Texas Medical Center Vacations

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Your Texas Medical Center Vacation

Texas Medical Center is calling! Whatever type of break you're organizing, you can see and experience the best of this neighborhood with a Texas Medical Center vacation package. Your trip to Texas Medical Center wouldn't be complete without a stop at top attractions nearby such as Houston Zoo, Houston Natural Science Museum and Childrens Museum of Houston. Whatever your travel plans or the size of your budget, booking a perfect Texas Medical Center vacation is quick and easy with Expedia.

The Latest Texas Medical Center Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • Jul 14 - Jul 16

    Experience a First Class Stay - 2 BDRM + Flight

    Humble
    2 nights
    3.5 star property
    8.0/10 - Very Good (5 reviews)
    "This people have water that smells like poop. Sewage water is what they use for water. Remnants of trash, sticky nastiness in drawers, air vents falling off ceilings. Random kids belts found? Candy stuck to floor? Trash wasn’t even taken out. Mind you I have kids that found these things as well. Oh and don’t even try and ask for them to refund you for their disgusting rental. They will give you the run around and then IGNORE YOU. Awful establishment and these people NEED TO BE SHUTDOWN."
    Reviewed March 11, 2022
    Roundtrip Atlanta (ATL) - Houston (IAH)
    ATL - IAHNonstop IAH - ATLNonstop
    Save 100% on your flight
    $446
    $293
    per traveler
    found 2 days ago
    Experience a First Class Stay - 2 BDRM
  • Aug 5 - Aug 9

    Hilton Houston North + Flight

    Northside
    4 nights
    3.5 star property
    8.4/10 - Very Good (1,007 reviews)
    "Ok"
    Reviewed June 10, 2026
    Roundtrip Atlanta (ATL) - Houston (IAH)
    ATL - IAHNonstop IAH - ATLNonstop
    Save 100% on your flight
    $477
    $300
    per traveler
    found 2 days ago
    Hilton Houston North
  • Aug 5 - Aug 9

    The Moran CITYCENTRE + Flight

    Memorial
    4 nights
    4.0 star property
    9.0/10 - Wonderful (1,052 reviews)
    "Everything was perfect! Location, rooms, amenities and price!"
    Reviewed June 9, 2026
    Roundtrip Atlanta (ATL) - Houston (IAH)
    ATL - IAHNonstop IAH - ATLNonstop
    Save 100% on your flight
    $535
    $351
    per traveler
    found 2 days ago
    The Moran CITYCENTRE
  • Aug 11 - Aug 16

    La Colombe d'Or Hotel + Flight

    Montrose
    5 nights
    5.0 star property
    9.4/10 - Exceptional (189 reviews)
    "I could not have been more pleased with my stay! I have already booked 2 more stays at this lovely hotel. The staff was phenomenal. Friendly, helpful, and kind. I was in Houston for care at MD Anderson Cancer Hospital and the staff made every effort to keep me comfortable and make every second perfect for me. The food is spectacular and the pool is wonderful. I cannot wait to go back!!"
    Reviewed June 6, 2026
    Roundtrip New York (LGA) - Houston (HOU)
    LGA - HOUNonstop IAH - JFKNonstop
    Save 100% on your flight
    $1,748
    $1,193
    per traveler
    found 2 days ago
    La Colombe d'Or Hotel
  • Aug 5 - Aug 9

    The Royal Sonesta Houston Galleria + Flight

    The Galleria
    4 nights
    4.0 star property
    8.6/10 - Excellent (1,999 reviews)
    "Spend a week with daughter staying here, 12min walking from my room to the Galleria."
    Reviewed June 9, 2026
    Roundtrip Atlanta (ATL) - Houston (IAH)
    ATL - IAHNonstop IAH - ATLNonstop
    Save 100% on your flight
    $468
    $331
    per traveler
    found 2 days ago
    The Royal Sonesta Houston Galleria

Where to stay in Texas Medical Center

Find the best Texas Medical Center areas and neighborhoods for the activities you enjoy most. Learn more about Texas Medical Center

Texas Medical Center Hotel Deals

Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton

4 out of 5
7118 Bertner Ave Houston TX
Fully refundableReserve now, pay when you stay
$161 nightly
The price is $188 total per night from Jul 5 to Jul 6
$188 total
Jul 5 - Jul 6
Total with taxes and fees
9/10 Wonderful! (3,885 reviews)
"Beautiful property. Wonderful staff. A private shuttle will carry you anywhere you need to go within three miles of the hotel. You can request to be dropped off at a certain entrance for MD Anderson. I would stay here again. The week days are most enjoyable here."

Reviewed on Jun 10, 2026

Blossom Hotel Houston, Curio Collection by Hilton
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 out of 5
6633 Travis St Houston TX
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $117 total per night from Jul 5 to Jul 6
$117 total
Jul 5 - Jul 6
Total with taxes and fees
8.4/10 Very Good! (1,962 reviews)
"It was close to everything. Perfect hub for checking out apartments throughout Houston for my son who’s moving there. The staff was great, especially Francisco the bartender in the restaurant! We were also able to get early check in & late checkout. Enjoyed the pool briefly. Definitely would stay ..."

Reviewed on Jun 9, 2026

Hilton Houston Plaza/Medical Center
Hyatt Place Houston Medical Center

Hyatt Place Houston Medical Center

3 out of 5
7329 FANNIN STREET Building 2 Houston TX
$127 nightly
The price is $149 total per night from Jul 5 to Jul 6
$149 total
Jul 5 - Jul 6
Total with taxes and fees
9.2/10 Wonderful! (2,536 reviews)
"Easy check-in and nice accommodations"

Reviewed on Jun 9, 2026

Hyatt Place Houston Medical Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.