Downtown San Francisco Vacations from $410
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Your Downtown San Francisco Vacation
Experience everything Downtown San Francisco has to offer with a tailor-made Downtown San Francisco vacation package. From its history and shopping to its dining, prepare to be captivated by this busy neighborhood. When it's time to see the sights, you'll find plenty of big-name attractions nearby including Pier 39, Alcatraz Island and Lombard Street. Tick off one, two or all during your trip to Downtown San Francisco. Don't just think about it — turn it into reality! Book your ultimate Downtown San Francisco vacation with Expedia and experience travel your way.
The Latest Downtown San Francisco Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Cathedral Hill Hotel
Downtown San Francisco
$523
per person
Oct 22 - Oct 28
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to San Francisco (SFO)
7.2/10 Good! (737 reviews)
I only stayed for two days, but the experience was disappointing.
I arrived at 2:30 PM, just 30 minutes before the 3:00 PM check-in time, and had to wait standing because the reception area had no chairs.
The room was never cleaned or organized during my stay. Used towels were not exchanged, but after informing the front desk, I was simply given new towels and had to carry them myself to the third floor.
The Wi‑Fi was very slow, frequently disconnected, and unreliable.
Overall, I do not recommend this place.
Reviewed on Sep 11, 2026
Where to stay in Downtown San Francisco
Find the best Downtown San Francisco areas and neighborhoods for the activities you enjoy most. Learn more about Downtown San Francisco
Fisherman's Wharf
1 out of top 10 points of interest in this area
Discover Pier 39, Ghirardelli Square, and the San Francisco Maritime National Historical Park in this bustling tourist hotspot. Savor seafood at family-owned restaurants and explore the sea lion colony, while enjoying convenient cable car access.
Union Square
Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.
South of Market
From baseball games to top-notch art exhibits, find endless entertainment in one of San Francisco’s fastest-growing neighborhoods.
Nob Hill
Luxury hotels, historic mansions, and Michelin-starred restaurants abound in this upscale area. Explore Union Square shopping district, Grace Cathedral, and the SF Masonic Auditorium for a taste of culture and history.
Mission District
Visit this San Francisco neighborhood brimming with culture, history, a lively art scene, buzzing nightlife and some of the city’s best burritos.
Downtown San Francisco Hotel Deals
Handlery Union Square Hotel
351 Geary St San Francisco CA
Fully refundableReserve now, pay when you stay
$150 nightly
$176 total
Sep 20 - Sep 21
Total with taxes and fees
8.8/10 Excellent! (3,563 reviews)
"The bathroom light was hard tofind"
Reviewed on Sep 17, 2026
Holiday Inn Golden Gateway by IHG
1500 Van Ness Ave San Francisco CA
Fully refundableReserve now, pay when you stay
$161 nightly
$189 total
Sep 20 - Sep 21
Total with taxes and fees
Hilton San Francisco Financial District
750 Kearny St San Francisco CA
Fully refundableReserve now, pay when you stay
$149 nightly
$175 total
Sep 18 - Sep 19
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Downtown San Francisco attractions
Moscone Convention Center
8.2/10 (2,926 reviews)
During your trip, find out what's happening at Moscone Convention Center, a top convention center in San Francisco. Discover the acclaimed theater scene and notable monuments in this vibrant area.
Oracle Park
8.8/10 (7,978 reviews)
Whether or not you’re a baseball fan, this charming ballpark with outstanding views should be on your San Francisco sightseeing list.
Chase Center
8.8/10 (1,176 reviews)
Catch an event at Chase Center during your trip to San Francisco. Amble around this vibrant area's Chinatown or experience its fascinating museums.
Photo by Kathy Appleby
Union Square
8.6/10 (1,277 reviews)
You can search for that perfect souvenir at Union Square during your trip to San Francisco. Discover the top-notch restaurants and fascinating museums in this walkable area.
Embarcadero Center
9.2/10 (94 reviews)
During your visit to San Francisco, you can browse for the perfect souvenirs at Embarcadero Center. Amble around this vibrant area's Chinatown or experience its acclaimed theater scene.
San Francisco Museum of Modern Art
9.0/10 (2,422 reviews)
Displaying artworks from Frida Kahlo to Andy Warhol, this museum of modern and contemporary art is one of the largest of its kind in the United States.
San Francisco City Hall
8.6/10 (653 reviews)
After visiting San Francisco City Hall, make a plan to see the other sights and activities in San Francisco. Discover the fascinating museums and notable monuments in this vibrant area.
Bill Graham Civic Auditorium
8.4/10 (45 reviews)
You can get tickets for a performance at Bill Graham Civic Auditorium during your trip to San Francisco. Discover the acclaimed art scene and notable monuments in this vibrant area.
Things to do
California Sunset Cruise (2-hours)
$58
per adult
94% of travellers recommend
San Francisco, Aquarium of the Bay General Admission Ticket
$29
per adult
100% of travellers recommend
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