Picayune Vacations from $550

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Your Picayune Vacation

Enjoy unforgettable adventures when you lock in a vacation package to Picayune. Whether you're a history buff, foodie or just a traveler who loves discovering new places, there's something for everyone in this exciting city. Crosby Aboretum and Millbrook Country Club are among the must-see sights to check out during your trip to Picayune. A couple of clicks is all it takes to build a tailored Picayune vacation on Expedia.

The Latest Picayune vacation packages

Price found within the past 48 hours. Click for updated prices.
The Pass Picture Book

The Pass Picture Book

2.5 out of 5
Save 100% on your flight
Price was $771, price is now $550 per person
$550
per person
Sep 3 - Sep 7
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Gulfport (GPT)
No reviews
Porter Condos

Porter Condos

3 out of 5
Price was $730, price is now $561 per person
$561
per person
Sep 3 - Sep 7
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Gulfport (GPT)
10/10 Exceptional! (8 reviews)
Very nice apartment with a quiet atmosphere. It was very clean and newly furnished. It was a very good price, cheaper than other stays in the same area. Very close to downtown Ocean Springs for good food, shopping, and nightlife.

Reviewed on May 3, 2026

The Downtown Cedar

The Downtown Cedar

2 out of 5
Price was $895, price is now $699 per person
$699
per person
Sep 3 - Sep 7
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Gulfport (GPT)
9/10 Wonderful! (2 reviews)
Nice little home that’s located close to downtown. It was great for what we needed. It is not handicapped friendly, tho. Currently (May 2026), there is a high 1-step front door entry that could be easily fixed with a sturdy second platform step up from the nice front porch to make it easier to get in and out. It also has a nice upgraded single bathroom, but the claw tub is deep without a handrail and no suction in-tub bath mat to keep a person from falling. The rain shower is great however. Kitchen has good amenities, and the dining and living room areas are nice. Good amount of seating, large TV. Overall, for an older home, it’s nice and, a big plus, it doesn’t have a musty smell.

Reviewed on Jun 3, 2026

Hollywood Casino Gulf Coast

Hollywood Casino Gulf Coast

3.5 out of 5
Price was $843, price is now $681 per person
$681
per person
Sep 3 - Sep 7
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Gulfport (GPT)
8/10 Very Good! (1,013 reviews)
Service was great on a rainy day.

Reviewed on Jun 1, 2026

Cottages at Oak Park

Cottages at Oak Park

3 out of 5
Price was $732, price is now $598 per person
$598
per person
Sep 3 - Sep 7
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Gulfport (GPT)
10/10 Exceptional! (1 review)
Great stay…..could of used a 2nd roll of toilet paper

Reviewed on Apr 15, 2026

Don't see what you're looking for?
See all available trips from Columbus to Picayune
View all trips

Discover the most popular places to visit in Picayune

Millbrook Country Club

Enjoy a round of golf in Picayune at Millbrook Country Club. Wander the riverfront in this family-friendly area.

Millbrook Country Club

Picayune Hotel Deals

Holiday Inn Express Picayune-Stennis Space Center by IHG

Holiday Inn Express Picayune-Stennis Space Center by IHG

2.5 out of 5
1001 Dauphin Street Picayune MS
Fully refundable
$110 nightly
The price is $120 total per night from Jul 19 to Jul 20
$120 total
Jul 19 - Jul 20
Total with taxes and fees
8.8/10 Excellent! (685 reviews)
"Close to family"

Reviewed on May 13, 2026

Holiday Inn Express Picayune-Stennis Space Center by IHG
Heritage Inn Picayune

Heritage Inn Picayune

2 out of 5
1122 Memorial Blvd. Picayune MS
$80 nightly
The price is $87 total per night from Jun 25 to Jun 26
$87 total
Jun 25 - Jun 26
Total with taxes and fees
8.2/10 Very Good! (303 reviews)
"Amazing experience...cleanliness I loved it 😍 Bed quality and softness will take your whole day tiredness out ... I LOVED THE MATRESS"

Reviewed on May 27, 2026

Heritage Inn Picayune
Ramada by Wyndham Diamondhead I-10/Gulfport

Ramada by Wyndham Diamondhead I-10/Gulfport

2.5 out of 5
103 Live Oak Drive Diamondhead MS
Fully refundableReserve now, pay when you stay
$72 nightly
The price is $78 total per night from Jun 22 to Jun 23
$78 total
Jun 22 - Jun 23
Total with taxes and fees
7.8/10 Good! (712 reviews)
"We stayed two non-consecutive nights. One on our way to our destination and the next on our return trip. On 5/28/26 we stopped on our drive to Florida. We were surprised with the room, it was very clean, quiet, and the A/C worked fine to remove the humidity which during this time was more important ..."

Reviewed on Jun 8, 2026

Ramada by Wyndham Diamondhead I-10/Gulfport
See all 1,069 properties in Picayune
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Picayune Vacation Packages

Picayune Essential Information

Language
English
Currency
U.S dollars
Population
10,700
Max Temp Winter
65ºF
Max Temp Summer
90ºF
Top Sights
Crosby Aboretum and Millbrook Country Club

More vacations you might like

All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Frequently asked questions

How much does a Picayune vacation package cost?
Offering great value package deals from $550 on Expedia, you'll be surprised at how little a vacation to Picayune costs! Our packages make travel planning easier and save you more.
What are the cheapest months to go to Picayune?
If you're looking to score a cheap Picayune vacation package, consider planning a trip in July, September and October. You're likely to find better rates on flights and hotels during these months — perfect for a budget-friendly break.
How many days is enough for Picayune?
Usually, a handful of days is enough to visit the major sights during your Picayune vacation. But if you want to have time to unwind or go on day trips, consider extending your itinerary.
How to find the best Picayune package deals?
Landing a cheap Picayune package deal is a cinch with Expedia. Once you've entered your destination and preferred dates under our "Packages" tab, set your budget range, add a few filters and see what's available. You can tailor your search by "Amenities," "Property type," "Popular locations" and more. Sort the results by "Price: low to high" to discover the most wallet-friendly Picayune package deals. Want a simple trick to score even more savings? Have some flexibility with your departure dates and consider traveling on a weekday, when prices are often lower.
Is it cheaper to book a Picayune vacation as a package?
You can enjoy significant savings on your next Picayune getaway by booking a customized vacation package. Click on the "Package" heading, then enter your destination and travel dates to see the best hotel prices and airfares. Bundling can save travelers hundreds of dollars. Consider adding a rental car and you may score a better deal.
When to book a vacation package to Picayune?
If you've got your Picayune vacation dates confirmed, book early to snap up some terrific deals. With Expedia, you can generally reserve some flights up to a year in advance. Prefer spur-of-the-moment adventures? Our last-minute deals are perfect for quick escapes.
Does Expedia offer Book Now, Pay Later Picayune vacation packages?
Jet off on your dream trip to Picayune with help from Expedia's Book Now, Pay Later vacations. No need to scrimp and save or wait until your next paycheck — we've partnered with online lender Affirm to give you financial flexibility. Our vacation packages with payment plans mean you can split the cost across 3, 6 or 12 months. With no late payment fees or hidden charges, it's easy to budget for your trip and snap up bargains before they sell out.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.