$247 Cheap Flights from Cleveland (CLE) to Guayaquil (GYE)

View $247 flight on Mon, Oct 6, 2025Opens in a new window

Popular airlines from Cleveland Hopkins International Airport (CLE) to Jose Joaquin de Olmedo Intl. Airport (GYE)

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Cheap Flights from Cleveland to Guayaquil (CLE-GYE)

Prices were available within the past 7 days and start at $247 for one-way flights and $569 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

JetBlue Airways
Mon, Oct 6 - Thu, Oct 9
CLE
Cleveland
GYE
Guayaquil
$569 Roundtrip, found 2 days ago
$569
Roundtrip
found 2 days ago
Select JetBlue Airways flight, departing Mon, Oct 6 from Cleveland to Guayaquil, returning Thu, Oct 9, priced at $569 found 2 days ago
JetBlue Airways
Thu, Sep 11 - Fri, Sep 26
CLE
Cleveland
GYE
Guayaquil
$571 Roundtrip, found 7 hours ago
$571
Roundtrip
found 7 hours ago
Select JetBlue Airways flight, departing Thu, Sep 11 from Cleveland to Guayaquil, returning Fri, Sep 26, priced at $571 found 7 hours ago
JetBlue Airways
Sat, Sep 6 - Mon, Sep 22
CLE
Cleveland
GYE
Guayaquil
$573 Roundtrip, found 6 days ago
$573
Roundtrip
found 6 days ago
Select JetBlue Airways flight, departing Sat, Sep 6 from Cleveland to Guayaquil, returning Mon, Sep 22, priced at $573 found 6 days ago
JetBlue Airways
Thu, Sep 25 - Fri, Sep 26
CLE
Cleveland
GYE
Guayaquil
$580 Roundtrip, found 1 day ago
$580
Roundtrip
found 1 day ago
Select JetBlue Airways flight, departing Thu, Sep 25 from Cleveland to Guayaquil, returning Fri, Sep 26, priced at $580 found 1 day ago
United
Mon, Sep 8 - Tue, Sep 23
CLE
Cleveland
GYE
Guayaquil
$587 Roundtrip, found 7 hours ago
$587
Roundtrip
found 7 hours ago
Select United flight, departing Mon, Sep 8 from Cleveland to Guayaquil, returning Tue, Sep 23, priced at $587 found 7 hours ago
JetBlue Airways
Thu, Sep 25 - Sun, Sep 28
CLE
Cleveland
GYE
Guayaquil
$594 Roundtrip, found 1 day ago
$594
Roundtrip
found 1 day ago
Select JetBlue Airways flight, departing Thu, Sep 25 from Cleveland to Guayaquil, returning Sun, Sep 28, priced at $594 found 1 day ago
JetBlue Airways
Fri, Sep 5 - Fri, Sep 26
CLE
Cleveland
GYE
Guayaquil
$596 Roundtrip, found 7 hours ago
$596
Roundtrip
found 7 hours ago
Select JetBlue Airways flight, departing Fri, Sep 5 from Cleveland to Guayaquil, returning Fri, Sep 26, priced at $596 found 7 hours ago
Delta
Sat, Mar 28 - Sat, Apr 4
CLE
Cleveland
GYE
Guayaquil
$606 Roundtrip, found 6 days ago
$606
Roundtrip
found 6 days ago
Select Delta flight, departing Sat, Mar 28 from Cleveland to Guayaquil, returning Sat, Apr 4, priced at $606 found 6 days ago
American Airlines
Sun, Oct 5 - Sat, Oct 18
CLE
Cleveland
GYE
Guayaquil
$614 Roundtrip, found 5 days ago
$614
Roundtrip
found 5 days ago
Select American Airlines flight, departing Sun, Oct 5 from Cleveland to Guayaquil, returning Sat, Oct 18, priced at $614 found 5 days ago
LATAM Airlines Group
Sat, Mar 28 - Sat, Apr 4
CLE
Cleveland
GYE
Guayaquil
$622 Roundtrip, found 6 days ago
$622
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Sat, Mar 28 from Cleveland to Guayaquil, returning Sat, Apr 4, priced at $622 found 6 days ago

Alternative airports near Guayaquil

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Jose Joaquin de Olmedo Intl. GYE. Cheapest and Closest option available. Average driving time to city center is 9 minutes. Flights from $804
GYE
Jose Joaquin de Olmedo Intl.
CheapestClosest
Average driving time to city center9 min
Flights from $804
Flights from Cleveland (CLE) to Guayaquil (GYE)
Origin airport
Hopkins Intl.
Destination airport
Jose Joaquin de Olmedo Intl.
Airlines serving
American Airlines, Copa, Delta, JetBlue Airways, LATAM Airlines Group, United, avianca
Roundtrip price
$568
Distance
3011 mi

Cleveland to Guayaquil Flights

The cheapest times to fly from Cleveland to Guayaquil

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Cleveland to Guayaquil are during the month of October. You can find some of the cheapest flights from Cleveland to Guayaquil with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Cleveland to Guayaquil

Sunday is one of the best days to book for cheap flights from Cleveland to Guayaquil: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Cleveland to Guayaquil

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Cleveland to Guayaquil in 2025. You can also book with separate airlines for your outbound and return journeys, from $247 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Cleveland to Guayaquil flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Cleveland to Guayaquil airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Hopkins Intl. Airport (CLE) to Jose Joaquin de Olmedo Intl. Airport (GYE) cost?
Discover the latest flight deals from CLE to GYE by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from CLE to GYE?
The cheapest flights from CLE to GYE are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from CLE to GYE?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from CLE to GYE. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Hopkins Intl. Airport (CLE) to Jose Joaquin de Olmedo Intl. Airport (GYE)?
You'll need to hop on a flight with a layover if you're traveling from Hopkins Intl. Airport (CLE) to Jose Joaquin de Olmedo Intl. Airport (GYE). Direct flights don't operate daily on this route. However, simply filter your search to include one or more stops to find an option that works for you.
What day of the week has the most flights from CLE to GYE?
Friday is usually the busiest day for flights, while Tuesday is often the quietest.* Just remember that flight schedules can change based on a range of factors, including the time of year and carrier.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Hopkins Intl. Airport (CLE) to Jose Joaquin de Olmedo Intl. Airport (GYE)?
To avoid possible delays on the Hopkins Intl. Airport (CLE) to Jose Joaquin de Olmedo Intl. Airport (GYE) route, aim to fly before 3 PM. Departures after this time have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Hopkins Intl. Airport (CLE) to Jose Joaquin de Olmedo Intl. Airport (GYE) last-minute?
Last-minute bookings from CLE to GYE are typically more expensive. To lock in the cheapest rates, start looking for flights as early as possible. That said, if your travel plans are flexible, you may land a cheap ticket right before your journey.
Is it cheaper to book a CLE to GYE flight and hotel package?
Compared with arranging flights and hotels separately, booking a CLE to GYE flight and hotel package with Expedia could lead to significant savings. Better still, having everything in one easy place will take the hassle out of planning your trip. Simply secure your flights and select from our extensive range of stays, then customize your trip with other add-ons like activities, tours and car rentals.
Can I cancel or change the date of my flight from Hopkins Intl. Airport (CLE) to Jose Joaquin de Olmedo Intl. Airport (GYE)?
Usually, it's possible to reschedule or cancel your CLE to GYE flight. However, for bookings made more than 24 hours ago, additional charges may apply. Check your airline's policies in your itinerary to see what changes are allowed and if any costs are involved. You'll also find further details on our Customer Service portal.

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*Available to One Key members.