Find spa resorts & hotels in Sexton Cove Estates, Key Largo from $275

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Check availability on Sexton Cove Estates Resorts & Hotels with Spas

Our top choices for Sexton Cove Estates hotels with a spa

Reefhouse Resort & Marina

Reefhouse Resort & Marina
3.5 star property
Key Largo
9.2 out of 10, Wonderful, (1332)
"Nice hotel with great staff."
United States
David
$269 nightly
The price is $298
Dec 15 - Dec 16
Total with taxes and fees
Reefhouse Resort & Marina

Kona Kai Resort and Gallery - Adults Only

Kona Kai Resort and Gallery - Adults Only
2.5 star property
Rock Harbor
9.8 out of 10, Exceptional, (294)
"The Kona Kai Resort was perfect for us. We especially appreciated the small resort with quiet spaces to relax, read and admire the view. "
United States
Bastianella
$244 nightly
The price is $275
Dec 15 - Dec 16
Total with taxes and fees
Kona Kai Resort and Gallery - Adults Only

Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection
4.5 star property
Rock Harbor
8.8 out of 10, Excellent, (1002)
"Beautiful location, great views, very clean property, room was great (great bed), friendly staff."
United States
Scott
$378 nightly
The price is $425
Dec 15 - Dec 16
Total with taxes and fees
Playa Largo Resort & Spa, Autograph Collection

Premium Floating Bungalow by Stay Ombi

Premium Floating Bungalow by Stay Ombi
3.5 star property
Key Largo
$1,259 nightly
The price is $1,417
Jan 1 - Jan 2, 2026
Total with taxes and fees
Premium Floating Bungalow by Stay Ombi
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Sexton Cove Estates Hotel Reviews

Frequently asked questions

Looking for a spa hotel in Sexton Cove Estates?
Treat yourself to some pampering and book a hotel with a spa. Hotels with spas are a great way to break away from your daily routine and add a layer of luxury to your vacation.
What's there to see and do in Sexton Cove Estates?
Take in the sights and attractions that Sexton Cove Estates offers with a visit to Caribbean Club Bar, MarineLab Undersea Laboratory, and John Pennekamp Coral Reef State Park. If you have a little extra time during your trip, you might want to check out Jimmy Johnson's Big Chill and Dagny Johnson Key Largo Hammock Botanical State Park.
What is a Sexton Cove Estates spa hotel?
Spa hotels in Sexton Cove Estates provide lodging and have a full on-site spa offering services such as therapies as well as body treatments. Some also offer in-room treatments. Spa hotels are a must if you want to give yourself an extra treat while on vacation.

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