St. Charles Vacation Rentals

  • Bundle & Save

    Get more, spend less whenever you see Bundle & Save deals
  • OneKeyCash

    Earn OneKeyCash on all your eligible bookings
  • Upfront pricing

    We are not like the others - we include taxes and fees

Check prices for these dates

In two weeks
In two months
In three months
In four months

Our top choices for St. Charles vacation rentals

Aparthotel in Folwell

The Berkman
3.0 star property
9.6 out of 10, Exceptional, (380 reviews)
"The room was amazing, spacious, nicely decorated, super clean, complete kitchen, bedroom separated from living… High quality finishes. Very good location accross the street from Mayo. "
United States
Juliana
$164 nightly
The price is $189
Jan 24 - Jan 25
Total with taxes and fees
The Berkman
3.0 star property
9.2 out of 10, Wonderful, (42 reviews)
"Place was clean and comfortable. "
United States
Tristan
$94 nightly
The price is $100
Feb 2 - Feb 3
Total with taxes and fees
Big River Escape Riverside Cabins
3.0 star property
9.2 out of 10, Wonderful, (170 reviews)
"Great staff, clean room, spacious kitchen and living room."
United States
silvia
$161 nightly
The price is $185
Jan 24 - Jan 25
Total with taxes and fees
Broadway Plaza, Trademark Collection by Wyndham

Cabin in Spring Valley

Valley Cabin
9.2 out of 10, Wonderful, (7 reviews)
"Great property with plenty of outdoor activities. Had fun fishing the stream and exploring the area. Dan is a great host and I will be visiting again."
United States
JAKE I.
$118 nightly
The price is $127
Jan 24 - Jan 25
Total with taxes and fees
Valley Cabin
9.2 out of 10, Wonderful, (21 reviews)
"Great location , close to Mayo clinic as needed. Owner addressed the shower head issue immediately, great communication. "
United States
Barb W.
$183 nightly
The price is $211
Jan 24 - Jan 25
Total with taxes and fees
Discounted Oasis! 5 Star-3 Bedroom Showstopping Duplex 4 Minutes to Mayo Clinic!
10.0 out of 10, Exceptional, (9 reviews)
"It was amazing stay, it was very comfy, welcoming and definitely something we would book again!!"
United States
Jessica Z.
$188 nightly
The price is $216
Jan 25 - Jan 26
Total with taxes and fees
Discounted 5-Star 3 Bedroom Duplex 5 Minutes to Mayo Clinic!
9.6 out of 10, Exceptional, (9 reviews)
"Great relaxing place! "
United States
James H.
$160 nightly
The price is $172
Jan 24 - Jan 25
Total with taxes and fees
Treehouse Cabin in the Bluff Woodlands North
8.6 out of 10, Excellent, (14 reviews)
"Great place in the heart of Alma"
United States
Kevin B.
$207 nightly
The price is $230
Jan 25 - Jan 26
Total with taxes and fees
Big River Inn - 3 bedroom apartment in Alma
9.8 out of 10, Exceptional, (15 reviews)
"Beautiful area enjoyed our stay immensely"
United Kingdom
I.M l.
$131 nightly
The price is $141
Feb 10 - Feb 11
Total with taxes and fees
Treehouse Cabin in the Bluff Woodlands
2.0 star property
8.0 out of 10, Very Good, (1 review)
"Easy check in/ Secure entry system "
United States
Ann R.
$130 nightly
The price is $149
Jan 25 - Jan 26
Total with taxes and fees
Across from St Mary hospital Covered By Faith 2
2.0 star property
10.0 out of 10, Exceptional, (1 review)
"Nice little place and close to the Mayo Clinic. It was perfect. "
United States
Philip
$192 nightly
The price is $221
Jan 25 - Jan 26
Total with taxes and fees
1 mile Mayo 2 step entry Encourage Covered ByFaith
10.0 out of 10, Exceptional, (1 review)
"We enjoyed our stay and really enjoyed the screened in porch. Spent a lot of time sitting at the table in the screened in porch playing cards."
United States
Jenny D.
$153 nightly
The price is $162
Jan 25 - Jan 26
Total with taxes and fees
Great River Road Cabin on the Mississippi Backwaters Fox Cabin
3.0 star property
10.0 out of 10, Exceptional, (1 review)
"We had a wonderful time and would defiinitely stay again. "
United States
Julie
$206 nightly
The price is $230
Jan 25 - Jan 26
Total with taxes and fees
Big River Escape Parkside Bungalow
2.0 star property
$151 nightly
The price is $162
Jan 28 - Jan 29
Total with taxes and fees
Viola Suite #1 / 1 bed, 1.5 Bath, Pets Welcome!

Vacation Home in Minnesota City

Vintage Lustron Home Piece of History
10.0 out of 10, Exceptional, (29 reviews)
"I loved staying here! The interior was comfortable, cozy, and fascinating! "
United States
melanie
$197 nightly
The price is $212
Jan 24 - Jan 25
Total with taxes and fees
Vintage Lustron Home Piece of History
9.8 out of 10, Exceptional, (12 reviews)
"Very comfortable home away from home"
United States
ROBERT B.
$218 nightly
The price is $251
Jan 27 - Jan 28
Total with taxes and fees
Apple Blossom Cottage // 2 Miles from Downtown ~ 10 Min to Mayo
10.0 out of 10, Exceptional, (1 review)
"Quiet, clean and in a friendly neighborhood. Staying there took some of the stress out of my Mayo Clinic visits. I always worry about my follow-up visits, but a good quiet place to stay helps me let that go."
United States
Maria L E.
$140 nightly
The price is $201
Jan 24 - Jan 25
Total with taxes and fees
Charming 2-bedroom apartment in delightful Rochester with WiFi, AC
10.0 out of 10, Exceptional, (26 reviews)
"Beautiful home we had a wonderful stay!!!"
United States
Thomas L.
$284 nightly
The price is $306
Jan 24 - Jan 25
Total with taxes and fees
Charming 3-bedroom, 2 bathroom house with outdoor space in Winona
10.0 out of 10, Exceptional, (18 reviews)
"I love staying in their properties. I always know I am going to be comfortable and have a great stay. "
United States
Carissa W.
$203 nightly
The price is $234
Feb 1 - Feb 2
Total with taxes and fees
The Little House // Stylish & Cozy ~ 2 mi from Mayo Clinic
9.8 out of 10, Exceptional, (87 reviews)
"The house is charming. We had a pleasant stay."
United States
Susan D.
$186 nightly
The price is $200
Jan 25 - Jan 26
Total with taxes and fees
The Hen House Retreat - A Comfortable Place to Roost
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top St. Charles Hotel Reviews

Find out more about St. Charles

Everything you need to know about St. Charles vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the St. Charles vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect St. Charles vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

St. Charles vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in St. Charles. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit St. Charles in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $100 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on St. Charles rentals

At Expedia, we put the best St. Charles vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top St. Charles rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream St. Charles vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around St. Charles. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently asked questions

Can I find vacation rentals in St. Charles?

Yes, we offer vacation rentals close to the most popular attractions in St. Charles, or you can go with a more remote option if you want a relaxing place to stay. St. Charles is known for its parks.

What are some of the best vacation rentals that St. Charles has to offer?

Meet Don - A Modern, Zero-step, Pet-friendly home in Rochester: Visitors like this St. Charles vacation home rental. It has air-conditioning and laundry facilities to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a dishwasher, a stovetop, and a microwave.

What can I see and do in St. Charles?

While you're exploring the area, Whitewater River and Root River are a couple of picturesque spots to get outside and enjoy nature. Whitewater State Park and St. Mary's University of Minnesota are a couple of places you'll find in the larger area.

What are vacation rentals like in St. Charles?

Vacation rentals are privately owned properties you can book for short or long periods in St. Charles. Vacation rentals feature amenities such as patios, hot tubs, and fire pits so your stay will be comfortable. If you're concerned about a clean environment, a vacation rental can offer a sense of seclusion away from public hotel elevators and lobbies bustling with people while still allowing you to travel. You'll also find more space in a vacation rental than in a traditional hotel, which is another reason why a vacation rental is an attractive choice for families.