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Lake City Vacation Rentals

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Check prices for these dates

In two weeks
Jul 3 - Jul 5
In two months
Aug 14 - Aug 16
In three months
Sep 11 - Sep 13
In four months
Oct 9 - Oct 11

Our top choices for Lake City vacation rentals

TV, fireplace

Come Stay A While

Come Stay A While
Florence
10.0 out of 10, Exceptional, (2 reviews)
"Will definitely stay here again. Host was very responsive and allowed me to check in early. Beautiful spacious home !"
United States
Aaliyah M.
$203 nightly
The price is $227
Jun 23 - Jun 24
Total with taxes and fees
Come Stay A While
Interior

Walking distance from one of South Carolina's top Medical centers.

Walking distance from one of South Carolina's top Medical centers.
Florence
9.8 out of 10, Exceptional, (53 reviews)
"Our third time staying at this home and always have had a great experience. Such a comfy home and very well stocked. Great hosts!"
United States
Kelly W.
$205 nightly
The price is $230
Jun 23 - Jun 24
Total with taxes and fees
Walking distance from one of South Carolina's top Medical centers.
Interior

Wonderful 2-bedroom house charming ranch style home

Wonderful 2-bedroom house charming ranch style home
Florence
$151 nightly
The price is $169
Jun 23 - Jun 24
Total with taxes and fees
Wonderful 2-bedroom house charming ranch style home
Dining

Charming 3-bedroom, 2.5 bath townhome. Largest with accommodations in Florence.

Charming 3-bedroom, 2.5 bath townhome. Largest with accommodations in Florence.
Florence
8.6 out of 10, Excellent, (4 reviews)
"Convenient location"
United States
Bonney W.
$456 nightly
The price is $511
Jun 26 - Jun 27
Total with taxes and fees
Charming 3-bedroom, 2.5 bath townhome. Largest with accommodations in Florence.
Fridge, microwave, oven, stovetop

Creekside Country Cottage- minutes away from I-95

Creekside Country Cottage- minutes away from I-95
Manning
10.0 out of 10, Exceptional, (9 reviews)
"Great place beautiful and the dogs loved it"
United States
Jennifer T.
$383 nightly
The price is $425
Jun 23 - Jun 24
Total with taxes and fees
Creekside Country Cottage- minutes away from I-95
Interior

Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's

Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's
Florence
10.0 out of 10, Exceptional, (55 reviews)
"Great place, always clean and a top notch stay!"
United States
K H.
$247 nightly
The price is $276
Jul 9 - Jul 10
Total with taxes and fees
Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Lake City Hotel Reviews

Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

8/10 Good
"The room was very nice considering a pet was expected."
Barbara 1-night trip
Posted 2 hours ago
Quality Inn & Suites Florence Civic Center

Find out more about Lake City

Everything you need to know about Lake City vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Lake City vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Lake City vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Lake City vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Lake City. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Lake City in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $169 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Lake City rentals

At Expedia, we put the best Lake City vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Lake City rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Lake City vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Lake City. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia

Frequently asked questions

Can I find a vacation rental in Lake City?

Yes, we offer vacation rentals in Lake City near Moore Farms Botanical Garden, or you can choose a secluded option if you want a relaxing stay. Visitors to Lake City speak positively about the lakeside and restaurants in this destination. Make sure you have time to check out the shopping and parks during your trip.

What are some of the best vacation rentals that Lake City has to offer?

Charming 3-bedroom, 2.5 bath townhome. Largest with accommodations in Florence.: This vacation home rental outside of Lake City has air-conditioning and laundry facilities to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop.

What can I see and do in Lake City?

Moore Farms Botanical Garden and Lions Park are a couple of lovely local spots to get outside and enjoy nature. Lynches Lake Historical Society and The Bean Market are other places to visit while you're in town.

What are vacation rentals like in Lake City?

Vacation rentals are private properties you can stay in for a couple days or more in Lake City. Vacation rentals feature amenities such as WiFi and washers and dryers so your stay will be comfortable. If you're concerned about a clean environment, vacation rentals can offer a sense of seclusion away from public hotel elevators and bustling concierge desks while still allowing you the excitement and enjoyment of travel. You'll also have more space in a vacation rental than in a traditional hotel, which is another reason why a vacation rental is a great choice for family trips or small group gatherings.