Clayton Vacations from $454
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Your Clayton Vacation
Lock in a Clayton vacation package and prepare to experience all this lively city has to offer. Consider staying in the neighborhood of Soulard, which is good for distilleries and craft breweries, bars and pubs and markets. Fill your spare time with tours of St. Louis Zoo, St. Louis Art Museum and Cathedral Basilica of St. Louis, some of the attractions you just have to see during a trip to Clayton. A couple of clicks is all it takes to put together the perfect Clayton vacation on Expedia.
The Latest Clayton Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Crowne Plaza St. Louis Airport by IHG
Price was $587, price is now $454 per person
$454
per person
May 11 - May 15
found 1 day ago
Roundtrip flight included
Baltimore (BWI) to St. Louis (STL)
8/10 Very Good! (1,002 reviews)
Everything was amazing but parking was not enough. We had to park on ur median. Rooms are older but still nice. Good area. Friendly staff.
Reviewed on Feb 21, 2026
The Wildwood Hotel
Price was $730, price is now $483 per person
$483
per person
May 11 - May 15
found 1 day ago
Roundtrip flight included
Baltimore (BWI) to St. Louis (STL)
9.2/10 Wonderful! (1,600 reviews)
Great place to stay! We arrived later at night around 11pm and the front desk gal working at that time was wonderful. Nice, quiet, clean and in a very nice area.
Reviewed on Feb 27, 2026
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
Grand Center
Price was $768, price is now $567 per person
$567
per person
May 11 - May 15
found 1 day ago
Roundtrip flight included
Baltimore (BWI) to St. Louis (STL)
8.8/10 Excellent! (1,022 reviews)
Great customer service. The locals there are friendly as well as the staff members
Reviewed on Feb 23, 2026
DoubleTree by Hilton St. Louis Forest Park
Central West End
Price was $827, price is now $633 per person
$633
per person
May 11 - May 15
found 1 day ago
Roundtrip flight included
Baltimore (BWI) to St. Louis (STL)
8.2/10 Very Good! (1,003 reviews)
Room was nice.
Staff was very friendly
Warm cookies were good
Reviewed on Feb 26, 2026
Where to stay in Clayton
Find the best Clayton areas and neighborhoods for the activities you enjoy most. Learn more about Clayton
Downtown St. Louis
4 out of top 10 points of interest in this area
4/5(4,004 area reviews)
Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.
Clayton Hotel Deals
Clayton Plaza Hotel & Extended Stay
7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
$105 nightly
The price is $122 total per night from Mar 29 to Mar 30
$122 total
Mar 29 - Mar 30
Total with taxes and fees
8.8/10 Excellent! (3,088 reviews)
Staff Checking in was quick and easy.
Reviewed on Feb 27, 2026
The Ritz-Carlton, St. Louis
100 Carondelet Plaza St. Louis MO
Fully refundableReserve now, pay when you stay
$499 nightly
The price is $583 total per night from Mar 1 to Mar 2
$583 total
Mar 1 - Mar 2
Total with taxes and fees
9.2/10 Wonderful! (557 reviews)
Excellent hotel with various restaurants and expansive lobby area.. staff very attentive.
Reviewed on Feb 6, 2026
Le Méridien St. Louis Clayton
7730 Bonhomme Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $159 total per night from Mar 15 to Mar 16
$159 total
Mar 15 - Mar 16
Total with taxes and fees
8.8/10 Excellent! (696 reviews)
Clean room & good included breakfast
Reviewed on Feb 24, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Clayton
Washington University in St. Louis
Enjoy the collegiate vibe at Washington University in St. Louis during your stay in St. Louis. Amble around the area's lush forest or attend a sporting event.
Chapel of St. Timothy And St. Titus, Concordia Seminary
Find out about the history of St. Louis when you take a trip to Chapel of St. Timothy And St. Titus, Concordia Seminary. Experience the area's fascinating museums or attend a sporting event.
Things to do
St. Louis Ghost Tour: Sinister Sins & Shadows
$32
per adult
Lemp Haunted Neighborhood Walking Tour
$27
per adult
84% of travellers recommend
St. Louis Premium Driving Tour with Boat Ride & Arch
$174
per adult
100% of travellers recommend
Explore a world of travel with Expedia
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- St. Louis Zoo
- Chapel of St. Timothy And St. Titus
- St. Louis Art Museum
- Washington University in St. Louis
- Saint Louis Galleria Mall
- St. Louis Walk of Fame
- Visit Richmond Heights
- Tivoli Theatre
- The Muny Theater
- Turtle Playground
- Jewel Box
- Missouri History Museum
- The Focal Point
- Brentwood Vacations
- Visit University City
- Pagoda Circle
- Cabanne House
- Car rentals near Washington University in St. Louis
- Midsize Car Rentals near Washington University in St. Louis
- Car rentals near Richmond Heights
- Car rentals near Delmar Loop
- Car rentals near Saint Louis Galleria Mall
- Car rentals near University City
- Car rentals near St. Louis Zoo
- Minivan Car Rentals near St. Louis Zoo
- Car rentals near Maplewood
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- Avis Rental Cars in Brentwood
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.