$966 Cheap American Airlines flights Düsseldorf (DUS) to Knoxville (TYS)

Grab affordable round-trip American Airlines flights from DUS to TYS by sorting your results from "Price (lowest to highest)" on Expedia. Or look for deals from $966 for a one-way trip.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Look for American Airlines flights from DUS to TYS about one month before you want to go. The most affordable time to book an international flight is generally 18 to 29 days ahead of your travel date when you can save 17% versus booking four to five months in advance. No matter your itinerary or fare class, the best day of the week to book international airfare is usually Sunday. Friday is often the most expensive. Passengers who book on a Sunday can save 17% on average compared to those who book on a Friday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

To find the earliest departure from DUS to TYS with American Airlines, sort your results by "Morning" and "Early Morning." Choosing an early flight generally means cancellations are less likely.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.