Adrian, TX

Travel Guide

Route 66 midpoint sign
Route 66 midpoint sign
The midway point along Route 66
Midway point of historic Route 66 between Chicago and Los Angeles (both 1139 miles) in Adrian, Texas
Adrian is just off Interstate 40. It is also the midpoint of the historic Route 66. From here it is 1139 miles East to Chicago and 1139 miles West to Los Angeles. There is also Midpoint Cafe, a 50's style diner with a great burger and fries. However, if you stop you have to ask about their "Ugly Pie."
Capital O Route 66 Country Inn Vega Tx

Capital O Route 66 Country Inn Vega Tx

2.5 out of 5
1800 West Vega Boulevard Vega TX
Fully refundableReserve now, pay when you stay
$77 nightly
The price is $85 total per night from Feb 8 to Feb 9
$85 total
Feb 8 - Feb 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Vega. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ...
7.6/10 Good! (359 reviews)
We enjoyed a quick one night stay while driving across the country, happy to have found this motel as there are few options in this remote area. The new owners are wonderful and doing a great job. Clean, comfortable, quiet and safe. Pet friendly. And… the hosts provide everyone with coffee and a ...

Reviewed on Jan 8, 2026

Capital O Route 66 Country Inn Vega Tx
Days Inn by Wyndham Vega TX

Days Inn by Wyndham Vega TX

2 out of 5
1005 S Main St Vega TX
$81 nightly
The price is $90 total per night from Feb 10 to Feb 11
$90 total
Feb 10 - Feb 11
Total with taxes and fees
Stay at this hotel in Vega. Enjoy free breakfast, free WiFi, and free parking. Popular attraction Magnolia Gas Station is located nearby.
6.6/10 (399 reviews)
We had a clean room with a good bed.

Reviewed on Jan 9, 2026

Days Inn by Wyndham Vega TX
Bonanza Motel Vega

Bonanza Motel Vega

2 out of 5
607 Vega Blvd Vega TX
Fully refundableReserve now, pay when you stay
$62 nightly
The price is $69 total per night from Feb 8 to Feb 9
$69 total
Feb 8 - Feb 9
Total with taxes and fees
Stay at this motel in Vega. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attraction Magnolia Gas Station is located nearby.
8/10 Very Good! (370 reviews)
Everything about the room was satisfactory.

Reviewed on Dec 29, 2025

Bonanza Motel Vega
See all 21 properties in Adrian
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street Houston TX
Book a stay at this luxury aparthotel in Houston. Enjoy free WiFi, a full-service spa, and a rooftop terrace. Our guests praise the helpful staff in our reviews. ...
8.8/10 Excellent! (1,892 reviews)
Great location

Reviewed on Feb 1, 2026

Hotel Zaza Houston Museum District
Canvas Hotel Dallas

Canvas Hotel Dallas

4 out of 5
1325 S Lamar St Dallas TX
Book a stay at this boutique aparthotel in Dallas. Enjoy free WiFi, free parking, and a rooftop terrace. Our guests praise the pool and the helpful staff in ...
8.8/10 Excellent! (2,846 reviews)
Have no complaints this place is fantastic

Reviewed on Feb 1, 2026

Canvas Hotel Dallas
Casa De La Sirena--Beachfront Retreat in Spanish Grant!

Casa De La Sirena--Beachfront Retreat in Spanish Grant!

2 out of 5
Galveston TX
Book a stay at this beach vacation home in Galveston. Enjoy a beach locale, laundry facilities, and patios. Popular attractions Galveston Island Beaches and ...
9.4/10 Exceptional! (72 reviews)
We had a very good stay at this beach house. Our only disappointment was that the living room storm shutters didn’t open , but the owner had let us know ahead of time.

Reviewed on Sep 23, 2025

Casa De La Sirena--Beachfront Retreat in Spanish Grant!
See all 81,593 properties in Texas
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Midway Point of Route 66

You can find out about the history of Adrian with a stop at Midway Point of Route 66. Discover the area's museums and shops.

Midway Point of Route 66

Cities near Adrian

Cow at sunset

Vega

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