Clayton Vacations from $265

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Your Clayton Vacation

Lock in a Clayton vacation package and prepare to experience all this lively city has to offer. Consider staying in the neighborhood of Soulard, which is good for distilleries and craft breweries, bars and pubs and markets. Fill your spare time with tours of St. Louis Zoo, St. Louis Art Museum and Cathedral Basilica of St. Louis, some of the attractions you just have to see during a trip to Clayton. A couple of clicks is all it takes to put together the perfect Clayton vacation on Expedia.

The Latest Clayton Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Courtyard by Marriott St. Louis Downtown/Convention Center
The Wildwood Hotel
Hilton Garden Inn Chesterfield
Ameristar Casino Resort and Spa
Hermann Grain Bins BNB

Where to stay in Clayton

Find the best Clayton areas and neighborhoods for the activities you enjoy most. Learn more about Clayton

Clayton Hotel Deals

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue, St. Louis, MO
Fully refundableReserve now, pay when you stay
$103 nightly
The price is $120 total per night from Sep 21 to Sep 22
$120 total
Sep 21 - Sep 22
Total with taxes and fees
8.8/10 Excellent! (2,902 reviews)
"Easy access to Metro to get to sports event"

Reviewed on Aug 22, 2025

Clayton Plaza Hotel & Extended Stay
AC Hotel St. Louis Clayton

AC Hotel St. Louis Clayton

3 out of 5
227 South Central Ave, St. Louis, MO
Fully refundableReserve now, pay when you stay
$130 nightly
The price is $151 total per night from Sep 1 to Sep 2
$151 total
Sep 1 - Sep 2
Total with taxes and fees
9/10 Wonderful! (148 reviews)
"Great hotel. Clean!!!"

Reviewed on Aug 11, 2025

AC Hotel St. Louis Clayton
The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis

5 out of 5
100 Carondelet Plaza, St. Louis, MO
Fully refundableReserve now, pay when you stay
$519 nightly
The price is $605 total per night from Sep 21 to Sep 22
$605 total
Sep 21 - Sep 22
Total with taxes and fees
9.2/10 Wonderful! (544 reviews)
"Excellent"

Reviewed on Jul 18, 2025

The Ritz-Carlton, St. Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Clayton

Things to do

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.