
Clayton Vacations from $265
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Your Clayton Vacation
Lock in a Clayton vacation package and prepare to experience all this lively city has to offer. Consider staying in the neighborhood of Soulard, which is good for distilleries and craft breweries, bars and pubs and markets. Fill your spare time with tours of St. Louis Zoo, St. Louis Art Museum and Cathedral Basilica of St. Louis, some of the attractions you just have to see during a trip to Clayton. A couple of clicks is all it takes to put together the perfect Clayton vacation on Expedia.
The Latest Clayton Vacation Packages

Courtyard by Marriott St. Louis Downtown/Convention Center
Reviewed on Aug 20, 2025

The Wildwood Hotel
Reviewed on Aug 24, 2025

Hilton Garden Inn Chesterfield
Reviewed on Jul 26, 2025

Where to stay in Clayton

Downtown St. Louis
Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.
Clayton Hotel Deals

Clayton Plaza Hotel & Extended Stay
Reviewed on Aug 22, 2025

AC Hotel St. Louis Clayton
Reviewed on Aug 11, 2025

The Ritz-Carlton, St. Louis
Reviewed on Jul 18, 2025
Discover the most popular places to visit in Clayton
Washington University in St. Louis
Enjoy the collegiate vibe at Washington University in St. Louis during your stay in St. Louis. Amble around the area's lush forest or attend a sporting event.
Chapel of St. Timothy And St. Titus, Concordia Seminary
Find out about the history of St. Louis when you take a trip to Chapel of St. Timothy And St. Titus, Concordia Seminary. Experience the area's acclaimed theater scene or attend a sporting event.
Things to do

St Louis Ghost Tours: Sinister Sins & Shadows Ghost Tour

Best of St. Louis Small Group Tour w/ Arch & River Cruise

St. Louis Ghosts: Gateway Ghouls and Hauntings
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