Photo by Michael True
Find all hotels by Independent in Defiance, MO from $66
Upfront pricingOur total price for your stay includes taxes and fees
Treat yourselfSave 10% or more on over 100,000 hotels worldwide with Member Prices
Be pickySearch almost a million properties worldwide
Check prices for these dates
Our top choices for Defiance Independent
6.6 out of 10, (1007)
"Great place to stay "
Askar
$58 nightly
The price is $67
Dec 24 - Dec 25
Total with taxes and fees
9.2 out of 10, Wonderful, (1609)
"Great place!"
Biju
$95 nightly
The price is $111
Dec 29 - Dec 30
Total with taxes and fees
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport WestMaryland Heights
7.4 out of 10, Good, (1003)
"Clean lobby, super friendly staff, effortless check in. There’s even a small market with food and essentials right next to the check in desk. "
Jen
$59 nightly
The price is $69
Jan 6 - Jan 7, 2026
Total with taxes and fees
6.4 out of 10, (506)
"Parking field safe just off the side of the highway wentzville police is always patrolling actually I was here on Thanksgiving and guess what they had Thanksgiving Day plates they were handing out to people"
Christopher
$60 nightly
The price is $68
Dec 16 - Dec 17
Total with taxes and fees
5.2 out of 10, (401)
"Nice"
Quentin
$54 nightly
The price is $66
Dec 16 - Dec 17
Total with taxes and fees
8.8 out of 10, Excellent, (133)
"Great place for a weekend getaway! The Inn was clean, staff is extremely helpful. The Inn is within walking distance with unique shops, restaurants, anything you needed."
Angelia
$132 nightly
The price is $151
Dec 16 - Dec 17
Total with taxes and fees
6.4 out of 10, (15)
"Staff was courteous and responsive. "
Paul
$62 nightly
The price is $71
Dec 16 - Dec 17
Total with taxes and fees
5.6 out of 10, (30)
"I enjoyed it! And the owners were so sweet and understanding. I would absolutely stay there again!"
Evelyn
$68 nightly
The price is $76
Jan 9 - Jan 10, 2026
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Top Defiance Hotel Reviews
Best Western Plus The Charles Hotel
10/10 Excellent
Explore a world of travel with Expedia
- Hotels near Yellow Farmhouse Winery
- Hotels near Chandler Hill Vineyards
- Hotels near Sugar Creek Winery
- Hamburg Hotels
- Saint Albans Hotels
- Villas in Saint Albans
- Cottages in Saint Albans
- Vacation Homes in Saint Albans
- Hotels near Historic Daniel Boone Home and Heritage Center
- Hotels near Babler State Park
- Hotels near Dr. Edmund A. Babler Memorial State Park
- Hotels near Weldon Spring Site Interpretive Center
- Hotels near Montelle Winery
- Hotels near August A. Busch Memorial Conservation Area
- Hotels near Broemmelsiek Park
- Drury Inn & Suites Hotels in Augusta
- Wyndham Hotels in Weldon Spring Heights
- Augusta Hotels
- B&B in Augusta
- Cottages in Augusta
- RV Parks in Augusta
- Romantic Hotels in Augusta
- Cabin Rentals in Augusta
- Hotels with Hot Tubs in Augusta
- Lodges in Augusta
- Resorts & Hotels with Spas in Augusta
- Chalets in Augusta
- Hotels & Resorts for Couples in Augusta
- Historic Hotels in Augusta
- 5 Star Hotels in Augusta
- 3 Star Hotels in Augusta
- Motels in Augusta
- Villas in Augusta
- Winery Hotels in Augusta
- Guest Houses in Augusta
- Hotels near St. Louis Premium Outlets
- Weldon Spring Heights Hotels
- B&B in Weldon Spring Heights
- Chalets in Weldon Spring Heights
- Motels in Weldon Spring Heights
- 4 Star Hotels in Weldon Spring Heights
- Cabin Rentals in Weldon Spring Heights
- 3 Star Hotels in Weldon Spring Heights
- Villas in Weldon Spring Heights
- Hotels near Missouri Bluffs Golf Course
- Hotels near Augusta Winery
- Weldon Spring Hotels
- Hotels near Spirit of St. Louis
- Hotels near Noboleis Vineyard
- Flights from Saint Albans
- Flights from Augusta
- Flights to Weldon Spring Heights
- Flights from Spirit of St. Louis
- Flights from Poplar Bluff (POF) to St. Louis (SUS)
- Flights from St. Louis (STL) to St. Louis (SUS)
- Flights from Mount Vernon (MVN) to St. Louis (SUS)
- Flights from Grand Rapids (GRR) to St. Louis (SUS)
- Flights from Los Angeles (LAX) to St. Louis (SUS)
- Flights from Joplin (JLN) to St. Louis (SUS)
- Flights from Atlanta (ATL) to St. Louis (SUS)
- Flights from Enid (WDG) to St. Louis (SUS)
- Flights from Minneapolis (MSP) to St. Louis (SUS)
- Flights from Detroit (DTW) to St. Louis (SUS)
- Flights from Las Vegas (LAS) to St. Louis (SUS)
- Flights from Lexington (LEX) to St. Louis (SUS)
- Flights from Chicago (ORD) to St. Louis (SUS)
- Flights from Kansas City (MCI) to St. Louis (SUS)
- Flights from Nashville (BNA) to St. Louis (SUS)
- Flights from Philadelphia (PHL) to St. Louis (SUS)
- Flights from Cincinnati (CVG) to St. Louis (SUS)
- Flights from Denver (DEN) to St. Louis (SUS)
- Yellow Farmhouse Winery
- Chandler Hill Vineyards
- Sugar Creek Winery
- Visit Saint Albans
- Historic Daniel Boone Home and Heritage Center
- Babler State Park
- Dr. Edmund A. Babler Memorial State Park
- Weldon Spring Site Interpretive Center
- Montelle Winery
- August A. Busch Memorial Conservation Area
- Broemmelsiek Park
- Augusta Vacations
- Visit Weldon Spring Heights
- St. Louis Premium Outlets
- Missouri Bluffs Golf Course
- Augusta Winery
- Car rentals near Hamburg
- Car rentals near Saint Albans
- Car rentals near Babler State Park
- Car rentals near Augusta
- Midway Car Rental Rental Cars in Augusta
- Car rentals near Weldon Spring Heights
- Car rentals near Weldon Spring
- Car rental St. Louis Airport (SUS)
- Enterprise Rental Cars in Spirit of St. Louis
- Budget Rental Cars in Spirit of St. Louis