Visit Pamplico: 2026 Travel Guide for Pamplico, South Carolina

Park Inn by Radisson Florence, SC

1729 Mandeville Road Florence SC

$89 nightly

$100 total

Oct 4 - Oct 5

Total with taxes and fees

Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...

9/10 Wonderful! (2,442 reviews)

"All was great! Stayed here last week and decided to come back again this week. We travel a lot and that’s the first time we stayed in the same hotel two weeks in a row. Great place! Highly recommend staying here."

Reviewed on Sep 19, 2026

Howard Johnson by Wyndham Florence

2038 W Lucas Street Florence SC

$65 nightly

$72 total

Sep 21 - Sep 22

Total with taxes and fees

Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...

Quality Inn & Suites Florence Civic Center

150 Dunbarton Dr Florence SC

$89 nightly

$100 total

Sep 27 - Sep 28

Total with taxes and fees

Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...

8.4/10 Very Good! (375 reviews)

"The room and bathroom were clean. Bed was comfy and the room had everything needed. I didn't realize that room access was from the outside but I didn't pay attention when I booked the room so that's on me. Breakfast was good and everything was neat and clean . The AC in my room only worked correctly ..."

Reviewed on Sep 19, 2026

See all 172 properties in Pamplico

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hideaway Haven – A Private Retreat on 100 Acres

Marion SC

Stay at this cabin in Marion. Enjoy laundry facilities, patios, and cable/satellite TV service.

9.6/10 Exceptional! (186 reviews)

"This place is peaceful beyond measure. You won't wanna leave"

Reviewed on Sep 17, 2026

Charming Cottage with easy access to local attractions-pet and kid friendly

Sellers SC

Stay at this cottage in Sellers. Enjoy free WiFi, laundry facilities, and patios.

9.6/10 Exceptional! (30 reviews)

"Great communication! Such a cute place to stay!"

Reviewed on Sep 7, 2026

Stunning historic home w/ large rooms. Close to attractions. Kid & pet friendly!

Sellers SC

Book a stay at this family-friendly vacation home in Sellers. Enjoy free WiFi, breakfast (surcharge), and a garden.

9.8/10 Exceptional! (26 reviews)

"Beautiful historic home. It was clean and the host was very quick to respond when we messaged."

Reviewed on Sep 6, 2026

See all properties in Pamplico

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Frequently asked questions

When is the best time to visit Pamplico?

The best time to visit Pamplico is from July through September, when the destination is most popular. For travelers seeking fewer crowds and potentially better value, the quieter months of January through March offer a different experience, typically with cooler weather.

Can I book a refundable hotel in Pamplico?

Yes, Expedia offers many flexible booking options, and you can look for refundable hotels in Pamplico by entering your dates and using the refundable or fully refundable filter. Always check the hotel's cancellation policy before you book, since terms can vary by hotel, and visit Expedia help center for further details.

Why book a trip to Pamplico with Expedia?

Expedia makes it easier to plan your Pamplico trip with travel tools, flexible search options, and bookable trip components all in one place. You can organize your plans in one account and use Expedia to help build a trip that fits your budget and travel style. Find out more about how by visiting Expedia's Trip Planner page.

Should I stay in a hotel or vacation rental in Pamplico?

The best choice depends on your travel style. Hotels in Pamplico can be a good fit for convenience, on-site amenities, and shorter stays, while vacation rentals may offer more space, privacy, and home-style amenities for longer trips, families, or groups. With Expedia, you can compare both options side by side, read traveler reviews, and filter by amenities to find the right fit for your trip.

How can I manage my Pamplico trip on Expedia?

Once you've booked your Pamplico trip, you can manage it through your Expedia account or the Expedia app. You can view your itinerary, access booking details, make eligible changes, and check for updates in My Trips. The Expedia app can also help you stay organized while you travel.

What if I need help during my Pamplico trip?

Expedia offers customer support before, during, and after your Pamplico trip. If your plans change or something unexpected happens, you can review your booking in My Trips and use Expedia help center channels for help with eligible changes, cancellations, or travel issues.

How can Expedia help me plan my first trip to Pamplico?

If it's your first trip to Pamplico, Expedia can help you plan by bringing together stays, flights, activities, traveler reviews, and trip-planning tools in one place. With Expedia's Trip Planner you can compare options, read reviews from other travelers, and build an itinerary that matches your interests and budget.

How can I save on my Pamplico hotel booking with Expedia?

Join One Key™ for free to unlock instant discounts with Member Prices on select hotels. You can also earn and use OneKeyCash™* on eligible bookings on Expedia. Booking in advance is usually another great way to save on your Pamplico hotel.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.