$154 Cheap American Airlines flights Chicago (ORD) to Knoxville (TYS)

Finding cheap one-way American Airlines flights from ORD to TYS from $154 on Expedia is a breeze — just filter by "Price (lowest to highest)." Or check out our budget-friendly return fares from $189 for your next getaway.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Search for affordable American Airlines flights from O'Hare Intl. Airport (ORD) to McGhee Tyson Airport (TYS) one to three months ahead of your day of departure. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. Regardless of fare class and itinerary, the ideal day to book a domestic flight is generally Sunday and the most expensive day tends to be Monday. Passengers who book on a Sunday can save 6% on average compared to those who book on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

The earliest flight from ORD to TYS with American Airlines departs at 8:30AM UTC-6. You'll land at 11:14AM UTC-5. The final American Airlines flight of the day leaves at 3:40PM UTC-6 and arrives at 6:21PM UTC-5. With approximately 20% fewer cancellations for morning and mid-morning departures, starting your travel day early is typically the smartest option.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.