Clayton Vacations from $265
Book a Hotel + Flight or Car together to unlock savings
Your Clayton Vacation
Lock in a Clayton vacation package and prepare to experience all this lively city has to offer. Consider staying in the neighborhood of Soulard, which is good for distilleries and craft breweries, bars and pubs and markets. Fill your spare time with tours of St. Louis Zoo, St. Louis Art Museum and Cathedral Basilica of St. Louis, some of the attractions you just have to see during a trip to Clayton. A couple of clicks is all it takes to put together the perfect Clayton vacation on Expedia.
The Latest Clayton Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Courtyard by Marriott St. Louis Downtown/Convention Center
Downtown St. Louis
Price was $331, price is now $265 per person
$265
per person
Oct 24 - Oct 26
found 1 day ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
9/10 Wonderful! (1,004 reviews)
I was very surprised at how empty the streets were but I asked a local policeman and he said it usually is. The streets were very clean. However like most big cities just be careful
Reviewed on Aug 20, 2025
The Wildwood Hotel
Save 100% on your flight
Price was $521, price is now $332 per person
$332
per person
Oct 18 - Oct 20
found 1 day ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
9.2/10 Wonderful! (1,561 reviews)
Very clean and staff were nice and attentive. The breakfast was disappointing, that’s my only negative.
Reviewed on Aug 24, 2025
Hilton Garden Inn Chesterfield
Price was $358, price is now $271 per person
$271
per person
Oct 24 - Oct 26
found 1 day ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
8.2/10 Very Good! (762 reviews)
I booked online and paid via the app. When I arrived on site they explained they had overbooked and had no rooms available. The staff was amazing and went above and beyond and secured a room at another location. Thank you to the staff for taking care of us.
Reviewed on Jul 26, 2025
Where to stay in Clayton
Find the best Clayton areas and neighborhoods for the activities you enjoy most. Learn more about Clayton
Downtown St. Louis
3 out of top 10 points of interest in this area
4/5(4,004 area reviews)
Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.
Clayton Hotel Deals
Clayton Plaza Hotel & Extended Stay
7750 Carondelet Avenue, St. Louis, MO
Fully refundableReserve now, pay when you stay
$103 nightly
The price is $120 total per night from Sep 21 to Sep 22
$120 total
Sep 21 - Sep 22
Total with taxes and fees
8.8/10 Excellent! (2,902 reviews)
"Easy access to Metro to get to sports event"
Reviewed on Aug 22, 2025
AC Hotel St. Louis Clayton
227 South Central Ave, St. Louis, MO
Fully refundableReserve now, pay when you stay
$130 nightly
The price is $151 total per night from Sep 1 to Sep 2
$151 total
Sep 1 - Sep 2
Total with taxes and fees
9/10 Wonderful! (148 reviews)
"Great hotel. Clean!!!"
Reviewed on Aug 11, 2025
The Ritz-Carlton, St. Louis
100 Carondelet Plaza, St. Louis, MO
Fully refundableReserve now, pay when you stay
$519 nightly
The price is $605 total per night from Sep 21 to Sep 22
$605 total
Sep 21 - Sep 22
Total with taxes and fees
9.2/10 Wonderful! (544 reviews)
"Excellent"
Reviewed on Jul 18, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Clayton
Washington University in St. Louis
4.5/5(479 reviews)
Enjoy the collegiate vibe at Washington University in St. Louis during your stay in St. Louis. Amble around the area's lush forest or attend a sporting event.
Chapel of St. Timothy And St. Titus, Concordia Seminary
Find out about the history of St. Louis when you take a trip to Chapel of St. Timothy And St. Titus, Concordia Seminary. Experience the area's acclaimed theater scene or attend a sporting event.
Things to do
St Louis Ghost Tours: Sinister Sins & Shadows Ghost Tour
$32
per adult
Best of St. Louis Small Group Tour w/ Arch & River Cruise
$169
per adult
84% of travellers recommend
St. Louis Ghosts: Gateway Ghouls and Hauntings
$26
per adult
100% of travellers recommend
Explore a world of travel with Expedia
Explore a world of travel with Expedia
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- St. Louis Zoo
- Chapel of St. Timothy And St. Titus
- St. Louis Art Museum
- Washington University in St. Louis
- Saint Louis Galleria Mall
- St. Louis Walk of Fame
- Visit Richmond Heights
- Tivoli Theatre
- The Muny Theater
- Turtle Playground
- Jewel Box
- Missouri History Museum
- The Focal Point
- Brentwood Vacations
- Visit University City
- Pagoda Circle
- Cabanne House
- Car rentals near Washington University in St. Louis
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- Car rentals near Richmond Heights
- Car rentals near Delmar Loop
- Car rentals near Saint Louis Galleria Mall
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.