$164 Cheap American Airlines flights Jacksonville (JAX) to Knoxville (TYS)

Finding cheap one-way American Airlines flights from JAX to TYS from $164 on Expedia is simple --- just filter by "Price (lowest to highest)." Alternatively, check out our budget-friendly round-trip fares from $251 for your next break.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Look for cheap American Airlines flights from Jacksonville Intl. Airport (JAX) to McGhee Tyson Airport (TYS) one to three months before your day of departure. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. Regardless of fare class and journey, the best day of the week to book a domestic flight is generally Sunday and the most expensive day tends to be Monday. Passengers who book on a Sunday can save 6% on average compared to those who book their travel on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Search American Airlines's earliest flights from JAX to TYS by checking our "Morning" and "Early Morning" filters. Not only will you get to where you're going sooner, early departures are also 20% less likely to be canceled.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.