Clayton Vacations from $439
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Your Clayton Vacation
Lock in a Clayton vacation package and prepare to experience all this lively city has to offer. Consider staying in the neighborhood of Soulard, which is good for distilleries and craft breweries, bars and pubs and markets. Fill your spare time with tours of St. Louis Zoo, St. Louis Art Museum and Cathedral Basilica of St. Louis, some of the attractions you just have to see during a trip to Clayton. A couple of clicks is all it takes to put together the perfect Clayton vacation on Expedia.
The Latest Clayton Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Hampton Inn & Suites Clayton/St. Louis-Galleria Area
Clayton
Price was $519, price is now $439 per person
$439
per person
Jul 9 - Jul 11
found 14 hours ago
Roundtrip flight included
Denver (DEN) to St. Louis (STL)
9/10 Wonderful! (953 reviews)
Room clean and bed comfortable . You have to pay for parking 20 dollars a night breakfast good nice server good for 1 night
Reviewed on Apr 11, 2026
The Wildwood Hotel
Price was $711, price is now $530 per person
$530
per person
May 23 - May 25
found 16 hours ago
Roundtrip flight included
Baltimore (BWI) to St. Louis (STL)
9.2/10 Wonderful! (1,624 reviews)
The hotel was very charming and clean, room was comfortable. I have some back problems so I was worried when I saw other reviews complaining about the beds but I personally had no issues, they were very comfortable. Lots of parking, and lots of good restaurants within walking distance.
Reviewed on Apr 15, 2026
Hilton Pennywell St. Louis at the Arch
Downtown St. Louis
Price was $657, price is now $555 per person
$555
per person
Jun 9 - Jun 12
found 20 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to St. Louis (STL)
8.8/10 Excellent! (1,023 reviews)
This hotel had a very elegant modern vibe while encapsulating the big city bustle, it was very convenient to the stadiums, the arch and the river. The only downfall which is not their fault is the dilapidated hotel right across the street, definitely an eyesore but hopefully the city will have an amazing opportunity to revitalize that area! But back to this idea hotel, it was very clean and comfortable!
Reviewed on Apr 15, 2026
Comfort Inn Collinsville near St. Louis
Eastport
Price was $606, price is now $515 per person
$515
per person
May 22 - May 25
found 1 day ago
Roundtrip flight included
New York (NYC) to St. Louis (STL)
8.6/10 Excellent! (932 reviews)
Stayed one night with family and had a good overall experience. The property was clean, though it hasn’t been recently upgraded. Breakfast buffet was decent. The location is convenient—about 15 minutes from the Gateway Arch in St. Louis and close to I-55—with free parking available. One inconvenience was the room key card repeatedly getting deactivated, requiring multiple trips to the front desk.
Reviewed on Apr 1, 2026
Hilton Garden Inn Chesterfield
Price was $1,071, price is now $910 per person
$910
per person
Jun 25 - Jun 28
found 21 hours ago
Roundtrip flight included
Los Angeles (LAX) to St. Louis (STL)
8.4/10 Very Good! (813 reviews)
The staff is very nice but the blow dryer was broken (open blades 😳), the shade was broken and the light next to the bed was broken. But the proximity to things is great.
Reviewed on Apr 11, 2026
Where to stay in Clayton
Find the best Clayton areas and neighborhoods for the activities you enjoy most. Learn more about Clayton
Downtown St. Louis
3 out of top 10 points of interest in this area
4/5(4,044 area reviews)
Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.
Clayton Hotel Deals
Clayton Plaza Hotel & Extended Stay
7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $111 total per night from Apr 19 to Apr 20
$111 total
Apr 19 - Apr 20
Total with taxes and fees
9/10 Wonderful! (3,151 reviews)
The room had been recently upgraded and it was well done. Easy parking and great location for getting around Clayton on foot. Love the shower system
Reviewed on Apr 16, 2026
The Ritz-Carlton, St. Louis
100 Carondelet Plaza St. Louis MO
Fully refundableReserve now, pay when you stay
$499 nightly
The price is $583 total per night from Apr 19 to Apr 20
$583 total
Apr 19 - Apr 20
Total with taxes and fees
9.2/10 Wonderful! (564 reviews)
Friendly staff and very clean room.
Reviewed on Apr 15, 2026
AC Hotel St. Louis Clayton
227 South Central Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $158 total per night from May 10 to May 11
$158 total
May 10 - May 11
Total with taxes and fees
9/10 Wonderful! (282 reviews)
The room was lovely. The staff was congenial. Well done, AC Clayton.
Reviewed on Apr 14, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Clayton
Washington University in St. Louis
4.5/5(483 reviews)
Enjoy the collegiate vibe at Washington University in St. Louis during your stay in St. Louis. Amble around the area's lush forest or attend a sporting event.
Chapel of St. Timothy And St. Titus, Concordia Seminary
Find out about the history of St. Louis when you take a trip to Chapel of St. Timothy And St. Titus, Concordia Seminary. Experience the area's acclaimed theater scene or attend a sporting event.
Things to do
St. Louis Ghost Tour: Sinister Sins & Shadows
$24
per adult
Lemp Haunted Neighborhood Walking Tour
$30
per adult
84% of travellers recommend
St. Louis Walking Tour with St Louis Arch Ticket
$79
per adult
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- Chapel of St. Timothy And St. Titus
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- St. Louis Walk of Fame
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- Turtle Playground
- Jewel Box
- Missouri History Museum
- The Focal Point
- Brentwood Vacations
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- Cabanne House
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.