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Discover Santa Maria hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

DC Suites Aeropuerto

3.0 star property
9.0 out of 10, Wonderful, (547)
"Staff was very friendly and had a quick check-in. Loved the cat in the lobby."
$31 nightly
The price is $32
Jul 20 - Jul 21
DC Suites Aeropuerto

Holiday Inn Guayaquil Airport by IHG

3.5 star property
9.2 out of 10, Wonderful, (1001)
"Great location "
$88 nightly
The price is $99
Aug 3 - Aug 4
Holiday Inn Guayaquil Airport by IHG

Hotel del Parque

4.5 star property
9.8 out of 10, Exceptional, (92)
"Beautiful overnight stay. Thoroughly enjoyed dinner at Casa Julian, the comfortable room, gym, breakfast and the airport shuttle service, as well as the environment in the historic park. Great service. "
$369 nightly
The price is $406
Jul 28 - Jul 29
Hotel del Parque

Wyndham Guayaquil Puerto Santa Ana

4.5 star property
9.2 out of 10, Wonderful, (1003)
"Restaurant have great menu and the "
$122 nightly
The price is $137
Jul 20 - Jul 21
Wyndham Guayaquil Puerto Santa Ana

TRYP by Wyndham Guayaquil Airport

4.5 star property
8.8 out of 10, Excellent, (1003)
"Friendly staff. "
$89 nightly
The price is $100
Jul 20 - Jul 21
TRYP by Wyndham Guayaquil Airport

Oro Verde Guayaquil

5.0 star property
9.4 out of 10, Exceptional, (1005)
"I love the hotel it’s so clean it smells delicious in all places even the pool, great staff and excellent environment super recommended "
$90 nightly
The price is $102
Aug 17 - Aug 18
Oro Verde Guayaquil

Hotel Puerto Pacifico Guayaquil Airport

4.0 star property
8.8 out of 10, Excellent, (197)
"Nice to stay "
$56 nightly
The price is $58
Aug 17 - Aug 18
Hotel Puerto Pacifico Guayaquil Airport

Wyndham Garden Guayaquil

3.5 star property
9.0 out of 10, Wonderful, (1004)
"Excellent location, friendly staff"
$75 nightly
The price is $84
Aug 11 - Aug 12
Wyndham Garden Guayaquil

Unipark by Oro Verde Hotels

4.0 star property
9.0 out of 10, Wonderful, (1001)
"Comfy fair price we like the mall attached to it ,very convenient…great breakfast "
$78 nightly
The price is $88
Aug 17 - Aug 18
Unipark by Oro Verde Hotels

Courtyard by Marriott Guayaquil

3.5 star property
9.0 out of 10, Wonderful, (1003)
"Excellent stay"
$60 nightly
The price is $67
Aug 8 - Aug 9
Courtyard by Marriott Guayaquil

Ibis Styles El Malecon Guayaquil

4.0 star property
9.4 out of 10, Exceptional, (222)
"This hotel is a good value for your money..."
$55 nightly
The price is $62
Aug 1 - Aug 2
Ibis Styles El Malecon Guayaquil

Sheraton Guayaquil Hotel

5.0 star property
9.0 out of 10, Wonderful, (560)
"I love that the property is clean, and you can walk to the Mall of the Sol, which is safe and offers a nice spa, pool, and Jacuzzi. "
$98 nightly
The price is $111
Aug 9 - Aug 10
Sheraton Guayaquil Hotel

Mansión del Río

3.5 star property
8.8 out of 10, Excellent, (124)
"Mansion del Rio is like staying in a museum. We had a great time. It was close to Malecon 2000 as well as the revitalized Santa Ana area along the river. Staff were great, and the breakfast was very good."
$50 nightly
The price is $55
Jul 20 - Jul 21
Mansión del Río

MundialCity Hotel Guayaquil

3.0 star property
8.4 out of 10, Very Good, (161)
"everything great "
MundialCity Hotel Guayaquil

Luxva Hotel Boutique

3.0 star property
9.4 out of 10, Exceptional, (156)
"Friendly staff. "
$60 nightly
The price is $61
Aug 18 - Aug 19
Luxva Hotel Boutique

Hotel Suites Guayaquil

2.5 star property
7.4 out of 10, Good, (58)
"It's a unique property, in the mid of historic old part of Quito. Like the vibe of the old city around the place. Nice layout and upper level dining area has a beautiful view of the city and the landmark Angel, thus the name of the business."
$45 nightly
The price is $45
Jul 20 - Jul 21
Hotel Suites Guayaquil

Hotel Palace Guayaquil

4.0 star property
9.2 out of 10, Wonderful, (881)
"Nice staff, clean room, good food "
$60 nightly
The price is $68
Jul 26 - Jul 27
Hotel Palace Guayaquil

Luxury Suites Riverfront GYE

3.5 star property
9.4 out of 10, Exceptional, (90)
"Beautiful view"
$101 nightly
The price is $102
Aug 2 - Aug 3
Luxury Suites Riverfront GYE

Grand Hotel Guayaquil, Ascend Hotel Collection

4.0 star property
9.2 out of 10, Wonderful, (915)
"Great location, clean, staff was wonderful!!! "
$81 nightly
The price is $90
Aug 2 - Aug 3
Grand Hotel Guayaquil, Ascend Hotel Collection

Hilton Colon Guayaquil

4.5 star property
8.6 out of 10, Excellent, (738)
"Very close to restaurant & stores."
$98 nightly
The price is $110
Aug 10 - Aug 11
Hilton Colon Guayaquil
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santa Maria

Find the best Santa Maria areas and neighborhoods for the activities you enjoy most.
Ecuador map

Ecuador

Though Ecuador might not have many top sights, you can venture to the surrounding area to see attractions like C.C. Riocentro Sur and Mall del Sur.

Downtown Guayaquil map

Downtown Guayaquil

Travelers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like Central Market and Sports Federation of Guayas while you're in town.

Puerto Santa Ana map

Puerto Santa Ana

Well-liked for its restaurants and river views, you might stop by Santa Ana Hill and La Perla while you're exploring Puerto Santa Ana and the surrounding neighborhoods.

Kennedy map

Kennedy

1 out of top 10 points of interest in this area

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or Policentro while you're exploring the area.

Urdesa map

Urdesa

Urdesa is well-liked for its restaurants. If you'd like to do some sightseeing in the greater Guayaquil area, you might plan a trip to Alban Borja Commercial Center or San Marino Mall.

Frequently asked questions

Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Santa Maria.
How can I save on a Santa Maria hotel booking with Expedia?
One Key™ - Expedia's free travel rewards program - gives you instant access to perks and Member Prices on Santa Maria hotels. Plus, you'll earn OneKeyCash™* on eligible bookings to use on future trips. Booking an Expedia hotel and flight package is another great way to save, where bundling can result in significant savings.

*OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a Santa Maria hotel?
Hotel prices in Santa Maria often vary, but you can find a great deal on Expedia. Different factors affect nightly hotel rates, such as the time of year or the days of the week you want to book. To find the best deals for your stay, be flexible with your dates, and sort search results by "Price: low to high" for our cheapest rates.