Downtown San Francisco Vacations from $431

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Your Downtown San Francisco Vacation

Experience everything Downtown San Francisco has to offer with a tailor-made Downtown San Francisco vacation package. From its history and shopping to its dining, prepare to be captivated by this busy neighborhood. When it's time to see the sights, you'll find plenty of big-name attractions nearby including Pier 39, Alcatraz Island and Lombard Street. Tick off one, two or all during your trip to Downtown San Francisco. Don't just think about it — turn it into reality! Book your ultimate Downtown San Francisco vacation with Expedia and experience travel your way.

The Latest Downtown San Francisco Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Shashi Hotel Mountain View Palo Alto
The Grove Inn
Appellation Healdsburg
Alila Napa Valley, a Hyatt Luxury Resort
Claremont Resort & Club

Where to stay in Downtown San Francisco

Find the best Downtown San Francisco areas and neighborhoods for the activities you enjoy most. Learn more about Downtown San Francisco

Downtown San Francisco Hotel Deals

Hyatt Regency San Francisco

Hyatt Regency San Francisco

4 out of 5
5 Embarcadero Center, San Francisco, CA
Fully refundableReserve now, pay when you stay
$228 nightly
The price is $268 total per night from Sep 25 to Sep 26
$268 total
Sep 25 - Sep 26
Total with taxes and fees
9.2/10 Wonderful! (1,880 reviews)
"Great location, good staff, impressive building architecture. However, I have two small complains: my minibar was empty and the girl at the market wasn´t nice when I went to buy a sandwich."

Reviewed on Sep 16, 2025

Hyatt Regency San Francisco
Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

3.5 out of 5
1500 Van Ness Ave, San Francisco, CA
Fully refundable
$128 nightly
The price is $150 total per night from Sep 21 to Sep 22
$150 total
Sep 21 - Sep 22
Total with taxes and fees
8.8/10 Excellent! (4,584 reviews)
"Everything was fine but not OUTSTANDING. Would recommend!"

Reviewed on Sep 18, 2025

Holiday Inn Golden Gateway by IHG
Hilton San Francisco Financial District

Hilton San Francisco Financial District

4 out of 5
750 Kearny St, San Francisco, CA
Fully refundableReserve now, pay when you stay
$131 nightly
The price is $154 total per night from Sep 21 to Sep 22
$154 total
Sep 21 - Sep 22
Total with taxes and fees
8.6/10 Excellent! (1,766 reviews)
"Everything was super nice"

Reviewed on Sep 15, 2025

Hilton San Francisco Financial District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Downtown San Francisco

Things to do

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.