Lake City Vacation Rentals

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Check prices for these dates

In two weeks
Feb 6 - Feb 8
In two months
Mar 20 - Mar 22
In three months
Apr 17 - Apr 19
In four months
May 15 - May 17

Our top choices for Lake City vacation rentals

Dining

Charming 3-bedroom, 2.5 bath townhome. Largest with accommodations in Florence.

Charming 3-bedroom, 2.5 bath townhome. Largest with accommodations in Florence.
Florence
9.0 out of 10, Wonderful, (2 reviews)
"Beautiful home and had all the amenities just like home. It was my home away from home."
United States
Yvette M.
$416 nightly
The price is $466
Jan 27 - Jan 28
Total with taxes and fees
Charming 3-bedroom, 2.5 bath townhome. Largest with accommodations in Florence.
Interior

Walking distance from one of South Carolina's top Medical centers.

Walking distance from one of South Carolina's top Medical centers.
Florence
9.8 out of 10, Exceptional, (42 reviews)
"The house was beautiful. We would stay there again!!"
United States
Stephanie L.
$207 nightly
The price is $232
Jan 26 - Jan 27
Total with taxes and fees
Walking distance from one of South Carolina's top Medical centers.
Fridge, microwave, oven, stovetop

Creekside Country Cottage- minutes away from I-95

Creekside Country Cottage- minutes away from I-95
Manning
10.0 out of 10, Exceptional, (9 reviews)
"Great place beautiful and the dogs loved it"
United States
Jennifer T.
$384 nightly
The price is $426
Jan 26 - Jan 27
Total with taxes and fees
Creekside Country Cottage- minutes away from I-95
Interior

Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's

Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's
Florence
10.0 out of 10, Exceptional, (39 reviews)
"I would definitely stay again! Great location."
United States
LaDara D.
$229 nightly
The price is $257
Jan 26 - Jan 27
Total with taxes and fees
Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Lake City Hotel Reviews

Days Inn by Wyndham Lake City

Days Inn by Wyndham Lake City

10/10 Excellent
"My room was very clean and comfortable the air-conditioning was great the heat worked very nice also. The staff were very nice and pleasant to talk to. I will definitely stay here when ever I am working in the area "
Robert 2-night trip
Posted 2 days ago
Days Inn by Wyndham Lake City

Find out more about Lake City

Everything you need to know about Lake City vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Lake City vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Lake City vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Lake City vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Lake City. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Lake City in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $230 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Lake City rentals

At Expedia, we put the best Lake City vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Lake City rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Lake City vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Lake City. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia

Frequently asked questions

Can I find a vacation rental in Lake City?

Yes, we offer vacation rentals in Lake City near Moore Farms Botanical Garden, or you can choose a secluded option if you want a relaxing stay. Visitors to Lake City speak positively about the lakeside and restaurants in this destination. Make sure you have time to check out the shopping and parks during your trip.

What are some of the best vacation rentals that Lake City has to offer?

Walking distance from one of South Carolina's top Medical centers.: This vacation home rental outside of Lake City offers a garden, a selection of games, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family.

What can I see and do in Lake City?

Lions Park and Moore Farms Botanical Garden are a couple of lovely local spots to get outside and enjoy nature. The Country Club at Lake City and Lynches Lake Historical Society are other places to visit while you're in town.

What are vacation rentals like in Lake City?

Vacation rentals are private properties you can stay in for a couple days or more in Lake City. Vacation rentals feature amenities such as WiFi and washers and dryers so your stay will be comfortable. If you're concerned about a clean environment, vacation rentals can offer a sense of seclusion away from public hotel elevators and bustling concierge desks while still allowing you the excitement and enjoyment of travel. You'll also have more space in a vacation rental than in a traditional hotel, which is another reason why a vacation rental is a great choice for family trips or small group gatherings.