Downtown San Francisco Vacations from $346

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Your Downtown San Francisco Vacation

Experience everything Downtown San Francisco has to offer with a tailor-made Downtown San Francisco vacation package. From its history and shopping to its dining, prepare to be captivated by this busy neighborhood. When it's time to see the sights, you'll find plenty of big-name attractions nearby including Pier 39, Alcatraz Island and Lombard Street. Tick off one, two or all during your trip to Downtown San Francisco. Don't just think about it — turn it into reality! Book your ultimate Downtown San Francisco vacation with Expedia and experience travel your way.

The Latest Downtown San Francisco Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Embassy Hotel
Parc 55 San Francisco - A Hilton Hotel
SF Central Hotel
RiverPointe Napa Valley Resort
Bay Bridge Inn

Where to stay in Downtown San Francisco

Find the best Downtown San Francisco areas and neighborhoods for the activities you enjoy most. Learn more about Downtown San Francisco

Downtown San Francisco Hotel Deals

Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

3.5 out of 5
1500 Van Ness Ave San Francisco CA
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $159 total per night from Mar 29 to Mar 30
$159 total
Mar 29 - Mar 30
Total with taxes and fees
9/10 Wonderful! (5,387 reviews)
Location is excellent! The room is spacious and clean. Water pressure in the shower is very good, however the sink faucet the water is very slow it was a struggle to wash your hands!

Reviewed on Mar 11, 2026

Holiday Inn Golden Gateway by IHG
Handlery Union Square Hotel

Handlery Union Square Hotel

3.5 out of 5
351 Geary St San Francisco CA
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $176 total per night from Apr 1 to Apr 2
$176 total
Apr 1 - Apr 2
Total with taxes and fees
8.8/10 Excellent! (2,934 reviews)
Across the street from union square, this hotel is close to many restaurants and quick dining spots. Definitely an ideal place to stay if you don’t have a car. Super close to Powell BART, you can walk there with your luggage. Short walk to Chinatown. Hotel was very clean and I always wipe down my ...

Reviewed on Mar 11, 2026

Handlery Union Square Hotel
YOTEL San Francisco

YOTEL San Francisco

3 out of 5
1095 Market St San Francisco CA
Fully refundableReserve now, pay when you stay
$107 nightly
The price is $126 total per night from Mar 31 to Apr 1
$126 total
Mar 31 - Apr 1
Total with taxes and fees
8.2/10 Very Good! (1,000 reviews)
Inside, the staff is very helpful and accommodating without being invasive. The rooms are peculiarly engineered, so make sure that you know what you are about to spend the night in. I think the room that I rented for two nights is made for single travelers or a close couple because I was in a sky ...

Reviewed on Mar 10, 2026

YOTEL San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.