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Compare 23 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Quality Inn Cairo I-57

2.5 star property
6.6 out of 10, (262)
"The hotel is in need of some serious upkeep and cleaning. It is in fairly poor condition, but it the only hotel in town."
$74 nightly
The price is $82
Aug 3 - Aug 4
Total includes taxes and fees
Quality Inn Cairo I-57

La Center Motel

2.0 star property
7.8 out of 10, Good, (14)
"Front desk staff was amazing. Room was comfy and quiet! Clean! Husband and I needed a place to crash on our long ride home and this motel did not disappoint!"
$59 nightly
The price is $63
Jul 28 - Jul 29
Total includes taxes and fees
La Center Motel

Eagle Inn Charleston

2.0 star property
6.8 out of 10, (100)
"Comfortable bed, easy access to room"
$66 nightly
The price is $73
Jul 28 - Jul 29
Total includes taxes and fees
Eagle Inn Charleston

Super 8 by Wyndham Charleston/Sikeston East MO

2.0 star property
6.6 out of 10, (576)
"Everything worked like it should and bed was comfortable "
$64 nightly
The price is $71
Aug 3 - Aug 4
Total includes taxes and fees
Super 8 by Wyndham Charleston/Sikeston East MO

Quality Inn Charleston - Sikeston

2.5 star property
6.8 out of 10, (394)
"Very efficient staff was assigned a ground floor room in a very quiet area. Great staff."
$69 nightly
The price is $76
Jul 30 - Jul 31
Total includes taxes and fees
Quality Inn Charleston - Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about Cairo

Escape to quaint Cairo! Enjoy its ruins, history, and entertainment.

Stay near popular Cairo attractions

Fort Defiance State Park

Fort Defiance State Park

You can take time to visit Fort Defiance State Park during your travels to Cairo. Stroll along the riverfront or visit the churches while you're in the area.

Top Cairo Hotel Reviews

Find out more about Cairo

Find out more about Cairo

Top reasons to visit Cairo

  • Scenic Outdoor Adventures: Cairo, Illinois, is a haven for outdoor enthusiasts, featuring recreational areas and scenic parks perfect for hiking and relaxation.
  • Historic Charm: The city's rich history is reflected in its educational sites and notable statues, providing cultural insights for visitors.
  • Paducah Riverwalk: Enjoy picturesque views along the Paducah Riverwalk, ideal for leisurely strolls and photography.
  • Family-Friendly Attractions: Cairo offers various activities suitable for families, ensuring fun for all ages.
  • Diverse Accommodations: A range of budget-friendly hotels and motels cater to every traveler's needs, making your stay comfortable.

Find great hotels in Cairo

Cairo, Illinois, offers a diverse selection of hotels and motels, perfect for travelers seeking budget-friendly or comfortable accommodations. With options ranging from 2 to 3.5 stars, visitors can enjoy a variety of amenities tailored for families, business travelers, and pet owners. Whether you're searching for the best hotels in Cairo or looking for nearby options in Cape Girardeau or Rosemont, you'll discover welcoming places to unwind during your stay.

  • Auburn Place Hotel And Suites: Located 30 miles from Cairo, Auburn Place Hotel And Suites is a perfect choice for travelers seeking a blend of business and pet-friendly accommodations. This hotel caters to business needs with amenities such as a 24-hour business center and meeting rooms, ensuring a productive stay. Pet owners will appreciate the welcoming environment, with specific policies allowing pets and service animals. Enjoy a comfortable stay while balancing work and leisure at this versatile property.
  • Pear Tree Inn Cape Girardeau West: Also situated 30 miles from Cairo, Pear Tree Inn Cape Girardeau West is an excellent family-friendly option that doesn’t compromise on business amenities. With a 24-hour business center and free cribs for children, it’s designed to accommodate families traveling for both leisure and work. The hotel is pet-friendly, permitting pets with certain restrictions, which makes it ideal for those who want to bring their furry friends along. Experience a welcoming atmosphere that caters to all your needs.
  • Drury Plaza Hotel Cape Girardeau Conference Center: A 3-star hotel located 30 miles from Cairo, Drury Plaza Hotel Cape Girardeau Conference Center offers a comprehensive experience for families and business travelers alike. With multiple meeting rooms, a conference center, and a 24-hour business center, it’s equipped for productive stays. Families will find amenities like free cribs, while pet lovers can enjoy the convenience of bringing their dogs and cats with them. This hotel strikes a perfect balance between comfort, convenience, and family-friendly service.

Discover the best areas to stay in Cairo

Cairo, Illinois, offers a delightful blend of outdoor adventures and historical charm. Nestled near the confluence of the Mississippi and Ohio Rivers, this unique city invites travelers to explore scenic parks and family-friendly attractions. Just a short drive away, you can discover vibrant neighborhoods and excursions in nearby Kentucky and other cities. Whether you're seeking a peaceful getaway or an exciting adventure, Cairo is a perfect base for your vacation experience.

  • Cape Girardeau: Located 28 miles from Cairo, Cape Girardeau is a vibrant city known for its outdoor adventures and scenic landscapes. Visitors flock here primarily in the spring and early summer months, drawn by the recreational areas, a lively casino, and educational attractions. The city is surrounded by natural beauty, featuring a national park, serene lakes, and lush forests, making it an ideal destination for nature lovers and thrill-seekers alike.
  • Wickliffe: Just 6 miles from Cairo, Wickliffe is a charming city that offers a blend of outdoor fun and cultural experiences. The best times to visit are in the spring and late summer, when travelers can enjoy the local arts center, relaxing resorts, and expansive recreational areas. Highlights include nearby lakes and a national state park, perfect for hiking and picnicking, ensuring a delightful escape into nature.
  • Mound City: Also situated 6 miles from Cairo, Mound City is perfect for outdoor enthusiasts seeking adventure and picturesque scenery. The peak travel months are March, July, and October, attracting visitors to its beautiful golf courses and recreational areas. With attractions such as a national park, tranquil lakes, and surrounding forests, Mound City promises a refreshing getaway for those looking to explore the great outdoors.

Things to do in Cairo

Cairo, Illinois, offers a delightful mix of outdoor adventures and scenic beauty. Visitors can explore the recreational areas, enjoy a round of golf at the local golf course, and stroll along the Paducah Riverwalk, taking in the picturesque views. With various attractions to discover, Cairo is perfect for those seeking adventure and relaxation in a charming small-town setting.

Food and drinks

In Cairo, Illinois, indulge in local flavors at The Landing Restaurant, known for its hearty American fare, and visit The Riverfront Wine Bar for a delightful selection of wines. For a unique experience, check out The Red Fox for classic comfort food with a twist.

Adventure

Limekin Springs Trail Trailhead offers an exhilarating hiking experience located 20 miles from Cairo. The trail features stunning outdoor scenery, perfect for adventurers seeking a mix of nature and excitement. Enjoy breathtaking views, wildlife encounters, and the invigorating atmosphere of the great outdoors.

Booking tips and Expedia advantages for Cairo

To save money on your trip to Cairo, Illinois, consider visiting during the off-peak months of July and November to December for lower accommodation rates. Use Expedia’s search tool to find budget-friendly, eco-certified hotels, and take advantage of package deals by combining flights and activities. Joining Expedia's One Key membership can also provide exclusive discounts and the chance to earn OneKeyCash for future stays. For public transport, walking is a great option to explore the city without additional costs. Always check for the latest hotel deals to maximize your savings.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in Cairo are July and November to December, where the prices are slightly lower. This is in comparison to February to April, where prices are slightly higher.
  • Find cheap hotels on Expedia: Utilize Expedia’s search tool to refine your choices based on your budget, desired location, and preferred hotel type. For instance, selecting the "Eco-certified" filter will showcase sustainable and eco-friendly accommodations currently available. To find the best prices and deals, simply adjust the price filter to sort from lowest to highest.
  • Consider bundling your trip: You can save money by combining your hotel reservations in Cairo with your flights and activities through an Expedia package deal.
  • Become a One Key member: Join Expedia's One Key membership program for exclusive discounts and deals on hotel bookings. You can also earn OneKeyCash to use on future selected hotels.

Find the best attractions in Cairo

Cairo, Illinois, is perfect for outdoor lovers and adventure seekers, offering a blend of scenic beauty and cultural experiences. Visitors can explore educational sites, national parks, and notable statues, making it an ideal destination for families and those interested in nature and culture. Whether you’re hiking in the parks or enjoying local heritage, Cairo promises a memorable vacation filled with diverse activities.

  • Ballard Wildlife Management Area: Just 5 miles from Cairo, this wildlife reserve offers a serene escape into nature. Perfect for birdwatching and photography, visitors can enjoy the historical significance of the area while exploring its diverse ecosystems, all without breaking the bank.
  • Fort Defiance State Park: Nestled within Cairo, this historic fort presents an opportunity to delve into local culture and history. With scenic views where the Mississippi and Ohio rivers converge, it's an ideal spot for leisurely walks and picnics.
  • Columbus-Belmont State Park: Located 17 miles away, this national park is perfect for outdoor enthusiasts. Offering hiking trails, fishing, and stunning scenery, visitors can immerse themselves in adventure while appreciating the park's rich Civil War history.

Best time to go to Cairo

The best time to visit Cairo can depend on the weather and when visitor numbers rise and fall. The hottest average temperature in Cairo falls in July, when visitor numbers are average and weather is mostly sunny with light rain. The coolest average temperature in Cairo falls in January, visitor numbers are moderately low and weather is mostly sunny with light rain.

calendar iconCalendar Monthtemperature iconTemperaturerain iconPrecipitationmostly cloudy iconCloudinessoccupation rate iconOccupancyprice iconPricing
January35.2°F (1.8°C)Light RainMostly SunnyModerately LowAverage
February38.5°F (3.6°C)Light RainMostly SunnyModerately LowSlightly High
March48.7°F (9.3°C)Light RainMostly SunnyModerately HighSlightly High
April57.7°F (14.3°C)Light RainMostly SunnyModerately HighSlightly High
May67.5°F (19.7°C)Light RainMostly SunnyAverageAverage
June76.5°F (24.7°C)Light RainMostly SunnyAverageAverage
July79.0°F (26.1°C)Light RainMostly SunnyAverageSlightly Low
August77.2°F (25.1°C)Light RainMostly SunnyModerately HighAverage
September71.6°F (22.0°C)Light RainMostly SunnyAverageAverage
October60.1°F (15.6°C)Light RainMostly SunnyAverageAverage
November47.8°F (8.8°C)Light RainMostly SunnyModerately LowSlightly Low
December40.6°F (4.8°C)Light RainMostly SunnyAverageSlightly Low

The nearest major airports for your trip to Cairo

Traveling to Cairo, Illinois is convenient with several nearby airports. Paducah, KY (PAH-Barkley Regional) is located 23 miles away and features hotel options like The Respite Bed and Breakfast, Harrah's Metropolis Hotel & Casino, and The 1857, all within 10 miles of the airport. Marion, IL (MWA-Williamson County Regional) is 52 miles from Cairo, offering accommodations such as Drury Inn & Suites Marion and Holiday Inn Carbondale-Conference Center, both within 8 miles. Cape Girardeau, MO (CGI-Cape Girardeau Municipal) is 26 miles away, with excellent hotels including Drury Inn & Suites Cape Girardeau and Courtyard by Marriott Cape Girardeau Downtown, both about 6 miles from the airport.

Frequently asked questions

What are the best budget hotels in Cairo?
Quality Inn Cairo I-57 stands out as a fantastic budget-friendly option for travelers seeking comfort and convenience without breaking the bank. This hotel offers a range of amenities designed to make your stay enjoyable and stress-free, including complimentary full breakfast and free WiFi, ensuring you stay connected and well-fed during your adventures. View all budget hotels in Cairo.
When is the best time to go to Cairo?
The most popular time to visit Cairo is during the spring months of March to May. During this period, the weather is pleasantly warm, with average temperatures ranging from the mid-70s to low 80s Fahrenheit, making it superb for exploring the city's iconic landmarks like the Pyramids of Giza and the Egyptian Museum.

As you plan your visit, you'll find that this peak season attracts many travelers eager to experience Cairo's rich history and vibrant culture. The pleasant climate allows for comfortable outdoor activities, whether you're wandering through bustling markets or enjoying a leisurely felucca ride on the Nile River.

For those who appreciate a more tranquil experience, October can be an excellent time to visit. The temperatures begin to cool down, and the crowds are fewer, allowing for a more intimate exploration of the city's treasures. This month also offers the opportunity to immerse yourself in local events and festivals, giving you a deeper understanding of Egyptian traditions.
Can I cancel my hotel reservation on Expedia?
Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline – this is often within 24-48 hours of your scheduled arrival. If you have a non-refundable booking, it might still be possible to receive a refund if you cancel it within 24 hours of booking. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use our "Fully refundable property" filter during your search to find the right Cairo hotel for you.
How can I save on a Cairo hotel booking with Expedia?
With Expedia, you earn OneKeyCash™* on eligible Cairo hotel bookings for every dollar you spend – just join our One Key™ travel rewards program to get started. It's free to join, and you'll unlock our lowest Member Prices as soon as you're signed in. On top of this, you could also save significantly by bundling your hotel and flights together on Expedia.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a Cairo hotel?
Prices for hotels in Cairo often vary, but you can find a great deal from $63 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.