Title: Lake City Vacation Rentals from $195: Search Short-Term Rentals | Expedia.com

[Lake City Travel Guide](https://expedia.com/Lake-City.dx8506)[Hotels in Lake City](https://expedia.com/Lake-City-Hotels.d8506.Travel-Guide-Hotels)[Flights to Lake City](https://expedia.com/Cheap-Flights-To-Lake-City.d8506.Travel-Guide-Flights)[Car Rentals in Lake City](https://expedia.com/Car-Rentals-In-Lake-City.d8506.Car-Rental-Guide)[Lake City Vacation Packages](https://expedia.com/Lake-City.d8506.Destination-Travel-Guides)

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## Check prices for these dates

In two weeks

[Mar 27 - Mar 29](https://www.expedia.com/Hotel-Search?regionId=8506&startDate=2026-03-27&endDate=2026-03-29&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[May 8 - May 10](https://www.expedia.com/Hotel-Search?regionId=8506&startDate=2026-05-08&endDate=2026-05-10&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[Jun 5 - Jun 7](https://www.expedia.com/Hotel-Search?regionId=8506&startDate=2026-06-05&endDate=2026-06-07&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[Jul 3 - Jul 5](https://www.expedia.com/Hotel-Search?regionId=8506&startDate=2026-07-03&endDate=2026-07-05&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Lake City vacation rentals

![Interior](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/c148491e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, books, printers](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/e827b164.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, books, printers](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/24f777ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/d862c686.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Florence

[](https://www.expedia.com/Florence-Hotels-Walking-Distance-From-One-Of-South-Carolinas-Top-Medical-Centers.h79668437.Hotel-Information)

9.8/10

Exceptional

(45 reviews)

"Everything was great!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Debra B.

$175 nightly

$195 total

Mar 11 - Mar 12

Total with taxes and fees

[](https://www.expedia.com/Florence-Hotels-Walking-Distance-From-One-Of-South-Carolinas-Top-Medical-Centers.h79668437.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/e85ce030.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/78ec87e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, iron/ironing board, travel crib, WiFi](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/de384ec0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/c362269a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Florence

[](https://www.expedia.com/Florence-Hotels-Take-A-Rest-In-Florence-Ideal-For-I95-Traveler-And-Florence-Center-And-Buc-Ees.h103861731.Hotel-Information)

10/10

Exceptional

(47 reviews)

"I would definitely stay again! Great location."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

LaDara D.

$260 nightly

$291 total

Mar 11 - Mar 12

Total with taxes and fees

[](https://www.expedia.com/Florence-Hotels-Take-A-Rest-In-Florence-Ideal-For-I95-Traveler-And-Florence-Center-And-Buc-Ees.h103861731.Hotel-Information)

![Dining](https://images.trvl-media.com/lodging/124000000/123130000/123127500/123127484/c3d44dee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/124000000/123130000/123127500/123127484/93bab7ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/124000000/123130000/123127500/123127484/5d047f8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/124000000/123130000/123127500/123127484/25419117.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Florence

[](https://www.expedia.com/Florence-Hotels-Charming-3-Bedroom.h123127484.Hotel-Information)

8.8/10

Excellent

(3 reviews)

"Convenient location"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Bonney W.

$458 nightly

$513 total

Mar 11 - Mar 12

Total with taxes and fees

[](https://www.expedia.com/Florence-Hotels-Charming-3-Bedroom.h123127484.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/84000000/83970000/83966800/83966776/81b1f193.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/84000000/83970000/83966800/83966776/befd5d8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/84000000/83970000/83966800/83966776/6be5fea4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/84000000/83970000/83966800/83966776/a2a22dc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cottage in Manning

[](https://www.expedia.com/Manning-Hotels-Creekside-Country-Cottage-Minutes-Away-From-I-95.h83966776.Hotel-Information)

10/10

Exceptional

(9 reviews)

"Great place beautiful and the dogs loved it"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jennifer T.

$394 nightly

$437 total

Mar 11 - Mar 12

Total with taxes and fees

[](https://www.expedia.com/Manning-Hotels-Creekside-Country-Cottage-Minutes-Away-From-I-95.h83966776.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.com/Hotel-Search?startDate=2026-03-24&endDate=2026-03-25&regionId=8506&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

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## 

The Annual Vacation Sale

Members save up to 40% on hotels and homes. Plan this year’s big trip and save.

[Book now](https://expedia.com/deals?rfrr=VR_SPRING_PROMO_8506)

## Find vacation rentals that suit your style

Cottages

[](https://www.expedia.com/Hotel-Search?destination=Lake+City%2C+South+Carolina%2C+United+States+of+America&regionId=8506&latLong=33.872719%2C-79.754379&adults=2&startDate=2026-06-08&d1=2026-06-08&endDate=2026-06-11&d2=2026-06-11&lodging=COTTAGE)

Private vacation homes

[](https://www.expedia.com/Hotel-Search?destination=Lake+City%2C+South+Carolina%2C+United+States+of+America&regionId=8506&latLong=33.872719%2C-79.754379&adults=2&startDate=2026-06-08&d1=2026-06-08&endDate=2026-06-11&d2=2026-06-11&lodging=VACATION_HOME)

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## Top Lake City Hotel Reviews

![Quality Inn & Suites Florence Civic Center](https://images.trvl-media.com/lodging/1000000/20000/11600/11535/8dae8685_y.jpg)

### Quality Inn & Suites Florence Civic Center

8/10 Good

"Clean, quiet and safe location to spend the night. "

[](https://expedia.com/Florence-Hotels-Quality-Inn-And-Suites-Civic.h11535.Hotel-Information)

![TownePlace Suites by Marriott Florence](https://images.trvl-media.com/lodging/11000000/10630000/10620800/10620701/cd925f1d_y.jpg)

### TownePlace Suites by Marriott Florence

10/10 Excellent

"Pretty good "

[](https://expedia.com/Florence-Hotels-TownePlace-Suites-By-Marriott-Florence.h10620701.Hotel-Information)

![Days Inn by Wyndham Florence Near Civic Center](https://images.trvl-media.com/lodging/1000000/20000/11800/11724/1b5fb4c0_y.jpg)

### Days Inn by Wyndham Florence Near Civic Center

6/10 Okay

"Clean room, nice staff. Tv didn't work, very noisy upstairs neighbor. Front desk did not answer room phone call or call from cell. Tried multiple times. "

[](https://expedia.com/Florence-Hotels-Days-Inn-By-Wyndham-Florence-Near-Civic-Center.h11724.Hotel-Information)

![Staybridge Suites Florence - Civic Center by IHG](https://images.trvl-media.com/lodging/22000000/21760000/21758600/21758593/89338f8a_y.jpg)

### Staybridge Suites Florence - Civic Center by IHG

10/10 Excellent

"Nice room and great breakfast "

[](https://expedia.com/Florence-Hotels-Staybridge-Suites-Florence-Civic-Center.h21758593.Hotel-Information)

![Hilton Garden Inn Florence](https://images.trvl-media.com/lodging/2000000/1370000/1367300/1367205/ddbd2495_y.jpg)

### Hilton Garden Inn Florence

10/10 Excellent

"Very nice stay. Very clean hotel"

[](https://expedia.com/Florence-Hotels-Hilton-Garden-Inn-Florence.h1367205.Hotel-Information)

![Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG](https://images.trvl-media.com/lodging/2000000/1510000/1509700/1509674/9c0353ec_y.jpg)

### Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG

8/10 Good

"Good location easy accessible parking."

[](https://expedia.com/Florence-Hotels-Holiday-Inn-Ex-Hotel-Suites-Florence-I-95-I-20-Civic-Ctr.h1509674.Hotel-Information)

![Fairfield Inn & Suites by Marriott Florence I-20](https://images.trvl-media.com/lodging/18000000/17040000/17036000/17035960/5dc20640_y.jpg)

### Fairfield Inn & Suites by Marriott Florence I-20

10/10 Excellent

"Great stay, will stay again👏👍"

[](https://expedia.com/Florence-Hotels-Fairfield-Inn-Suites-By-Marriott-Florence-I-20.h17035960.Hotel-Information)

![Comfort Inn & Suites Florence Center Area](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/64840011_y.jpg)

### Comfort Inn & Suites Florence Center Area

8/10 Good

"At 8am breakfast was missing many items. Oatmeal low and no sugar or cinnamon etc. no yogurt. Granted it was a full hotel but planning for capacity seemed amiss. "

[](https://expedia.com/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information)

![SpringHill Suites by Marriott Florence](https://images.trvl-media.com/lodging/1000000/980000/975000/974962/bad3cc5c_y.jpg)

### SpringHill Suites by Marriott Florence

4/10 Poor

"Room furniture and bedding were old and untidy."

[](https://expedia.com/Florence-Hotels-SpringHill-Suites-By-Marriott-Florence.h974962.Hotel-Information)

## Find out more about Lake City

**Everything you need to know about Lake City vacation rentals**

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Lake City vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Lake City vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

**Lake City vacation rentals: An excellent choice for every season**

Whenever you want to travel, a warm welcome awaits you in Lake City. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Lake City in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $195 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

**How to find incredible deals on Lake City rentals**

At Expedia, we put the best Lake City vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Lake City rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Lake City vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Lake City. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

## Explore a world of travel with Expedia

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- [Vacation Homes in Lake City ](https://expedia.com/Lake-City-Private-Vacation-Homes.d8506-aaPrivateVacationHomes.Travel-Guide-Accommodation)
- [Cottages in Lake City ](https://expedia.com/Lake-City-Cottages.d8506-aaCottages.Travel-Guide-Accommodation)
- [Motels in Lake City ](https://expedia.com/Lake-City-Motels.d8506-aaMotels.Travel-Guide-Accommodation)
- [Condo Rentals in Lake City ](https://expedia.com/Lake-City-Condos.d8506-aaCondos.Travel-Guide-Accommodation)
- [Cabin Rentals in Lake City ](https://expedia.com/Lake-City-Cabins.d8506-aaCabins.Travel-Guide-Accommodation)
- [Apartments in Lake City ](https://expedia.com/Lake-City-Apartments.d8506-aaApartments.Travel-Guide-Accommodation)
- [RV Parks in Lake City ](https://expedia.com/Lake-City-RV-Parks.d8506-aaRVParks.Travel-Guide-Accommodation)

## Frequently asked questions

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### What are some of the best vacation rentals that Lake City has to offer?

### What can I see and do in Lake City?

### What are vacation rentals like in Lake City?

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Hotels

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- [Hotels in North Myrtle Beach](https://expedia.com/North-Myrtle-Beach-Hotels.d8929.Travel-Guide-Hotels)
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- [Hotels in Columbia](https://expedia.com/Columbia-Hotels.d764.Travel-Guide-Hotels)
- [Hotels in Florence](https://expedia.com/Florence-Hotels.d1221.Travel-Guide-Hotels)
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Flights

- [Flights to Columbia](https://expedia.com/Cheap-Flights-To-Columbia.d764.Travel-Guide-Flights)
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- [Flights to Myrtle Beach](https://expedia.com/Cheap-Flights-To-Myrtle-Beach.d601685.Travel-Guide-Flights)

Cars

- [Car rentals in Columbia](https://expedia.com/Car-Rentals-In-Columbia.d764.Car-Rental-Guide)
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- [Car rentals in Greenville](https://expedia.com/Car-Rentals-In-Greenville.d1388.Car-Rental-Guide)

Cruises

- [Cruises from Charleston](https://expedia.com/Cruises-from-Charleston.d179997.Cruise-Departure-Port)

Activities

- [Things to do in Myrtle Beach](https://expedia.com/Things-To-Do-In-Myrtle-Beach.d601685.Travel-Guide-Activities)

Packages

- [Myrtle Beach Vacation](https://expedia.com/Myrtle-Beach.d601685.Destination-Travel-Guides)

Vacation Rentals

- [Myrtle Beach Vacation Rentals](https://expedia.com/Myrtle-Beach-Vacation-Rentals.d601685.Travel-Guide-VacationRentals)

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