Clayton Vacations
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Your Clayton Vacation
Lock in a Clayton vacation package and prepare to experience all this lively city has to offer. Consider staying in the neighborhood of Soulard, which is good for distilleries and craft breweries, bars and pubs and markets. Fill your spare time with tours of St. Louis Zoo, St. Louis Art Museum and Cathedral Basilica of St. Louis, some of the attractions you just have to see during a trip to Clayton. A couple of clicks is all it takes to put together the perfect Clayton vacation on Expedia.
Price found within the past 48 hours. Click for updated prices.
- Hilton Garden Inn Chesterfield
Jul 9 - Jul 12Hilton Garden Inn Chesterfield + Flight
Chesterfield3 nights8.4/10 - Very Good (824 reviews)Roundtrip • Atlanta (ATL) - St. Louis (STL)ATL - STL • Nonstop STL - ATL • Nonstop$543$420found 1 day agoper traveler - The Wildwood Hotel
Jul 9 - Jul 12The Wildwood Hotel + Flight
Wildwood3 nights9.2/10 - Wonderful (1,655 reviews)"I like the hotel but for the price that I paid the breakfast was terrible Frozen food and no cooked food Very disappointing for expensive hotel not to offer warm breakfast The next night we switched the hotel with holiday express because they offer good cooked breakfast"Reviewed May 28, 2026Roundtrip • Atlanta (ATL) - St. Louis (STL)ATL - STL • Nonstop STL - ATL • Nonstop - The Knight Center at Washington University
Jul 9 - Jul 12The Knight Center at Washington University + Flight
St. Louis3 nights9.4/10 - Exceptional (560 reviews)"Great location, restaurant was good too. Staff was nice."Reviewed May 26, 2026Roundtrip • Atlanta (ATL) - St. Louis (STL)ATL - STL • Nonstop STL - ATL • Nonstop$605$457found 1 day agoper traveler - The Cheshire
Jul 9 - Jul 12The Cheshire + Flight
Richmond Heights3 nights8.8/10 - Excellent (1,004 reviews)"A"Reviewed May 30, 2026Roundtrip • Atlanta (ATL) - St. Louis (STL)ATL - STL • Nonstop STL - ATL • Nonstop$622$474found 1 day agoper traveler - Ameristar Casino Resort and Spa
Jul 9 - Jul 12Ameristar Casino Resort and Spa + Flight
St. Charles3 nights8.6/10 - Excellent (1,002 reviews)"Great as always!"Reviewed May 31, 2026Roundtrip • Atlanta (ATL) - St. Louis (STL)ATL - STL • Nonstop STL - ATL • Nonstop$650$508found 1 day agoper traveler
Where to stay in Clayton
Find the best Clayton areas and neighborhoods for the activities you enjoy most. Learn more about Clayton
Downtown St. Louis
3 out of top 10 points of interest in this area
4/5(4,044 area reviews)
Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.
Clayton Hotel Deals
Clayton Plaza Hotel & Extended Stay
7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $111 total per night from Jun 14 to Jun 15
$111 total
Jun 14 - Jun 15
Total with taxes and fees
9/10 Wonderful! (3,217 reviews)
"Good place to stay!"
Reviewed on May 31, 2026
Le Méridien St. Louis Clayton
7730 Bonhomme Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$152 nightly
The price is $179 total per night from Jun 21 to Jun 22
$179 total
Jun 21 - Jun 22
Total with taxes and fees
AC Hotel St. Louis Clayton
227 South Central Ave St. Louis MO
$135 nightly
The price is $158 total per night from Jun 7 to Jun 8
$158 total
Jun 7 - Jun 8
Total with taxes and fees
9/10 Wonderful! (309 reviews)
"A"
Reviewed on May 30, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Clayton
Washington University in St. Louis
Enjoy the collegiate vibe at Washington University in St. Louis during your stay in St. Louis. Amble around the area's lush forest or attend a sporting event.
Chapel of St. Timothy And St. Titus, Concordia Seminary
Find out about the history of St. Louis when you take a trip to Chapel of St. Timothy And St. Titus, Concordia Seminary. Experience the area's great live music or attend a sporting event.
Things to do
St. Louis Ghost Tour: Sinister Sins & Shadows
$32
per adult
St. Louis Premium Driving Tour with Boat Ride & Arch
$174
per adult
100% of travellers recommend
St. Louis Premium Small Group Tour With Arch & River Cruise
$161
per adult
84% of travellers recommend
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- St. Louis Zoo
- Chapel of St. Timothy And St. Titus
- St. Louis Art Museum
- Washington University in St. Louis
- Saint Louis Galleria Mall
- St. Louis Walk of Fame
- Visit Richmond Heights
- Tivoli Theatre
- The Muny Theater
- Turtle Playground
- Jewel Box
- Missouri History Museum
- The Focal Point
- Brentwood Vacations
- Visit University City
- Pagoda Circle
- Cabanne House
- Car rentals near Washington University in St. Louis
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- Car rentals near Richmond Heights
- Car rentals near Delmar Loop
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- Car rentals near Maplewood
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- Avis Rental Cars in Brentwood
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.