Texas Medical Center Vacations from $262
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Your Texas Medical Center Vacation
Texas Medical Center is calling! Whatever type of break you're organizing, you can see and experience the best of this neighborhood with a Texas Medical Center vacation package. Your trip to Texas Medical Center wouldn't be complete without a stop at top attractions nearby such as Houston Zoo, Houston Natural Science Museum and Childrens Museum of Houston. Whatever your travel plans or the size of your budget, booking a perfect Texas Medical Center vacation is quick and easy with Expedia.
The Latest Texas Medical Center Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Kompose Residences Houston Cy-Fair
Save 100% on your flight
Price was $377, price is now $262 per person
$262
per person
Mar 26 - Mar 29
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
10/10 Exceptional! (2 reviews)
Very clean, modern hotel, big rooms with great amenities, good staff
Reviewed on Jan 23, 2026
Margaritaville Lake Resort, Lake Conroe/Houston
Save 100% on your flight
Price was $685, price is now $461 per person
$461
per person
Apr 10 - Apr 13
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
8.2/10 Very Good! (1,006 reviews)
Beautiful property with plenty of great amenities. Very friendly staff throughout. Comfortable rooms with plenty of space.
Reviewed on Jan 16, 2026
Hotel Granduca Houston
The Galleria
Save 100% on your flight
Price was $1,672, price is now $1,169 per person
$1,169
per person
Mar 27 - Apr 1
found 19 hours ago
Roundtrip non-stop flight included
Chicago (CHI) to Houston (IAH)
9.2/10 Wonderful! (1,002 reviews)
December 2023 the pool was warm and hot tub was hot. December 2025 the pool was very cold, no longer temp controlled, and hot tub was chilly, with very little temp control. So pool was disappointing. Everything else was great!
Reviewed on Dec 25, 2025
The Houstonian Hotel, Club & Spa
Greater Uptown
Save 100% on your flight
Price was $1,781, price is now $1,268 per person
$1,268
per person
Mar 27 - Apr 1
found 19 hours ago
Roundtrip non-stop flight included
Chicago (CHI) to Houston (IAH)
9.4/10 Exceptional! (1,004 reviews)
Excellent venue, parking and restaurant facilities
Reviewed on Dec 17, 2025
Where to stay in Texas Medical Center
Find the best Texas Medical Center areas and neighborhoods for the activities you enjoy most. Learn more about Texas Medical Center
Downtown Houston
3 out of top 10 points of interest in this area
4.5/5(2,300 area reviews)
Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.
Texas Medical Center Hotel Deals
Blossom Hotel Houston, Curio Collection by Hilton
7118 Bertner Ave Houston TX
Fully refundableReserve now, pay when you stay
$161 nightly
The price is $188 total per night from Feb 5 to Feb 6
$188 total
Feb 5 - Feb 6
Total with taxes and fees
9/10 Wonderful! (3,686 reviews)
Great rooms.
Reviewed on Jan 22, 2026
Hilton Houston Plaza/Medical Center
6633 Travis St Houston TX
Fully refundableReserve now, pay when you stay
$86 nightly
The price is $100 total per night from Feb 22 to Feb 23
$100 total
Feb 22 - Feb 23
Total with taxes and fees
8.2/10 Very Good! (1,819 reviews)
Staff is extremely hospitable.
Reviewed on Jan 19, 2026
Hyatt Place Houston Medical Center
7329 FANNIN STREET Building 2 Houston TX
Fully refundableReserve now, pay when you stay
$118 nightly
The price is $138 total per night from Feb 5 to Feb 6
$138 total
Feb 5 - Feb 6
Total with taxes and fees
9/10 Wonderful! (2,281 reviews)
Clean room, good included breakfast, spacious room, and good customer service by staff.
Reviewed on Jan 24, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Texas Medical Center
Texas Children's Hospital
4.5/5(26 reviews)
Though Texas Children's Hospital might be what brings you to town, perhaps you'll have a chance to explore more of Houston while you are here.
MD Anderson Cancer Center
4.5/5(788 reviews)
Though MD Anderson Cancer Center might be what brings you to town, perhaps you'll have a chance to explore more of Houston while you are here.
Harris Health System - Ben Taub General Hospital
Though Harris Health System - Ben Taub General Hospital might be what brings you to town, perhaps you'll have a chance to explore more of Houston while you are here.
Things to do
Houston: Houston Botanic Garden Entry Ticket
$12
per adult
80% of travellers recommend
Astroville Tunnel Tour of Downtown Houston (Air-Conditioned)
$25
per adult
100% of travellers recommend
Houston Museum of Natural Science: Cockrell Butterfly Center
$15
per adult
100% of travellers recommend
Explore a world of travel with Expedia
- Houston Hotels
- Hotels near MD Anderson Cancer Center
- Hotels near Downtown Houston
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- Houston Zoo
- MD Anderson Cancer Center
- Hermann Park
- Rice University
- Reckling Park
- Houston Vacations
- Rice Stadium
- Miller Outdoor Theater
- NRG Stadium
- Visit Astrodome
- James Turrell's Twilight Epiphany Skyscape
- Houston Natural Science Museum
- Houston Museum of Fine Arts
- NRG Park
- Houston Museum District Vacations
- Children's Museum of Houston
- Holocaust Museum Houston
- Cullen Sculpture Garden
- Visit Riverside Terrace
- Buffalo Soldiers National Museum
- Visit Houston Museum District
- Car rentals near Houston
- Car rentals near MD Anderson Cancer Center
- Standard Car Rentals near MD Anderson Cancer Center
- Car rentals near Houston Zoo
- Sportscar Car Rentals near Houston Zoo
- Car rentals near Hermann Park
- Car rentals near Rice University
- Pickup Car Rentals near Rice University
- SUV Car Rentals near Rice University
- Van Car Rentals near Rice University
- Car rentals near James Turrell's Twilight Epiphany Skyscape
- Car rentals near Houston Museum District
- Thrifty Car Rental Rental Cars in Houston Museum District
- Hertz Rental Cars in Houston Museum District
- Alamo Rent A Car Rental Cars in Houston Museum District
- Pickup Car Rentals in Houston Museum District
- Sixt Rental Cars in Houston Museum District
- Discount Quebec Rental Cars in Houston Museum District
- Budget Rental Cars in Houston Museum District
- Enterprise Rental Cars in Houston Museum District
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.