Clayton Vacations from $431
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Your Clayton Vacation
Lock in a Clayton vacation package and prepare to experience all this lively city has to offer. Consider staying in the neighborhood of Soulard, which is good for distilleries and craft breweries, bars and pubs and markets. Fill your spare time with tours of St. Louis Zoo, St. Louis Art Museum and Cathedral Basilica of St. Louis, some of the attractions you just have to see during a trip to Clayton. A couple of clicks is all it takes to put together the perfect Clayton vacation on Expedia.
The Latest Clayton Vacation Packages
Price found within the past 48 hours. Click for updated prices.
The Cheshire
$531
per person
Nov 2 - Nov 7
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (1,014 reviews)
A nice, interesting place, in an excellent location, right off the park. Zoo and art museum an easy stroll. My wife and I used a different St. Louis hotel for our annual trip to see my son and his family, but we tried this hotel on a whim and the Cheshire has become our new favorite.
Reviewed on Aug 31, 2026
Remodeled and Inviting Free EV
$524
per person
Oct 22 - Oct 25
found 20 hours ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
9/10 Wonderful! (2 reviews)
It was nice to stay for a weekend but the neighborhood was nice I like the location where it wasn't too far from grocery stores food areas the only thing I was saying is it's nothing for the kids to do but overall I like it
Reviewed on Aug 7, 2026
Where to stay in Clayton
Find the best Clayton areas and neighborhoods for the activities you enjoy most. Learn more about Clayton
Downtown St. Louis
3 out of top 10 points of interest in this area
Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.
Central West End
Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.
Creve Coeur
Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.
St. Charles Historic District
Discover a national historic district featuring over 100 buildings, including the First Missouri State Capitol and St. Charles Odd Fellows Hall, showcasing architectural styles like Greek Revival and Italianate.
Downtown West
2 out of top 10 points of interest in this area
If you're spending some time in Downtown West, St. Louis Union Station and St. Louis Aquarium at Union Station are top sights worth seeing.
Clayton Hotel Deals
Clayton Plaza Hotel & Extended Stay
7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
$80 nightly
$93 total
Sep 20 - Sep 21
Total with taxes and fees
9/10 Wonderful! (3,366 reviews)
"This is my go to place when I need to travel to St. Louis for business. It’s in a safe location with many great places in the area to walk to. I find the ladies at the front counter, extremely helpful and welcoming."
Reviewed on Sep 1, 2026
AC Hotel St. Louis Clayton
227 South Central Ave St. Louis MO
$135 nightly
$158 total
Sep 6 - Sep 7
Total with taxes and fees
9.2/10 Wonderful! (381 reviews)
"room was clean and comfortable"
Reviewed on Aug 31, 2026
Hampton Inn & Suites Clayton/St. Louis-Galleria Area
216 N Meramec Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$130 nightly
$154 total
Sep 6 - Sep 7
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Clayton attractions
Chapel of St. Timothy And St. Titus, Concordia Seminary
Find out about the history of St. Louis when you take a trip to Chapel of St. Timothy And St. Titus, Concordia Seminary. Experience the area's acclaimed art scene or attend a sporting event.
Shaw Park Tennis Center
Catch an event at Shaw Park Tennis Center during your trip to St. Louis. Check out the shops and top-notch restaurants in this family-friendly area.
Things to do
St. Louis Ghost Tour: Sinister Sins & Shadows
$24
per adult
100% of travellers recommend
St. Louis Burlesque & Nightlife Experience at The Boom Boom Room
$60
per adult
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- Christ Church Cathedral
- St. Louis Zoo
- Pagoda Circle
- St. Louis Cathedral
- Tower Grove Park
- Chapel of St. Timothy And St. Titus
- St. Louis Walk of Fame
- Wainwright Building
- Grant's Farm
- St. Louis Science Center
- Saint Louis Galleria Mall
- Chaifetz Arena
- Eads Bridge
- Missouri History Museum
- The MOTO Museum
- St. Alphonsus Liguori Catholic Church
- City Museum
- Fox Theater
- Cathedral Basilica of St. Louis
- Gateway Arch National Park
- St. Louis Art Museum
- Washington Avenue Historic District
- Busch Stadium
- Visit St. Louis
- Old Post Office
- Jewel Box
- Downtown St. Louis Vacations
- St. Louis City Hall
- Samuel Cupples House
- Citygarden Sculpture Park
- Washington University in St. Louis
- Museum at the Gateway Arch
- Meeting of the Waters Fountain
- The Muny Theater
- Gateway Arch
- Magic House - St. Louis Children's Museum
- St. Mary of Victories Catholic Church
- Eugene Field House & St. Louis Toy Museum
- Citygarden
- St. Louis Vacations
- Tivoli Theatre
- St. Louis Aquarium at Union Station
- Sky Zone Indoor Trampoline Park - St. Louis
- Missouri Botanical Gardens and Arboretum
- Bruno David Gallery
- Cabanne House
- Brentwood Vacations
- Forest Park
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.