Title: Best Mesopotamia Lodge Rentals from $71 | Expedia.com [Mesopotamia Travel Guide](https://expedia.com/Mesopotamia.dx6208836)[Hotels in Mesopotamia](https://expedia.com/Mesopotamia-Hotels.d6208836.Travel-Guide-Hotels)[Vacation Rentals in Mesopotamia](https://expedia.com/Mesopotamia-Vacation-Rentals.d6208836.Travel-Guide-VacationRentals)[Flights to Mesopotamia](https://expedia.com/Cheap-Flights-To-Mesopotamia.d6208836.Travel-Guide-Flights)[Car Rentals in Mesopotamia](https://expedia.com/Car-Rentals-In-Mesopotamia.d6208836.Car-Rental-Guide)[Mesopotamia Vacation Packages](https://expedia.com/Mesopotamia.d6208836.Destination-Travel-Guides) ![](https://images.trvl-media.com/place/6171898/bb162948-b907-405b-9053-fc054127c668.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6171898/bb162948-b907-405b-9053-fc054127c668.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light_bundle_and_save.svg) ### Bundle & Save Get more, spend less whenever you see Bundle & Save deals - ![](https://a.travel-assets.com/travel-assets-manager/pictograms-expedia/light__onekey.svg) ### OneKeyCash Earn OneKeyCash on all your eligible bookings - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light_ftc.svg) ### Upfront pricing We are not like the others - we include taxes and fees ## Check prices for these dates Next weekend [Apr 10 - Apr 12](https://www.expedia.com/Hotel-Search?regionId=6208836&startDate=2026-04-10&endDate=2026-04-12&adults=2&lodging=LODGE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Apr 17 - Apr 19](https://www.expedia.com/Hotel-Search?regionId=6208836&startDate=2026-04-17&endDate=2026-04-19&adults=2&lodging=LODGE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In one month [May 1 - May 3](https://www.expedia.com/Hotel-Search?regionId=6208836&startDate=2026-05-01&endDate=2026-05-03&adults=2&lodging=LODGE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [May 29 - May 31](https://www.expedia.com/Hotel-Search?regionId=6208836&startDate=2026-05-29&endDate=2026-05-31&adults=2&lodging=LODGE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Mesopotamia lodges ![Exterior](https://images.trvl-media.com/lodging/121000000/120720000/120713200/120713176/5a0bc70a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/121000000/120720000/120713200/120713176/b05a90aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/121000000/120720000/120713200/120713176/8be36161.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Triple Room, Park View | Minibar, in-room safe, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/121000000/120720000/120713200/120713176/5ce32c6f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Regina Lodge [](https://www.expedia.com/Municipo-De-Itati-Hotels-La-Regina-Lodge.h120713176.Hotel-Information) Municipo de Itati 10/10 Exceptional (1 review) "Excelente pousada, piscina fantástica com visual do rio" ![Brazil](https://a.travel-assets.com/egds/marks/flags/br.svg) Marcos $71 nightly $71 total Apr 24 - Apr 25 [](https://www.expedia.com/Municipo-De-Itati-Hotels-La-Regina-Lodge.h120713176.Hotel-Information) ![Food and drink](https://images.trvl-media.com/lodging/5000000/4310000/4304600/4304547/48f28ed1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium House, Multiple Beds | Individually decorated, desk, blackout drapes, cribs/infant beds](https://images.trvl-media.com/lodging/5000000/4310000/4304600/4304547/29539b08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic area](https://images.trvl-media.com/lodging/5000000/4310000/4304600/4304547/308b5970.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/5000000/4310000/4304600/4304547/69e2ac6d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Rincón del Socorro [](https://www.expedia.com/Colonia-Carlos-Pellegrini-Hotels-Rincon-Del-Socorro.h4304547.Hotel-Information) Mercedes 10/10 Exceptional (6 reviews) "People could not be nicer. It is a jewel that needs to be protected and cherished" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Anonymous traveler $800 nightly $800 total Apr 12 - Apr 13 [](https://www.expedia.com/Colonia-Carlos-Pellegrini-Hotels-Rincon-Del-Socorro.h4304547.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-13&endDate=2026-04-14®ionId=6208836&adults=2&lodging=LODGE&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FMesopotamia-Lodges.d6208836-aaLodges.Travel-Guide-Accommodation)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FMesopotamia-Lodges.d6208836-aaLodges.Travel-Guide-Accommodation) ## Top Mesopotamia Hotel Reviews ![O2 Hotel Gualeguaychú](https://images.trvl-media.com/lodging/77000000/76460000/76459400/76459363/dbe6098c_y.jpg) ### O2 Hotel Gualeguaychú 2/10 Terrible "Las sabanas estaban sucias No andaba la tele para ver No salía agua caliente y el desayuno horrible" [](https://expedia.com/Gualeguaychu-Hotels-O2-Gualeguaychu.h76459363.Hotel-Information) ![Intersur Colon](https://images.trvl-media.com/lodging/115000000/114110000/114109800/114109755/cb01ff56_y.jpg) ### Intersur Colon 2/10 Terrible "Staff as friendly but room was very dirty, toilet had not been flushed, broken lamps and dirty napkins on the floor. " [](https://expedia.com/Colon-Hotels-Intersur-Colon.h114109755.Hotel-Information) ![Holiday Inn Rosario by IHG](https://images.trvl-media.com/lodging/1000000/580000/570400/570357/08f67295_y.jpg) ### Holiday Inn Rosario by IHG 8/10 Good "frienly and competent staff speaking English. room was fine" [](https://expedia.com/Rosario-Hotels-Holiday-Inn-Rosario.h570357.Hotel-Information) ![Casa del Árbol Hostel](https://images.trvl-media.com/lodging/37000000/36660000/36653400/36653372/a1bc361e_y.jpg) ### Casa del Árbol Hostel 2/10 Terrible "La plataforma por.donde contrate te reserva aunque no haya lugar en el hostel Un desastre todo. No tienen verguenza. Poco serio " [](https://expedia.com/Concepcion-Del-Uruguay-Hotels-Casa-Del-Arbol.h36653372.Hotel-Information) ![Club Valle Termal Resort](https://images.trvl-media.com/lodging/12000000/11880000/11876000/11875903/60e3bf31_y.jpg) ### Club Valle Termal Resort 10/10 Excellent "La habitación estaba impecable, la limpieza de todo el complejo fue excelente, pero quiero destacar la atención de todo su personal, la disponibilidad constante para atender todas nuestras necesidades. Lo recomiendo y espero poder volver pronto." [](https://expedia.com/Federacion-Hotels-Club-Valle-Termal-Resort.h11875903.Hotel-Information) ![Costarenas Hotel & Spa](https://images.trvl-media.com/lodging/16000000/15370000/15362200/15362145/a0cc5957_y.jpg) ### Costarenas Hotel & Spa 2/10 Terrible "Short Version See pictures for detailed information) - Rooms and bathrooms are small, shower already tight spaced with doors that don’t close properly. - By day 3, construction noise and chemicals smells from remodeling work became a big issue. - Receptionist did not offer solutions and lied about remodeling hours. Felt uncomfortable when asked for manager’s name, and refused to give any other information. - Same receptionist reached out later to apologize and acknowledged we should have not been placed in those rooms to begin with. Offered to move us to “upgraded” rooms. - “Upgraded” rooms were even worse. One of the rooms was directly under the ones being remodeled and worked on. Noise began at 8 AM - The other two rooms did not have a functioning air conditioner. Staff gave poor excuse and just said to open windows. There’s tons of noise far into the night from motor bikes and people playing music right across the hotel. - Hotel breakfast was motel level at best. You get eggs swimming in water and some cut up ham. Toasters barely worked, and when staff was asked for replacement they appeared completely clueless. - The spa experience was good when it came to the massage. However “quiet” policy is not enforced and hearing toilets go off right next to the spa area don’t help with the experience. - Check out was the final straw. Desk staff was rude and dismissive of concerns, stating that the room “upgrade” was sufficient compensation for the troubles. " [](https://expedia.com/Colon-Hotels-Costarenas-Hotel-Spa.h15362145.Hotel-Information) ![Hotel y Spa Termas del Este](https://images.trvl-media.com/lodging/34000000/33350000/33347000/33346911/e90b77a7_y.jpg) ### Hotel y Spa Termas del Este 8/10 Good "good for a 1 night stay" [](https://expedia.com/Federacion-Hotels-Hotel-Y-Spa-Termas-Del-Este.h33346911.Hotel-Information) ## Find out more about Mesopotamia ## Mesopotamia Lodges information | Number of reviews | 1 | | ----------------- | --------- | | Accommodation | 10 Lodges | | Lowest Price | $71 | | Highest Price | $800 | ## Explore a world of travel with Expedia - More ways to book - [Book Lodges in Mesopotamia on Expedia.com.ar ](https://www.expedia.com.ar/Mesopotamia-Lodges.d6208836-aaLodges.Guia-Viajes-Alojamiento)