Title: Texas Medical Center Vacation Packages 2026 from $376 | Expedia.com [Texas Medical Center Travel Guide](https://expedia.com/Houston-Texas-Medical-Center.dx6143504)[Hotels in Texas Medical Center](https://expedia.com/Texas-Medical-Center-Houston-Hotels.0-n6143504-0.Travel-Guide-Filter-Hotels)[Flights to Houston](https://expedia.com/Cheap-Flights-To-Houston.d178265.Travel-Guide-Flights)[Things to do in Houston](https://expedia.com/Things-To-Do-In-Houston.d178265.Travel-Guide-Activities)[Car Rentals in Texas Medical Center](https://expedia.com/Car-Rentals-In-Texas-Medical-Center.d6143504.Car-Rental-Guide) ![](https://images.trvl-media.com/place/6143504/f45257e8-ab2c-4d2e-9332-ef0898a9cb17.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Texas Medical Center Vacations from $376 ## Book a Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to $1,045 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ## Your Texas Medical Center Vacation Texas Medical Center is calling! Whatever type of break you're organizing, you can see and experience the best of this neighborhood with a Texas Medical Center vacation package. Your trip to Texas Medical Center wouldn't be complete without a stop at top attractions nearby such as [Houston Zoo](https://www.expedia.com/Houston-Zoo-South-Central-Houston.d6082223.Vacation-Attraction), [Houston Natural Science Museum](https://www.expedia.com/Houston-Natural-Science-Museum-South-Central-Houston.d501256.Vacation-Attraction) and [Childrens Museum of Houston](https://www.expedia.com/Childrens-Museum-Of-Houston-South-Central-Houston.d6082211.Vacation-Attraction). Whatever your travel plans or the size of your budget, booking a perfect Texas Medical Center vacation is quick and easy with Expedia. ## The Latest Texas Medical Center Vacation Packages Price found within the past 48 hours. Click for updated prices. ![Blossom Hotel Houston, Curio Collection by Hilton](https://images.trvl-media.com/lodging/59000000/58990000/58985900/58985846/w3837h2505x3y0-1cfabad9_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Blossom Hotel Houston, Curio Collection by Hilton Texas Medical Center Save 100% on your flight $376 per person Jun 3 - Jun 6 found 1 day ago Roundtrip flight included Atlanta (ATL) to Houston (IAH) 9/10 Wonderful! (3,780 reviews) Did not eat breakfast Reviewed on Apr 1, 2026 ![Hotel Zaza Houston Museum District](https://images.trvl-media.com/lodging/1000000/10000/3400/3306/0f950f88_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel Zaza Houston Museum District South Central Houston Save 100% on your flight $495 per person May 21 - May 25 found 1 day ago Roundtrip flight included Atlanta (ATL) to Houston (IAH) 9/10 Wonderful! (1,917 reviews) All around excellent spot, as always Reviewed on Mar 22, 2026 ![Holiday Inn Club Vacations Galveston Seaside Resort by IHG](https://images.trvl-media.com/lodging/16000000/15740000/15733500/15733448/ee8ed318_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Holiday Inn Club Vacations Galveston Seaside Resort by IHG West End Save 100% on your flight $717 per person May 15 - May 21 found 1 day ago Roundtrip flight included Newark Liberty Intl. Airport (EWR) to Houston (IAH) 8.8/10 Excellent! (741 reviews) At first I was worried I wasn't' going to get the beach view. Because their were properties on both sides of the highway. As I checked in they told me our stay was on the other side beach front. They gave us a choice of which floor we wanted. Unfortunately they told us the elevator did not go up all the way to our floor and we would have to take the stairs one flight. That was not a deal breaker. Our room was absolutely amazing, the pictures do not do it justice. It was very clean, the view was amazing of the beach, sunsets and sunrises. I would definitely recommend to anyone. Just make sure you request a signature room to get the best room and views. Reviewed on Mar 30, 2026 ![Luxury 3BR for Families Nurses and Group](https://images.trvl-media.com/lodging/119000000/118470000/118468400/118468367/718db91c_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Luxury 3BR for Families Nurses and Group Northside $615 per person Jun 16 - Jun 19 found 21 hours ago Roundtrip non-stop flight included Boston (BOS) to Houston (IAH) No reviews ![Hotel Granduca Houston](https://images.trvl-media.com/lodging/2000000/1510000/1503900/1503827/dece3e6f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel Granduca Houston The Galleria Save 100% on your flight $681 per person May 24 - May 27 found 7 hours ago Roundtrip flight included New York (LGA) to Houston (IAH) 9.2/10 Wonderful! (1,001 reviews) Hotel is very convenient and beautiful. Our stay was great. Room was convenient and clean. Beds are very comfortable with great white bedding. Bathroom was big and nice. Bar area is excellent and lunch the provided was very tasty. It was very very nice stay. Thanks Reviewed on Mar 31, 2026 ## Where to stay in Texas Medical Center Find the best Texas Medical Center areas and neighborhoods for the activities you enjoy most. [Learn more about Texas Medical Center](https://expedia.com/Houston-Texas-Medical-Center.dx6143504) ![Downtown Houston](https://images.trvl-media.com/place/6082195/fa70078e-ab30-43a5-aa06-e3a763da2444.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Downtown Houston 3 out of top 10 points of interest in this area 4.5/5(2,329 area reviews) Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines. [Find hotel + flight trips in Downtown Houston](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Downtown%20Houston&DestID=800037&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Man at the famous Water Wall in Houston, Texas USA](https://images.trvl-media.com/place/501263/0678cf84-c367-4c94-a162-d3e16a0367a7.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### The Galleria 4.5/5(1,992 area reviews) Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower. [Find hotel + flight trips in The Galleria](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=The%20Galleria&DestID=501263&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![EyeEm Custom Shoots Q4 2018](https://images.trvl-media.com/place/3000663145/5fc14982-6419-4f20-a21b-2dee7a209053.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Montrose 4/5(128 area reviews) Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area. [Find hotel + flight trips in Montrose](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Montrose&DestID=3000663145&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Houston Central Business District](https://images.trvl-media.com/place/1503/584a0ee8-b413-46fb-ad95-8f02fd4ce2b2.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Houston Central Business District If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station. [Find hotel + flight trips in Houston Central Business District](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Houston%20Central%20Business%20District&DestID=553248635976473213&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Phoenix midtown skyline with a Saguaro Cactus and other desert scenery in the foreground.](https://images.trvl-media.com/place/6282039/f3a43cb9-8929-48c1-b277-aa868fe68431.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Midtown 4.5/5(46 area reviews) Characterized by a vibrant nightlife and young residents, this central Houston neighborhood boasts Ensemble Theatre, the largest African-American theater company in the US, and various parks like Midtown Park and Elizabeth Baldwin Park. Easily accessible via METRORail Red Line. [Find hotel + flight trips in Midtown](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Midtown&DestID=6282039&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ## Texas Medical Center Hotel Deals ![Blossom Hotel Houston, Curio Collection by Hilton](https://images.trvl-media.com/lodging/59000000/58990000/58985900/58985846/w3837h2505x3y0-1cfabad9_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Blossom Hotel Houston, Curio Collection by Hilton 7118 Bertner Ave Houston TX Fully refundableReserve now, pay when you stay $174 nightly $203 total Apr 5 - Apr 6 Total with taxes and fees 9/10 Wonderful! (3,753 reviews) Did not eat breakfast Reviewed on Apr 1, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F5%2F2026&endDate=4%2F6%2F2026&selected=58985846&PinnedHotelID=58985846&HadPinnedHotel=true®ionId=6143504) ![Hilton Houston Plaza/Medical Center](https://images.trvl-media.com/lodging/1000000/30000/25200/25188/77443f8e_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hilton Houston Plaza/Medical Center 6633 Travis St Houston TX Fully refundableReserve now, pay when you stay $123 nightly $144 total Apr 19 - Apr 20 Total with taxes and fees 8.4/10 Very Good! (1,869 reviews) Room was clean. Staff was great. Reviewed on Apr 1, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F19%2F2026&endDate=4%2F20%2F2026&selected=25188&PinnedHotelID=25188&HadPinnedHotel=true®ionId=6143504) ![InterContinental Houston by IHG](https://images.trvl-media.com/lodging/24000000/23840000/23830900/23830866/2ea79db9_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### InterContinental Houston by IHG 6750 Main St Houston TX Fully refundable $180 nightly $211 total Apr 4 - Apr 5 Total with taxes and fees 9.2/10 Wonderful! (1,001 reviews) Everyone is always friendly as usual! Reviewed on Mar 27, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F4%2F2026&endDate=4%2F5%2F2026&selected=23830866&PinnedHotelID=23830866&HadPinnedHotel=true®ionId=6143504) [See all 6,604 properties in Texas Medical Center](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=4%2F3%2F2026&endDate=4%2F4%2F2026®ionId=6143504) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Kid Friendly Vacations [](https://expedia.com/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Kid_Friendly%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Vacations [](https://expedia.com/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Vacations [](https://expedia.com/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Vacations [](https://expedia.com/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Vacations [](https://expedia.com/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click) ![Gay Friendly Vacations](https://forever.travel-assets.com/flex/flexmanager/images/2023/06/15/LGBTQIA_Holiday_Package.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) LGBTQ Friendly Vacations [](https://expedia.com/lp/theme-holidays/gay-friendly-holidays?rfrr=editorial.LGBTQ_Friendly%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2017/07/05/170615_Adventure_1320_2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Adventure Vacations [](https://expedia.com/lp/theme-vacations/adventure-vacations?rfrr=editorial.Adventure_Vacations.click) ![Vacations in Month](https://forever.travel-assets.com/flex/flexmanager/images/2023/05/10/mesog-34434-card-venice.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Where to go when [](https://expedia.com/lp/b/where-to-go-when?rfrr=editorial.Where_to%20go%20when.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/21/honeymoon_hawaii.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Honeymoon Vacations [](https://expedia.com/lp/theme-vacations/honeymoon-vacations?rfrr=editorial.Honeymoon_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/Mountain-vacations.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Mountain Vacations [](https://expedia.com/lp/theme-vacations/mountain-vacations?rfrr=editorial.Mountain_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/fishing-vacations-2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Fishing Vacations [](https://expedia.com/lp/theme-vacations/fishing-vacations?rfrr=editorial.Fishing_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2019/05/16/Hyatt%20Zilara%20Cancun%20-%20All%20Inclusive%20-%20Adults%20Only.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Adults Only Vacations [](https://expedia.com/lp/theme-vacations/adults-only-vacations?rfrr=editorial.Adults_Only%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/waterpark-vacations.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Waterpark Vacations [](https://expedia.com/lp/theme-vacations/waterpark-vacations?rfrr=editorial.Waterpark_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/Caribean_scuba_diving.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Scuba Diving Vacations [](https://expedia.com/lp/theme-vacations/scuba-diving-vacations?rfrr=editorial.Scuba_Diving%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/aruba_yoga.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Yoga Vacations [](https://expedia.com/lp/theme-vacations/yoga-vacations?rfrr=editorial.Yoga_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2023/04/04/EPS-RBC-SummerBeachVacations-AdobeStock_206356322.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Cheap Vacations [](https://expedia.com/lp/theme-vacations/cheap-vacations?rfrr=editorial.Cheap_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/06/26/1175883311.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Solo Vacations [](https://expedia.com/lp/b/vacations/solo-vacations?rfrr=editorial.Solo_Vacations.click) ### Discover the most popular places to visit in Texas Medical Center ![Houston, Texas Reflections ](https://images.trvl-media.com/place/6248539/6889f51a-3f76-4c25-a331-3602ec8e8c5a.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### MD Anderson Cancer Center 4.5/5(802 reviews) Though MD Anderson Cancer Center might be what brings you to town, perhaps you'll have a chance to explore more of Houston while you are here. [](https://expedia.com/MD-Anderson-Cancer-Center-Texas-Medical-Center.d6248539.Vacation-Attraction) ![Houston_TexasChildrensHospital_553248635389801905_9](https://images.trvl-media.com/place/553248635389801905/db4dee74-4310-41e3-8220-625d7fc800e9.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Texas Children's Hospital 4.5/5(26 reviews) Though Texas Children's Hospital might be what brings you to town, perhaps you'll have a chance to explore more of Houston while you are here. [](https://expedia.com/Texas-Childrens-Hospital-Texas-Medical-Center.d553248635389801905.Vacation-Attraction) #### Harris Health System - Ben Taub General Hospital Though Harris Health System - Ben Taub General Hospital might be what brings you to town, perhaps you'll have a chance to explore more of Houston while you are here. [](https://expedia.com/Harris-Health-System-Ben-Taub-General-Hospital-Texas-Medical-Center.d553248635997987089.Vacation-Attraction) ### Things to do ![Astroville Tunnel Tour of Downtown Houston](https://mediaim.expedia.com/localexpert/1358845/6701a89c-a4de-4a0b-ba2a-aae33d8a7249.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Astroville Tunnel Tour of Downtown Houston (Air-Conditioned) $25 per adult **100%** of travellers recommend [](https://expedia.com/things-to-do/astroville-tunnel-tour-of-downtown-houston-air-conditioned.a1358845.activity-details) ![Houston Museum of Natural Science: Cockrell Butterfly Center](https://mediaim.expedia.com/localexpert/44625315/13581a0d-ea47-46d7-8fcf-d3fc7aa4909c.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Houston Museum of Natural Science: Butterfly Center Ticket $15 per adult **100%** of travellers recommend [](https://expedia.com/things-to-do/houston-museum-of-natural-science-butterfly-center-ticket.a44625315.activity-details) ![Houston: Houston Botanic Garden Entry Ticket](https://mediaim.expedia.com/localexpert/46150646/bfc34474-c86f-4151-a485-5cc63efe2aab.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Houston: Houston Botanic Garden Entry Ticket $12 per adult **80%** of travellers recommend [](https://expedia.com/things-to-do/houston-houston-botanic-garden-entry-ticket.a46150646.activity-details) [See all activities in Houston](https://expedia.com/things-to-do/search?rid=6143504) ## Explore a world of travel with Expedia - 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Savings not available on all packages.