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Sep 28 - Sep 29
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Oct 2 - Oct 4
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Our top choices for Mayo hotels

A hotel room with a bed, a blue sofa, a wooden coffee table, a desk with a chair, and a framed abstract painting on the wall.
A hotel room with a blue sofa, a wooden coffee table, a bed with white linens, a desk with a chair, and a large window.
A hotel reception area with a wooden reception desk, a receptionist, and a revolving door.
A food service counter with a sign that reads "EXPRESS START".

1. Holiday Inn Express Hotel & Suites Spartanburg-North by IHG

Holiday Inn Express Hotel & Suites Spartanburg-North by IHG
Spartanburg
United States
Michael
$106 nightly
$118 total
Oct 4 - Oct 5
Total with taxes and fees
Holiday Inn Express Hotel & Suites Spartanburg-North by IHG
A conference room with a long table, blue and orange chairs, and a reception desk in the background.
A conference room with two desks, two chairs, and a small table.
A Hampton Inn hotel with a clear entrance, well-maintained lawn, and a flagpole.
A coffee station with labeled dispensers for hot water, decaf roast, light roast, and dark roast coffee.

2. Hampton Inn Spartanburg-North I-85

Hampton Inn Spartanburg-North I-85
Spartanburg
United States
Britt
$106 nightly
$117 total
Oct 25 - Oct 26
Total with taxes and fees
Hampton Inn Spartanburg-North I-85
A modern lobby with a blue sofa, a reception desk, and a large cityscape painting.
A modern restaurant with a bar area, large windows, and a kitchen visible in the background.
A gym with treadmills, dumbbells, and a wall with motivational words.
A hotel room with two beds, a nightstand, and a wall-mounted TV.

3. Best Western Plus Spartanburg

Best Western Plus Spartanburg
Spartanburg
United States
Jamie
$93 nightly
$103 total
Oct 4 - Oct 5
Total with taxes and fees
Best Western Plus Spartanburg
A hotel room with two beds, a desk, a refrigerator, a television, and a bathroom visible through an arched doorway.
A hotel with a well-lit entrance, multiple parking spaces, and a clear view of the sky.
A hotel kitchen with a buffet setup, including a coffee station, a refrigerator, and a microwave.
A reception desk with a wooden finish, a clock, and two card readers.

4. Comfort Inn & Suites Spartanburg North

Comfort Inn & Suites Spartanburg North
Spartanburg
United States
Lisa
$84 nightly
$93 total
Oct 25 - Oct 26
Total with taxes and fees
Comfort Inn & Suites Spartanburg North
A modern bedroom with a large bed, a built-in TV, and a small desk.
A modern bathroom with a shower, toilet, and sink.
A motel with multiple floors, balconies, and a parking lot.
A reception area with a modern design, including a large number '6' sign, a coffee machine, and a TV mounted on the wall.

5. Motel 6 Spartanburg, Sc – Northwest / Business 85

Motel 6 Spartanburg, Sc – Northwest / Business 85
Spartanburg
United States
Tyler
$58 nightly
$64 total
Oct 7 - Oct 8
Total with taxes and fees
Motel 6 Spartanburg, Sc – Northwest / Business 85
A hotel room with two beds, a desk, a door, and a window with curtains.
A Red Roof Inn with a modern architectural design, featuring a prominent red roof and a signboard.
A Red Roof Inn with a two-story structure, multiple balconies, and a parking area.
A vending machine with snacks and a drink dispenser.

6. Red Roof Inn Spartanburg - I-85

Red Roof Inn Spartanburg - I-85
Spartanburg
United States
Walker
$65 nightly
$72 total
Oct 5 - Oct 6
Total with taxes and fees
Red Roof Inn Spartanburg - I-85
A hotel dining area with multiple tables and chairs, a television mounted on a wall, and a kitchen area visible in the background.
A hotel with a swimming pool, lounge chairs, and a covered seating area.
A hotel reception area with a counter, a refrigerator, and a sign indicating a Sleep Inn.
A living room with a sofa, two armchairs, a coffee table, and a patterned rug.

7. Sleep Inn Gaffney at I-85

Sleep Inn Gaffney at I-85
Gaffney
United States
Wendy
$67 nightly
$75 total
Oct 19 - Oct 20
Total with taxes and fees
Sleep Inn Gaffney at I-85
A hotel room with a bed, a desk with a computer, a television, and a microwave.
A single-story motel with a flat roof, large windows, and a small porch area.
A room with two beds, each with a wooden headboard and a floral bedspread. There is a small wooden table beside the beds.
A bedroom with a bed, wooden headboard, bedside tables, and a ceiling light.

8. SUN AND SAND MOTEL

SUN AND SAND MOTEL
Spartanburg
United States
Jeffrey
$68 nightly
$75 total
Oct 3 - Oct 4
Total with taxes and fees
SUN AND SAND MOTEL
A lobby with a leather sofa, two lamps, a painting, and potted plants.
A hotel room with two beds, a desk, a chair, a TV, and a bathroom visible through an open door.
A dining area with a high ceiling, wooden chairs, a table, and a kitchen area with a TV and food display.
A swimming pool with a brick border and a metal ladder, surrounded by a fence and a house in the background.

9. Quality Inn Gaffney I-85

Quality Inn Gaffney I-85
Gaffney
United States
Betina
$55 nightly
$62 total
Oct 25 - Oct 26
Total with taxes and fees
Quality Inn Gaffney I-85
A modern lobby with a large white reception desk, brown leather sofas, a round coffee table, and a ceiling light fixture.
A modern kitchen with wooden cabinets, a built-in oven, and a coffee station.
A reception area with wooden reception desks, framed artwork, and a white door.

10. Days Inn by Wyndham Spartanburg

Days Inn by Wyndham Spartanburg
Boiling Springs
United States
antonio
$79 nightly
$88 total
Sep 29 - Sep 30
Total with taxes and fees
Days Inn by Wyndham Spartanburg
A buffet with various food items, including omelets and cheese.
A vending area with Coca-Cola and Sprite refrigerated drinks, a 'happy place' sign, and snack baskets on shelves.
A hotel room with two beds, a desk, and a view of the outdoors.
A modern lobby with a sofa, chairs, a desk, and a map mural on the wall.

11. Holiday Inn Express Gaffney by IHG

Holiday Inn Express Gaffney by IHG
Gaffney
United States
Luis
$76 nightly
$83 total
Oct 4 - Oct 5
Total with taxes and fees
Holiday Inn Express Gaffney by IHG
A hotel lobby with a bar area, seating with patterned upholstery, and a central coffee table.
A hotel room with a large bed, a desk with a television, a chair, and a small table.
A hotel reception desk with a 'Welcome to the Palmetto State' sign, a 'Manager On Duty' sign, and a 'Hilton Honors' sign.
A fitness center with treadmills, a bench, and exercise equipment.

12. Hampton Inn Gaffney

Hampton Inn Gaffney
Gaffney
United States
George
$122 nightly
$133 total
Oct 18 - Oct 19
Total with taxes and fees
Hampton Inn Gaffney
A modern living room with a fireplace, two sofas, and a coffee table.
A reception area with two wooden reception desks, a blue accent wall, and a mounted television.
A hotel lobby with multiple seating areas, a reception desk, and a fireplace.
A hotel room with two beds, a desk, a TV, and a window with curtains.

13. Best Western Spartanburg Northwest

Best Western Spartanburg Northwest
Spartanburg
United States
Darius
$99 nightly
$110 total
Oct 4 - Oct 5
Total with taxes and fees
Best Western Spartanburg Northwest
A modern reception area with a counter, seating, and a bookshelf with various items.
A clinical setting with medical equipment, a large mirror, and a window providing natural light.
A multi-story hotel with a stone facade and multiple windows, featuring a parking lot and landscaped areas.
A bar area with a long counter, bar stools, and a variety of bottles and glasses.

14. Holiday Inn Spartanburg Northwest by IHG

Holiday Inn Spartanburg Northwest by IHG
Spartanburg
United States
Carla
$101 nightly
$112 total
Oct 4 - Oct 5
Total with taxes and fees
Holiday Inn Spartanburg Northwest by IHG
A hotel lobby with a curved outdoor seating area, a fire pit, and a pool.
A modern kitchen with marble countertops, wooden shelves, and a wine station.
A grand hotel lobby with a marble staircase, ornate carpet, and large landscape paintings on the walls.
A spacious lobby with a high ceiling, chandeliers, a registration desk, and potted plants.

15. Spartanburg Marriott

Spartanburg Marriott
Spartanburg
Canada
Sarah
$118 nightly
$131 total
Oct 25 - Oct 26
Total with taxes and fees
Spartanburg Marriott
Two white front-loading washing machines in a corner with a tiled floor.
A restaurant with red chairs and a counter with food items.
A hotel room with two beds, a desk, a chair, a television, and a mirror.
Two vending machines, one with a Pepsi logo and the other with a FreshChoices label.

16. Red Roof Inn Gaffney

Red Roof Inn Gaffney
Gaffney
United States
Belinda
$62 nightly
$70 total
Oct 5 - Oct 6
Total with taxes and fees
Red Roof Inn Gaffney
A modern kitchen with a central island, equipped with a microwave, toaster, and coffee machine.
A hotel room with a desk, office chair, sofa, and a large wall art piece.
A hotel room with a bed, a gray sofa, two ottomans, a window with a view, and abstract artwork on the wall.
A gym with treadmills, elliptical machines, and weight machines.

17. Comfort Suites At WestGate Mall

Comfort Suites At WestGate Mall
Spartanburg
United States
tara
$91 nightly
$101 total
Oct 25 - Oct 26
Total with taxes and fees
Comfort Suites At WestGate Mall
A hotel lobby with a reception desk, green sofa, patterned armchairs, and a potted plant.
A hotel room with a bed, desk, chair, television, and lamps.
A kitchen with wooden cabinets, a black refrigerator, and a dining area with chairs and a table.
A motel with multiple rooms, a blue awning, and a red car parked in front.

18. Baymont by Wyndham Gaffney

Baymont by Wyndham Gaffney
Gaffney
United States
Kelly
$72 nightly
$81 total
Oct 19 - Oct 20
Total with taxes and fees
Baymont by Wyndham Gaffney
An outdoor seating area with sofas, a fire pit, and string lights.
A modern lounge area with seating arrangements, a large window offering a view of the outdoors, and contemporary lighting fixtures.
A modern interior with hanging chairs, tables, and a view of the parking lot.
A self-service kiosk with a variety of snacks and beverages, a microwave, and a refrigerated display.

19. Tru by Hilton Spartanburg

Tru by Hilton Spartanburg
Spartanburg
United States
Anthony
$107 nightly
$118 total
Oct 25 - Oct 26
Total with taxes and fees
Tru by Hilton Spartanburg
A hotel room with two beds, a desk, a chair, and a large window with autumn foliage artwork.
A self-service coffee station with a Folgers Select Brew coffee maker and a vintage-themed beverage dispenser.
A hotel room with a wooden desk, a black chair, a small refrigerator, a microwave, and a TV on the wall.
A spacious indoor area with a large glass door leading outside, a ceiling fan, and a counter with various items.

20. Days Inn by Wyndham Spartanburg Waccamaw

Days Inn by Wyndham Spartanburg Waccamaw
Spartanburg
United States
Rebecca
$65 nightly
$73 total
Oct 1 - Oct 2
Total with taxes and fees
Days Inn by Wyndham Spartanburg Waccamaw
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Top Mayo Hotel Reviews

AC Hotel by Marriott Spartanburg

AC Hotel by Marriott Spartanburg

10/10 Excellent
"Very rude staff near the bar area."
Charlie 1-night trip
Posted 8 hours ago
AC Hotel by Marriott Spartanburg
Four Points by Sheraton Spartanburg

Four Points by Sheraton Spartanburg

8/10 Good
"W we have stayed here a few times now visiting Wofford. The place is very clean. Bring your own pillows though. There pillows are like sleeping on a sheet of paper."
William 2-night trip
Posted 9 hours ago
Four Points by Sheraton Spartanburg
Best Western Spartanburg I-26

Best Western Spartanburg I-26

10/10 Excellent
"The room was clean and comfortable, the bed was firm and the pillows were a little too firm. The breakfast was good with real eggs, very thin bacon, pancakes, juice and a weird little coffee machine that made pretty good coffee!"
Connie 1-night trip
Posted 9 hours ago
Best Western Spartanburg I-26
Spartanburg Marriott

Spartanburg Marriott

10/10 Excellent
"Professional and polite staff, the grounds were well maintained, ample useful and attractive all while being well located for my purposes."
Daniel 2-night trip
Posted 9 hours ago
Spartanburg Marriott
Comfort Suites At WestGate Mall

Comfort Suites At WestGate Mall

10/10 Excellent
"The rooms are always clean!"
tara 3-night trip
Posted 20 hours ago
Comfort Suites At WestGate Mall
Tru by Hilton Spartanburg

Tru by Hilton Spartanburg

10/10 Excellent
"Large room, bed, clean. Staff was very nice"
Lena 1-night trip
Posted 2 days ago
Tru by Hilton Spartanburg
Hampton Inn Gaffney

Hampton Inn Gaffney

10/10 Excellent
"Great hotel for an overnight stay. We were pleasantly surprised how nice this place was. Quiet, clean, comfy beds and a great breakfast with more options than normal for the included ones. Would definitely recommend this for a clean quiet place to stay while visiting the National Battlefields!"
George 1-night trip
Posted 4 days ago
Hampton Inn Gaffney
University Inn

University Inn

10/10 Excellent
"Great place to stay while visiting the university."
James 2-night trip
Posted 7 days ago
University Inn

More cheap stays in Mayo

Rodeway Inn Expo Center

Rodeway Inn Expo Center

2070 New Cut Rd Spartanburg SC
$57 nightly
$64 total
Oct 19 - Oct 20
Total with taxes and fees
Rodeway Inn Expo Center
Motel 6 Spartanburg, Sc – Northwest / Business 85

Motel 6 Spartanburg, Sc – Northwest / Business 85

820 Hospitality Drive Spartanburg SC
$58 nightly
$64 total
Oct 7 - Oct 8
Total with taxes and fees
Motel 6 Spartanburg, Sc – Northwest / Business 85
WoodSpring Suites Spartanburg - Duncan

WoodSpring Suites Spartanburg - Duncan

255 Frontage Rd. Duncan SC
$64 nightly
$72 total
Sep 29 - Sep 30
Total with taxes and fees
6/10 (293 reviews)
WoodSpring Suites Spartanburg - Duncan
Comfort Suites At WestGate Mall

Comfort Suites At WestGate Mall

458 West Blackstock Road Spartanburg SC
$91 nightly
$101 total
Oct 25 - Oct 26
Total with taxes and fees
8.4/10 Very Good! (1,004 reviews)
Comfort Suites At WestGate Mall
Best Western Spartanburg I-26

Best Western Spartanburg I-26

488 South Blackstock Road Spartanburg SC
$93 nightly
$103 total
Oct 11 - Oct 12
Total with taxes and fees
9.2/10 Wonderful! (45 reviews)
Best Western Spartanburg I-26
Holiday Inn Express Hotel & Suites Spartanburg-North by IHG

Holiday Inn Express Hotel & Suites Spartanburg-North by IHG

161 Sha Ln Spartanburg SC
$106 nightly
$118 total
Oct 4 - Oct 5
Total with taxes and fees
Holiday Inn Express Hotel & Suites Spartanburg-North by IHG

Hotels in Mayo with star-rating

Frequently asked questions

What is the best area to stay in Mayo?
The best area to stay in Mayo is the town center, particularly around Main Street, as it offers the most convenience for visitors.This central area of Mayo is where you'll find the majority of local businesses, including eateries and shops. It's a compact and walkable district, making it easy to access amenities. The town hall and the local library are also situated here, providing a central point for navigation.For solo travelers or couples, staying in the town center provides easy access to local dining and any community events that might be happening.
When is the best time to go to Mayo?
The best time to visit Mayo, South Carolina, is during the spring (April to June) and fall (September to November) months.During these periods, the weather is pleasantly mild, with comfortable temperatures and lower humidity, making it ideal for outdoor activities and exploring the local area without the intense heat of summer. You'll find many local events and festivals taking place, offering a great way to experience the community's culture.For travelers looking for a relaxed experience, these seasons offer peaceful surroundings.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Mayo.
How much is the nightly rate at a Mayo hotel?
Prices for hotels in Mayo often vary, but you can find a great deal from $62 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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