Medical District Vacations from $612

Book a Hotel + Flight or Car together to unlock savings

Photo by Georgie
  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Your Medical District Vacation

Our Medical District vacation packages are an easy and handy way to plan and book your next getaway. Discover the true character of this unique neighborhood without the burden of organizing everything yourself. When it's time to sightsee, you'll find plenty of top attractions nearby including Memphis Zoo, Orpheum Theatre and Sun Studio. Visit one, two (or even all!) during your trip to Medical District. Whatever your dream Medical District vacation looks like, you can turn it into reality with Expedia.

The Latest Medical District Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Magnolia Inn And Suites

Magnolia Inn And Suites

$612
per person
Oct 13 - Oct 16
found 15 hours ago
Roundtrip non-stop flight included
New York (JFK) to Memphis (MEM)
8/10 Very Good! (1,013 reviews)
Sleep Inn Horn Lake - Southaven

Sleep Inn Horn Lake - Southaven

$642
per person
Oct 13 - Oct 16
found 15 hours ago
Roundtrip non-stop flight included
New York (JFK) to Memphis (MEM)
7.8/10 Good! (763 reviews)
Best Western Plus Goodman Inn & Suites

Best Western Plus Goodman Inn & Suites

$658
per person
Oct 13 - Oct 16
found 17 hours ago
Roundtrip non-stop flight included
New York (JFK) to Memphis (MEM)
8/10 Very Good! (604 reviews)
Odd shaped room but good sized, there was a space that must have been used in past for something but I can’t imagine what! I liked the amenities-they were actual bottles of shampoo, etc. Bed pillows were terrible, they were simply throw pillow sized hardish blobs. My biggest complaint was the carpet. Most of the time I wear flip flops but occasionally I make a few steps barefoot. When I stepped into the shower I left BLACK footprints, totally disgusting. Carpet needs shampooing in the worst way.

Reviewed on Sep 7, 2026

Comfort Inn Horn Lake - Southhaven

Comfort Inn Horn Lake - Southhaven

$683
per person
Oct 13 - Oct 16
found 15 hours ago
Roundtrip non-stop flight included
New York (JFK) to Memphis (MEM)
8.2/10 Very Good! (653 reviews)
NA

Reviewed on Aug 31, 2026

Comfort Suites Southaven - Memphis South

Comfort Suites Southaven - Memphis South

$701
per person
Oct 13 - Oct 16
found 15 hours ago
Roundtrip non-stop flight included
New York (JFK) to Memphis (MEM)
7.8/10 Good! (1,003 reviews)
We had a great stay at Comfort Suites! The hotel was clean, comfortable, and very welcoming. The staff was friendly and helpful throughout our stay, and our room was clean and well maintained. Everything was convenient and made our trip that much more enjoyable. We had a very pleasant experience and would definitely stay here again. Highly recommend!

Reviewed on Sep 8, 2026

Where to stay in Medical District

Find the best Medical District areas and neighborhoods for the activities you enjoy most. Learn more about Medical District
A bustling street lined with neon signs and a crowd of people walking.

Downtown Memphis

4 out of top 10 points of interest in this area

Home to the Memphis Redbirds and Grizzlies NBA team, this central business district offers entertainment, dining, and attractions like Beale Street, FedExForum, and AutoZone Park. Easily accessible via major highways and public transit options.

A large stone building with a green roof, arched windows, and a central entrance.

East Memphis

2 out of top 10 points of interest in this area

East Memphis is beloved for its popular shops. Take some time to explore sights in the area like Theatre Memphis and Memphis Botanic Garden.

A building with Egyptian-themed columns and hieroglyphs, a tall obelisk, and a crowd of people.

Midtown

1 out of top 10 points of interest in this area

Immerse yourself in the arts scene with institutions like Playhouse on the Square and Brooks Museum of Art, or explore Overton Park's Memphis Zoo. Enjoy live music at Cooper-Young's vibrant bars and restaurants, and easily navigate via bike lanes and trolley lines.

A pink Cadillac with chrome detailing, parked indoors.

Whitehaven

1 out of top 10 points of interest in this area

Graceland mansion, a major tourist attraction, and the renovated David Carnes Park await visitors in this South Memphis neighborhood. Do some shopping at Southland Mall or explore along Elvis Presley Boulevard.

A cityscape with a prominent bridge, a river, and a large building with a unique architectural design.

Southwind

Travelers come to Southwind for its abundant dining options, and you can see top attractions like Mike Rose Soccer Complex and TPC Southwind while you're in town.

Medical District Hotel Deals

Motel 6 Memphis, TN - Downtown

Motel 6 Memphis, TN - Downtown

210 S Pauline St Memphis TN
Fully refundableReserve now, pay when you stay
$48 nightly
$59 total
Sep 21 - Sep 22
Total with taxes and fees
5.4/10 (1,009 reviews)
"ac broken; alternate room tv broken; staff n phone entire time and didn't care. i went somewhere else"

Reviewed on Sep 8, 2026

Motel 6 Memphis, TN - Downtown
Kings Inn

Kings Inn

42 S Camilla St Memphis TN
Fully refundableReserve now, pay when you stay
$52 nightly
$64 total
Sep 10 - Sep 11
Total with taxes and fees
6.6/10 (75 reviews)
"Trash around the building. Rooms doesn’t have fridge or microwave and the laundry room only has one washer/dryer. The dryer didn’t dry my clothes fully so I told the front desk. He eventually gave me a refund with a side-eye."

Reviewed on Sep 4, 2026

Kings Inn
Hu. Hotel

Hu. Hotel

79 Madison Avenue Memphis TN
Fully refundableReserve now, pay when you stay
$93 nightly
$112 total
Sep 27 - Sep 28
Total with taxes and fees
Hu. Hotel
See all 1,524 properties in Medical District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Medical District attractions

Sun Studio

9.2/10 (679 reviews)
Known as The Birthplace of Rock and Roll, this recording studio presents a trip down memory lane with music icons such as Elvis Presley and Johnny Cash.
See properties

NAACP Memphis

Find out about the history of Memphis with a stop at NAACP Memphis.
See properties

Hunt-Phelan Home

You can find out about the history of Memphis with a trip to Hunt-Phelan Home. Experience the area's great live music and acclaimed theater scene.
See properties

Things to do

Memphis: Stax Museum of American Soul Music

Memphis: Stax Museum of American Soul Music

$20
per adult
94% of travellers recommend
Memphis: Stax Museum of American Soul Music
Haunted Memphis Walking Ghost Tour

Haunted Memphis Walking Ghost Tour

$30
per adult
84% of travellers recommend
Haunted Memphis Walking Ghost Tour
Mobsters, Mayhem, & Murder of Memphis Ghost Tour

Mobsters, Mayhem, & Murder of Memphis Ghost Tour

$32
per adult
Mobsters, Mayhem, & Murder of Memphis Ghost Tour
See all activities in Memphis

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.