Texas Medical Center Vacations from $326
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Your Texas Medical Center Vacation
Texas Medical Center is calling! Whatever type of break you're organizing, you can see and experience the best of this neighborhood with a Texas Medical Center vacation package. Your trip to Texas Medical Center wouldn't be complete without a stop at top attractions nearby such as Houston Zoo, Houston Natural Science Museum and Childrens Museum of Houston. Whatever your travel plans or the size of your budget, booking a perfect Texas Medical Center vacation is quick and easy with Expedia.
The Latest Texas Medical Center Vacation Packages
Price found within the past 48 hours. Click for updated prices.
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Greater Uptown
Save 100% on your flight
Price was $490, price is now $326 per person
$326
per person
Apr 3 - Apr 7
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
8.2/10 Very Good! (2,889 reviews)
all the staff was really great and kind, except from the lady from the breakfast desk Witney, i had a very bad experience at my breakfast that day, i didn’t even finished my meal
Reviewed on Jan 23, 2026
Margaritaville Lake Resort, Lake Conroe/Houston
Save 100% on your flight
Price was $707, price is now $483 per person
$483
per person
Apr 10 - Apr 13
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
8.2/10 Very Good! (1,006 reviews)
Beautiful property with plenty of great amenities. Very friendly staff throughout. Comfortable rooms with plenty of space.
Reviewed on Jan 16, 2026
Hotel Granduca Houston
The Galleria
Save 100% on your flight
Price was $1,672, price is now $1,169 per person
$1,169
per person
Mar 27 - Apr 1
just found
Roundtrip non-stop flight included
Chicago (CHI) to Houston (IAH)
9.2/10 Wonderful! (1,002 reviews)
December 2023 the pool was warm and hot tub was hot. December 2025 the pool was very cold, no longer temp controlled, and hot tub was chilly, with very little temp control. So pool was disappointing. Everything else was great!
Reviewed on Dec 25, 2025
The Mansion on 17th
East End
Save 100% on your flight
Price was $929, price is now $656 per person
$656
per person
Apr 5 - Apr 11
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
9.6/10 Exceptional! (740 reviews)
Clean room pleasant helpful staff great recommendations for dinner. The breakfast and service was very good. The Mansion has been restored beautifully. There is a calm welcoming scent in every room . I would definitely recommend to others for a unique and pleasant place to stay. I would stay here again when in Galveston.
Reviewed on Jan 21, 2026
The Houstonian Hotel, Club & Spa
Greater Uptown
Save 100% on your flight
Price was $1,781, price is now $1,268 per person
$1,268
per person
Mar 27 - Apr 1
just found
Roundtrip non-stop flight included
Chicago (CHI) to Houston (IAH)
9.4/10 Exceptional! (1,004 reviews)
Excellent venue, parking and restaurant facilities
Reviewed on Dec 17, 2025
Where to stay in Texas Medical Center
Find the best Texas Medical Center areas and neighborhoods for the activities you enjoy most. Learn more about Texas Medical Center
Downtown Houston
3 out of top 10 points of interest in this area
4.5/5(2,300 area reviews)
Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.
Texas Medical Center Hotel Deals
Blossom Hotel Houston, Curio Collection by Hilton
7118 Bertner Ave Houston TX
Fully refundableReserve now, pay when you stay
$137 nightly
The price is $160 total per night from Feb 22 to Feb 23
$160 total
Feb 22 - Feb 23
Total with taxes and fees
9/10 Wonderful! (3,686 reviews)
Great rooms.
Reviewed on Jan 22, 2026
Hilton Houston Plaza/Medical Center
6633 Travis St Houston TX
Fully refundableReserve now, pay when you stay
$87 nightly
The price is $102 total per night from Feb 22 to Feb 23
$102 total
Feb 22 - Feb 23
Total with taxes and fees
8.2/10 Very Good! (1,819 reviews)
Staff is extremely hospitable.
Reviewed on Jan 19, 2026
Hyatt Place Houston Medical Center
7329 FANNIN STREET Building 2 Houston TX
Fully refundableReserve now, pay when you stay
$118 nightly
The price is $138 total per night from Feb 5 to Feb 6
$138 total
Feb 5 - Feb 6
Total with taxes and fees
9/10 Wonderful! (2,259 reviews)
Initially when I arrived which was later in the evening, I tried to have a shower and had no water pressure and it was cold, which was really frustrating because it was a long travel day. However, they fixed it asap in the morning and it was the best shower after that, hot with plenty of pressure. ...
Reviewed on Jan 17, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Texas Medical Center
Texas Children's Hospital
4.5/5(26 reviews)
Though Texas Children's Hospital might be what brings you to town, perhaps you'll have a chance to explore more of Houston while you are here.
MD Anderson Cancer Center
4.5/5(788 reviews)
Though MD Anderson Cancer Center might be what brings you to town, perhaps you'll have a chance to explore more of Houston while you are here.
Harris Health System - Ben Taub General Hospital
Though Harris Health System - Ben Taub General Hospital might be what brings you to town, perhaps you'll have a chance to explore more of Houston while you are here.
Things to do
Houston: Houston Botanic Garden Entry Ticket
$12
per adult
80% of travellers recommend
Astroville Tunnel Tour of Downtown Houston (Air-Conditioned)
$25
per adult
100% of travellers recommend
Houston Museum of Natural Science: Cockrell Butterfly Center
$15
per adult
100% of travellers recommend
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- Houston Zoo
- MD Anderson Cancer Center
- Hermann Park
- Rice University
- Reckling Park
- Houston Vacations
- Rice Stadium
- Miller Outdoor Theater
- NRG Stadium
- Visit Astrodome
- James Turrell's Twilight Epiphany Skyscape
- Houston Natural Science Museum
- Houston Museum of Fine Arts
- NRG Park
- Houston Museum District Vacations
- Children's Museum of Houston
- Holocaust Museum Houston
- Cullen Sculpture Garden
- Visit Riverside Terrace
- Buffalo Soldiers National Museum
- Visit Houston Museum District
- Car rentals near Houston
- Car rentals near MD Anderson Cancer Center
- Standard Car Rentals near MD Anderson Cancer Center
- Car rentals near Houston Zoo
- Sportscar Car Rentals near Houston Zoo
- Car rentals near Hermann Park
- Car rentals near Rice University
- Pickup Car Rentals near Rice University
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- Van Car Rentals near Rice University
- Car rentals near James Turrell's Twilight Epiphany Skyscape
- Car rentals near Houston Museum District
- Thrifty Car Rental Rental Cars in Houston Museum District
- Hertz Rental Cars in Houston Museum District
- Alamo Rent A Car Rental Cars in Houston Museum District
- Pickup Car Rentals in Houston Museum District
- Sixt Rental Cars in Houston Museum District
- Discount Quebec Rental Cars in Houston Museum District
- Budget Rental Cars in Houston Museum District
- Enterprise Rental Cars in Houston Museum District
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.