Lake City Vacation Rentals

Start date: Check-in selected.
To Date
End date: Check-out

Check prices for these dates

Our top choices for Lake City vacation rentals

Vacation Home in Florence

10.0 out of 10, Exceptional, (35)
"Perfect stay for our family wedding weekend!! Home was immaculate and a perfect layout! Host has thought of everything you may need during your stay from extra linens to a fully stocked kitchen. Awesome location and super nice neighborhood!"
United States
Cathy D.
$281 nightly
The price is $315
Dec 23 - Dec 24
Total with taxes and fees
Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's

Vacation Home in Florence

9.6 out of 10, Exceptional, (19)
"This was a very nice property and very comfortable. We enjoyed our stay there."
United States
Gary B.
Pineapple House: Historic. Southern Charm. Walk Downtown.

Cabin in Florence

2.0 star property
Charming 1-bedroom cabin in welcoming Florence with AC and heating

Vacation Home in Florence

9.8 out of 10, Exceptional, (42)
"The house was beautiful. We would stay there again!!"
United States
Stephanie L.
$206 nightly
The price is $231
Dec 11 - Dec 12
Total with taxes and fees
Walking distance from one of South Carolina's top Medical centers.

Vacation Home in Timmonsville

9.6 out of 10, Exceptional, (9)
"Great property for a guys weekend. Matthew was very responsive with questions I had. I would absolutely stay here again. "
United States
Frank V.
Great Home in the Greater Florence Area

Cottage in Manning

10.0 out of 10, Exceptional, (9)
"Great place beautiful and the dogs loved it"
United States
Jennifer T.
$394 nightly
The price is $437
Dec 10 - Dec 11
Total with taxes and fees
Creekside Country Cottage- minutes away from I-95

Mobile Home in Florence

10.0 out of 10, Exceptional, (1)
"We had a great stay for a quick weekend wedding. "
United States
John D.
3-bedroom mobile home in peaceful Florence with AC, WiFi

Vacation Home in Florence

9.8 out of 10, Exceptional, (6)
"Everything about this location was great and the host was very kind. Thank you for making our stay comfortable. "
United States
Shatia G.
Charming and Cozy 4BR 2BA House with Parking, Minutes from I-95 and Buc-ees

Cabin in Florence

10.0 out of 10, Exceptional, (1)
"Great location and property."
United States
Jerry W.
Family Retreat for vacations, weddings, family reunions and corporate retreats.

Vacation Home in Cades

Relaxing 3-Bedroom Getaway in Peaceful Cades – Sleeps 8

Vacation Home in Florence

9.6 out of 10, Exceptional, (19)
"This home was perfect for our family. Would definitely recommend to anyone looking for a place to stay in the Florence area. "
United States
Bryan B.
Hickory Haven 3Br Elegant Downtown Hidden Gem

Cottage in Florence

3.0 star property
3-story Home w/ Private Backyard in Florence!

Vacation Home in Florence

2.0 star property
8.0 out of 10, Very Good, (1)
"Tracey was very accomodating given our last minute request since a previous host had cancelled on us the day before our trip. However, the home was not clean upon arrival and one of the hosts had to fix a breaker, a chirping smoke detector, and bring us towels. He pointed out the newly water damaged ceilings as well. "
United States
Emily S.
Charming 3-bedroom, 2.5 bath townhome. Largest with accommodations in Florence.

Vacation Home in Florence

8.0 out of 10, Very Good, (1)
"Property was clean and inviting. The only issue we had was the ac wasnt cool enough for us. (We work outside)"
United States
Ben P.
Charming 3-bedroom house in Florence, SC

Vacation Home in Florence

8.0 out of 10, Very Good, (1)
"We came to visit my godchild and enjoyed visiting with his family. This home is a beautiful house and with it being a fairly new listing it had some hiccups that could be work on, but other then that the neighborhood is quite"
United States
Nikki R.
Elegant Historic Home w/ Modern Touch in Florence

Vacation Home in Kingstree

Charming 1-bedroom house in awesome Kingstree with AC, WiFi

Vacation Home in Florence

9.0 out of 10, Wonderful, (2)
"We needed a place to stay, close to a wedding venue and this house was Perfect for our large family. Very clean, roomy, and well stocked. Zilola was so nice and quick to respond."
United States
Minette E.
Luxury stay at 4 bedroom house

Condo in Florence County

9.0 out of 10, Wonderful, (10)
"Great place to stay and work from home and great tv for movie nights!"
United States
Tj R.
Cozy Work Friendly Condo in Florence

Camping in Kingstree

Camping it is!

Vacation Home in Florence

Cozy Retreat in Florence, SC
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top Lake City Hotel Reviews

Find out more about Lake City

Everything you need to know about Lake City vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Lake City vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Lake City vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Lake City vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Lake City. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Lake City in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $231 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Lake City rentals

At Expedia, we put the best Lake City vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Lake City rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Lake City vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Lake City. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently asked questions

Can I find a vacation rental in Lake City?

Yes, we offer vacation rentals in Lake City near Moore Farms Botanical Garden, or you can choose a secluded option if you want a relaxing stay. Visitors to Lake City speak positively about the lakeside and restaurants in this destination. Make sure you have time to check out the shopping and parks during your trip.

What are some of the best vacation rentals that Lake City has to offer?

Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's: This vacation home rental outside of Lake City offers a fireplace, a patio, and air-conditioning to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Make the most of the garden in this rental home to help you unwind.

What can I see and do in Lake City?

Lions Park and Ronald E. McNair Life History Center are a couple of lovely local spots to get outside and enjoy nature. The Country Club at Lake City and Lynches Lake Historical Society are other places to visit while you're in town.

What are vacation rentals like in Lake City?

Vacation rentals are private properties you can stay in for a couple days or more in Lake City. Vacation rentals feature amenities such as WiFi and washers and dryers so your stay will be comfortable. If you're concerned about a clean environment, vacation rentals can offer a sense of seclusion away from public hotel elevators and bustling concierge desks while still allowing you the excitement and enjoyment of travel. You'll also have more space in a vacation rental than in a traditional hotel, which is another reason why a vacation rental is a great choice for family trips or small group gatherings.