Title: Visit Orangeburg County: 2026 Travel Guide for Orangeburg County, South Carolina | Expedia.com [Orangeburg County Hotels](https://expedia.com/Destinations-In-Orangeburg-County.d553248635996998003.Hotel-Destinations)[Vacation Rentals in Orangeburg County](https://expedia.com/Destinations-In-Orangeburg-County.d553248635996998003.Vacation-Rental-Destinations)[Orangeburg County Flights](https://expedia.com/Destinations-In-Orangeburg-County.d553248635996998003.Flight-Destinations)[Car Rentals in Orangeburg County](https://expedia.com/Destinations-In-Orangeburg-County.d553248635996998003.Car-Rental-Destinations)[Orangeburg County Vacations](https://expedia.com/Orangeburg-County.d553248635996998003.Destination-Travel-Guides) # Orangeburg County, SC ## South Carolina ![DEG7A9 Bald cypress forest in autumn at the Cuddo Unit of the Santee Refuge, SC.](https://images.trvl-media.com/place/9953/a26d5a16-8cd2-405d-94ab-122a2f63e661.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![DEG7A9 Bald cypress forest in autumn at the Cuddo Unit of the Santee Refuge, SC.](https://images.trvl-media.com/place/9953/a26d5a16-8cd2-405d-94ab-122a2f63e661.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Claflin University, located in Orangeburg, South Carolina, was founded in 1869 by Alonzo Webster (1818-1887), a Vermont minister. Webster came to South Carolina to teach at the Baker Bible Institute in Charleston training African American ministers for the Methodist Episcopal Church (today the United Methodist Church). In 1869 he received a charter from the state of South Carolina to establish a college that would prepare freed slaves for the responsibilities of citizenship. The first charter banned discrimination among the faculty, staff and students, making the Academy the first South Carolina university open to all regardless of race. Nonetheless, all of the students at the Academy were African American.](https://images.trvl-media.com/place/6058108/6d44fbcd-b983-4c8e-a1d2-65c7bc68a751.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![The Branchville Railroad Depot is listed on the National Register of Historic Places. The front of the structure now houses a museum/shrine of railroad memorabilia, including a caboose. It is open by appointment and children are welcome. Informal tours are led by John Norris, a retired railroad company executive. Admission is free but donations toward the upkeep of the museum are appreciated. Call (803) 707-1788 for information. The rear of the structure houses the Eatery at the Depot, which serves dinners on Thursday, Friday and Saturday evenings. Reservations are recommended but not required. Call (803) 274-8001 or (803) 515-](https://images.trvl-media.com/place/3000455875/43d228a3-3ea8-4c0d-b974-e33e83be19a7.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ### Popular cities in Orangeburg County [Orangeburg Known for Dining, Universities and Sports ](https://expedia.com/Orangeburg.dx6058108) Orangeburg is calling! Discover its gardens, university life, cafes, and more. ## Reasons to visit - Claflin University [Explore City](https://expedia.com/Orangeburg.dx6058108)[Find Hotels](https://expedia.com/Orangeburg-Hotels.d6058108.Travel-Guide-Hotels) [Santee Known for Friendly people, Dining and Golf ](https://expedia.com/Santee.dx9953) Love dining out, golf, and fishing? Get away to Santee! [Explore City](https://expedia.com/Santee.dx9953)[Find Hotels](https://expedia.com/Santee-Hotels.d9953.Travel-Guide-Hotels) [Eutawville ](https://expedia.com/Eutawville.dx3000455924) Check out the local area in Eutawville—home to attractions like Lake Marion and Ferguson Island. [Explore City](https://expedia.com/Eutawville.dx3000455924)[Find Hotels](https://expedia.com/Eutawville-Hotels.d3000455924.Travel-Guide-Hotels) [Holly Hill ](https://expedia.com/Holly-Hill.dx3000455972) Check out Santee Cooper Country Club and Santee National Golf Club—just a couple of the sights around Holly Hill. [Explore City](https://expedia.com/Holly-Hill.dx3000455972)[Find Hotels](https://expedia.com/Holly-Hill-Hotels.d3000455972.Travel-Guide-Hotels) [Elloree ](https://expedia.com/Elloree.dx3000455923) Head to sights like Lake Marion and Orangeburg County Library Mentor Branch as you discover Elloree. [Explore City](https://expedia.com/Elloree.dx3000455923)[Find Hotels](https://expedia.com/Elloree-Hotels.d3000455923.Travel-Guide-Hotels) [Vance ](https://expedia.com/Vance.dx3000456153) Head to sights like Lake Marion as you discover the local area in Vance. [Explore City](https://expedia.com/Vance.dx3000456153)[Find Hotels](https://expedia.com/Vance-Hotels.d3000456153.Travel-Guide-Hotels) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. 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