Texas Medical Center Vacations from $419
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to $2,000 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Your Texas Medical Center Vacation
Texas Medical Center is calling! Whatever type of break you're organizing, you can see and experience the best of this neighborhood with a Texas Medical Center vacation package. Your trip to Texas Medical Center wouldn't be complete without a stop at top attractions nearby such as Houston Zoo, Houston Natural Science Museum and Childrens Museum of Houston. Whatever your travel plans or the size of your budget, booking a perfect Texas Medical Center vacation is quick and easy with Expedia.
The Latest Texas Medical Center Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Hilton Houston Plaza/Medical Center
Texas Medical Center
Save 100% on your flight
Price was $680, price is now $419 per person
$419
per person
Jul 8 - Jul 13
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
8.4/10 Very Good! (1,898 reviews)
A clean and spacious room and parking area available.
Reviewed on May 7, 2026
Holiday Inn Club Vacations Galveston Seaside Resort by IHG
West End
Save 100% on your flight
Price was $963, price is now $605 per person
$605
per person
Jun 28 - Jul 2
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
8.8/10 Excellent! (806 reviews)
It was a great property, apartment style and had enough room for 4 adults and 2 kids.
Reviewed on May 7, 2026
Where to stay in Texas Medical Center
Find the best Texas Medical Center areas and neighborhoods for the activities you enjoy most. Learn more about Texas Medical Center
Downtown Houston
3 out of top 10 points of interest in this area
4.5/5(2,329 area reviews)
Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.
Texas Medical Center Hotel Deals
Blossom Hotel Houston, Curio Collection by Hilton
7118 Bertner Ave Houston TX
Fully refundableReserve now, pay when you stay
$151 nightly
The price is $177 total per night from Jun 7 to Jun 8
$177 total
Jun 7 - Jun 8
Total with taxes and fees
Hilton Houston Plaza/Medical Center
6633 Travis St Houston TX
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $110 total per night from May 25 to May 26
$110 total
May 25 - May 26
Total with taxes and fees
8.4/10 Very Good! (1,904 reviews)
A clean and spacious room and parking area available.
Reviewed on May 7, 2026
Hyatt Place Houston Medical Center
7329 FANNIN STREET Building 2 Houston TX
Fully refundableReserve now, pay when you stay
$128 nightly
The price is $149 total per night from May 22 to May 23
$149 total
May 22 - May 23
Total with taxes and fees
9.2/10 Wonderful! (2,476 reviews)
Recommend it
Reviewed on May 8, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Texas Medical Center
NRG Stadium
4.5/5(634 reviews)
Catch an event at NRG Stadium during your trip to Houston. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
George R. Brown Convention Center
4/5(971 reviews)
During your trip, find out what's happening at George R. Brown Convention Center, a top convention center in Houston. Experience the entertainment choices and acclaimed art scene in this vibrant area.
Daikin Park
4.5/5(915 reviews)
Catch an event at Daikin Park during your trip to Houston. Experience the lively festivals and entertainment choices in this vibrant area.
Things to do
Space Center Houston Admission Ticket
$33
per adult
92% of travellers recommend
Houston: Space Center Houston Admission Ticket
$30
per adult
92% of travellers recommend
NASA's Space Center Admission Plus Official Houston City Tour
$109
per adult
92% of travellers recommend
Explore a world of travel with Expedia
- Houston Hotels
- Hotels near MD Anderson Cancer Center
- Hotels near Downtown Houston
- Hotels near NRG Stadium
- Cheap Hotels in Houston
- Hotels near TMC Transit Center
- Condo Rentals in TMC Transit Center
- Apartments in Dryden/TMC Station
- Hotels near Dryden/TMC Station
- Aparthotels in Dryden/TMC Station
- Hotels near Smith Lands Station
- Hotels near Houston Zoo
- Hotels near Astrodome
- Apartments in Memorial Hermann Hospital/Houston Zoo Station
- Vacation Homes in Memorial Hermann Hospital/Houston Zoo Station
- Hotels near Memorial Hermann Hospital/Houston Zoo Station
- Resorts in Memorial Hermann Hospital/Houston Zoo Station
- Condo Rentals in Memorial Hermann Hospital/Houston Zoo Station
- Hotels near Reckling Park
- Hotels near Rice University
- Hotels near Hermann Park
- Hotels near Rice Stadium
- Hotels near Miller Outdoor Theater
- Hotels near NRG Center
- Apartments in Stadium Park/Astrodome Station
- Hotels near Stadium Park/Astrodome Station
- Hotels near Museum District
- Hotels near James Turrell's Twilight Epiphany Skyscape
- Hotels near Riverside Terrace
- Hotels near Houston Natural Science Museum
- Hotels near NRG Park
- Pet-Friendly Hotels in Museum District
- Historic Hotels in Museum District
- Hotels with Free Breakfast in Museum District
- Family Hotels in Museum District
- Boutique Hotels in Museum District
- Hotels with Free Parking in Museum District
- Cheap Hotels in Museum District
- Hotels with a Gym in Museum District
- Luxury Hotels in Museum District
- Resorts & Hotels with Spas in Museum District
- Hotels with an Indoor Pool in Museum District
- 5 Star Hotels in Museum District
- Hotels with Hot Tubs in Museum District
- Hyatt Hotels in Museum District
- Hotels with Early Check-in in Museum District
- Casino Hotels in Museum District
- 3 Star Hotels in Museum District
- Hotels with Connecting Rooms in Museum District
- 4 Star Hotels in Museum District
- Winery Hotels in Museum District
- Hotels with Bars in Museum District
- Adults Only Resorts & in Museum District
- Motel 6 Hotels in Museum District
- Wyndham Hotels in Museum District
- Romantic Hotels in Museum District
- Houston Zoo
- Md Anderson Cancer Center
- Hermann Park
- Rice University
- Reckling Park
- Houston Vacations
- Rice Stadium
- Miller Outdoor Theater
- Nrg Stadium
- Visit Astrodome
- James Turrell's Twilight Epiphany Skyscape
- Houston Natural Science Museum
- Houston Museum of Fine Arts
- Nrg Park
- Museum District Vacations
- Children's Museum of Houston
- Holocaust Museum Houston
- Cullen Sculpture Garden
- Visit Riverside Terrace
- Buffalo Soldiers National Museum
- Visit Museum District
- Car rentals near Houston
- Car rentals near MD Anderson Cancer Center
- Standard Car Rentals near MD Anderson Cancer Center
- Car rentals near Houston Zoo
- Sportscar Car Rentals near Houston Zoo
- Car rentals near Hermann Park
- Car rentals near Rice University
- Pickup Car Rentals near Rice University
- Suv Car Rentals near Rice University
- Van Car Rentals near Rice University
- Car rentals near James Turrell's Twilight Epiphany Skyscape
- Car rentals near Museum District
- Thrifty Car Rental Rental Cars in Museum District
- Hertz Rental Cars in Museum District
- Alamo Rent A Car Rental Cars in Museum District
- Pickup Car Rentals in Museum District
- Sixt Rental Cars in Museum District
- Discount Quebec Rental Cars in Museum District
- Budget Rental Cars in Museum District
- Enterprise Rental Cars in Museum District
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.