Find hotels in Main Street Fort Pierce, Fort Pierce

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Dec 10 - Dec 11
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Dec 11 - Dec 12
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Dec 12 - Dec 14
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Dec 19 - Dec 21

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Our top choices for Main Street Fort Pierce hotels

Lobby
Vero Beach Inn & Suites I-95

Vero Beach Inn & Suites I-95

Vero Beach Inn & Suites I-95
3.0 star property
17.4 mi from Main Street Fort Pierce
8.6 out of 10, Excellent, (1318)
"The room was very clean. Staff very courteous. I would stay here again. "
United States
Jesse
$99 nightly
The price is $111
Dec 16 - Dec 17
Total with taxes and fees
Vero Beach Inn & Suites I-95
Outdoor pool, pool umbrellas, sun loungers
Costa d'Este Beach Resort and Spa

Costa d'Este Beach Resort and Spa

Costa d'Este Beach Resort and Spa
4.0 star property
14.3 mi from Main Street Fort Pierce
9.2 out of 10, Wonderful, (1000)
"Great vibe and location"
United States
Stephanie
$301 nightly
The price is $337
Dec 11 - Dec 12
Total with taxes and fees
Costa d'Este Beach Resort and Spa
Free daily on-the-go breakfast
Flamingo inn and suites

Flamingo inn and suites

Flamingo inn and suites
2.5 star property
17.8 mi from Main Street Fort Pierce
7.4 out of 10, Good, (1000)
"Clean room convenient decent breakfast "
United States
Andrew
$85 nightly
The price is $96
Dec 11 - Dec 12
Total with taxes and fees
Flamingo inn and suites
Breakfast, lunch, dinner served; American cuisine, beach views
Ocean Breeze Inn Vero Beach

Ocean Breeze Inn Vero Beach

Ocean Breeze Inn Vero Beach
3.5 star property
14.4 mi from Main Street Fort Pierce
8.6 out of 10, Excellent, (1086)
"Love love this place! Most definitely will be back! "
United States
Silvia
$133 nightly
The price is $150
Dec 17 - Dec 18
Total with taxes and fees
Ocean Breeze Inn Vero Beach
Exterior
Howard Johnson by Wyndham Vero Beach / Downtown

Howard Johnson by Wyndham Vero Beach / Downtown

Howard Johnson by Wyndham Vero Beach / Downtown
2.0 star property
13.5 mi from Main Street Fort Pierce
7.0 out of 10, Good, (1000)
"Very good"
United States
Carlos
$94 nightly
The price is $106
Dec 11 - Dec 12
Total with taxes and fees
Howard Johnson by Wyndham Vero Beach / Downtown
Exterior
Kimpton Vero Beach Hotel & Spa by IHG

Kimpton Vero Beach Hotel & Spa by IHG

Kimpton Vero Beach Hotel & Spa by IHG
4.0 star property
14.6 mi from Main Street Fort Pierce
9.4 out of 10, Exceptional, (1001)
"Extremely friendly hosts and beautiful hotel "
United States
Aaron
$256 nightly
The price is $287
Jan 6 - Jan 7, 2026
Total with taxes and fees
Kimpton Vero Beach Hotel & Spa by IHG
Outdoor pool, sun loungers
Best Western Port St. Lucie

Best Western Port St. Lucie

Best Western Port St. Lucie
2.5 star property
8.7 mi from Main Street Fort Pierce
8.6 out of 10, Excellent, (1000)
"Love this place. Great place with a lot of space."
United States
Bradley
$99 nightly
The price is $111
Dec 28 - Dec 29
Total with taxes and fees
Best Western Port St. Lucie
Exterior
Holiday Inn Express - Vero Beach by IHG

Holiday Inn Express - Vero Beach by IHG

Holiday Inn Express - Vero Beach by IHG
2.5 star property
17.9 mi from Main Street Fort Pierce
8.2 out of 10, Very Good, (839)
"I like the room it was clean and also not a smell at cigarette or other kind of smell. It was nice."
United States
Maria
$113 nightly
The price is $127
Dec 14 - Dec 15
Total with taxes and fees
Holiday Inn Express - Vero Beach by IHG
Exterior
Comfort Suites Vero Beach I-95

Comfort Suites Vero Beach I-95

Comfort Suites Vero Beach I-95
2.5 star property
17.7 mi from Main Street Fort Pierce
8.8 out of 10, Excellent, (1000)
"Very clean and attractive room, staff was very friendly."
United States
Jean
$97 nightly
The price is $109
Dec 21 - Dec 22
Total with taxes and fees
Comfort Suites Vero Beach I-95
3 outdoor pools, open 7:00 AM to 10:00 PM, pool umbrellas, sun loungers
Marriott Hutchinson Island Beach Resort, Golf & Marina

Marriott Hutchinson Island Beach Resort, Golf & Marina

Marriott Hutchinson Island Beach Resort, Golf & Marina
4.0 star property
18.5 mi from Main Street Fort Pierce
8.2 out of 10, Very Good, (382)
"The room was awesome and the location was great. "
United States
Robin
$206 nightly
The price is $231
Dec 14 - Dec 15
Total with taxes and fees
Marriott Hutchinson Island Beach Resort, Golf & Marina
Sundeck
Prestige Hotel Vero Beach

Prestige Hotel Vero Beach

Prestige Hotel Vero Beach
2.0 star property
12.7 mi from Main Street Fort Pierce
8.4 out of 10, Very Good, (1001)
"Great place"
United States
Rosa
$139 nightly
The price is $156
Dec 11 - Dec 12
Total with taxes and fees
Prestige Hotel Vero Beach
Outdoor spa tub
Hutchinson Island Hotel

Hutchinson Island Hotel

Hutchinson Island Hotel
2.5 star property
1.9 mi from Main Street Fort Pierce
8.4 out of 10, Very Good, (1361)
"The breakfast and view is the best!"
United States
Marisa
$107 nightly
The price is $120
Dec 14 - Dec 15
Total with taxes and fees
Hutchinson Island Hotel
Terrace/patio
Home2 Suites by Hilton Vero Beach I-95

Home2 Suites by Hilton Vero Beach I-95

Home2 Suites by Hilton Vero Beach I-95
3.0 star property
17.6 mi from Main Street Fort Pierce
9.6 out of 10, Exceptional, (431)
"Rooms were clean, the staff was amazing. Great stay!"
United States
Danielle
$110 nightly
The price is $123
Dec 23 - Dec 24
Total with taxes and fees
Home2 Suites by Hilton Vero Beach I-95
On the beach, sun loungers, beach umbrellas, beach towels
Hutchinson Shores Resort & Spa

Hutchinson Shores Resort & Spa

Hutchinson Shores Resort & Spa
4.0 star property
15.7 mi from Main Street Fort Pierce
9.4 out of 10, Exceptional, (1000)
"Room was clean and comfortable, staff was very kind and helpful, I will definitely visit again "
United States
Andrekiss
$238 nightly
The price is $267
Dec 22 - Dec 23
Total with taxes and fees
Hutchinson Shores Resort & Spa
BBQ/picnic area
Residence Inn by Marriott Port St. Lucie

Residence Inn by Marriott Port St. Lucie

Residence Inn by Marriott Port St. Lucie
3.0 star property
11.1 mi from Main Street Fort Pierce
9.2 out of 10, Wonderful, (1000)
"Great stay! Very friendly staff "
United States
Giovanni
$118 nightly
The price is $132
Dec 14 - Dec 15
Total with taxes and fees
Residence Inn by Marriott Port St. Lucie
Exterior
SpringHill Suites Port St. Lucie

SpringHill Suites Port St. Lucie

SpringHill Suites Port St. Lucie
3.0 star property
10.7 mi from Main Street Fort Pierce
8.6 out of 10, Excellent, (1002)
"Great stay"
United States
Craig
$87 nightly
The price is $97
Dec 15 - Dec 16
Total with taxes and fees
SpringHill Suites Port St. Lucie
Exterior
Hampton Inn & Suites Stuart-North

Hampton Inn & Suites Stuart-North

Hampton Inn & Suites Stuart-North
2.5 star property
16.2 mi from Main Street Fort Pierce
8.8 out of 10, Excellent, (1001)
"The best possible stay in every way."
United States
Erinn
$95 nightly
The price is $107
Dec 21 - Dec 22
Total with taxes and fees
Hampton Inn & Suites Stuart-North
Lobby
Mainstay Suites at PGA Village

Mainstay Suites at PGA Village

Mainstay Suites at PGA Village
2.5 star property
11.2 mi from Main Street Fort Pierce
6.4 out of 10, (816)
"It was a good stay."
United States
Miranda L
$67 nightly
The price is $75
Dec 17 - Dec 18
Total with taxes and fees
Mainstay Suites at PGA Village
Courtyard
Star Suites: An Extended Stay Hotel

Star Suites: An Extended Stay Hotel

Star Suites: An Extended Stay Hotel
2.5 star property
15.1 mi from Main Street Fort Pierce
9.6 out of 10, Exceptional, (566)
"Was perfect for our trip, will stay again! "
United States
Christopher
$99 nightly
The price is $111
Dec 21 - Dec 22
Total with taxes and fees
Star Suites: An Extended Stay Hotel
Property amenity
Staybridge Suites Vero Beach by IHG

Staybridge Suites Vero Beach by IHG

Staybridge Suites Vero Beach by IHG
3.0 star property
15 mi from Main Street Fort Pierce
9.8 out of 10, Exceptional, (571)
"I would definitely stay at this place again great people great atmosphere very clean"
United States
Kristi
$126 nightly
The price is $141
Dec 14 - Dec 15
Total with taxes and fees
Staybridge Suites Vero Beach by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Main Street Fort Pierce

Find the best Main Street Fort Pierce areas and neighborhoods for the activities you enjoy most.

Lakewood Park

While Lakewood Park isn't home to many top sights, Lakewood Park Regional Park / Pool and McKee Botanical Garden are some notable places to visit nearby.

Spanish Lakes Country Club Village

While there might not be top attractions in Spanish Lakes Country Club Village, you can explore the larger area and discover places like Lakewood Park Regional Park / Pool and McKee Botanical Garden.

Spanish Lakes Fairways

While Spanish Lakes Fairways might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Lakewood Park Regional Park / Pool and Indrio Road Park / Schoolhouse.

Meadowood

If you're looking for some top things to see and do in Meadowood and surrounding area, you can visit Endless Summer Vineyard & Winery and Lakewood Park Regional Park / Pool.

Panther Woods

If you're looking for some top things to see and do in Panther Woods and surrounding area, you can visit Endless Summer Vineyard & Winery and Lakewood Park Regional Park / Pool.

Top Main Street Fort Pierce Hotel Reviews

Hampton Inn & Suites Stuart-North

Hampton Inn & Suites Stuart-North

10/10 Excellent
"desk clerk norlyne was especially helpful "
Joseph 1-night trip
Posted 1 day ago
Hampton Inn & Suites Stuart-North

Frequently asked questions

Can I cancel my hotel reservation on Expedia?
Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline – this is often within 24-48 hours of your scheduled arrival. If you have a non-refundable booking, it might still be possible to receive a refund if you cancel it within 24 hours of booking. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use our "Fully refundable property" filter during your search to find the right Main Street Fort Pierce hotel for you.
How can I save on a Main Street Fort Pierce hotel booking with Expedia?
One Key™ - Expedia's free travel rewards program - gives you instant access to perks and Member Prices on Main Street Fort Pierce hotels. Plus, you'll earn OneKeyCash™* on eligible bookings to use on future trips. Booking an Expedia hotel and flight package is another great way to save, where bundling can result in significant savings.

*OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a Main Street Fort Pierce hotel?
Prices for hotels in Main Street Fort Pierce often vary, but you can find a great deal on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.