Find hotels in Oregon, MO from $71

The best area to stay in Oregon, Missouri, is within the town center itself, particularly along Main Street, for access to local amenities and a quiet atmosphere.Oregon's town center provides a convenient base for exploring the small community. Main Street is where you'll find the few local businesses, including a grocery store and a couple of eateries, making it easy to manage daily needs. The layout is straightforward, with most points of interest within a short walking distance.For solo travelers or couples looking for a peaceful retreat, staying in the heart of Oregon is ideal. The town offers a relaxed pace, and its location provides access to the nearby Squaw Creek National Wildlife Refuge, which is excellent for birdwatching and enjoying nature.

The best time to visit Oregon, Missouri is during the late spring (May to early June) or early fall (September to October) when the weather is pleasant and outdoor activities are most enjoyable.During late spring, the temperatures are mild, and the natural landscape around Oregon is lush and green. This is an excellent time for visitors who enjoy outdoor activities like hiking or exploring the local parks, as the conditions are comfortable and the scenery is at its peak.Early fall offers crisp air and comfortable temperatures, making it ideal for exploring the historic town and its surroundings. The changing leaves provide a beautiful backdrop, especially for those interested in photography or scenic drives through the countryside.

With Expedia, you earn OneKeyCash™* on eligible Oregon hotel bookings for every dollar you spend – just join our One Key™ travel rewards program to get started. It's free to join, and you'll unlock our lowest Member Prices as soon as you're signed in. On top of this, you could also save significantly by bundling your hotel and flights together on Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.