Downtown San Francisco Vacations from $351

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Your Downtown San Francisco Vacation

Experience everything Downtown San Francisco has to offer with a tailor-made Downtown San Francisco vacation package. From its history and shopping to its dining, prepare to be captivated by this busy neighborhood. When it's time to see the sights, you'll find plenty of big-name attractions nearby including Pier 39, Alcatraz Island and Lombard Street. Tick off one, two or all during your trip to Downtown San Francisco. Don't just think about it — turn it into reality! Book your ultimate Downtown San Francisco vacation with Expedia and experience travel your way.

The Latest Downtown San Francisco Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Sonesta Emeryville - San Francisco Bay Bridge
The Grove Inn
Claremont Resort & Club
RiverPointe Napa Valley Resort
SF Central Hotel

Where to stay in Downtown San Francisco

Find the best Downtown San Francisco areas and neighborhoods for the activities you enjoy most. Learn more about Downtown San Francisco

Downtown San Francisco Hotel Deals

Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

3.5 out of 5
1500 Van Ness Ave San Francisco CA
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $159 total per night from Mar 29 to Mar 30
$159 total
Mar 29 - Mar 30
Total with taxes and fees
9/10 Wonderful! (5,382 reviews)
Breakfast NOT included. Scary area if you arrive late at night. Not even vending machines with food. Gym crowded and dirty, pool outside so no way to use it other than maybe in the summer. And they charge $50 for parking !! Inside the room it feels they are opening the door inside and are other rooms ...

Reviewed on Mar 11, 2026

Holiday Inn Golden Gateway by IHG
Handlery Union Square Hotel

Handlery Union Square Hotel

3.5 out of 5
351 Geary St San Francisco CA
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $176 total per night from Apr 1 to Apr 2
$176 total
Apr 1 - Apr 2
Total with taxes and fees
8.8/10 Excellent! (2,930 reviews)
I have been waiting for this pool to open for nearly a year. Keep bringing a bath suit bc they say it’s either open or will be open by the 3/6. Didn’t happen. No snacks and restaurants close early in the area. Also restaurants are extremely expensive.

Reviewed on Mar 10, 2026

Handlery Union Square Hotel
YOTEL San Francisco

YOTEL San Francisco

3 out of 5
1095 Market St San Francisco CA
Fully refundableReserve now, pay when you stay
$107 nightly
The price is $126 total per night from Mar 31 to Apr 1
$126 total
Mar 31 - Apr 1
Total with taxes and fees
8.2/10 Very Good! (1,000 reviews)
Inside, the staff is very helpful and accommodating without being invasive. The rooms are peculiarly engineered, so make sure that you know what you are about to spend the night in. I think the room that I rented for two nights is made for single travelers or a close couple because I was in a sky ...

Reviewed on Mar 10, 2026

YOTEL San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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