Clayton Vacations from $432
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Your Clayton Vacation
Lock in a Clayton vacation package and prepare to experience all this lively city has to offer. Consider staying in the neighborhood of Soulard, which is good for distilleries and craft breweries, bars and pubs and markets. Fill your spare time with tours of St. Louis Zoo, St. Louis Art Museum and Cathedral Basilica of St. Louis, some of the attractions you just have to see during a trip to Clayton. A couple of clicks is all it takes to put together the perfect Clayton vacation on Expedia.
The Latest Clayton Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Hilton Garden Inn Chesterfield
Price was $579, price is now $432 per person
$432
per person
Feb 18 - Feb 23
found 6 hours ago
Roundtrip non-stop flight included
New York (JFK) to St. Louis (STL)
8.2/10 Very Good! (779 reviews)
Staff was informative during check-in. Room was clean and the TV even had WELCOME with my name on it. Would stay here again.
Reviewed on Dec 22, 2025
The Wildwood Hotel
Save 100% on your flight
Price was $898, price is now $521 per person
$521
per person
Feb 13 - Feb 16
found 7 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to St. Louis (STL)
9.2/10 Wonderful! (1,600 reviews)
We enjoyed our stay! Close to skiing and tubing. Lots of restaurants close. Kids loves the small swimming pool
Reviewed on Jan 7, 2026
21C Museum Hotel St Louis
Downtown West
Price was $790, price is now $581 per person
$581
per person
Mar 15 - Mar 20
found 15 hours ago
Roundtrip flight included
New York (NYC) to St. Louis (STL)
9/10 Wonderful! (1,458 reviews)
Our room wasn’t ready at 5pm, could not check in for about 1.5 hrs. Luckily they have a fantastic bar. Room was small but well appointed. The doors to some cabinets would not shut. The shower door would not shut. We did not have enough shampoo conditioner or body wash. The museum was nice. The restaurant is great. Probably wouldn’t stay again but would definitely eat at the restaurant or have drinks at the bar.
Reviewed on Jan 5, 2026
Hilton Pennywell St. Louis at the Arch
Downtown St. Louis
Price was $874, price is now $671 per person
$671
per person
Mar 15 - Mar 20
found 15 hours ago
Roundtrip flight included
New York (NYC) to St. Louis (STL)
8.8/10 Excellent! (996 reviews)
Beautiful hotel, very clean. Dinner at restaurant was subpar.
Reviewed on Jan 7, 2026
Where to stay in Clayton
Find the best Clayton areas and neighborhoods for the activities you enjoy most. Learn more about Clayton
Downtown St. Louis
4 out of top 10 points of interest in this area
4/5(4,004 area reviews)
Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.
Clayton Hotel Deals
Clayton Plaza Hotel & Extended Stay
7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $109 total per night from Jan 24 to Jan 25
$109 total
Jan 24 - Jan 25
Total with taxes and fees
8.8/10 Excellent! (3,059 reviews)
The room was very cozy and welcoming. The staff was great and friendly from checking in to the breakfast host to checking out.
Reviewed on Jan 5, 2026
Hampton Inn & Suites Clayton/St. Louis-Galleria Area
216 N Meramec Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $144 total per night from Jan 18 to Jan 19
$144 total
Jan 18 - Jan 19
Total with taxes and fees
8.8/10 Excellent! (925 reviews)
All was fine
Reviewed on Dec 31, 2025
Le Méridien St. Louis Clayton
7730 Bonhomme Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$143 nightly
The price is $169 total per night from Jan 25 to Jan 26
$169 total
Jan 25 - Jan 26
Total with taxes and fees
8.8/10 Excellent! (682 reviews)
The gym was amazing!
Reviewed on Dec 21, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Clayton
Washington University in St. Louis
4.5/5(479 reviews)
Enjoy the collegiate vibe at Washington University in St. Louis during your stay in St. Louis. Amble around the area's lush forest or attend a sporting event.
Chapel of St. Timothy And St. Titus, Concordia Seminary
Find out about the history of St. Louis when you take a trip to Chapel of St. Timothy And St. Titus, Concordia Seminary. Experience the area's acclaimed theater scene or attend a sporting event.
Things to do
St. Louis Ghost Tour: Sinister Sins & Shadows
$24
per adult
St. Louis Premium Driving Tour with Boat Ride & Arch
$174
per adult
100% of travellers recommend
Best of St. Louis Small Group Tour w/ Arch & River Cruise
$169
per adult
84% of travellers recommend
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- St. Louis Zoo
- Chapel of St. Timothy And St. Titus
- St. Louis Art Museum
- Washington University in St. Louis
- Saint Louis Galleria Mall
- St. Louis Walk of Fame
- Visit Richmond Heights
- Tivoli Theatre
- The Muny Theater
- Turtle Playground
- Jewel Box
- Missouri History Museum
- The Focal Point
- Brentwood Vacations
- Visit University City
- Pagoda Circle
- Cabanne House
- Car rentals near Washington University in St. Louis
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.