Clayton Vacations from $502
Book a Hotel + Flight or Car together to unlock savings
Your Clayton Vacation
Lock in a Clayton vacation package and prepare to experience all this lively city has to offer. Consider staying in the neighborhood of Soulard, which is good for distilleries and craft breweries, bars and pubs and markets. Fill your spare time with tours of St. Louis Zoo, St. Louis Art Museum and Cathedral Basilica of St. Louis, some of the attractions you just have to see during a trip to Clayton. A couple of clicks is all it takes to put together the perfect Clayton vacation on Expedia.
The Latest Clayton Vacation Packages
Price found within the past 48 hours. Click for updated prices.
White House at Grand Central
Grand Center
Price was $717, price is now $502 per person
$502
per person
Feb 13 - Feb 19
found 2 days ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to St. Louis (STL)
17.2/10 Exceptional! (123 reviews)
Very clean and very friendly people
Reviewed on Nov 11, 2025
Hilton St. Louis Airport
Woodson Terrace
Save 100% on your flight
Price was $853, price is now $572 per person
$572
per person
Feb 13 - Feb 19
found 2 days ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to St. Louis (STL)
15.2/10 Exceptional! (1,000 reviews)
The room was clean, the staff was nice, and the hotel had a good atmosphere. The lobby restaurant/bar was busy but not overly crowded. The food was good. The floors with the rooms are quiet.
Reviewed on Nov 15, 2025
Tru By Hilton St. Louis Downtown
Downtown West
Price was $765, price is now $531 per person
$531
per person
Feb 13 - Feb 19
found 2 days ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to St. Louis (STL)
15.2/10 Exceptional! (558 reviews)
I felt that the staff and facility were fine. Location met my needs well. However the phone system was down for the entire time of my stay. There was no communication with the hotel from the room, which may have contributed to my room being opened by staff while I was in the room BOTH DAYS! This was unacceptable.
Reviewed on Nov 18, 2025
The Cheshire
Save 100% on your flight
Price was $977, price is now $684 per person
$684
per person
Feb 13 - Feb 19
found 2 days ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to St. Louis (STL)
17.2/10 Exceptional! (1,002 reviews)
Great stay! The room could have been a tiny bit cleaner but nothing crazy! Mainly stains on the table and some dusty areas but beds and bathrooms were clean!
The staff was super nice and the place was nicely decorated.
Reviewed on Nov 15, 2025
The West End
Central West End
Price was $728, price is now $528 per person
$528
per person
Feb 13 - Feb 19
found 2 days ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to St. Louis (STL)
16.8/10 Exceptional! (389 reviews)
Room was clean, facilities were clean, parking was good.
Downsides, needs more furniture in the room. A dresser, and possible a sitting chair. Hot water could be a littlw faster so not so much is wasted.
Reviewed on Nov 22, 2025
Where to stay in Clayton
Find the best Clayton areas and neighborhoods for the activities you enjoy most. Learn more about Clayton
Downtown St. Louis
3 out of top 10 points of interest in this area
4/5(4,004 area reviews)
Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.
Clayton Hotel Deals
Clayton Plaza Hotel & Extended Stay
7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $110 total per night from Nov 30 to Dec 1
$110 total
Nov 30 - Dec 1
Total with taxes and fees
8.8/10 Excellent! (3,002 reviews)
Breakfast was only fair
Reviewed on Nov 21, 2025
AC Hotel St. Louis Clayton
227 South Central Ave St. Louis MO
$130 nightly
The price is $152 total per night from Dec 14 to Dec 15
$152 total
Dec 14 - Dec 15
Total with taxes and fees
9/10 Wonderful! (215 reviews)
Bar well stocked and friendly service
Reviewed on Nov 18, 2025
The Ritz-Carlton, St. Louis
100 Carondelet Plaza St. Louis MO
$469 nightly
The price is $548 total per night from Nov 28 to Nov 29
$548 total
Nov 28 - Nov 29
Total with taxes and fees
9.2/10 Wonderful! (551 reviews)
Service is exceptional!!!
Reviewed on Sep 2, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Clayton
Washington University in St. Louis
4.5/5(479 reviews)
Enjoy the collegiate vibe at Washington University in St. Louis during your stay in St. Louis. Amble around the area's lush forest or attend a sporting event.
Chapel of St. Timothy And St. Titus, Concordia Seminary
Find out about the history of St. Louis when you take a trip to Chapel of St. Timothy And St. Titus, Concordia Seminary. Experience the area's fascinating museums or attend a sporting event.
Things to do
St. Louis Ghost Tour: Sinister Sins & Shadows
$32
per adult
St. Louis Premium Driving Tour with Boat Ride & Arch
$148
per adult
100% of travellers recommend
Lemp Haunted Neighborhood Walking Tour
$27
per adult
84% of travellers recommend
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- St. Louis Zoo
- Chapel of St. Timothy And St. Titus
- St. Louis Art Museum
- Washington University in St. Louis
- Saint Louis Galleria Mall
- St. Louis Walk of Fame
- Visit Richmond Heights
- Tivoli Theatre
- The Muny Theater
- Turtle Playground
- Jewel Box
- Missouri History Museum
- The Focal Point
- Brentwood Vacations
- Visit University City
- Pagoda Circle
- Cabanne House
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.