$452 Cheap American Airlines flights Charlotte (CLT) to Florence (FLR)

Use the "Price (lowest to highest)" filter on Expedia to find cheap American Airlines round-trip flights from $627 from CLT to FLR. Affordable one-way options from $452 are also available.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Snagging the best American Airlines deals from CLT to FLR often comes down to booking at the right moment. You can save 17% on international flights when you book 18 to 29 days before takeoff instead of four to five months ahead. Better still, you can pocket 17% on average by buying your tickets on a Sunday rather than a Friday, which is usually the most expensive day to book.* It's a good idea to start searching for flights about one month before your travel dates.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Sort your results by "Morning" and "Early Morning" to see the earliest departures from CLT to FLR. Jetting off early means you're less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.