Downtown San Francisco Vacations from $395
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Your Downtown San Francisco Vacation
Experience everything Downtown San Francisco has to offer with a tailor-made Downtown San Francisco vacation package. From its history and shopping to its dining, prepare to be captivated by this busy neighborhood. When it's time to see the sights, you'll find plenty of big-name attractions nearby including Pier 39, Alcatraz Island and Lombard Street. Tick off one, two or all during your trip to Downtown San Francisco. Don't just think about it — turn it into reality! Book your ultimate Downtown San Francisco vacation with Expedia and experience travel your way.
The Latest Downtown San Francisco Vacation Packages
Where to stay in Downtown San Francisco
Fisherman's Wharf
Discover Pier 39, Ghirardelli Square, and the San Francisco Maritime National Historical Park in this bustling tourist hotspot. Savor seafood at family-owned restaurants and explore the sea lion colony, while enjoying convenient cable car access.
Union Square
Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.
South of Market
From baseball games to top-notch art exhibits, find endless entertainment in one of San Francisco’s fastest-growing neighborhoods.
Nob Hill
Luxury hotels, historic mansions, and Michelin-starred restaurants abound in this upscale area. Explore Union Square shopping district, Grace Cathedral, and the SF Masonic Auditorium for a taste of culture and history.
Mission District
Visit this San Francisco neighborhood brimming with culture, history, a lively art scene, buzzing nightlife and some of the city’s best burritos.
Downtown San Francisco Hotel Deals
Holiday Inn Golden Gateway by IHG
"Staff"
Reviewed on Sep 11, 2026
Hilton San Francisco Union Square
"Never will I stay there"
Reviewed on Sep 11, 2026
The Pickwick Hotel
"Really old and very small rooms. The strangest toilet I've ever seen. The bar that's connected was great. Area not too bad."
Reviewed on Sep 11, 2026
Stay near popular Downtown San Francisco attractions
Moscone Convention Center
Oracle Park
Chase Center
Union Square
Embarcadero Center
San Francisco Museum of Modern Art
Ferry Building
Bill Graham Civic Auditorium
Things to do
San Francisco, Aquarium of the Bay General Admission Ticket
San Francisco Bridge to Bridge Cruise (90-minutes)
Explore a world of travel with Expedia
- Alamo Square
- Yerba Buena Ice Skating Center
- Golden Gate Theatre
- Commercial Street
- Tin How Temple
- De Young Museum
- Shn Curran Theatre
- Greek Theater
- Coit Tower
- Sf Masonic Auditorium
- Bill Graham Civic Auditorium
- Japanese Tea Garden
- National Shrine of Saint Francis of Assisi
- Jack Kerouac Alley
- Union Square Ice Rink
- Civic Center Plaza
- Crocker Bank Building
- Dragon's Gate
- San Francisco Federal Building
- Conservatory of Flowers
- 555 California Street
- Van Ness Avenue
- San Francisco Mint
- Ghirardelli Chocolate Experience
- Civic Center Vacations
- Aquarium of the Bay
- American Conservatory Theater
- Saints Peter and Paul Church
- Uss Pampanito
- Chinese Historical Society of America
- San Francisco Zoo
- The Regency Ballroom
- Yerba Buena Gardens
- Lombard Street
- Grace Cathedral
- Telephone Pioneers Communication Museum
- Golden Gate Bridge
- Old St. Mary's Cathedral
- San Francisco Museum of Modern Art
- Alcatraz Island
- Kong Chow Temple
- Museum of Craft and Folk Art
- Cable Car Museum
- Balmy Alley
- Crocker Galleria
- San Francisco Vacations
- Sf Playhouse
- Musée Mécanique
- Children's Creativity Museum
- Columbus Tower
- Palace Hotel
- Oracle Park
- Walter S. Johnson Park
- Chase Center
- Moscone Convention Center
- San Francisco Maritime National Historical Park
- Palace of Fine Arts
- Maxwell Galleries
- Sf Armory
- Westfield San Francisco Centre
- Academy of Art University
- Mission San Francisco de Asís
- 450 Sutter Building
- Transamerica Redwood Forest
- Orpheum Theatre
- One Montgomery Terrace
- Muir Woods National Monument
- Chinatown Vacations
- Yerba Buena Center for the Arts
- Full House House
- Eleonore Austerer Gallery
- Transamerica Pyramid
- Ferry Building
- Crissy Field
- San Francisco City Hall
- Mrs. Doubtfire House
- Fisherman's Wharf Vacations
- St. Mary Square
- Union Square
- Union Square Vacations
- Wells Fargo History Museum
- United Nations Plaza
- Warfield Theatre
- Magowan's Infinite Mirror Maze
- Asian Art Museum of San Francisco
- Maiden Lane
- Pier 39
- Marines Memorial Theater
- The Cannery at Del Monte Square
- Lotta's Fountain
- Baker Beach
- Pacific-Union Club
- California Academy of Sciences
- Embarcadero Center
- Ripley's Believe It Or Not Museum
- Walt Disney Family Museum
- Ghirardelli Square
- St. Patrick Catholic Church
- Westin St Francis Hotel Glass Elevators