Santo Spirito

Florence

A grand church interior with high vaulted ceilings, large columns, and a central altar.
A stone bridge over a calm river, with historic buildings on either side.
A bustling outdoor market with white tents and various stalls.
A church with a bell tower, a circular window, and a weather vane.
A cityscape with a river, a bridge, and mountains in the background.

Stay near popular Santo Spirito attractions

A historic church with a dome and bell tower, surrounded by trees and a fountain in a public square.

Piazza Santo Spirito

9.6/10 (8 reviews)
Learn about the local history of Florence with a stop at Piazza Santo Spirito. Discover the fascinating museums and notable monuments in this vibrant area.
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Things to do

City Sightseeing Florence Hop-on Hop-off

City Sightseeing Florence Hop-on Hop-off Bus Tour

$26
per adult
74% of travellers recommend
City Sightseeing Florence Hop-on Hop-off Bus Tour
The Best of Tuscany in One Day Sightseeing Tour

The Best of Tuscany Tour: Siena, San Gimignano, Pisa and Lunch at a Winery

$90
per adult
98% of travellers recommend
The Best of Tuscany Tour: Siena, San Gimignano, Pisa and Lunch at a Winery
Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour

Reserved Entry Florence Duomo: Express Guided Tour

$27
per adult
80% of travellers recommend
Reserved Entry Florence Duomo: Express Guided Tour
Tuscany Experience In Pisa, Siena, San Gimignano & Chianti

Tuscany Experience In Pisa, Siena, San Gimignano & Chianti

$62
per adult
92% of travellers recommend
Tuscany Experience In Pisa, Siena, San Gimignano & Chianti
Florence: Pasta Cooking Class with Unlimited Wine

Florence: Pasta Cooking Class with Unlimited Wine

$20
per adult
94% of travellers recommend
Florence: Pasta Cooking Class with Unlimited Wine
Picture 13 for Activity Florence: Palazzo Vecchio Premium Entry Ticket & Audio Guide

Florence: Palazzo Vecchio Secrets Skip-the-Line &Audio Guide

$45
per adult
Florence: Palazzo Vecchio Secrets Skip-the-Line &Audio Guide
See all activities in Florence

Santo Spirito Hotel Deals

Hotel Horto Convento

Hotel Horto Convento

4 out of 5
Viale Ariosto, 13 Florence FI
Fully refundable
$125 nightly
The price is $153 total per night from Dec 8 to Dec 9
$153 total
Dec 8 - Dec 9
Total with taxes and fees
Stay at this hotel in Florence. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
Hotel Horto Convento
UNA Hotels Vittoria Firenze

UNA Hotels Vittoria Firenze

4 out of 5
Via Pisana 59 Florence FI
$75 nightly
The price is $99 total per night from Nov 15 to Nov 16
$99 total
Nov 15 - Nov 16
Total with taxes and fees
Book a stay at this boutique hotel in Florence. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (1,001 reviews)
"Conveniently located, easy parking, extremely friendly staff, delicious breakfast, quirky rooms."

Reviewed on Oct 27, 2026

UNA Hotels Vittoria Firenze
Palazzo Mannaioni Suites

Palazzo Mannaioni Suites

4 out of 5
Via Maffia 9 - 17r Florence FI
$85 nightly
The price is $109 total per night from Nov 30 to Dec 1
$109 total
Nov 30 - Dec 1
Total with taxes and fees
Stay at this residence in Florence. Enjoy free WiFi, concierge services, and premium bedding. Our guests praise the helpful staff in our reviews. Popular attractions ...
Palazzo Mannaioni Suites
La Torre Del Cestello

La Torre Del Cestello

Via Borgo San Frediano, 8 Florence FI
$73 nightly
The price is $96 total per night from Nov 10 to Nov 11
$96 total
Nov 10 - Nov 11
Total with taxes and fees
Stay at this residence in Florence. Enjoy free WiFi, valet parking (surcharge), and daily housekeeping. Popular attractions Ponte Vecchio and Piazza del Duomo ...
La Torre Del Cestello
Hostel Santa Monaca

Hostel Santa Monaca

Via Santa Monaca 6 Florence FI
$57 nightly
The price is $72 total per night from Nov 10 to Nov 11
$72 total
Nov 10 - Nov 11
Total with taxes and fees
Stay at this hostel in Florence. Enjoy free WiFi, daily housekeeping, and dry cleaning or laundry services. Popular attractions Ponte Vecchio and Piazza del ...
Hostel Santa Monaca
Casa Santo Nome di GesĆ¹

Casa Santo Nome di GesĆ¹

Piazza del Carmine, 21 Florence FI
$105 nightly
The price is $128 total per night from Nov 19 to Nov 20
$128 total
Nov 19 - Nov 20
Total with taxes and fees
Stay at this guesthouse in Florence. Enjoy free breakfast, free WiFi, and parking (surcharge). Our guests praise the helpful staff in our reviews. Popular attractions ...
9/10 Wonderful! (401 reviews)
"Beautiful old converted church , room was clean and lovely high ceilings. Good location, value for money"

Reviewed on Nov 8, 2026

Casa Santo Nome di GesĆ¹
See all 533 properties in Santo Spirito
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santo Spirito

Find the best Santo Spirito areas and neighborhoods for the activities you enjoy most. Learn more about Santo Spirito
Learn more about Santo Spirito
A river with buildings on the right bank.

Historic Centre of Florence

Known for its fascinating museums, stunning cathedral, and stunning river views, there's plenty to explore in Historic Centre of Florence. Top attractions like Piazza del Duomo and Piazza di Santa Maria Novella are major draws. Catch the metro at UnitĆ  Tram Stop or Valfonda - Stazione Santa Maria Novella Tram Stop to see more of the city.

A historic church with intricate architecture and a large open plaza with people.

Santa Maria Novella

Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Florence.

A historic building with intricate architectural details, including a dome and ornate facades.

Duomo

Piazza del Duomo and Piazza di Santa Maria Novella are just a few worthwhile attractions to visit in Duomo. Travelers also love the fascinating museums, stunning cathedral, and popular shops.

A historic bridge with arches over a river, surrounded by yellow buildings and a crowd of people.

San Giovanni

If you're spending some time in San Giovanni, Piazza della Repubblica and Via de' Calzaiuoli are top sights worth seeing.

A grand cathedral with intricate architectural details, including statues and ornate decorations.

Santa Croce

Travelers come to Santa Croce for its interesting museums, and you can see top attractions like Basilica of Santa Croce and Piazza Santa Croce while you're in town.

Santo Spirito

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