Find Adults Only Resorts & Hotels in Clayton, MO from $118

Top Adults only hotels in Clayton

AC Hotel St. Louis Clayton
3 out of 5
227 South Central Ave, St. Louis, MO
$139 nightly
The price is $162 total per night from Sep 28 to Sep 29
$162 total
Sep 28 - Sep 29
Total with taxes and fees
9.2/10 Wonderful! (152 reviews)
"Good"

Reviewed on Aug 26, 2025

AC Hotel St. Louis Clayton
Seven Gables, St. Louis West, a Tribute Portfolio Hotel
3.5 out of 5
26 North Meramec Avenue, St. Louis, MO
$125 nightly
The price is $145 total per night from Sep 1 to Sep 2
$145 total
Sep 1 - Sep 2
Total with taxes and fees
8.2/10 Very Good! (564 reviews)
"Very quiet. Moved to the first floor. Room very nice. Elevator was out."

Reviewed on Aug 7, 2025

Seven Gables, St. Louis West, a Tribute Portfolio Hotel
21C Museum Hotel St Louis
4.5 out of 5
1528 Locust street, St. Louis, MO
$148 nightly
The price is $173 total per night from Sep 1 to Sep 2
$173 total
Sep 1 - Sep 2
Total with taxes and fees
21C Museum Hotel St Louis
Drury Plaza Hotel St. Louis at the Arch
3 out of 5
2 South 4th Street, St. Louis, MO
$120 nightly
The price is $140 total per night from Sep 28 to Sep 29
$140 total
Sep 28 - Sep 29
Total with taxes and fees
Drury Plaza Hotel St. Louis at the Arch
Hyatt Regency St. Louis at The Arch
4 out of 5
315 Chestnut St, St. Louis, MO
$135 nightly
The price is $159 total per night from Sep 1 to Sep 2
$159 total
Sep 1 - Sep 2
Total with taxes and fees
Hyatt Regency St. Louis at The Arch
Clayton Plaza Hotel & Extended Stay
3.5 out of 5
7750 Carondelet Avenue, St. Louis, MO
$101 nightly
The price is $118 total per night from Aug 31 to Sep 1
$118 total
Aug 31 - Sep 1
Total with taxes and fees
Clayton Plaza Hotel & Extended Stay
Residence Inn By Marriott St. Louis Clayton
3 out of 5
8125 Forsyth Blvd, St. Louis, MO
$179 nightly
The price is $209 total per night from Sep 21 to Sep 22
$209 total
Sep 21 - Sep 22
Total with taxes and fees
Residence Inn By Marriott St. Louis Clayton
Le Méridien St. Louis Clayton
4 out of 5
7730 Bonhomme Ave, St. Louis, MO
$170 nightly
The price is $200 total per night from Sep 28 to Sep 29
$200 total
Sep 28 - Sep 29
Total with taxes and fees
Le Méridien St. Louis Clayton
Hampton Inn & Suites Clayton/St. Louis-Galleria Area
3 out of 5
216 N Meramec Ave, St. Louis, MO
$150 nightly
The price is $176 total per night from Sep 28 to Sep 29
$176 total
Sep 28 - Sep 29
Total with taxes and fees
Hampton Inn & Suites Clayton/St. Louis-Galleria Area
The Ritz-Carlton, St. Louis
5 out of 5
100 Carondelet Plaza, St. Louis, MO
$519 nightly
The price is $605 total per night from Sep 21 to Sep 22
$605 total
Sep 21 - Sep 22
Total with taxes and fees
The Ritz-Carlton, St. Louis
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about Clayton

Find out more about Clayton

Discover top Clayton attractions

Clayton, a charming neighborhood in St. Louis, offers a delightful blend of culture, dining, and outdoor activities perfect for the discerning traveler. Start your visit at the St. Louis Art Museum, where you can explore an impressive collection of artworks spanning centuries, all set within the picturesque Forest Park. Families will appreciate the interactive exhibits at the Magic House, a children's museum that invites young minds to explore, play, and learn in a fun-filled environment. For a taste of local culture, take a leisurely stroll through the quaint streets of downtown Clayton, lined with boutique shops and upscale dining options, such as the acclaimed Pappy's Smokehouse, known for its mouthwatering barbecue. Nature enthusiasts can unwind at Shaw Park, featuring beautiful walking trails, tennis courts, and a serene pond perfect for a family picnic. After a day of exploration, retreat to one of the elegant hotels in the area, like the Crowne Plaza St. Louis, which boasts spacious rooms and top amenities, ensuring you feel pampered throughout your stay. Enjoy attentive service and convenient access to all the neighborhood has to offer, allowing you to relax and indulge while planning your next adventure.

Top Clayton Hotel Reviews

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