Louisiana, MO

Travel Guide

A river with a large, rusted metal bridge and a smaller bridge in the background.
A waterfront town with a prominent American flag, houses, and autumn-colored trees.
A waterfront town with a hill in the background, a flag on a pole, and buildings along the shore.
A river with a dam, surrounded by greenery and a clear sky.
A tree-lined landscape with a river and fields.
River's Edge Motel

River's Edge Motel

2 out of 5
201 Mansion St Louisiana MO
$88 nightly
The price is $100 total per night from Nov 8 to Nov 9
$100 total
Nov 8 - Nov 9
Total with taxes and fees
Stay at this motel in Louisiana. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews.
8.8/10 Excellent! (395 reviews)
"Nice location."

Reviewed on Oct 28, 2026

River's Edge Motel
The Eagles Nest Inn

The Eagles Nest Inn

3 out of 5
215 Georgia St Louisiana MO
$113 nightly
The price is $128 total per night from Dec 4 to Dec 5
$128 total
Dec 4 - Dec 5
Total with taxes and fees
Stay at this inn in Louisiana. Enjoy free WiFi, free parking, and housekeeping.
9.6/10 Exceptional! (28 reviews)
"Our 3rd stay there. Will definitely go back."

Reviewed on Oct 25, 2026

The Eagles Nest Inn
The Yellow Rose Historic Home

The Yellow Rose Historic Home

Louisiana MO
$321 nightly
The price is $349 total per night from Nov 5 to Nov 6
$349 total
Nov 5 - Nov 6
Total with taxes and fees
Book a stay at this family-friendly vacation home in Louisiana. Enjoy free WiFi, laundry facilities, and an in-room coffeemaker.
9.8/10 Exceptional! (20 reviews)
"Large home that easily accommodated myself and 10 family members. Place is like stepping into a time machine which is cool. Not a lot of options in this area but this one is definitely worth consideration. Awesome host that communicates well and property is slightly aged (in a good way) but beautiful ..."

Reviewed on Oct 22, 2026

The Yellow Rose Historic Home
See all 119 properties in Louisiana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
The Yellow Rose Historic Home

The Yellow Rose Historic Home

Louisiana MO
Book a stay at this family-friendly vacation home in Louisiana. Enjoy free WiFi, laundry facilities, and an in-room coffeemaker.
9.8/10 Exceptional! (20 reviews)
"Large home that easily accommodated myself and 10 family members. Place is like stepping into a time machine which is cool. Not a lot of options in this area but this one is definitely worth consideration. Awesome host that communicates well and property is slightly aged (in a good way) but beautiful ..."

Reviewed on Oct 22, 2026

The Yellow Rose Historic Home
Lighthouse Inn & Suites

Lighthouse Inn & Suites

4 out of 5
612 Mark Twain Ave Hannibal MO
Stay at this aparthotel in Hannibal. Enjoy free WiFi, free parking, and dry cleaning or laundry services. Popular attractions Molly Brown Museum and Home and ...
8.8/10 Excellent! (47 reviews)
"We had to cancel our 2nd night of a 2 night stay due to illness but the motel would not reimburse us for the second night. Rooms are nice but over priced, I will not stay there again."

Reviewed on Sep 29, 2026

Lighthouse Inn & Suites
Peaceful, Country Cottage with Open Floor Plan

Peaceful, Country Cottage with Open Floor Plan

Quincy IL
Stay at this vacation home in Quincy. Enjoy free WiFi, patios, and cable/satellite TV service. Popular attractions Bay Island and Murphy Island are located ...
9.8/10 Exceptional! (227 reviews)
"The cottage was in a quiet location, clean, and with easy access to both Quincy, IL and Hannibal, MO. The property owner was available and easy to contact."

Reviewed on Oct 20, 2026

Peaceful, Country Cottage with Open Floor Plan
See all properties in Louisiana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

When is the best time to visit Louisiana?
The best time to visit Louisiana is from May through September, when the climate is generally favorable. For travelers seeking fewer crowds and better value, the quieter months of November through February offer cooler weather and a more relaxed experience.
What cuisines can you find in Louisiana?
In Louisiana you can find Italian cuisine, with classic dishes like pasta, pizza, lasagna, and tiramisu. Travelers can also enjoy a variety of other dining options, including North American, Asian, European, and Latin American flavors.
Can I book a refundable hotel in Louisiana?
Yes, Expedia offers many flexible booking options, and you can look for refundable hotels in Louisiana by entering your dates and using the refundable or fully refundable filter. Always check the hotel's cancellation policy before you book, since terms can vary by hotel, and visit Expedia help center for further details.
Why book a trip to Louisiana with Expedia?
Expedia makes it easier to plan your Louisiana trip with travel tools, flexible search options, and bookable trip components all in one place. You can organize your plans in one account and use Expedia to help build a trip that fits your budget and travel style. Find out more about how by visiting Expedia's Trip Planner page.
Should I stay in a hotel or vacation rental in Louisiana?
The best choice depends on your travel style. Hotels in Louisiana can be a good fit for convenience, on-site amenities, and shorter stays, while vacation rentals may offer more space, privacy, and home-style amenities for longer trips, families, or groups. With Expedia, you can compare both options side by side, read traveler reviews, and filter by amenities to find the right fit for your trip.
How can I manage my Louisiana trip on Expedia?
Once you've booked your Louisiana trip, you can manage it through your Expedia account or the Expedia app. You can view your itinerary, access booking details, make eligible changes, and check for updates in My Trips. The Expedia app can also help you stay organized while you travel.
What if I need help during my Louisiana trip?
Expedia offers customer support before, during, and after your Louisiana trip. If your plans change or something unexpected happens, you can review your booking in My Trips and use Expedia help center channels for help with eligible changes, cancellations, or travel issues.
How can Expedia help me plan my first trip to Louisiana?
If it's your first trip to Louisiana, Expedia can help you plan by bringing together stays, flights, activities, traveler reviews, and trip-planning tools in one place. With Expedia's Trip Planner you can compare options, read reviews from other travelers, and build an itinerary that matches your interests and budget.
How can I save on my Louisiana hotel booking with Expedia?
Join One Key™ for free to unlock instant discounts with Member Prices on select hotels. You can also earn and use OneKeyCash™* on eligible bookings on Expedia. Booking in advance is usually another great way to save on your Louisiana hotel.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.

Cities near Louisiana

A vast landscape with rolling green fields, dense forests, and a winding road.

Bowling Green

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