Mesopotamia Adventure Vacations

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Top Adventure vacation packages in Mesopotamia

Price found within the past 48 hours. Click for updated prices.
Posada Puerto Bemberg

Posada Puerto Bemberg

$320
per person
Nov 3 - Nov 6
found 1 day ago
Roundtrip flight included
Buenos Aires (AEP) to Iguazu (IGR)
9.6/10 Exceptional! (18 reviews)
Loi Suites Iguazú Hotel

Loi Suites Iguazú Hotel

Save 100% on your flight
$638
per person
Nov 3 - Nov 6
found 1 day ago
Roundtrip flight included
Buenos Aires (AEP) to Iguazu (IGR)
9.2/10 Wonderful! (1,004 reviews)
The staff was phenomenal. The constant banging due to improvement was the only downside to the hotel. We traveled 24 hours n wanted a quick nap but the banging was right outside the balcony. Loved the chocolates on the made up beds, felt special our entire stay. Breakfast was great....had 1 hiccups w room service and another one at dinner the next night. Have already recommended f

Reviewed on Aug 26, 2026

Amérian Portal del Iguazú Hotel

Amérian Portal del Iguazú Hotel

$403
per person
Oct 15 - Oct 18
found 1 day ago
Roundtrip flight included
Buenos Aires (BUE) to Iguazu (IGR)
8.6/10 Excellent! (430 reviews)
Our room - 203 - was supposed to have been one of the "renovated" ones. If that is true, I'd hate to see how to non-renovated rooms look like. The shower head was rusted and clearly ancient and the hand shower came apart (we showed to photo to the receptionist) . When we arrived, 3 out of 4 towels were dirty or stained (we asked them to be changed) The breakfast is mediocre. On the balcony there were 2 small chairs but no table (not even a small table to put a coffee cup on!). The only good thing about this hotel is the view to the river, otherwise is not worth it. It is definitely NOT a 5 star hotel.

Reviewed on Aug 6, 2026

Iguazu Grand Resort Spa & Casino

Iguazu Grand Resort Spa & Casino

$504
per person
Nov 3 - Nov 6
found 1 day ago
Roundtrip flight included
Buenos Aires (AEP) to Iguazu (IGR)
9.2/10 Wonderful! (678 reviews)
Excellent location, lovely friendly staff, beautiful property full of amenities Very spacious room. Great value for money. Would highly recommend it.

Reviewed on Aug 31, 2026

Gran Melia Iguazú

Gran Melia Iguazú

$2,865
per person
Oct 9 - Oct 13
found 24 hours ago
Roundtrip non-stop flight included
Córdoba (COR) to Iguazu (IGR)
9.4/10 Exceptional! (1,005 reviews)
We stayed two nights to enjoy Iguazu National Park. The location was excellent inside the national park. We booked a 2 queens mountain view room and it was as I expected and other facilities in the hotel, such as restaurants, bar, and pool etc. are great design and maintained well. There was a timely communication after the booking, then check-in, check-out, concierge, room services are all smooth and professional. Breakfast was included in the plan and all foods were delicious including western style dishes and some local taste foods. We also had dinners two times and the variety of the menu, wine list, services were great. Sometimes I had to wait a while to order additional drink etc., but overall experience was pretty high.

Reviewed on Aug 20, 2026

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5* Adventure vacations in Mesopotamia

Price found within the past 48 hours. Click for updated prices.
Iguazu Grand Resort Spa & Casino

Iguazu Grand Resort Spa & Casino

$504
per person
Nov 3 - Nov 6
found 1 day ago
Roundtrip flight included
Buenos Aires (AEP) to Iguazu (IGR)
9.2/10 Wonderful! (678 reviews)
Excellent location, lovely friendly staff, beautiful property full of amenities Very spacious room. Great value for money. Would highly recommend it.

Reviewed on Aug 31, 2026

Loi Suites Iguazú Hotel

Loi Suites Iguazú Hotel

Save 100% on your flight
$638
per person
Nov 3 - Nov 6
found 1 day ago
Roundtrip flight included
Buenos Aires (AEP) to Iguazu (IGR)
9.2/10 Wonderful! (1,004 reviews)
The staff was phenomenal. The constant banging due to improvement was the only downside to the hotel. We traveled 24 hours n wanted a quick nap but the banging was right outside the balcony. Loved the chocolates on the made up beds, felt special our entire stay. Breakfast was great....had 1 hiccups w room service and another one at dinner the next night. Have already recommended f

Reviewed on Aug 26, 2026

Gran Melia Iguazú

Gran Melia Iguazú

$2,865
per person
Oct 9 - Oct 13
found 24 hours ago
Roundtrip non-stop flight included
Córdoba (COR) to Iguazu (IGR)
9.4/10 Exceptional! (1,005 reviews)
We stayed two nights to enjoy Iguazu National Park. The location was excellent inside the national park. We booked a 2 queens mountain view room and it was as I expected and other facilities in the hotel, such as restaurants, bar, and pool etc. are great design and maintained well. There was a timely communication after the booking, then check-in, check-out, concierge, room services are all smooth and professional. Breakfast was included in the plan and all foods were delicious including western style dishes and some local taste foods. We also had dinners two times and the variety of the menu, wine list, services were great. Sometimes I had to wait a while to order additional drink etc., but overall experience was pretty high.

Reviewed on Aug 20, 2026

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See all available trips from Columbus to Mesopotamia
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3 Night Adventure vacations in Mesopotamia

Price found within the past 48 hours. Click for updated prices.
Amérian Portal del Iguazú Hotel

Amérian Portal del Iguazú Hotel

$403
per person
Oct 15 - Oct 18
found 1 day ago
Roundtrip flight included
Buenos Aires (BUE) to Iguazu (IGR)
8.6/10 Excellent! (430 reviews)
Our room - 203 - was supposed to have been one of the "renovated" ones. If that is true, I'd hate to see how to non-renovated rooms look like. The shower head was rusted and clearly ancient and the hand shower came apart (we showed to photo to the receptionist) . When we arrived, 3 out of 4 towels were dirty or stained (we asked them to be changed) The breakfast is mediocre. On the balcony there were 2 small chairs but no table (not even a small table to put a coffee cup on!). The only good thing about this hotel is the view to the river, otherwise is not worth it. It is definitely NOT a 5 star hotel.

Reviewed on Aug 6, 2026

Loi Suites Iguazú Hotel

Loi Suites Iguazú Hotel

Save 100% on your flight
$638
per person
Nov 3 - Nov 6
found 1 day ago
Roundtrip flight included
Buenos Aires (AEP) to Iguazu (IGR)
9.2/10 Wonderful! (1,004 reviews)
The staff was phenomenal. The constant banging due to improvement was the only downside to the hotel. We traveled 24 hours n wanted a quick nap but the banging was right outside the balcony. Loved the chocolates on the made up beds, felt special our entire stay. Breakfast was great....had 1 hiccups w room service and another one at dinner the next night. Have already recommended f

Reviewed on Aug 26, 2026

Iguazu Grand Resort Spa & Casino

Iguazu Grand Resort Spa & Casino

Save 100% on your flight
$628
per person
Oct 15 - Oct 18
found 1 day ago
Roundtrip flight included
Buenos Aires (BUE) to Iguazu (IGR)
9.2/10 Wonderful! (678 reviews)
Excellent location, lovely friendly staff, beautiful property full of amenities Very spacious room. Great value for money. Would highly recommend it.

Reviewed on Aug 31, 2026

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See all available trips from Columbus to Mesopotamia
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4 Night Adventure vacations in Mesopotamia

Price found within the past 48 hours. Click for updated prices.
 Complexo Eco Cataratas Resort by SJ

Complexo Eco Cataratas Resort by SJ

Cataratas
$759
per person
Nov 12 - Nov 16
found 1 day ago
Roundtrip flight included
São Paulo (GRU) to Iguassu Falls (IGU)
9.2/10 Wonderful! (1,007 reviews)
The property was beautiful well kept. Close to airport and mall shopping area. The only problem was they advertise shuttle transportation to airport when we left I said I needed to go to airport they said wait 3 min and a car came once dropped off at airport they charged us. So they have to be clear with that. Breakfast WAS UNREAL big selection clean unreal. Best ever! Easy check in -

Reviewed on Aug 30, 2026

Hotel das Cataratas, A Belmond Hotel, Iguassu Falls

Hotel das Cataratas, A Belmond Hotel, Iguassu Falls

Save 100% on your flight
$1,885
per person
Nov 12 - Nov 16
found 1 day ago
Roundtrip flight included
São Paulo (GRU) to Iguassu Falls (IGU)
10/10 Exceptional! (1,013 reviews)
The location of the hotel is second to none. Having access to the trails before and after the park is open means you get views of the waterfalls without the crowds. The hotel provides sparkling wine to watch the sunset over the falls each evening. The food at the restaurants is excellent and they go out their way to customize the menus for my daughter who is vegetarian.

Reviewed on Aug 31, 2026

Falls Iguazú Hotel & Spa

Falls Iguazú Hotel & Spa

$2,107
per person
Oct 9 - Oct 13
found 24 hours ago
Roundtrip non-stop flight included
Córdoba (COR) to Iguazu (IGR)
9.2/10 Wonderful! (487 reviews)
The hotel is a standard type with beautiful grounds and pool. The rooms are clean and roomy with all the traditional comforts of contemporary hotel. The stay includes breakfast and dinner but the dinner service is basic. The staff is very professional and helpful- they assisted us with our last minute requests.

Reviewed on Jul 18, 2026

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Find awesome Mesopotamia adventure vacations

How can I book the best Mesopotamia adventure trips?

Choose your own adventure in Mesopotamia, whether that’s a white-knuckle experience or a weekend walk. Read the reviews of the adventures that have gone before to be sure your chosen stay is your idea of fun.

How can I plan the perfect Mesopotamia family adventure vacation?

Adventure awaits when you select the family-friendly filter. There’s plenty of excitement for all ages in Mesopotamia. Just make sure to check your chosen escapade is within the realms of can-do for the whole clan and will have the whole team grinning.

Can I book all-inclusive Mesopotamia adventure vacation packages?

By refining your filters, you can explore all-amazing, all-adventurous, all-inclusive vacation packages. Amp up the extravagance with a few more filters too. Pick pristine pools, sensational spas, or wondrous waterparks for a sensational adventure getaway.

Why should I book a Mesopotamia adventure vacation for couples?

Book a Mesopotamia couples adventure vacation for the ultimate in romance and memory-making. Stunning scenery, heart-racing happenings, and the grandeur of the great outdoors—it’s the best way to bond.

How can I find the best deals on adventure packages in Mesopotamia?

It’s easy to unleash fabulously affordable adventures. Enter the dates for your caper, then sort your search results by price or deals.

Can I book an adventure vacation package in Mesopotamia with free cancellation and/or flexible dates?

Yes! When you’re searching for a great getaway, filter by payment option for free cancellation, so a change of plans won’t mess up your adventures. You’ll find buy now, pay later options, too, for full-on flexibility.

Why should I book a Mesopotamia adventure trip with Expedia?

Adventure, airfare, accommodation, ATOL protection, and activities—all on one site. And that’s just the benefits that begin with A.

Top Adventure Mesopotamia Hotels

Iguazu Grand Resort Spa & Casino

Iguazu Grand Resort Spa & Casino

Route 12 Km 1640 Puerto Iguazú Misiones
  • 17 hours drive from Termas de Federacion
Book a stay at this luxury hotel in Puerto Iguazú. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ...
9.2/10 Wonderful! (676 reviews)
"Excellent location, lovely friendly staff, beautiful property full of amenities Very spacious room. Great value for money. Would highly recommend it."

Reviewed on Aug 31, 2026

Iguazu Grand Resort Spa & Casino
Hotel das Cataratas, A Belmond Hotel, Iguassu Falls

Hotel das Cataratas, A Belmond Hotel, Iguassu Falls

Rodovia Br 469 Km 32 Foz do Iguaçu PR
  • 17 hours drive from Termas de Federacion
Book a stay at this luxury hotel in Foz do Iguaçu. Enjoy free breakfast, free WiFi, and a full-service spa. Our guests praise the helpful staff and the property ...
10/10 Exceptional! (1,003 reviews)
"The location of the hotel is second to none. Having access to the trails before and after the park is open means you get views of the waterfalls without the crowds. The hotel provides sparkling wine to watch the sunset over the falls each evening. The food at the restaurants is excellent and they ..."

Reviewed on Aug 31, 2026

Hotel das Cataratas, A Belmond Hotel, Iguassu Falls
Gran Melia Iguazú

Gran Melia Iguazú

Parque Nacional Iguazu Puerto Iguazú Misiones
  • 17 hours drive from Termas de Federacion
Book a stay at this luxury hotel in Puerto Iguazú. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ...
9.4/10 Exceptional! (1,002 reviews)
"We stayed two nights to enjoy Iguazu National Park. The location was excellent inside the national park. We booked a 2 queens mountain view room and it was as I expected and other facilities in the hotel, such as restaurants, bar, and pool etc. are great design and maintained well. There was a timely ..."

Reviewed on Aug 20, 2026

Gran Melia Iguazú
See all 527 properties in Mesopotamia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.