A cityscape with a park, a river, and a large building with a red roof.

Texas Medical Center Vacations from $103

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Your Texas Medical Center Vacation

Texas Medical Center is calling! Whatever type of break you're organizing, you can see and experience the best of this neighborhood with a Texas Medical Center vacation package. Your trip to Texas Medical Center wouldn't be complete without a stop at top attractions nearby such as Houston Zoo, Houston Natural Science Museum and Childrens Museum of Houston. Whatever your travel plans or the size of your budget, booking a perfect Texas Medical Center vacation is quick and easy with Expedia.

The Latest Texas Medical Center Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • A hotel room with two beds, a desk with a lamp, a mirror, and a wall-mounted basket.
    Jan 29 - Jan 31

    GreenTree Hotel & Extended Stay I-10 FWY Houston, Channelview, Baytown + Flight

    Channelview
    2 nights
    3.0 star property
    8.6/10 - Excellent (877 reviews)
    Roundtrip • Atlanta (ATL) - Houston (IAH)
    ATL - IAH • Nonstop IAH - ATL • Nonstop
    $154
    $103
    per traveler
    found 20 hours ago
    GreenTree Hotel & Extended Stay I-10 FWY Houston, Channelview, Baytown
  • A modern kitchen with white cabinetry, stainless steel appliances, and a granite countertop.
    Jan 18 - Jan 23

    Experience a First Class Stay - 2 BDRM + Flight

    Humble
    5 nights
    3.5 star property
    8.0/10 - Very good (5 reviews)
    "This people have water that smells like poop. Sewage water is what they use for water. Remnants of trash, sticky nastiness in drawers, air vents falling off ceilings. Random kids belts found? Candy stuck to floor? Trash wasn’t even taken out. Mind you I have kids that found these things as well. Oh and don’t even try and ask for them to refund you for their disgusting rental. They will give you the run around and then IGNORE YOU. Awful establishment and these people NEED TO BE SHUTDOWN."
    Reviewed March 11, 2022
    Roundtrip • Atlanta (ATL) - Houston (IAH)
    ATL - IAH • Nonstop IAH - ATL • Nonstop
    $715
    $435
    per traveler
    found 4 hours ago
    Experience a First Class Stay - 2 BDRM
  • A modern restaurant with a bar area, seating with blue chairs, and a patterned carpet.
    Jan 29 - Jan 31

    Heritage Place Houston Brookhollow + Flight

    Lazybrook/Timbergrove
    2 nights
    3.0 star property
    9.0/10 - Wonderful (315 reviews)
    Roundtrip • Atlanta (ATL) - Houston (IAH)
    ATL - IAH • Nonstop IAH - ATL • Nonstop
    $217
    $135
    per traveler
    found 22 hours ago
    Heritage Place Houston Brookhollow
  • A modern kitchen with wooden cabinets, stainless steel appliances, and a buffet setup with glassware and plates.
    Feb 4 - Feb 8

    Homewood Suites by Hilton Houston Near the Galleria + Flight

    Greater Uptown
    4 nights
    3.0 star property
    8.2/10 - Very good (1,134 reviews)
    "Spacious rooms."
    Reviewed November 12, 2026
    Roundtrip • Atlanta (ATL) - Houston (IAH)
    ATL - IAH • Nonstop IAH - ATL • Nonstop
    Save 100% on your flight
    $445
    $304
    per traveler
    found 13 hours ago
    Homewood Suites by Hilton Houston Near the Galleria
  • A covered outdoor area with a bench, a trash can, and a glass door leading to a building.
    Jan 18 - Jan 23

    Staybridge Suites Houston IAH - Beltway 8 by IHG + Flight

    Aldine
    5 nights
    3.0 star property
    8.0/10 - Very good (1,000 reviews)
    "We stayed for a few hours, waiting for our next flight. But when we entered the room turned on the lights roaches in the kitchen went running. Front desk cleark was not very friendly."
    Reviewed November 10, 2026
    Roundtrip • Atlanta (ATL) - Houston (IAH)
    ATL - IAH • Nonstop IAH - ATL • Nonstop
    $421
    $289
    per traveler
    found 4 hours ago
    Staybridge Suites Houston IAH - Beltway 8 by IHG

Where to stay in Texas Medical Center

Find the best Texas Medical Center areas and neighborhoods for the activities you enjoy most. Learn more about Texas Medical Center
Learn more about Texas Medical Center
A bridge with the words "Welcome to Downtown Houston" and a star emblem.

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

A tall, modern building with a unique, vertical design, surrounded by trees and a partly cloudy sky.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

A city skyline with modern skyscrapers and a river flowing through a park.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

A modern cityscape with a tram and tall buildings.
Photo by George Zimzores
Open Photo by George Zimzores

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

A large white Victorian house with a steeply pitched roof, surrounded by lush greenery and flowering plants.

Houston Heights

Visitors to Houston Heights like its coffeehouses and live music, and The Heights Theater is a sight worth a stop.

What to do near Texas Medical Center

Picture 3 for Activity Houston: Space Center Houston Admission Ticket

Houston: Space Center Houston Admission Ticket

$30
per adult
92% of travelers recommend
Houston: Space Center Houston Admission Ticket
See all activities near Texas Medical Center

Texas Medical Center Hotel Deals

A spacious hotel lobby with high ceilings, large windows, a long bar area, and a seating area with a sofa and chairs.

Hyatt Place Houston Medical Center

Hyatt Place Houston Medical Center
3.0 star property
Texas Medical Center
9.2 out of 10, Wonderful, (2,739 reviews)
$125 nightly
The price is $146
Nov 15 - Nov 16
Total with taxes and fees
Hyatt Place Houston Medical Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
See all properties in Texas Medical Center
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.