Name: 21c Museum Hotel Cincinnati
Price range: $176 total
Rating: 8.6

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Your Southwest Ohio Vacation

When you book a Southwest Ohio vacation package, you can leave the travel details to us and concentrate on enjoying your escape. Whether it's the distilleries and craft breweries and dining, or the countless other highlights you're coming to see, this destination has plenty to offer. With so much to see on a trip to Southwest Ohio, it can be hard to know where to begin. Kick off your journey in Cincinnati at Great American Ball Park and Paycor Stadium — two much-loved attractions here. Another top city worthy of a spot on your itinerary is Dayton. Don't miss National Museum of the United States Air Force and Dayton Mall Shopping Center. Expedia has hotels, flights, car rentals and more to help you organize your own tailored Southwest Ohio vacation today.

The Latest Southwest Ohio vacation packages

Price found within the past 48 hours. Click for updated prices.

voco The Clair Cincinnati Downtown by IHG

Downtown Cincinnati

Save 100% on your flight

$209

per person

Jan 8 - Jan 11

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Cincinnati (CVG)

9.2/10 Wonderful! (1,007 reviews)

Room was very clean Would stay again

Reviewed on Nov 24, 2025

Le Méridien Columbus, The Joseph

Downtown Columbus

Save 100% on your flight

$603

per person

Feb 12 - Feb 15

just found

Roundtrip flight included

Orlando (MCO) to Columbus (CMH)

9.2/10 Wonderful! (634 reviews)

amazing rooms, great lobby, perfect location. Very clean and staff was awesome-oh yeah great bar

Reviewed on Nov 10, 2025

Hyatt Regency Cincinnati

Downtown Cincinnati

Save 100% on your flight

$254

per person

Jan 8 - Jan 11

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Cincinnati (CVG)

9/10 Wonderful! (1,570 reviews)

After having the bad experience of Hampton I could be in a clean place Very comfortable excellent service

Reviewed on Nov 30, 2025

Jungle House Luxury Stays - Downtown Columbus & Short North

Downtown Columbus

Save 100% on your flight

$552

per person

Feb 12 - Feb 15

just found

Roundtrip flight included

Orlando (MCO) to Columbus (CMH)

9.4/10 Exceptional! (8 reviews)

Nice, clean and cute

Reviewed on Nov 18, 2025

Jungle House Boutique Residences – Downtown Columbus & Short North

Downtown Columbus

Save 100% on your flight

$481

per person

Feb 12 - Feb 15

just found

Roundtrip flight included

Orlando (MCO) to Columbus (CMH)

10/10 Exceptional! (3 reviews)

I stayed at this rental for the weekend to watch Ohio State football game. The place was in a great neighborhood close to the college and lots of entertainment. The rental was asleep up to 12 people, but it only has one full bath so keep that in mind. I will definitely stay there again.

Reviewed on Oct 9, 2025

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Where to stay in Southwest Ohio

Find the best Southwest Ohio areas and neighborhoods for the activities you enjoy most. Learn more about Southwest Ohio

Downtown Cincinnati

4 out of top 10 points of interest in this area

4/5(1,452 area reviews)

Discover historic architecture and districts in the heart of the city, with museums like the Contemporary Arts Center and National Underground Railroad Freedom Center. Enjoy waterfront dining at The Banks, and take in the views from Carew Tower's observation deck.

Discover the most popular places to visit in Southwest Ohio

Kings Island

4.5/5(636 reviews)

This award-winning amusement and water park in Mason has more than 80 thrilling rides and attractions.

Drone shot of the stadium and Cincinnati

Paycor Stadium

4/5(335 reviews)

Catch an event at Paycor Stadium during your trip to Cincinnati. Experience the area's great live music and fascinating museums.

Newport Aquarium

4.5/5(705 reviews)

Find yourself face-to-face with thousands of aquatic species from around the world at this popular aquarium just across the river from Cincinnati.

What to do in Southwest Ohio

The Escape Game: Epic 60-Minute Adventures at Crocker Park

$42

per adult

100% of travellers recommend

The Escape Game: Epic 60-Minute Adventures at Crocker Park

$42

per adult

See all activities in Southwest Ohio

Southwest Ohio Hotel Deals

Hilton Cincinnati Netherland Plaza

35 W 5th St Cincinnati OH

Fully refundableReserve now, pay when you stay

$111 nightly

$133 total

Dec 25 - Dec 26

Total with taxes and fees

7.8/10 Good! (1,298 reviews)

The room was very nice. The hotel staff were very polite and friendly.

Reviewed on Nov 30, 2025

voco The Clair Cincinnati Downtown by IHG

701 Broadway Street Cincinnati OH

Fully refundable

$119 nightly

$142 total

Dec 7 - Dec 8

Total with taxes and fees

9/10 Wonderful! (1,019 reviews)

Staff were all fantastic - very attentive. The rooms were comfortable and clean.

Reviewed on Nov 28, 2025

21c Museum Hotel Cincinnati

609 Walnut St Cincinnati OH

Fully refundableReserve now, pay when you stay

$148 nightly

$176 total

Jan 1 - Jan 2, 2026

Total with taxes and fees

8.6/10 Excellent! (1,014 reviews)

Nice staff and great location

Reviewed on Nov 28, 2025

See all 3,287 properties in Southwest Ohio

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.