Texas Medical Center Vacations from $247
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
Better together
Save up to $1,045 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place
Your Texas Medical Center Vacation
Texas Medical Center is calling! Whatever type of break you're organizing, you can see and experience the best of this neighborhood with a Texas Medical Center vacation package. Your trip to Texas Medical Center wouldn't be complete without a stop at top attractions nearby such as Houston Zoo, Houston Natural Science Museum and Childrens Museum of Houston. Whatever your travel plans or the size of your budget, booking a perfect Texas Medical Center vacation is quick and easy with Expedia.
The Latest Texas Medical Center Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Palace Inn Blue Edgebrook
Southeast Houston
Save 100% on your flight
per person
Sep 11 - Sep 16
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
9.2/10 Wonderful! (117 reviews)
The area was under construction so it was a bit hard to find but the staff was nice and welcoming. We did find a small issue with the room but it didn’t affect the stay that much and just threw it away and had a good laugh about it.
Reviewed on Jul 1, 2025
Blossom Hotel Houston
Texas Medical Center
Save 100% on your flight
per person
Sep 11 - Sep 16
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
9.2/10 Wonderful! (3,362 reviews)
The staff was very helpful and friendly. The hotel was beautiful. I’ll definitely book again!
Reviewed on Jul 5, 2025
Moody Gardens Hotel, Spa and Convention Center
Near West End
Save 100% on your flight
per person
Sep 4 - Sep 7
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
8.8/10 Excellent! (1,818 reviews)
The staff are very nice. The rooms need some updating. We stayed here about 10 years ago and everything is the exact same. The bottom of the bathtub was peeling, the carpet has stains, but the room was clean. Check your bill before you leave, they charged us for valet when we parked ourselves. The issue was quickly fixed.
Reviewed on Jul 5, 2025
Where to stay in Texas Medical Center
Find the best Texas Medical Center areas and neighborhoods for the activities you enjoy most. Learn more about Texas Medical Center
Downtown Houston
3 out of top 10 points of interest in this area
4.5/5(2,300 area reviews)
Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.
Texas Medical Center Hotel Deals
Blossom Hotel Houston
7118 Bertner Ave, Houston, TX
Fully refundableReserve now, pay when you stay
$157 nightly
The price is $184 total per night from Jul 13 to Jul 14
$184 total
Jul 13 - Jul 14
Total includes taxes and fees
9/10 Wonderful! (3,374 reviews)
"The property is really nice. Convenient to MD Anderson for sure. Shuttle service was great. I will be back!"
Reviewed on Jul 4, 2025
Hilton Houston Plaza/Medical Center
6633 Travis St, Houston, TX
Fully refundableReserve now, pay when you stay
$96 nightly
The price is $113 total per night from Jul 20 to Jul 21
$113 total
Jul 20 - Jul 21
Total includes taxes and fees
8.2/10 Very Good! (1,411 reviews)
Great hotel clise to the TMC
"The stay was overall very enjoyable — the facilities were clean, comfortable, and well-maintained. The only inconvenience was having just one working elevator, as the other was under maintenance. This led to long wait times at certain hours, which was a bit of a hassle. Aside from that, everything ..."
Reviewed on Jun 29, 2025
Hyatt Place Houston Medical Center
7329 FANNIN STREET Building 2, Houston, TX
Fully refundableReserve now, pay when you stay
$130 nightly
The price is $152 total per night from Jul 12 to Jul 13
$152 total
Jul 12 - Jul 13
Total includes taxes and fees
9/10 Wonderful! (1,759 reviews)
Reviewed on Jul 2, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Texas Medical Center
MD Anderson Cancer Center
4.5/5(788 reviews)
Though MD Anderson Cancer Center might be what brings you to town, perhaps you'll have a chance to explore more of Houston while you are here.
Texas Children's Hospital
4.5/5(26 reviews)
Though Texas Children's Hospital might be what brings you to town, perhaps you'll have a chance to explore more of Houston while you are here.
Harris Health System - Ben Taub General Hospital
Though Harris Health System - Ben Taub General Hospital might be what brings you to town, perhaps you'll have a chance to explore more of Houston while you are here.
Things to do
Houston Museum of Natural Sciences: Planetarium Ticket
$12
per adult
78% of travellers recommend
Houston: Space Center Houston Admission Ticket
$30
per adult
92% of travellers recommend
Houston: Houston Botanic Garden Entry Ticket
$12
per adult
Explore a world of travel with Expedia
Explore a world of travel with Expedia
- Houston Hotels
- Hotels near MD Anderson Cancer Center
- Hotels near Downtown Houston
- Hotels near NRG Stadium
- Cheap Hotels in Houston
- Hotels near TMC Transit Center
- Condo Rentals in TMC Transit Center
- Apartments in Dryden/TMC Station
- Hotels near Dryden/TMC Station
- Aparthotels in Dryden/TMC Station
- Hotels near Smith Lands Station
- Hotels near Houston Zoo
- Hotels near Astrodome
- Apartments in Memorial Hermann Hospital/Houston Zoo Station
- Vacation Homes in Memorial Hermann Hospital/Houston Zoo Station
- Hotels near Memorial Hermann Hospital/Houston Zoo Station
- Resorts in Memorial Hermann Hospital/Houston Zoo Station
- Condo Rentals in Memorial Hermann Hospital/Houston Zoo Station
- Hotels near Reckling Park
- Hotels near Rice University
- Hotels near Hermann Park
- Hotels near Rice Stadium
- Hotels near Miller Outdoor Theater
- Hotels near NRG Center
- Apartments in Stadium Park/Astrodome Station
- Hotels near Stadium Park/Astrodome Station
- Hotels near Houston Museum District
- Hotels near James Turrell's Twilight Epiphany Skyscape
- Hotels near Riverside Terrace
- Hotels near Houston Natural Science Museum
- Hotels near NRG Park
- Pet-friendly Hotels in Houston Museum District
- Historic Hotels in Houston Museum District
- Hotels with Free Breakfast in Houston Museum District
- Family Hotels in Houston Museum District
- Boutique Hotels in Houston Museum District
- Hotels with Free Parking in Houston Museum District
- Cheap Hotels in Houston Museum District
- Hotels with a Gym in Houston Museum District
- Luxury Hotels in Houston Museum District
- Resorts & Hotels with Spas in Houston Museum District
- Hotels with an Indoor Pool in Houston Museum District
- 5 Star Hotels in Houston Museum District
- Hotels with Hot Tubs in Houston Museum District
- Hyatt Hotels in Houston Museum District
- Hotels with Early Check-in in Houston Museum District
- Casino Hotels in Houston Museum District
- 3 Star Hotels in Houston Museum District
- Hotels with Connecting Rooms in Houston Museum District
- 4 Star Hotels in Houston Museum District
- Winery Hotels in Houston Museum District
- Hotels with Bars in Houston Museum District
- Adults Only Resorts & in Houston Museum District
- Motel 6 Hotels in Houston Museum District
- Wyndham Hotels in Houston Museum District
- Romantic Hotels in Houston Museum District
- Houston Zoo
- MD Anderson Cancer Center
- Hermann Park
- Rice University
- Reckling Park
- Houston Vacations
- Rice Stadium
- Miller Outdoor Theater
- NRG Stadium
- Visit Astrodome
- James Turrell's Twilight Epiphany Skyscape
- Houston Natural Science Museum
- Houston Museum of Fine Arts
- NRG Park
- Houston Museum District Vacations
- Children's Museum of Houston
- Holocaust Museum Houston
- Cullen Sculpture Garden
- Visit Riverside Terrace
- Buffalo Soldiers National Museum
- Visit Houston Museum District
- Car rentals near Houston
- Car rentals near MD Anderson Cancer Center
- Standard Car Rentals near MD Anderson Cancer Center
- Car rentals near Houston Zoo
- Sportscar Car Rentals near Houston Zoo
- Car rentals near Hermann Park
- Car rentals near Rice University
- Pickup Car Rentals near Rice University
- SUV Car Rentals near Rice University
- Van Car Rentals near Rice University
- Car rentals near James Turrell's Twilight Epiphany Skyscape
- Car rentals near Houston Museum District
- Thrifty Car Rental Rental Cars in Houston Museum District
- Hertz Rental Cars in Houston Museum District
- Alamo Rent A Car Rental Cars in Houston Museum District
- Pickup Car Rentals in Houston Museum District
- Sixt Rental Cars in Houston Museum District
- Discount Quebec Rental Cars in Houston Museum District
- Budget Rental Cars in Houston Museum District
- Enterprise Rental Cars in Houston Museum District
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.