Find Business Hotels in Picayune, MS

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Check availability on Picayune Business Hotels

Tonight
Dec 4 - Dec 5
Tomorrow
Dec 5 - Dec 6
This weekend
Dec 5 - Dec 7
Next weekend
Dec 12 - Dec 14

Top Picayune Business Hotels

Exterior
Quality Inn Slidell I-10

Quality Inn Slidell I-10

2.5 star property
Slidell
7.6 out of 10, Good, (267)
"Clean, Friendly staff, great location, Continental Breakfast, great property !"
United States
Lester
$59 nightly
The price is $69
Dec 11 - Dec 12
Total with taxes and fees
Quality Inn Slidell I-10
Front of property
Comfort Inn & Suites

Comfort Inn & Suites

3.0 star property
Slidell
8.6 out of 10, Excellent, (1000)
"Clean hotel "
United States
Karen A
$93 nightly
The price is $107
Dec 24 - Dec 25
Total with taxes and fees
Comfort Inn & Suites
Exterior
Microtel Inn & Suites by Wyndham Pearl River/Slidell

Microtel Inn & Suites by Wyndham Pearl River/Slidell

2.5 star property
Pearl River
8.0 out of 10, Very Good, (1002)
"Clean room, very nice staff. "
United States
Lisa
$63 nightly
The price is $74
Dec 7 - Dec 8
Total with taxes and fees
Microtel Inn & Suites by Wyndham Pearl River/Slidell
Exterior
Holiday Inn Express Picayune-Stennis Space Center by IHG

Holiday Inn Express Picayune-Stennis Space Center by IHG

2.5 star property
Picayune
9.0 out of 10, Wonderful, (640)
"Clean room staff was great air conditioning was super and breakfast was great "
United States
Haley
$95 nightly
The price is $104
Dec 15 - Dec 16
Total with taxes and fees
Holiday Inn Express Picayune-Stennis Space Center by IHG
In-room safe, desk, iron/ironing board, free WiFi
Super 8 by Wyndham Picayune

Super 8 by Wyndham Picayune

2.0 star property
Picayune
6.6 out of 10, (228)
"The property was dated but clean and was a good value for the cost, overall. However, neighbors on both sides of us had a party in the parking lot with LOUD music and laughter until 11 pm 2 of the 3 nights of our stay. The bed was clean but most uncomfortable. We probably will choose another hotel for our next stay."
United States
Melna
$47 nightly
The price is $51
Jan 2 - Jan 3, 2026
Total with taxes and fees
Super 8 by Wyndham Picayune
Pool
Econo Lodge Picayune

Econo Lodge Picayune

2.0 star property
Picayune
6.2 out of 10, (135)
"The staff was friendly and it was very quiet. The pool was not open and the room could really use updating."
United States
Heather
$66 nightly
The price is $72
Dec 26 - Dec 27
Total with taxes and fees
Econo Lodge Picayune
Lobby
Ramada by Wyndham Diamondhead I-10/Gulfport

Ramada by Wyndham Diamondhead I-10/Gulfport

2.5 star property
Diamondhead
8.0 out of 10, Very Good, (562)
"Nice stay it served its purpose."
United States
josh
$67 nightly
The price is $73
Dec 19 - Dec 20
Total with taxes and fees
Ramada by Wyndham Diamondhead I-10/Gulfport
Suite, 2 Queen Beds | In-room safe, desk, iron/ironing board, free cribs/infant beds
Holiday Inn Express Slidell by IHG

Holiday Inn Express Slidell by IHG

2.5 star property
Slidell
9.4 out of 10, Exceptional, (928)
"Room was so nice and staff was amazing "
United States
Sianna
$103 nightly
The price is $119
Dec 11 - Dec 12
Total with taxes and fees
Holiday Inn Express Slidell by IHG
Lobby sitting area
La Quinta Inn & Suites by Wyndham Slidell - North Shore Area

La Quinta Inn & Suites by Wyndham Slidell - North Shore Area

3.0 star property
Slidell
7.8 out of 10, Good, (1001)
"Room was clean! Staff was very friendly and helpful! We especially liked the lady in charge of breakfast! She was so attentive to everyone, trying to make sure everyone had what they needed! "
United States
Sandra
$72 nightly
The price is $84
Jan 4 - Jan 5, 2026
Total with taxes and fees
La Quinta Inn & Suites by Wyndham Slidell - North Shore Area
3 restaurants, breakfast, lunch, dinner served; seafood
Silver Slipper Casino & Hotel - Adults Only

Silver Slipper Casino & Hotel - Adults Only

3.5 star property
Bay St Louis
8.6 out of 10, Excellent, (1000)
"Rooms were clean. Great location. Staff friendly"
United States
Amy
$44 nightly
The price is $48
Dec 8 - Dec 9
Total with taxes and fees
Silver Slipper Casino & Hotel - Adults Only
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Picayune Hotel Reviews

Best Western Slidell Hotel

Best Western Slidell Hotel

10/10 Excellent
"The room was nice and clean and the staff was friendly "
margaret 1-night trip
Posted 2 days ago
Best Western Slidell Hotel

Frequently asked questions

How much do business-friendly hotels in Picayune cost?
Rates for business hotels in Picayune range between $48 and $119 per night. No matter your budget, Expedia can help you find the right place for a smooth work trip. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the best business-friendly hotels in Picayune?
Picayune has multiple business-friendly hotels with a total average guest review rating of 7.8. One of the most popular is Holiday Inn Express Picayune-Stennis Space Center, an IHG Hotel. Get the job done from this 2.5-stars option, which includes pool sun loungers and a swimming pool. Another favorite with corporate travelers is Heritage Inn Picayune. It has a 2-stars rating and amenities such as complimentary breakfast and front desk services.
How many business-friendly hotels are there in Picayune?
Picayune offers 4 hotels that accommodate corporate travelers. Whether you're searching for a central location or conveniences such as conference rooms and dependable WiFi, you'll find the perfect property on Expedia.
What are the top business-friendly motels in Picayune?
Super 8 by Wyndham Picayune perfectly combines work and play. A garden and a barbecue grill are among the many amenities at this business-friendly option, located around 2 miles northeast of the center of Picayune.You'll find plenty of things to see and experience around Picayune. Take time out from your work schedule to visit leading attractions like Millbrook Country Club and Crosby Arboretum.
Are there any family-friendly hotels in Picayune that are also business friendly?
Family travelers and corporate guests are well cared for at Holiday Inn Express Picayune-Stennis Space Center, an IHG Hotel. This popular 2.5-stars property in Picayune comes with a good range of amenities, such as complimentary breakfast and housekeeping services. Picayune has loads of family-friendly attractions to discover when you're done with work. Take the kids on an outing to Crosby Arboretum and Millbrook Country Club.
Why book your business-friendly hotel in Picayune with Expedia?
With amenities like conference rooms, room service and on-site cafés, our business-friendly properties come with all you'll need to get the job done — and then unwind! Enter your preferred travel dates and destination and Expedia will help you organize the rest.
How can I find cheap business-friendly hotels in Picayune?
When work takes you on the road in Picayune, our "business friendly" filter will help you find the right hotel. From free WiFi and included breakfast to meeting rooms and workspaces, they come with the amenities you need to be productive. Another tip? Narrow your search by your budget and preferred star rating to see the most affordable accommodations.
What is there to do in Picayune near my business-friendly hotel?
If you want to make the most of your downtime in Picayune, don't miss Millbrook Country Club. It's popular with travelers and locals alike.

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