Downtown San Francisco Vacations from $509
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Your Downtown San Francisco Vacation
Experience everything Downtown San Francisco has to offer with a tailor-made Downtown San Francisco vacation package. From its history and shopping to its dining, prepare to be captivated by this busy neighborhood. When it's time to see the sights, you'll find plenty of big-name attractions nearby including Pier 39, Alcatraz Island and Lombard Street. Tick off one, two or all during your trip to Downtown San Francisco. Don't just think about it — turn it into reality! Book your ultimate Downtown San Francisco vacation with Expedia and experience travel your way.
The Latest Downtown San Francisco Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Where to stay in Downtown San Francisco
Find the best Downtown San Francisco areas and neighborhoods for the activities you enjoy most. Learn more about Downtown San Francisco
Fisherman's Wharf
1 out of top 10 points of interest in this area
Discover Pier 39, Ghirardelli Square, and the San Francisco Maritime National Historical Park in this bustling tourist hotspot. Savor seafood at family-owned restaurants and explore the sea lion colony, while enjoying convenient cable car access.
Union Square
Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.
South of Market
From baseball games to top-notch art exhibits, find endless entertainment in one of San Francisco’s fastest-growing neighborhoods.
Nob Hill
Luxury hotels, historic mansions, and Michelin-starred restaurants abound in this upscale area. Explore Union Square shopping district, Grace Cathedral, and the SF Masonic Auditorium for a taste of culture and history.
Mission District
Visit this San Francisco neighborhood brimming with culture, history, a lively art scene, buzzing nightlife and some of the city’s best burritos.
Downtown San Francisco Hotel Deals
Holiday Inn Golden Gateway by IHG
1500 Van Ness Ave San Francisco CA
Fully refundable
$152 nightly
$179 total
Sep 20 - Sep 21
Total with taxes and fees
9/10 Wonderful! (6,272 reviews)
"Fantastic location for our visit to San Francisco! We had an amazing view from the 20th floor. The room was very clean, staff were friendly and helpful, and parking was a breeze. We would definitely stay there again."
Reviewed on Sep 10, 2026
Hilton San Francisco Union Square
333 O'Farrell St. San Francisco CA
Fully refundableReserve now, pay when you stay
$164 nightly
$194 total
Sep 20 - Sep 21
Total with taxes and fees
The Pickwick Hotel
85 5th St San Francisco CA
Fully refundableReserve now, pay when you stay
$106 nightly
$124 total
Oct 4 - Oct 5
Total with taxes and fees
7.8/10 Good! (1,520 reviews)
"It’s an older building. I had an issue with the toilet that was repaired in a timely manner, staff was very friendly. The bed was too soft for me but I have this issue with most hotels. One block away from major transit lines which is super convenient. Overall value for price was reasonable and stay ..."
Reviewed on Sep 10, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Downtown San Francisco attractions
Moscone Convention Center
8.2/10 (2,926 reviews)
During your trip, find out what's happening at Moscone Convention Center, a top convention center in San Francisco. Discover the acclaimed theater scene and notable monuments in this vibrant area.
Oracle Park
8.8/10 (7,978 reviews)
Whether or not you’re a baseball fan, this charming ballpark with outstanding views should be on your San Francisco sightseeing list.
Chase Center
8.8/10 (1,176 reviews)
Catch an event at Chase Center during your trip to San Francisco. Amble around this vibrant area's Chinatown or experience its fascinating museums.
Union Square
8.6/10 (1,277 reviews)
You can search for that perfect souvenir at Union Square during your trip to San Francisco. Discover the top-notch restaurants and fascinating museums in this walkable area.
Embarcadero Center
9.2/10 (94 reviews)
During your visit to San Francisco, you can browse for the perfect souvenirs at Embarcadero Center. Amble around this vibrant area's Chinatown or experience its acclaimed theater scene.
San Francisco Museum of Modern Art
9.0/10 (2,422 reviews)
Displaying artworks from Frida Kahlo to Andy Warhol, this museum of modern and contemporary art is one of the largest of its kind in the United States.
Ferry Building
9.0/10 (348 reviews)
During your trip to San Francisco, you can enjoy retail therapy at Ferry Building. Discover the fascinating museums and notable monuments in this vibrant area.
Bill Graham Civic Auditorium
8.4/10 (45 reviews)
You can get tickets for a performance at Bill Graham Civic Auditorium during your trip to San Francisco. Discover the acclaimed art scene and notable monuments in this vibrant area.
Things to do
Alcatraz Inside Prison Tour with Free App Audio Packages
$86
per adult
94% of travellers recommend
California Academy of Sciences Daytime Admission
$49
per adult
86% of travellers recommend
California Sunset Cruise (2-hours)
$58
per adult
94% of travellers recommend
Explore a world of travel with Expedia
- Alamo Square
- Yerba Buena Ice Skating Center
- Golden Gate Theatre
- Commercial Street
- Tin How Temple
- De Young Museum
- Shn Curran Theatre
- Greek Theater
- Coit Tower
- Sf Masonic Auditorium
- Bill Graham Civic Auditorium
- Japanese Tea Garden
- National Shrine of Saint Francis of Assisi
- Jack Kerouac Alley
- Union Square Ice Rink
- Civic Center Plaza
- Crocker Bank Building
- Dragon's Gate
- San Francisco Federal Building
- Conservatory of Flowers
- 555 California Street
- Van Ness Avenue
- San Francisco Mint
- Ghirardelli Chocolate Experience
- Civic Center Vacations
- Aquarium of the Bay
- American Conservatory Theater
- Saints Peter and Paul Church
- Uss Pampanito
- Chinese Historical Society of America
- San Francisco Zoo
- The Regency Ballroom
- Yerba Buena Gardens
- Lombard Street
- Grace Cathedral
- Telephone Pioneers Communication Museum
- Golden Gate Bridge
- Old St. Mary's Cathedral
- San Francisco Museum of Modern Art
- Alcatraz Island
- Kong Chow Temple
- Museum of Craft and Folk Art
- Cable Car Museum
- Balmy Alley
- Crocker Galleria
- San Francisco Vacations
- Sf Playhouse
- Musée Mécanique
- Children's Creativity Museum
- Columbus Tower
- Palace Hotel
- Oracle Park
- Walter S. Johnson Park
- Chase Center
- Moscone Convention Center
- San Francisco Maritime National Historical Park
- Palace of Fine Arts
- Maxwell Galleries
- Sf Armory
- Westfield San Francisco Centre
- Academy of Art University
- Mission San Francisco de Asís
- 450 Sutter Building
- Transamerica Redwood Forest
- Orpheum Theatre
- One Montgomery Terrace
- Muir Woods National Monument
- Chinatown Vacations
- Yerba Buena Center for the Arts
- Full House House
- Eleonore Austerer Gallery
- Transamerica Pyramid
- Ferry Building
- Crissy Field
- San Francisco City Hall
- Mrs. Doubtfire House
- Fisherman's Wharf Vacations
- St. Mary Square
- Union Square
- Union Square Vacations
- Wells Fargo History Museum
- United Nations Plaza
- Warfield Theatre
- Magowan's Infinite Mirror Maze
- Asian Art Museum of San Francisco
- Maiden Lane
- Pier 39
- Marines Memorial Theater
- The Cannery at Del Monte Square
- Lotta's Fountain
- Baker Beach
- Pacific-Union Club
- California Academy of Sciences
- Embarcadero Center
- Ripley's Believe It Or Not Museum
- Walt Disney Family Museum
- Ghirardelli Square
- St. Patrick Catholic Church
- Westin St Francis Hotel Glass Elevators
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.