sonson](https://www.expedia.com/Cheap-Flights-To-Sonson.d6350774.Travel-Guide-Flights) - [Flights to Rionegro](https://www.expedia.com/Cheap-Flights-To-Rionegro.d181446.Travel-Guide-Flights) - [Flights to San Francisco](https://www.expedia.com/Cheap-Flights-To-San-Francisco.d553248635943694579.Travel-Guide-Flights) - [Flights to Puerto Triunfo](https://www.expedia.com/Cheap-Flights-To-Puerto-Triunfo.d6270785.Travel-Guide-Flights) - [Flights to El Peñol](https://www.expedia.com/Cheap-Flights-To-El-Penol.d6346467.Travel-Guide-Flights) - [Flights from Los Angeles (LAX) to Medellín (MDE)](https://www.expedia.com/lp/flights/lax/mde/los-angeles-to-medellin) - [Flights to La Ceja](https://www.expedia.com/Cheap-Flights-To-La-Ceja.d6294319.Travel-Guide-Flights) - [Flights to Puerto Nare](https://www.expedia.com/Cheap-Flights-To-Puerto-Nare.d2518.Travel-Guide-Flights) - [Flights from Houston (IAH) to Medellín (MDE)](https://www.expedia.com/lp/flights/iah/mde/houston-to-medellin) - [Flights from New York (JFK) to Medellín (MDE)](https://www.expedia.com/lp/flights/jfk/mde/new-york-to-medellin) - [Flights from Atlanta (ATL) to Medellín (MDE)](https://www.expedia.com/lp/flights/atl/mde/atlanta-to-medellin) - [Visit Cocorná](https://www.expedia.com/Cocorna.dx6270705) - [Visit Guatapé](https://www.expedia.com/Guatape.dx6154953) - [Natural Reserve Canondel Rio Claro](https://www.expedia.com/Natural-Reserve-Canondel-Rio-Claro-San-Francisco.d553248621532376352.Vacation-Attraction) - [Benedictine's Monastery](https://www.expedia.com/Benedictines-Monastery-Guatape.d830547893984186368.Vacation-Attraction) - [Rio Claro Valley](https://www.expedia.com/Rio-Claro-Valley-Antioquia.d553248621532467227.Vacation-Attraction) - [Where to stay in Guatapé](https://www.expedia.com/Guatape.dx6154953.Where-To-Stay) - [Guácharos Cave](https://www.expedia.com/Guacharos-Cave-San-Francisco.d553248621532376351.Vacation-Attraction) - [Visit Granada](https://www.expedia.com/Granada.dx553248635943694551) - [Visit San Rafael](https://www.expedia.com/San-Rafael.dx553248635933209788) - [La Planta Waterfall](https://www.expedia.com/La-Planta-Waterfall-San-Luis.d828034227077320704.Vacation-Attraction) - [Guatapé Vacations](https://www.expedia.com/Guatape.d6154953.Destination-Travel-Guides) - [Cocorná Vacations](https://www.expedia.com/Cocorna.d6270705.Destination-Travel-Guides) - [Visit San Carlos](https://www.expedia.com/San-Carlos.dx553248635943694491) - [Car rental Granada](https://www.expedia.com/Car-Rentals-In-Granada.d553248635943694551.Car-Rental-Guide) - [Suv Car Rentals in Guatapé](https://www.expedia.com/SUV-Car-Rentals-In-Guatape.d6154953-tSUV.Car-Rental-Guide-Class) - [Van Car Rentals in Guatapé](https://www.expedia.com/Van-Car-Rentals-In-Guatape.d6154953-tVan.Car-Rental-Guide-Class) - [Car rental Guatapé](https://www.expedia.com/Car-Rentals-In-Guatape.d6154953.Car-Rental-Guide) - [Car rental San Luis](https://www.expedia.com/Car-Rentals-In-San-Luis.d553248635943694119.Car-Rental-Guide) - [Alamo Rent A Car Rental Cars in Guatapé](https://www.expedia.com/Alamo-Rent-A-Car-Car-Rentals-In-Guatape.d6154953-c6.Car-Rental-Guide-Suppliers) - [Cocorná Vacation Rentals](https://www.expedia.com/Cocorna-Vacation-Rentals.d6270705.Travel-Guide-VacationRentals) - [Guatapé Vacation Rentals](https://www.expedia.com/Guatape-Vacation-Rentals.d6154953.Travel-Guide-VacationRentals) - [Things to do in El Peñol](https://www.expedia.com/Things-To-Do-In-El-Penol.d6346467.Travel-Guide-Activities) - [Things to do in Guatapé](https://www.expedia.com/Things-To-Do-In-Guatape.d6154953.Travel-Guide-Activities) - [Things to do in Rionegro](https://www.expedia.com/Things-To-Do-In-Rionegro.d181446.Travel-Guide-Activities) ## Trending flights to San Luis Prices were available within the past 7 days and start at $112 for one-way flights and $276 for roundtrip, for the period specified. Prices and availability are subject to change. All deals One way Roundtrip [Select Copa flight, departing Mon, Jan 25 from Fort Lauderdale to Medellín, returning Thu, Feb 4, priced at $276 Found 4 hours ago](https://www.expedia.com/Flights-Search?leg1=from:FLL,to:MDE,departure:1/25/2027TANYT&leg2=from:MDE,to:FLL,departure:2/4/2027TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:275.99&airProductToken=AQpiCi8Iw5oBEgMyNjYY5Vog78QBKLG%5FowMw78CjAzhBQABYAWoDQkFTcghBTEEyVFoyUwovCMOaARIDNzU2GO%5FEASDsICjBxqMDMJXHowM4QUAAWAFqA0JBU3IIQUxBMlRaMlMKYgovCMOaARIDMTY0GOwgIO%5FEASjvq6QDMMispAM4QUAAWAFqA0JBU3IIQUxBMlRaMlMKLwjDmgESAzI2NRjvxAEg5Voov62kAzCDr6QDOEFAAFgBagNCQVNyCEFMQTJUWjJTEgoIAhABGAEqAkNNGAEiBAgBEAEoAigDKAQwCw) Mon, Jan 25 - Thu, Feb 4 · FLL · MDE · Roundtrip \*Available to One Key members. ## Other language versions ```yaml hreflang: x-default: https://www.expedia.com/Cheap-Flights-To-San-Luis.d553248635943694119.Travel-Guide-Flights es-MX: https://www.expedia.mx/Vuelos-Baratos-San-Luis.d553248635943694119.Guia-de-vuelos en-US: https://www.expedia.com/Cheap-Flights-To-San-Luis.d553248635943694119.Travel-Guide-Flights en-AU: https://www.expedia.com.au/Flights-To-San-Luis.d553248635943694119.Travel-Guide-Flights ```