Find Extended Stay Hotels in Lake City, SC

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Top Lake City Extended Stay Hotels | Reserve now, pay later

Fridge, microwave, oven, stovetop
Walking distance from one of South Carolina's top Medical centers.

Walking distance from one of South Carolina's top Medical centers.

Florence
9.8 out of 10, Exceptional, (42)
"The house was beautiful. We would stay there again!!"
United States
Stephanie L.
$208 nightly
The price is $233
Dec 7 - Dec 8
Total with taxes and fees
Walking distance from one of South Carolina's top Medical centers.
Exterior
TownePlace Suites by Marriott Florence

TownePlace Suites by Marriott Florence

3.0 star property
Florence
9.0 out of 10, Wonderful, (697)
"Good stay, great staff"
United States
James
$99 nightly
The price is $111
Dec 7 - Dec 8
Total with taxes and fees
TownePlace Suites by Marriott Florence
Free daily on-the-go breakfast
Homewood Suites by Hilton Florence

Homewood Suites by Hilton Florence

3.0 star property
Florence
8.4 out of 10, Very Good, (657)
"The staff was amazing and the hotel is pretty fresh in terms of amenities "
United States
Shahid
$99 nightly
The price is $111
Jan 4 - Jan 5, 2026
Total with taxes and fees
Homewood Suites by Hilton Florence
Exterior
Staybridge Suites Florence - Civic Center by IHG

Staybridge Suites Florence - Civic Center by IHG

3.0 star property
Florence
9.4 out of 10, Exceptional, (921)
"Friendly staff, great breakfast, beautiful ammenities!"
United States
Brandi
$127 nightly
The price is $142
Dec 7 - Dec 8
Total with taxes and fees
Staybridge Suites Florence - Civic Center by IHG
Terrace/patio
Home2 Suites by Hilton Florence, SC

Home2 Suites by Hilton Florence, SC

3.0 star property
Florence
8.2 out of 10, Very Good, (1001)
"Clean room, good location, quick checkin"
United States
Brian
$103 nightly
The price is $116
Dec 14 - Dec 15
Total with taxes and fees
Home2 Suites by Hilton Florence, SC
View from property
Residence Inn Marriott Florence

Residence Inn Marriott Florence

3.0 star property
Florence
8.8 out of 10, Excellent, (467)
"Clean rooms and nice size suite area. "
United States
Yolanda
$95 nightly
The price is $107
Dec 14 - Dec 15
Total with taxes and fees
Residence Inn Marriott Florence
Fridge, microwave, oven, stovetop
Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's

Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's

Florence
10.0 out of 10, Exceptional, (35)
"It was absolutely beautiful and very clean! They provided everything one could think of to make the stay comfortable and enjoyable. I’m already looking forward to booking this place again next year. I highly recommend it! "
United States
Danielle G.
$233 nightly
The price is $261
Dec 8 - Dec 9
Total with taxes and fees
Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's
Interior
Creekside Country Cottage- minutes away from I-95

Creekside Country Cottage- minutes away from I-95

Manning
10.0 out of 10, Exceptional, (9)
"Great place beautiful and the dogs loved it"
United States
Jennifer T.
$394 nightly
The price is $437
Dec 8 - Dec 9
Total with taxes and fees
Creekside Country Cottage- minutes away from I-95
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Why book an extended stay hotel in Lake City through Expedia?
Lock in your extended stay hotel in Lake City through Expedia and get ready to save. In addition to our exclusive member offers and reward programs, we make finding the perfect long-term stay a piece of cake. Use our filter tool to search for accommodations based on location, ratings, nearby attractions and more. Some long-term rentals may offer weekly rates to help you keep extra money in your pocket. Usually equipped with many of the comforts of home like a laundry and kitchen, your next extended stay in Lake City is just a few clicks away!
What can I expect from an extended stay hotel?
With amenities such as kitchens, laundries and dining spaces, extended stay hotels in Lake City can be a comfortable and less expensive alternative to your standard property. Whip up delicious meals for your family and save money at the laundromat. Sometimes offering weekly rates, extended stay hotels range from modest studios to luxurious and spacious options with two or more bedrooms. They also have many of the same amenities you'd find in a standard hotel, like housekeeping or 24/7 guest services. If you're searching for flexibility, privacy and a relaxing retreat for a while, an extended stay hotel is a terrific choice.

Top Lake City Hotel Reviews

Hampton Inn & Suites Florence Center

Hampton Inn & Suites Florence Center

10/10 Excellent
"Very friendly and responsive staff. Very clean and comfortable room. Would definitely stay there again when we pass this way. "
Maggie 1-night trip
Posted 2 days ago
Hampton Inn & Suites Florence Center

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