Medical District Vacations from $264

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Your Medical District Vacation

Our Medical District vacation packages are an easy and handy way to plan and book your next getaway. Discover the true character of this unique neighborhood without the burden of organizing everything yourself. When it's time to sightsee, you'll find plenty of top attractions nearby including Memphis Zoo, Orpheum Theatre and Sun Studio. Visit one, two (or even all!) during your trip to Medical District. Whatever your dream Medical District vacation looks like, you can turn it into reality with Expedia.

The Latest Medical District Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hu. Hotel
Memphis Riverline Hotel
River Inn of Harbor Town
Residence Inn by Marriott Memphis Downtown
The Moose

Where to stay in Medical District

Find the best Medical District areas and neighborhoods for the activities you enjoy most. Learn more about Medical District

Medical District Hotel Deals

Motel 6 Memphis, TN - Downtown

Motel 6 Memphis, TN - Downtown

2 out of 5
210 S Pauline St Memphis TN
$49 nightly
The price is $60 total per night from Dec 7 to Dec 8
$60 total
Dec 7 - Dec 8
Total with taxes and fees
5.4/10 (1,001 reviews)
"Staff very unfriendly and not helpful. No room service whatsoever. We were there for 4 days, our bin was emptied on last day when we also received fresh towels. Had issues with TV but no maintenance guy arrived. If you’re a tourist do yourself a favour and DO NOT stay here."

Reviewed on Nov 14, 2026

Motel 6 Memphis, TN - Downtown
Kings Inn

Kings Inn

2 out of 5
42 S Camilla St Memphis TN
$59 nightly
The price is $71 total per night from Dec 15 to Dec 16
$71 total
Dec 15 - Dec 16
Total with taxes and fees
Kings Inn
Hu. Hotel

Hu. Hotel

3.5 out of 5
79 Madison Avenue Memphis TN
Fully refundableReserve now, pay when you stay
$102 nightly
The price is $123 total per night from Dec 15 to Dec 16
$123 total
Dec 15 - Dec 16
Total with taxes and fees
8.4/10 Very Good! (2,510 reviews)
"Hotel needed a much needed renovation. Not my quality of hotel. But, the staff was amazing. It was so conveniently located to everything."

Reviewed on Nov 14, 2026

Hu. Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Medical District attractions

Things to do

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.