$421 Cheap Flights from Florence (FLR) to Knoxville (TYS)

View $421 flight on Tue, Apr 7, 2026Opens in a new window

Popular airlines from Florence Airport, Peretola (FLR) to McGhee Tyson Airport (TYS)

    notification illustration

    Be in the know

    Get alerts if flight prices drop or rise*
    deals illustration

    Book smarter

    Save up to 30% on select hotels after you book a flight*
    trophy illustration

    Earn twice

    Earn your airline miles on top of our OneKeyCash
    Learn about One Key

Cheap Flights from Florence to Knoxville (FLR-TYS)

Prices were available within the past 7 days and start at $421 for one-way flights and $728 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Lufthansa
Sun, Jan 11 - Sat, Jan 17
FLR
Florence
TYS
Knoxville
$728 Roundtrip, found 6 days ago
$728
Roundtrip
found 6 days ago
Select Lufthansa flight, departing Sun, Jan 11 from Florence to Knoxville, returning Sat, Jan 17, priced at $728 found 6 days ago
Lufthansa
Sun, Jan 11 - Sat, Jan 17
FLR
Florence
TYS
Knoxville
$730 Roundtrip, found 6 days ago
$730
Roundtrip
found 6 days ago
Select Lufthansa flight, departing Sun, Jan 11 from Florence to Knoxville, returning Sat, Jan 17, priced at $730 found 6 days ago
United
Tue, Nov 25 - Wed, Dec 3
FLR
Florence
TYS
Knoxville
$743 Roundtrip, found 2 days ago
$743
Roundtrip
found 2 days ago
Select United flight, departing Tue, Nov 25 from Florence to Knoxville, returning Wed, Dec 3, priced at $743 found 2 days ago
Lufthansa
Sun, Jan 11 - Sat, Jan 17
FLR
Florence
TYS
Knoxville
$746 Roundtrip, found 6 days ago
$746
Roundtrip
found 6 days ago
Select Lufthansa flight, departing Sun, Jan 11 from Florence to Knoxville, returning Sat, Jan 17, priced at $746 found 6 days ago
Lufthansa
Sun, Jan 11 - Sat, Jan 17
FLR
Florence
TYS
Knoxville
$748 Roundtrip, found 6 days ago
$748
Roundtrip
found 6 days ago
Select Lufthansa flight, departing Sun, Jan 11 from Florence to Knoxville, returning Sat, Jan 17, priced at $748 found 6 days ago
United
Tue, Nov 25 - Wed, Dec 3
FLR
Florence
TYS
Knoxville
$749 Roundtrip, found 2 days ago
$749
Roundtrip
found 2 days ago
Select United flight, departing Tue, Nov 25 from Florence to Knoxville, returning Wed, Dec 3, priced at $749 found 2 days ago
Delta
Tue, Nov 25 - Wed, Dec 3
FLR
Florence
TYS
Knoxville
$752 Roundtrip, found 2 days ago
$752
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, Nov 25 from Florence to Knoxville, returning Wed, Dec 3, priced at $752 found 2 days ago
Delta
Tue, Nov 25 - Wed, Dec 3
FLR
Florence
TYS
Knoxville
$758 Roundtrip, found 2 days ago
$758
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, Nov 25 from Florence to Knoxville, returning Wed, Dec 3, priced at $758 found 2 days ago
Swiss International Air Lines
Tue, Nov 25 - Wed, Dec 3
FLR
Florence
TYS
Knoxville
$766 Roundtrip, found 2 days ago
$766
Roundtrip
found 2 days ago
Select Swiss International Air Lines flight, departing Tue, Nov 25 from Florence to Knoxville, returning Wed, Dec 3, priced at $766 found 2 days ago
KLM
Tue, Nov 25 - Wed, Dec 3
FLR
Florence
TYS
Knoxville
$780 Roundtrip, found 2 days ago
$780
Roundtrip
found 2 days ago
Select KLM flight, departing Tue, Nov 25 from Florence to Knoxville, returning Wed, Dec 3, priced at $780 found 2 days ago

Alternative airports near Knoxville

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to McGhee Tyson TYS. Cheapest and Closest option available. Average driving time to city center is 22 minutes. Flights from $782
TYS
McGhee Tyson
CheapestClosest
Average driving time to city center22 min
Flights from $782
Flights from Florence (FLR) to Knoxville (TYS)
Origin airport
Peretola
Destination airport
McGhee Tyson
Roundtrip price
$728
Distance
4794 mi

Florence to Knoxville Flights

The cheapest times to fly from Florence to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Florence to Knoxville are during the month of January. You can find some of the cheapest flights from Florence to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Florence to Knoxville

Sunday is one of the best days to book for cheap flights from Florence to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Florence to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Florence to Knoxville in 2025. You can also book with separate airlines for your outbound and return journeys, from $421 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Florence to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Florence to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Peretola Airport (FLR) to McGhee Tyson Airport (TYS) cost?
Get a cheap one-way flight from $421 or cheap return flight from $728 from Peretola Airport (FLR) to McGhee Tyson Airport (TYS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Peretola Airport (FLR) to McGhee Tyson Airport (TYS)?
January is the least expensive month to fly from FLR to TYS. Traveling during an off-peak travel window is often the key to landing a great deal.
What is the cheapest airline that flies from Peretola Airport (FLR) to McGhee Tyson Airport (TYS)?
To find the cheapest airline that'll fly you from FLR to TYS, use Expedia's filter tool. Customize your search based on your travel style, such as preferred carriers and flight duration. You can then sort your results by "Price (lowest to highest)" to discover the cheapest flight right away.
How many flights per day from Peretola Airport (FLR) to McGhee Tyson Airport (TYS)?
There are no daily nonstop flights departing from Peretola Airport (FLR) to McGhee Tyson Airport (TYS). But you can book flights with layovers. Filter your search on Expedia to include one or more stops, and you'll be cruising above the clouds in no time.
What day of the week has the most flights from FLR to TYS?
You'll typically find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can change from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Peretola Airport (FLR) to McGhee Tyson Airport (TYS)?
To arrive at McGhee Tyson Airport (TYS) without delays, choose a flight that leaves from Peretola Airport (FLR) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Peretola Airport (FLR) to McGhee Tyson Airport (TYS) last-minute?
Holding off until just before your departure to book a ticket from FLR to TYS generally means paying more. While it's possible to find some last-minute offers, they're not always guaranteed. Allow some flexibility in your schedule to maximize your chances of landing a bargain.
Is it cheaper to book a FLR to TYS flight and hotel package?
Compared with arranging hotels and flights separately, booking a FLR to TYS flight and hotel package with Expedia could result in significant savings. Better yet, having everything in one easy place will take the hassle out of travel planning. Just secure your flights and choose from our wide range of hotels, then customize your trip with other add-ons like tours, car rentals and activities.
Can I cancel or change the date of my flight from Peretola Airport (FLR) to McGhee Tyson Airport (TYS)?
In most cases, you can cancel or modify your FLR to TYS flight. However, there may be additional fees, especially if you made your booking over 24 hours ago. Double-check your itinerary for the airline's guidelines and fees on flight changes, or if you want further details, go to our Customer Service portal.

Explore a world of travel with Expedia

*Available to One Key members.