Medical District Vacations from $297
Book a Hotel + Flight or Car together to unlock savings
Photo by Georgie
- Plan, book, travel with confidence
- Better togetherSave up to $2,000 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Your Medical District Vacation
Our Medical District vacation packages are an easy and handy way to plan and book your next getaway. Discover the true character of this unique neighborhood without the burden of organizing everything yourself. When it's time to sightsee, you'll find plenty of top attractions nearby including Memphis Zoo, Orpheum Theatre and Sun Studio. Visit one, two (or even all!) during your trip to Medical District. Whatever your dream Medical District vacation looks like, you can turn it into reality with Expedia.
The Latest Medical District Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Hotel Pontotoc
Downtown Memphis
Price was $848, price is now $635 per person
$635
per person
Sep 29 - Oct 2
just found
Roundtrip non-stop flight included
Boston (BOS) to Memphis (MEM)
9.6/10 Exceptional! (28 reviews)
The Hotel Pontotoc was perfect. The rooms were comfortable, clean, and spacious. I will definitely return.
Reviewed on Jun 21, 2026
The Stallion
Downtown Memphis
Price was $618, price is now $498 per person
$498
per person
Sep 29 - Oct 2
just found
Roundtrip non-stop flight included
Boston (BOS) to Memphis (MEM)
9.8/10 Exceptional! (340 reviews)
We really enjoyed our stay. One of the best hotels I've ever stayed in. Very spacious bigger than most apartments, which is a plus especially with 2 young children. Great location and decent part of town. This will be my place to stay every time when coming to Memphis.
Reviewed on Jul 6, 2026
Landing Furnished Apartments Downtown Memphis
Downtown Memphis
Price was $519, price is now $420 per person
$420
per person
Sep 12 - Sep 15
found 3 hours ago
Roundtrip flight included
Dallas (DFW) to Memphis (MEM)
9.4/10 Exceptional! (3 reviews)
The apartment was clean and enough space to accommodate everyone. It was difficult to get in touch with the property especially on the weekends. We requested additional covers which we never received. There were only two rolls of toliet tissue in each bathroom and I was there for 4 nights/5 days. The beds could be more comfortable but overall it was a great stay.
Reviewed on May 6, 2026
Where to stay in Medical District
Find the best Medical District areas and neighborhoods for the activities you enjoy most. Learn more about Medical District
Downtown Memphis
4 out of top 10 points of interest in this area
4/5(1,806 area reviews)
Home to the Memphis Redbirds and Grizzlies NBA team, this central business district offers entertainment, dining, and attractions like Beale Street, FedExForum, and AutoZone Park. Easily accessible via major highways and public transit options.
Medical District Hotel Deals
Motel 6 Memphis, TN - Downtown
210 S Pauline St Memphis TN
Fully refundableReserve now, pay when you stay
$60 nightly
The price is $73 total per night from Jul 15 to Jul 16
$73 total
Jul 15 - Jul 16
Total with taxes and fees
5.4/10 (1,006 reviews)
"Very disappointing experience. The room was dirty when we arrived and clearly had not been cleaned to an acceptable standard. There was no microwave or refrigerator, which made our stay extremely inconvenient, especially for a family. The overall condition of the room did not match our expectations, ..."
Reviewed on Jul 8, 2026
Kings Inn
42 S Camilla St Memphis TN
Fully refundableReserve now, pay when you stay
$53 nightly
The price is $65 total per night from Jul 15 to Jul 16
$65 total
Jul 15 - Jul 16
Total with taxes and fees
6.4/10 (57 reviews)
"I booked the room, and it was a GREAT price! I arrived, thought it looked sketchy, but was surprised by helpful the staff were. It is an older hotel, so not alot of frills, but I found my stay to be comfortable and safe. Highly recommend."
Reviewed on Jul 8, 2026
Hu. Hotel
79 Madison Avenue Memphis TN
Fully refundableReserve now, pay when you stay
$78 nightly
The price is $94 total per night from Aug 6 to Aug 7
$94 total
Aug 6 - Aug 7
Total with taxes and fees
8.4/10 Very Good! (2,143 reviews)
"great spot. close enough to walk to anything you want and far enough from crowds for a quiet night."
Reviewed on Jul 8, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Medical District attractions
Things to do
Memphis: Stax Museum of American Soul Music
$20
per adult
94% of travellers recommend
Nashville to Memphis Daytrip with Graceland VIP Tour and Sun Studio Admission
$380
per adult
92% of travellers recommend
Haunted Memphis Walking Ghost Tour
$30
per adult
84% of travellers recommend
Explore a world of travel with Expedia
- Hotels with an Indoor Pool in Memphis
- Hotels near Memphis Intl.
- Cheap Hotels in Memphis
- Casino Hotels in Memphis
- Downtown Memphis Hotels
- Hotels with Hot Tubs in Memphis
- Hotels with Suites in Memphis
- Apartments in Memphis
- Pet-Friendly Hotels in Memphis
- Hotels near Graceland
- Cabin Rentals in Memphis
- Motels in Memphis
- Hotels with Free Airport Shuttle in Memphis
- East Memphis Hotels
- Hotels near Beale Street
- Memphis Hotels
- 5 Star Hotels in Memphis
- Extended Stay Hotels in Memphis
- Germantown Hotels
- Flights from Jacksonville (JAX) to Memphis (MEM)
- Flights from New York (LGA) to Memphis (MEM)
- Flights from Kansas City (MCI) to Memphis (MEM)
- Flights from Detroit (DTW) to Memphis (MEM)
- Flights from Baltimore (BWI) to Memphis (MEM)
- Flights from Charleston (CHS) to Memphis (MEM)
- Flights from Cincinnati (CVG) to Memphis (MEM)
- Flights from San Francisco (SFO) to Memphis (MEM)
- Flights from Fort Lauderdale (FLL) to Memphis (MEM)
- Flights from Houston (IAH) to Memphis (MEM)
- Flights from Milwaukee (MKE) to Memphis (MEM)
- Flights from Dallas (DFW) to Memphis (MEM)
- Flights from Miami (MIA) to Memphis (MEM)
- Flights from Los Angeles (LAX) to Memphis (MEM)
- Flights from St. Louis (STL) to Memphis (MEM)
- Flights from Memphis
- Flights from Orlando (MCO) to Memphis (MEM)
- Flights from Little Rock (LIT) to Memphis (MEM)
- Flights from Minneapolis (MSP) to Memphis (MEM)
- Flights from Tampa (TPA) to Memphis (MEM)
- Flights from Cleveland (CLE) to Memphis (MEM)
- Flights from Las Vegas (LAS) to Memphis (MEM)
- Flights from Chattanooga (CHA) to Memphis (MEM)
- Flights from Knoxville (TYS) to Memphis (MEM)
- Flights from Phoenix (PHX) to Memphis (MEM)
- Flights from Raleigh (RDU) to Memphis (MEM)
- Flights from Seattle (SEA) to Memphis (MEM)
- Flights from Newark Liberty Intl. Airport (EWR) to Memphis (MEM)
- Flights from Washington (DCA) to Memphis (MEM)
- Flights from Chicago (ORD) to Memphis (MEM)
- Flights from Denver (DEN) to Memphis (MEM)
- Flights to Memphis
- Flights from Austin (AUS) to Memphis (MEM)
- Flights from Boston (BOS) to Memphis (MEM)
- Flights from Charlotte (CLT) to Memphis (MEM)
- Flights from New Orleans (MSY) to Memphis (MEM)
- Flights from Memphis Intl.
- Flights from San Diego (SAN) to Memphis (MEM)
- Flights from Atlanta (ATL) to Memphis (MEM)
- Flights from Richmond (RIC) to Memphis (MEM)
- Flights from Nashville (BNA) to Memphis (MEM)
- Flights from Philadelphia (PHL) to Memphis (MEM)
- Gibson Guitar Museum
- Memphis Vacations
- Mississippi River Museum at Mud Island
- The Cotton Museum at the Memphis Cotton Exchange
- Autozone Park
- Mason Temple
- St. Jude Children's Research Hospital
- Victorian Village Historic District Vacations
- Memphis Museum of Science & History
- Beale Street
- Minglewood Hall
- Memphis Music Hall of Fame
- Sun Studio
- Visit Memphis
- Peabody Ducks
- Mississippi Boulevard Christian Church
- Stax Museum of American Soul Music
- Bass Pro Shops at the Pyramid
- Mallory-Neely House
- Memphis Brooks Museum of Art
- Graceland
- Memphis Zoo
- Memphis Rock 'n' Soul Museum
- National Civil Rights Museum
- Fedexforum
- Visit Downtown Memphis
- Hunt-Phelan Home
- Beale Street Landing
- Hernando de Soto Bridge
- Tom Lee Park
- Where to stay in Memphis
- Mud Island River Park
- Belz Museum of Asian and Judaic Art
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.