Southwest Ohio Vacations from $574

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $1,045 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Your Southwest Ohio Vacation

When you book a Southwest Ohio vacation package, you can leave the travel details to us and concentrate on enjoying your escape. Whether it's the distilleries and craft breweries and dining, or the countless other highlights you're coming to see, this destination has plenty to offer. With so much to see on a trip to Southwest Ohio, it can be hard to know where to begin. Kick off your journey in Cincinnati at Great American Ball Park and Paycor Stadium — two much-loved attractions here. Another top city worthy of a spot on your itinerary is Dayton. Don't miss National Museum of the United States Air Force and Dayton Mall Shopping Center. Expedia has hotels, flights, car rentals and more to help you organize your own tailored Southwest Ohio vacation today.

The Latest Southwest Ohio vacation packages

Price found within the past 48 hours. Click for updated prices.
Jungle House Urban Lofts - Short North & Convention Center
Jungle House Modern Lofts – Arena District & Short North
The Parkside by Jungle House – Short North Boutique Suites
Jungle House Historic Lofts – German Village
Don't see what you're looking for?
See all available trips from Columbus to Southwest Ohio
View all trips

The Annual Vacation Sale

Members save up to 40% on hotels and homes. Plan this year’s big trip and save.

Where to stay in Southwest Ohio

Find the best Southwest Ohio areas and neighborhoods for the activities you enjoy most. Learn more about Southwest Ohio

Discover the most popular places to visit in Southwest Ohio

What to do in Southwest Ohio

Southwest Ohio Hotel Deals

Hilton Cincinnati Netherland Plaza

Hilton Cincinnati Netherland Plaza

4 out of 5
35 W 5th St Cincinnati OH
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $146 total per night from Mar 1 to Mar 2
$146 total
Mar 1 - Mar 2
Total with taxes and fees
8/10 Very Good! (1,366 reviews)
Everything was great

Reviewed on Feb 11, 2026

Hilton Cincinnati Netherland Plaza
Drury Plaza Hotel Cincinnati Florence

Drury Plaza Hotel Cincinnati Florence

3 out of 5
7915 US Hwy 42 Florence KY
Fully refundable
$100 nightly
The price is $112 total per night from Feb 19 to Feb 20
$112 total
Feb 19 - Feb 20
Total with taxes and fees
9.6/10 Exceptional! (697 reviews)
Spotless rooms and great service

Reviewed on Feb 12, 2026

Drury Plaza Hotel Cincinnati Florence
Hyatt Regency Cincinnati

Hyatt Regency Cincinnati

4 out of 5
151 West Fifth Street Cincinnati OH
Fully refundableReserve now, pay when you stay
$178 nightly
The price is $212 total per night from Mar 1 to Mar 2
$212 total
Mar 1 - Mar 2
Total with taxes and fees
8.8/10 Excellent! (1,591 reviews)
Room was clean and staff were very courteous. The room itself could use additional lighting.

Reviewed on Feb 13, 2026

Hyatt Regency Cincinnati
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Southwest Ohio Vacation Packages

Southwest Ohio Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Cincinnati - Northern Kentucky Intl. Airport (CVG)

More vacations you might like

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.