A waterfall in a forest with a circular water pattern at the base.

Upfront pricing
Our total price for your stay includes taxes and fees
Treat yourself
Save 10% or more on over 100,000 hotels worldwide with Member Prices
Learn about One Key
Be picky
Search almost a million properties worldwide

Go beyond your typical stay in Northwest Alabama

Pet friendly

Apartment

Check prices for these dates

Tonight

Tomorrow

Next weekend

In two weeks

Our top choices for Northwest Alabama hotels

A hotel room with a bed, a desk, a chair, a mirror, a painting, and a nightstand with a lamp.

1. Days Inn by Wyndham Muscle Shoals Florence

Muscle Shoals

Shana

$71 nightly

Nov 8 - Nov 9

Total with taxes and fees

A hotel lobby with a seating area, a reception desk, and a check-in counter.

2. Residence Inn Florence Marriott

East Florence

Nathan

$121 nightly

Nov 22 - Nov 23

Total with taxes and fees

A modern kitchen with wooden cabinets, a countertop with various appliances, and a view of the outdoors.

3. Holiday Inn Express Hotel & Suites FLORENCE NORTHEAST by IHG

Florence

LaRhonda

$105 nightly

Nov 22 - Nov 23

Total with taxes and fees

An indoor swimming pool with tiled steps and a sunlit room with chairs and a window.

4. Comfort Suites Florence Shoals Area

Florence

Elizabeth

$86 nightly

Nov 29 - Nov 30

Total with taxes and fees

A hotel room with a bed, a desk with chairs, a small kitchenette, and a TV.

5. Microtel Inn & Suites by Wyndham Tuscumbia/Muscle Shoals

Tuscumbia

Brian

$63 nightly

Nov 9 - Nov 10

Total with taxes and fees

A spacious lobby with a reception desk, seating area, and a balcony.

6. Best Western Plus Tuscumbia Muscle Shoals Hotel and Suites

Tuscumbia

Colin

$104 nightly

Nov 15 - Nov 16

Total with taxes and fees

A spacious interior with a central staircase, a chandelier, and a view to the outdoors.

7. Spark by Hilton Tuscumbia Muscle Shoals

Tuscumbia

Patrick

$83 nightly

Nov 29 - Nov 30

Total with taxes and fees

A snack bar with shelves of snacks and a refrigerator with beverages.

8. Hampton Inn Florence Midtown near University of North Alabama

Florence

calvin

$130 nightly

Nov 15 - Nov 16

Total with taxes and fees

A hotel with a large pool area, a water tower, and a dome structure.

9. Renaissance Shoals Resort & Spa

East Florence

Christina

$269 nightly

Nov 23 - Nov 24

Total with taxes and fees

A hotel room with a large bed, a TV mounted on the wall, a desk with a chair, a mirror, and a painting on the wall.

10. Red Roof Inn Muscle Shoals

Muscle Shoals

Keith

$59 nightly

Nov 9 - Nov 10

Total with taxes and fees

A spacious lobby with seating areas, a reception desk, and large windows.

11. Clarion Inn Sheffield Muscle Shoals

Sheffield

Billy

$77 nightly

Dec 1 - Dec 2

Total with taxes and fees

A reception area with a counter, a television, and a door labeled "EMPLOYEES ONLY".

12. Budget Inn & Suites

East Florence

Nazul

$59 nightly

Nov 13 - Nov 14

Total with taxes and fees

A restaurant interior with a bar area, seating, and a counter with a coffee machine.

13. The Stricklin Hotel

Florence

Dana

$189 nightly

Dec 8 - Dec 9

Total with taxes and fees

A modern bathroom with a freestanding bathtub, a blue chair, and a wooden bench.

14. Comfort Inn & Suites Tuscumbia - Muscle Shoals

Tuscumbia

David

$101 nightly

Dec 6 - Dec 7

Total with taxes and fees

A reception area with a stone wall, a reception desk, and a door leading outside.

15. Econo Lodge Russellville

Russellville

Mark

$70 nightly

Nov 15 - Nov 16

Total with taxes and fees

A spacious living area with a staircase, a flat-screen TV, and a seating area with a coffee table.

16. Best Western Plus Russellville Hotel & Suites

Russellville

Dennis

$108 nightly

Nov 25 - Nov 26

Total with taxes and fees

A modern living room with a sofa, armchairs, a coffee table, and a TV.

17. Baymont by Wyndham Florence/Muscle Shoals

Florence

Alan

$68 nightly

Nov 22 - Nov 23

Total with taxes and fees

A spacious lobby with a blue sofa, a wooden table, and chairs. There is a TV on a stand and a painting on the wall.

18. Hampton Inn & Suites Florence-Downtown

Florence

Heather

$164 nightly

Nov 29 - Nov 30

Total with taxes and fees

A reception area with a reception desk, a seating area with chairs and a table, a plant, a lamp, a bulletin board, and a window with a view of the outside.

19. Keywest Inn - Tuscumbia/Muscle Shoals

Tuscumbia

Barbara

$75 nightly

Nov 8 - Nov 9

Total with taxes and fees

A hotel room with a bed, a desk, a chair, a nightstand, a lamp, a painting of a sunset, and a bathroom with a mirror and sink.

20. Days Inn by Wyndham Moulton

Moulton

Debra

$64 nightly

Nov 15 - Nov 16

Total with taxes and fees

View all properties

Vacation Rentals in Northwest Alabama

Cottage

A spacious living area with a dining table, chairs, a TV, and a kitchen area with cabinets and appliances.

A-frame Home ~ 6 Mi to Tennessee River!

Florence

"Cute cottage close to all amenities."

Cottage

A living room with a ceiling fan, a television, a leather sofa, and a wooden cabinet.

Killen Vacation Rental ~ 4 Mi to Wilson Lake!

Killen

"Great place to stay. "

Cottage

A covered patio with wicker furniture, a brick wall, and a view of the garden.

Charming Florence Getaway w/ Fireplace & Grill!

Florence

"The house was beautiful, clean, spacious, and very comfortable. It had all the amenities you could want and need. It was a quiet and nice neighborhood and close to dining and shopping. The owner kept in touch with us the entire stay and was very kind. We will definitely stay there again!"

Cottage

A modern kitchen with granite countertops, a stone backsplash, a built-in oven, and a large window overlooking a garden.

Expansive Florence Home ~ 6 Mi to Downtown!

Florence

"Our family totally loved staying here - close where we needed to be and we were so comfortable - especially with 3 bathrooms for 3 bedrooms! Loved it!"

Cottage

A modern living room with a blue leather sofa, two brown leather armchairs, a small round table, and a staircase leading to the upper floor.

7 Mi to Tennessee River: Home w/ Patio in Florence

Florence

"We loved the place huge rooms we had 10 people and had plenty of room .We would stay again but floors needed sweep and mopped but overall it was a great place ."

Cottage

A sunroom with a glass door, a ceiling fan, a hanging chair, and a view of the lake.

Waterfront Bliss: Wheeler Lake Retreat w/ Dock!

Athens

"Enjoyed your home"

See all vacation rentals

Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Northwest Alabama attractions

Dismals Canyon

9.0/10 (35 reviews)

Commune with nature and explore the great outdoors at Dismals Canyon during your travels in Phil Campbell. While you're in the area, wander around the natural setting.

See properties

Learn more about Northwest Alabama

Explore the family-friendly area of Northwest Alabama—live music, entertainment choices, and sights from Dismals Canyon to Cane Creek Canyon Nature Preserve.

See all hotels in Northwest Alabama

A waterfall cascading over rocks in a forested area.

Top Northwest Alabama Hotel Reviews

Best Western Plus Tuscumbia Muscle Shoals Hotel and Suites

10/10 Excellent

"We travel to Moulton every year for Cross Country State and even though Best Western is a little out the way, it is well worth it. We love this hotel."

Hampton Inn & Suites Florence-Downtown

10/10 Excellent

"This is the second time I stayed at this hotel, and I like it. I like the staff, the amenities, the location, and the convenience. I did pay a lot more this time for a room, though, and when I asked about it, I was told that it was because it was on Halloween night. Seems a little uncouth to raise the price of the room that much because it was Halloween."