Tenderloin Vacations from $275

Book a Hotel + Flight or Car together to unlock savings

Your Tenderloin Vacation

Our Tenderloin vacation packages are a time-saving and convenient way to organize and book your next exciting adventure. Discover the heart and soul of this unique neighborhood without the pressure of having to plan everything yourself. When it's time to sightsee, you'll find lots of popular attractions nearby including Pier 39, Alcatraz Island and Lombard Street. Visit one, two (or even all!) during your trip to Tenderloin. Stop dreaming and start doing. When it's time to book your dream vacation to Tenderloin, Expedia will help get you there.

The Latest Tenderloin Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Bay Landing San Francisco Airport Hotel
Aqua Breeze Inn
The Grove Inn
Alila Napa Valley, a Hyatt Luxury Resort
Hotel Riu Plaza Fisherman's Wharf

Where to stay in Tenderloin

Find the best Tenderloin areas and neighborhoods for the activities you enjoy most. Learn more about Tenderloin

Tenderloin Hotel Deals

Hotel EPIK

Hotel EPIK

4 out of 5
706 Polk Street, San Francisco, CA
Fully refundable
$100 nightly
The price is $118 total per night from Aug 25 to Aug 26
$118 total
Aug 25 - Aug 26
Total with taxes and fees
6.8/10 (443 reviews)
"Totally recommend. My absolute safe haven, and comfortable quiet place to be during the dead co celebratory weekend. Stayed four nights, no hitches, absolute convenience and access to everything San Francisco had to offer that weekend, super cool staff, friendly, clean, comfortable, quiet, affordable, ..."

Reviewed on Aug 9, 2025

Hotel EPIK
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St, San Francisco, CA
Fully refundableReserve now, pay when you stay
$148 nightly
The price is $174 total per night from Aug 26 to Aug 27
$174 total
Aug 26 - Aug 27
Total with taxes and fees
8.8/10 Excellent! (6,684 reviews)
"The location and good service adds to the charm of the hotel."

Reviewed on Aug 20, 2025

Hotel Riu Plaza Fisherman's Wharf
Hyatt Regency San Francisco

Hyatt Regency San Francisco

4 out of 5
5 Embarcadero Center, San Francisco, CA
Fully refundableReserve now, pay when you stay
$219 nightly
The price is $258 total per night from Aug 28 to Aug 29
$258 total
Aug 28 - Aug 29
Total with taxes and fees
9.2/10 Wonderful! (1,807 reviews)
"Its nice and cozy. But i need to say this: water pressure was so bad. No sleepers"

Reviewed on Aug 18, 2025

Hyatt Regency San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Tenderloin

Things to do

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.