A river winding through a dense forest.

Find 4 Star Hotels in Mesopotamia from $51

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Check availability on Mesopotamia 4 Star Hotels

Tonight
Aug 29 - Aug 30
Tomorrow
Aug 30 - Aug 31
Next weekend
Sep 4 - Sep 6
In two weeks
Sep 11 - Sep 13

Our top choices for Mesopotamia 4-star hotels

A pool with a water feature, a modern building with large windows, and palm trees in the background.
An indoor dining area with tables and chairs, large windows, and a view of palm trees.
A spacious lobby with modern furniture, a staircase, and a reception area.
A lobby with wooden panel walls, two elevators, a reception desk, and a seating area with wicker furniture.

1. Howard Johnson Plaza La Ribera

Howard Johnson Plaza La Ribera
Resistencia
Brazil
Augusto Miguel
$92 nightly
$92 total
Aug 30 - Aug 31
Howard Johnson Plaza La Ribera
A dining table with two plates of food, two drinks, and a QR code.
A pool area with lounge chairs and umbrellas, surrounded by tropical plants.
A modern living room with a large TV, a round coffee table, and a sofa.
A restaurant with tables and chairs arranged in rows, a ceiling with hanging lights, and walls covered with climbing plants.

2. Holiday Inn Rosario by IHG

Holiday Inn Rosario by IHG
Rosario Centro
United States
Thibauld
$114 nightly
$114 total
Sep 6 - Sep 7
Holiday Inn Rosario by IHG
A spacious lobby with a central circular area, a staircase, and a bar area with multiple seating options.
A multi-story hotel with a curved facade, a central entrance, and a balcony on the upper floors.
A patio area with wooden tables and chairs, a large umbrella, and potted plants.
A pool area with lounge chairs and a clear blue sky.

3. InterTower Hotel

InterTower Hotel
Santa Fe
Canada
Alfred Miels
$116 nightly
$116 total
Aug 30 - Aug 31
InterTower Hotel
A man standing in front of a building with an ornate entrance, large windows, and a chandelier.
An outdoor swimming pool with a tiled edge, surrounded by lounge chairs and potted plants.
A grand staircase with ornate railings and a chandelier, leading to a reception area with a black and white color scheme and a marble floor.
An outdoor seating area with tables and chairs, a decorative building with a dome and green accents, and potted plants.

4. Esplendor by Wyndham Savoy Rosario

Esplendor by Wyndham Savoy Rosario
Rosario Centro
United States
Megan Ann
$98 nightly
$98 total
Sep 27 - Sep 28
Esplendor by Wyndham Savoy Rosario
A modern outdoor seating area with wooden tables and benches, surrounded by lush greenery and flowering plants.
A modern lobby with a curved wooden wall, a central light fixture, and a reception desk.
A modern lounge area with wooden flooring, white cushioned seating, and large windows offering a view of the sea.
A modern interior with a sectional sofa, wooden chairs, a glass display case with pottery, and a large window with a view.

5. Marriott Corrientes Hotel

Marriott Corrientes Hotel
Corrientes
Australia
Marcus
$161 nightly
$161 total
Sep 4 - Sep 5
Marriott Corrientes Hotel
A nighttime pool area with lounge chairs, a stone facade, and a sign for 'AMERICAN HOTEL ZURICH'.
A lobby with a glass coffee table surrounded by green upholstered chairs, a reception desk, and a large potted plant.
A spacious lobby with a high ceiling, marble walls, and a central column. There are seating areas with chairs and tables, and a reception desk.
A modern building with a curved glass facade and a classical base.

6. Amérian Hotel Casino Gala

Amérian Hotel Casino Gala
Resistencia
United States
Daniel
$62 nightly
$62 total
Aug 30 - Aug 31
Amérian Hotel Casino Gala
A rooftop pool with a clear view of the city skyline at dusk.
A hotel entrance with a large illuminated sign reading "ROS TOWER HOTEL - SPA & CONVENTION CENTER".
A spacious lobby with a polished marble floor, a central staircase, and a large wooden column.
A modern hotel lobby with a marble floor, a staircase, and a dining area with tables and chairs.

7. Ros Tower Hotel

Ros Tower Hotel
Rosario Centro
United States
Agustín
$98 nightly
$98 total
Sep 5 - Sep 6
Ros Tower Hotel
A rooftop pool with wooden loungers and a city view.
A modern living room with a sectional sofa, a round coffee table, and a large abstract sculpture.
An outdoor seating area with white tables and chairs, surrounded by palm trees and greenery, with a modern building in the background.
A restaurant with large windows, indoor plants, and a tiled floor.

8. Los Silos Hotel

Los Silos Hotel
Santa Fe
United States
Russell
$130 nightly
$130 total
Sep 27 - Sep 28
Los Silos Hotel
A rooftop pool with a glass balustrade, offering a view of high-rise buildings and a body of water.
A rooftop terrace with a hot tub, red lounge chairs, and potted plants.
A modern hotel lobby with a marble reception desk, leather seating, and large windows offering natural light.
A modern interior with a wooden dining table, black upholstered chairs, and pendant lighting.

9. Dazzler by Wyndham Rosario

Dazzler by Wyndham Rosario
Rosario
United States
Amadeo
$95 nightly
$95 total
Aug 30 - Aug 31
Dazzler by Wyndham Rosario
A cozy room with a wooden interior, a large window with a view, a chandelier, and a flat-screen TV.
A bar area with a wooden counter, a clock, and shelves with bottles.
A multi-level atrium with a staircase, string lights, and potted plants.
A pool area with a long, narrow pool, surrounded by plants and trees. There are outdoor seating areas and a building with large windows in the background.

10. La Alondra Casa De Huéspedes

La Alondra Casa De Huéspedes
Corrientes
Mexico
Arturo Oscar
$86 nightly
$86 total
Sep 21 - Sep 22
La Alondra Casa De Huéspedes
A modern building with a reflective glass facade, vertical lines, and potted plants.
A spacious lobby with a central seating area, multiple lamps, and a view of the entrance.
A modern building with cylindrical structures and a glass facade.
A rooftop pool with a glass barrier, overlooking a cityscape and a body of water.

11. Puerto Norte Design Hotel

Puerto Norte Design Hotel
Rosario
United States
Francisco
$151 nightly
$151 total
Sep 27 - Sep 28
Puerto Norte Design Hotel
A modern hotel lobby with a marble floor, a reception desk, and a long corridor with wooden accents.
A modern building with multiple floors, large windows, and a covered entrance area.
A modern hotel corridor with a marble floor, dark walls, and a patterned wall on the right.
A modern hotel room with a sofa, two armchairs, a small round table, a bed, a TV, and a large window with curtains.

12. Azahar Hotel & Spa

Azahar Hotel & Spa
San Pedro
United States
Guido
$94 nightly
$98 total
Sep 2 - Sep 3
Azahar Hotel & Spa
A pool with a fountain, palm trees, and a sunset.
A hotel room with a large bed, a desk with a computer, a chair, and a view of the outdoors.
A restaurant with high ceilings, exposed beams, and hanging pendant lights. There are wooden tables and cushioned seating.
A hotel lobby with a reception desk, a staircase, potted plants, and a waterfall feature.

13. Turismo Hotel Casino

Turismo Hotel Casino
Corrientes
United States
Laura
$98 nightly
$98 total
Aug 30 - Aug 31
Turismo Hotel Casino
An indoor atrium with multiple levels connected by escalators, featuring a central water feature and a variety of arcade machines.
A modern hotel lobby with a large indoor tree, comfortable seating, and a bar area.
A spacious lobby with a glass ceiling, modern furniture, and potted plants.
A modern outdoor lounge area with seating and a view of palm trees and a distant cityscape.

14. Pullman Rosario City Center Hotel

Pullman Rosario City Center Hotel
Rosario
United States
juan
$137 nightly
$137 total
Sep 8 - Sep 9
Pullman Rosario City Center Hotel

15. Ámbar Suites

Ámbar Suites
Rosario Centro
Ámbar Suites
A modern interior with a glass staircase, seating area, and a view of the sky.
A sunlit outdoor seating area with lounge chairs and a planter with tall grasses.
A buffet with various food items including fruits, pastries, and desserts.
A modern hotel lobby with a reception desk, seating area with sofas and armchairs, and a large window providing a view of the outside.

16. Hotel Solans Presidente

Hotel Solans Presidente
Rosario Centro
United States
Juan
$86 nightly
$86 total
Aug 31 - Sep 1
Hotel Solans Presidente
A wooden deck with wicker furniture and a glass table, leading to a bedroom with a bed and a robe hanging.
A spacious interior with a high ceiling, wooden beams, a central wooden structure with a staircase, and a glass door leading to a smaller room.
A spacious indoor area with multiple seating arrangements, a staircase, and hanging pendant lights.
A building with a curved roof, a central entrance, and a sign reading "Centro Posada".

17. Hotel Maitei Posadas

Hotel Maitei Posadas
Posadas
United States
Fredy
Hotel Maitei Posadas
A large house with a swimming pool surrounded by lush greenery and a river in the background.
A resort with multiple swimming pools, lounge areas, and a large house.
A pathway leading to a building surrounded by palm trees and yellow flowers.
A hotel room with a wooden table, two beds, a large window, and a plant.

18. La Regina Lodge

La Regina Lodge
Municipo de Itati
Brazil
Marcos
$51 nightly
$51 total
Sep 10 - Sep 11
La Regina Lodge
A modern building with a glass facade, multiple floors, and a flat roof.
A reception area with a wooden reception desk, seating area, and a brick wall with framed pictures.
A hotel room with a large bed, a desk with a chair, a TV, and a kitchenette.
A modern kitchen with a marble countertop, stainless steel appliances, and a wooden floor.

19. Brickton, Rosario, Apartments By Marriott Bonvoy

Brickton, Rosario, Apartments By Marriott Bonvoy
Rosario Centro
$80 nightly
$80 total
Aug 30 - Aug 31
Brickton, Rosario, Apartments By Marriott Bonvoy
A modern pool area with lounge chairs and palm trees.
A modern interior with a bar area, seating, and large framed artworks.
A multi-level atrium with glass railings, a central column, and a reception area with red chairs.

20. Radisson RED Funes

Radisson RED Funes
Funes
$128 nightly
$128 total
Sep 27 - Sep 28
Radisson RED Funes
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Mesopotamia

The awe-inspiring Iguazú Falls is the centerpiece attraction of this northeastern Argentine region, which also hosts the country’s biggest carnival celebration.

See all hotels in Mesopotamia
A waterfall surrounded by dense forest and small islands.

Top Mesopotamia Hotel Reviews

InterTower Hotel

InterTower Hotel

10/10 Excellent
"We thoroughly enjoyed our stay at the Intertower Hotel and found the staff to be incredibly friendly and helpful. The breakfasts were ample and delicious. The cleaning staff did a superb job. The front desk staff were knowledgeable and very helpful with advice about local things to do. We really liked the option of having two adjoining rooms with the connecting door for our family of five. We would highly recommend!"
Jamin 7-night trip
Posted 4 hours ago
InterTower Hotel
Esplendor by Wyndham Savoy Rosario

Esplendor by Wyndham Savoy Rosario

8/10 Good
"I was charged an extra 120 dollars (approximately) in local taxes that were not included in the price Expedia quoted me. Also, the breakfast bar could use a little help with variety."
Gerardo 8-night trip
Posted 7 days ago
Esplendor by Wyndham Savoy Rosario
La Alondra Casa De Huéspedes

La Alondra Casa De Huéspedes

10/10 Excellent
"Me gusta mucho el lugar"
Patricia 1-night trip
Posted 13 days ago
La Alondra Casa De Huéspedes

Find out more about Mesopotamia

Mesopotamia Four Star Hotel Information

When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Mesopotamia, Argentina are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Mesopotamia 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service.

Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Mesopotamia. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Mesopotamia, Argentina, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop.

Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Mesopotamia hotels offer everything your heart desires.

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