Downtown San Francisco Vacations from $406

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Your Downtown San Francisco Vacation

Experience everything Downtown San Francisco has to offer with a tailor-made Downtown San Francisco vacation package. From its history and shopping to its dining, prepare to be captivated by this busy neighborhood. When it's time to see the sights, you'll find plenty of big-name attractions nearby including Pier 39, Alcatraz Island and Lombard Street. Tick off one, two or all during your trip to Downtown San Francisco. Don't just think about it — turn it into reality! Book your ultimate Downtown San Francisco vacation with Expedia and experience travel your way.

The Latest Downtown San Francisco Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Bay Landing San Francisco Airport Hotel
Aqua Breeze Inn
The Grove Inn
Hotel Zoe Fisherman's Wharf
Hotel Riu Plaza Fisherman's Wharf

Where to stay in Downtown San Francisco

Find the best Downtown San Francisco areas and neighborhoods for the activities you enjoy most. Learn more about Downtown San Francisco

Downtown San Francisco Hotel Deals

Hyatt Regency San Francisco

Hyatt Regency San Francisco

4 out of 5
5 Embarcadero Center, San Francisco, CA
Fully refundableReserve now, pay when you stay
$219 nightly
The price is $258 total per night from Aug 28 to Aug 29
$258 total
Aug 28 - Aug 29
Total includes taxes and fees
9.2/10 Wonderful! (1,807 reviews)
"Its nice and cozy. But i need to say this: water pressure was so bad. No sleepers"

Reviewed on Aug 18, 2025

Hyatt Regency San Francisco
Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

3.5 out of 5
1500 Van Ness Ave, San Francisco, CA
Fully refundableReserve now, pay when you stay
$123 nightly
The price is $145 total per night from Aug 24 to Aug 25
$145 total
Aug 24 - Aug 25
Total includes taxes and fees
8.8/10 Excellent! (4,430 reviews)
"Great property. Amazing staff, so kind and helpful. Not sure about parking. Decently located. Lots of public transportation around. I felt safe. The views and pool are the selling point. A touch outdated like ceilings carpets and light switches and bathroom doors. Main areas are updated though. Great ..."

Reviewed on Aug 18, 2025

Holiday Inn Golden Gateway by IHG
Hilton San Francisco Financial District

Hilton San Francisco Financial District

4 out of 5
750 Kearny St, San Francisco, CA
Fully refundableReserve now, pay when you stay
$121 nightly
The price is $143 total per night from Aug 24 to Aug 25
$143 total
Aug 24 - Aug 25
Total includes taxes and fees
8.6/10 Excellent! (1,645 reviews)
"Awesome staff! Very helpful! Will stay here again in the future for sure!"

Reviewed on Aug 19, 2025

Hilton San Francisco Financial District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Downtown San Francisco

Things to do

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.