Downtown San Francisco Vacations from $374

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Your Downtown San Francisco Vacation

Experience everything Downtown San Francisco has to offer with a tailor-made Downtown San Francisco vacation package. From its history and shopping to its dining, prepare to be captivated by this busy neighborhood. When it's time to see the sights, you'll find plenty of big-name attractions nearby including Pier 39, Alcatraz Island and Lombard Street. Tick off one, two or all during your trip to Downtown San Francisco. Don't just think about it — turn it into reality! Book your ultimate Downtown San Francisco vacation with Expedia and experience travel your way.

The Latest Downtown San Francisco Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Brannan Cottage Inn
Aqua Breeze Inn
Montage Healdsburg
Cavallo Point
1 Hotel San Francisco

Where to stay in Downtown San Francisco

Find the best Downtown San Francisco areas and neighborhoods for the activities you enjoy most. Learn more about Downtown San Francisco

Downtown San Francisco Hotel Deals

Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

3.5 out of 5
1500 Van Ness Ave San Francisco CA
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $140 total per night from Nov 29 to Nov 30
$140 total
Nov 29 - Nov 30
Total with taxes and fees
9/10 Wonderful! (6,474 reviews)
"Great place and good value for money"

Reviewed on Nov 10, 2026

Holiday Inn Golden Gateway by IHG
Hilton San Francisco Union Square

Hilton San Francisco Union Square

4 out of 5
333 O'Farrell St. San Francisco CA
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $182 total per night from Nov 13 to Nov 14
$182 total
Nov 13 - Nov 14
Total with taxes and fees
8.6/10 Excellent! (1,898 reviews)
"Our initial room was located at the far end of the building, which meant quite a long walk from the elevators. Unfortunately, the cleanliness of the room was also disappointing. It was noticeably dusty, to the point that I started experiencing itchiness and frequent sneezing. We requested a room ..."

Reviewed on Nov 10, 2026

Hilton San Francisco Union Square
FOUND Hotel Carlton, Nob Hill

FOUND Hotel Carlton, Nob Hill

2 out of 5
1075 Sutter St San Francisco CA
Fully refundableReserve now, pay when you stay
$82 nightly
The price is $97 total per night from Nov 22 to Nov 23
$97 total
Nov 22 - Nov 23
Total with taxes and fees
8.6/10 Excellent! (2,043 reviews)
"Clean , fresh lobby and room..very friendly employees and they accommodated us with early check in and letting us keep our bags in their car after check out while we waited for our flight time"

Reviewed on Nov 10, 2026

FOUND Hotel Carlton, Nob Hill
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Downtown San Francisco attractions

Things to do

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.