$159 Cheap American Airlines flights Charlotte (CLT) to Knoxville (TYS)

Make use of the "Price (lowest to highest)" filter on Expedia to look for cheap American Airlines round-trip flights from $388 from CLT to TYS. Affordable one-way fares from $159 are available too.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Look for cheap American Airlines flights from Charlotte-Douglas Intl. Airport (CLT) to McGhee Tyson Airport (TYS) one to three months before your departure date. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. Regardless of fare class and journey, the ideal day to book a domestic flight is generally Sunday and the most expensive day tends to be Monday. Passengers who book on a Sunday can save 6% on average compared to those who book on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

The earliest American Airlines flight from CLT to TYS takes off at 9:06AM UTC-5, landing at 10:36AM UTC-5. If you'd like to jet off later in the day, the last American Airlines flight leaves CLT at 10:44PM UTC-5 and lands at TYS at 11:58PM UTC-5. Flying early is generally a good option as morning flights are less likely to be canceled.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.