A cityscape with a park, a river, and a large building with a red roof.

Texas Medical Center Vacations from $295

Book a Hotel + Flight or Car together to unlock savings

Plan, book, travel with confidence
Better together
Save up to $2,000 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Your Texas Medical Center Vacation

Texas Medical Center is calling! Whatever type of break you're organizing, you can see and experience the best of this neighborhood with a Texas Medical Center vacation package. Your trip to Texas Medical Center wouldn't be complete without a stop at top attractions nearby such as Houston Zoo, Houston Natural Science Museum and Childrens Museum of Houston. Whatever your travel plans or the size of your budget, booking a perfect Texas Medical Center vacation is quick and easy with Expedia.

The Latest Texas Medical Center Vacation Packages

Price found within the past 48 hours. Click for updated prices.

Jan 8 - Jan 13
Moxy Houston Downtown + Flight
Downtown Houston
5 nights
3.0 star property
8.6/10 - Excellent (1,205 reviews)
Roundtrip • Atlanta (ATL) - Houston (IAH)
ATL - IAH • Nonstop IAH - ATL • Nonstop
~~$491~~
$295
per traveler
found 8 hours ago
Moxy Houston Downtown
Jan 13 - Jan 18
Dejs' Modern Retreat + Flight
Southeast Houston
5 nights
2.0 star property
10/10 - Exceptional (1 review)
Roundtrip • Atlanta (ATL) - Houston (IAH)
ATL - IAH • Nonstop IAH - ATL • Nonstop
~~$823~~
$503
per traveler
found 1 day ago
Dejs' Modern Retreat
Jan 21 - Jan 24
2824 Aeon Living + Flight
Southeast Houston
3 nights
3.5 star property
Roundtrip • Baltimore (BWI) - Houston (IAH)
BWI - IAH • Nonstop IAH - BWI • 1 stop
Save 100% on your flight
~~$654~~
$406
per traveler
found 1 day ago
2824 Aeon Living
Jan 13 - Jan 18
Palace Inn Blue I-45 & College Ave + Flight
Houston
5 nights
3.0 star property
9.2/10 - Wonderful (26 reviews)
"We had a wonderful stay at this hotel. Easy check in. Great location near the airport. Super clean. Smelled really good. Good parking. Safe. Nice decor. Highly recommend. "
Reviewed June 12, 2026
Roundtrip • Atlanta (ATL) - Houston (IAH)
ATL - IAH • Nonstop IAH - ATL • Nonstop
~~$474~~
$295
per traveler
found 1 day ago
Palace Inn Blue I-45 & College Ave
Jan 6 - Jan 9
Experience a First Class Stay - 2 BDRM + Flight
Humble
3 nights
3.5 star property
8.0/10 - Very good (5 reviews)
"This people have water that smells like poop. Sewage water is what they use for water. Remnants of trash, sticky nastiness in drawers, air vents falling off ceilings. Random kids belts found? Candy stuck to floor? Trash wasn’t even taken out. Mind you I have kids that found these things as well. Oh and don’t even try and ask for them to refund you for their disgusting rental. They will give you the run around and then IGNORE YOU. Awful establishment and these people NEED TO BE SHUTDOWN."
Reviewed March 11, 2022
Roundtrip • Baltimore (BWI) - Houston (IAH)
BWI - IAH • 1 stop IAH - BWI • 1 stop
~~$1,128~~
$709
per traveler
found 10 hours ago
Experience a First Class Stay - 2 BDRM

Where to stay in Texas Medical Center

Find the best Texas Medical Center areas and neighborhoods for the activities you enjoy most. Learn more about Texas Medical Center

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

See properties

A tall, modern building with a unique, vertical design, surrounded by trees and a partly cloudy sky.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

See properties

A city skyline with modern skyscrapers and a river flowing through a park.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

See properties

A modern cityscape with a tram and tall buildings.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

See properties